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Biomarkers for oralization during long-term proton pump inhibitor therapy predict survival in cirrhosis.

Horvath A, Rainer F, Bashir M, Leber B, Schmerboeck B, Klymiuk I, Groselj-Strele A, Durdevic M, Freedberg DE, Abrams JA, Fickert P, Stiegler P, Stadlbauer V.

Sci Rep. 2019 Aug 19;9(1):12000. doi: 10.1038/s41598-019-48352-5.


Dietary glycine decreases both tumor volume and vascularization in a combined colorectal liver metastasis and chemotherapy model.

Maneikyte J, Bausys A, Leber B, Horvath A, Feldbacher N, Hoefler G, Strupas K, Stiegler P, Schemmer P.

Int J Biol Sci. 2019 Jun 4;15(8):1582-1590. doi: 10.7150/ijbs.35513. eCollection 2019.


Safety and efficacy findings from the open-label, multicenter, phase 3b, expanded treatment protocol study of ruxolitinib for treatment of patients with polycythemia vera who are resistant/intolerant to hydroxyurea and for whom no alternative treatments are available.

Foltz L, Pica GM, Zerazhi H, Van Droogenbroeck J, Visanica S, Báez de la Fuente E, Leber B, de Almeida AM, Ranta D, Kiladjian JJ, Chrit L, Kandra A, Morando J, Devos T.

Leuk Lymphoma. 2019 Jul 30:1-10. doi: 10.1080/10428194.2019.1636985. [Epub ahead of print]


Author Correction: Structural and functional differences in gut microbiome composition in patients undergoing haemodialysis or peritoneal dialysis.

Stadlbauer V, Horvath A, Ribitsch W, Schmerböck B, Schilcher G, Lemesch S, Stiegler P, Rosenkranz AR, Fickert P, Leber B.

Sci Rep. 2019 Jun 6;9(1):8522. doi: 10.1038/s41598-019-43263-x.


Diethylnitrosamine (DENA) recapitulates formation of hepatic angiosarcoma in pigs.

Kessler SM, Leber B, Hoppstädter J, Golob-Schwarzl N, Hofer EM, Schultheiss CS, Mischinger HJ, Liegl-Atzwanger B, Lackner C, Stiegler P, Haybaeck J.

PLoS One. 2019 May 16;14(5):e0214756. doi: 10.1371/journal.pone.0214756. eCollection 2019.


Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2.

Liu Q, Osterlund EJ, Chi X, Pogmore J, Leber B, Andrews DW.

Elife. 2019 Mar 12;8. pii: e37689. doi: 10.7554/eLife.37689.


A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers.

Stadlbauer V, Horvath A, Komarova I, Schmerboeck B, Feldbacher N, Wurm S, Klymiuk I, Durdevic M, Rainer F, Blesl A, Stryeck S, Madl T, Stiegler P, Leber B.

PLoS One. 2019 Feb 1;14(2):e0211703. doi: 10.1371/journal.pone.0211703. eCollection 2019.


Dysbiosis in early sepsis can be modulated by a multispecies probiotic: a randomised controlled pilot trial.

Stadlbauer V, Horvath A, Komarova I, Schmerboeck B, Feldbacher N, Klymiuk I, Durdevic M, Rainer F, Blesl A, Stiegler P, Leber B.

Benef Microbes. 2019 Apr 19;10(3):265-278. doi: 10.3920/BM2018.0067. Epub 2019 Jan 29.


Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove.

Leber B, Kale J, Andrews DW.

Cancer Discov. 2018 Dec;8(12):1511-1514. doi: 10.1158/2159-8290.CD-18-1167.


Hand Mirror Cells and Hypercalcemia: A Rare Presentation of Pediatric Acute Lymphoblastic Leukemia.

Cacciotti C, Leber B, Cox S, Arredondo J, Bassilious E, Athale U.

J Pediatr Hematol Oncol. 2018 Nov 20. doi: 10.1097/MPH.0000000000001352. [Epub ahead of print]


Impact of Melatonin in Solid Organ Transplantation-Is It Time for Clinical Trials? A Comprehensive Review.

Stiegler P, Bausys A, Leber B, Strupas K, Schemmer P.

Int J Mol Sci. 2018 Nov 8;19(11). pii: E3509. doi: 10.3390/ijms19113509. Review.


Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS.

Leitch HA, Buckstein R, Zhu N, Nevill TJ, Yee KWL, Leber B, Keating MM, St Hilaire E, Kumar R, Delage R, Geddes M, Storring JM, Shamy A, Elemary M, Wells RA.

Leuk Res. 2018 Nov;74:21-41. doi: 10.1016/j.leukres.2018.09.005. Epub 2018 Sep 19. Review.


NMR spectroscopy enables simultaneous quantification of carbohydrates for diagnosis of intestinal and gastric permeability.

Stryeck S, Horvath A, Leber B, Stadlbauer V, Madl T.

Sci Rep. 2018 Oct 2;8(1):14650. doi: 10.1038/s41598-018-33104-8.


How we treat paroxysmal nocturnal hemoglobinuria: A consensus statement of the Canadian PNH Network and review of the national registry.

Patriquin CJ, Kiss T, Caplan S, Chin-Yee I, Grewal K, Grossman J, Larratt L, Marceau D, Nevill T, Sutherland DR, Wells RA, Leber B.

Eur J Haematol. 2019 Jan;102(1):36-52. doi: 10.1111/ejh.13176. Epub 2018 Oct 25. Review.


Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence.

Boyd AL, Aslostovar L, Reid J, Ye W, Tanasijevic B, Porras DP, Shapovalova Z, Almakadi M, Foley R, Leber B, Xenocostas A, Bhatia M.

Cancer Cell. 2018 Sep 10;34(3):483-498.e5. doi: 10.1016/j.ccell.2018.08.007.


A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia.

Aslostovar L, Boyd AL, Almakadi M, Collins TJ, Leong DP, Tirona RG, Kim RB, Julian JA, Xenocostas A, Leber B, Levine MN, Foley R, Bhatia M.

Blood Adv. 2018 Aug 14;2(15):1935-1945. doi: 10.1182/bloodadvances.2018015677.


Cyclic thrombocytopenia with statistically significant neutrophil oscillations.

Langlois GP, Arnold DM, Potts J, Leber B, Dale DC, Mackey MC.

Clin Case Rep. 2018 May 31;6(7):1347-1352. doi: 10.1002/ccr3.1611. eCollection 2018 Jul.


Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.

Kale J, Kutuk O, Brito GC, Andrews TS, Leber B, Letai A, Andrews DW.

EMBO Rep. 2018 Sep;19(9). pii: e45235. doi: 10.15252/embr.201745235. Epub 2018 Jul 9.


The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.

Song P, Zechner C, Hernandez G, Cánovas J, Xie Y, Sondhi V, Wagner M, Stadlbauer V, Horvath A, Leber B, Hu MC, Moe OW, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2018 Jun 5;27(6):1338-1347.e4. doi: 10.1016/j.cmet.2018.04.001. Epub 2018 Apr 12.


Soluble CD163 and soluble mannose receptor predict survival and decompensation in patients with liver cirrhosis, and correlate with gut permeability and bacterial translocation.

Rainer F, Horvath A, Sandahl TD, Leber B, Schmerboeck B, Blesl A, Groselj-Strele A, Stauber RE, Fickert P, Stiegler P, Møller HJ, Grønbaek H, Stadlbauer V.

Aliment Pharmacol Ther. 2018 Mar;47(5):657-664. doi: 10.1111/apt.14474. Epub 2017 Dec 21.


Structural and functional differences in gut microbiome composition in patients undergoing haemodialysis or peritoneal dialysis.

Stadlbauer V, Horvath A, Ribitsch W, Schmerböck B, Schilcher G, Lemesch S, Stiegler P, Rosenkranz AR, Fickert P, Leber B.

Sci Rep. 2017 Nov 15;7(1):15601. doi: 10.1038/s41598-017-15650-9. Erratum in: Sci Rep. 2019 Jun 6;9(1):8522.


Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche.

Boyd AL, Reid JC, Salci KR, Aslostovar L, Benoit YD, Shapovalova Z, Nakanishi M, Porras DP, Almakadi M, Campbell CJV, Jackson MF, Ross CA, Foley R, Leber B, Allan DS, Sabloff M, Xenocostas A, Collins TJ, Bhatia M.

Nat Cell Biol. 2017 Nov;19(11):1336-1347. doi: 10.1038/ncb3625. Epub 2017 Oct 16.


Anti-HCV treatment with ombitasvir/paritaprevir/ritonavir ± dasabuvir is associated with increased bile acid levels and pruritus.

Stauber RE, Fauler G, Rainer F, Leber B, Posch A, Streit A, Spindelboeck W, Stadlbauer V, Kessler HH, Mangge H.

Wien Klin Wochenschr. 2017 Nov;129(21-22):848-851. doi: 10.1007/s00508-017-1268-x. Epub 2017 Oct 4.


A predictive model of response to erythropoietin stimulating agents in myelodysplastic syndrome: from the Canadian MDS patient registry.

Houston BL, Jayakar J, Wells RA, Lenis M, Zhang L, Zhu N, Leitch HA, Nevill TJ, Yee KWL, Leber B, Sabloff M, St-Hilaire E, Kumar R, Geddes M, Shamy A, Storring JM, Keating MM, Elemary M, Delage R, Mamedov A, Buckstein R.

Ann Hematol. 2017 Dec;96(12):2025-2029. doi: 10.1007/s00277-017-3137-0. Epub 2017 Oct 3.


Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results.

Hughes TP, Leber B, Cervantes F, Spector N, Pasquini R, Clementino NCD, Schwarer AP, Dorlhiac-Llacer PE, Mahon FX, Rea D, Guerci-Bresler A, Kamel-Reid S, Bendit I, Acharya S, Glynos T, Dalal D, Branford S, Lipton JH.

Leukemia. 2017 Nov;31(11):2529-2531. doi: 10.1038/leu.2017.247. Epub 2017 Aug 3. No abstract available.


Treatment of older patients with acute myeloid leukemia (AML): revised Canadian consensus guidelines.

Brandwein JM, Zhu N, Kumar R, Leber B, Sabloff M, Sandhu I, Kassis J, Olney HJ, Elemary M, Schuh AC.

Am J Blood Res. 2017 Jul 25;7(4):30-40. eCollection 2017. Review.


Overall survival in lower IPSS risk MDS by receipt of iron chelation therapy, adjusting for patient-related factors and measuring from time of first red blood cell transfusion dependence: an MDS-CAN analysis.

Leitch HA, Parmar A, Wells RA, Chodirker L, Zhu N, Nevill TJ, Yee KWL, Leber B, Keating MM, Sabloff M, St Hilaire E, Kumar R, Delage R, Geddes M, Storring JM, Kew A, Shamy A, Elemary M, Lenis M, Mamedov A, Ivo J, Francis J, Zhang L, Buckstein R.

Br J Haematol. 2017 Oct;179(1):83-97. doi: 10.1111/bjh.14825. Epub 2017 Jul 5.


ITACA: A new validated international erythropoietic stimulating agent-response score that further refines the predictive power of previous scoring systems.

Buckstein R, Balleari E, Wells R, Santini V, Sanna A, Salvetti C, Crisà E, Allione B, Danise P, Finelli C, Clavio M, Poloni A, Salvi F, Cilloni D, Oliva EN, Musto P, Houston B, Zhu N, Geddes M, Leitch H, Leber B, Sabloff M, Nevill TJ, Yee KW, Storring JM, Francis J, Maurillo L, Latagliata R, Spiriti MAA, Andriani A, Piccioni AL, Fianchi L, Fenu S, Gumenyuk S, Buccisano F.

Am J Hematol. 2017 Oct;92(10):1037-1046. doi: 10.1002/ajh.24842. Epub 2017 Jul 29.


Sam68 Allows Selective Targeting of Human Cancer Stem Cells.

Benoit YD, Mitchell RR, Risueño RM, Orlando L, Tanasijevic B, Boyd AL, Aslostovar L, Salci KR, Shapovalova Z, Russell J, Eguchi M, Golubeva D, Graham M, Xenocostas A, Trus MR, Foley R, Leber B, Collins TJ, Bhatia M.

Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9. doi: 10.1016/j.chembiol.2017.05.026. Epub 2017 Jun 22.


A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

Niu X, Brahmbhatt H, Mergenthaler P, Zhang Z, Sang J, Daude M, Ehlert FGR, Diederich WE, Wong E, Zhu W, Pogmore J, Nandy JP, Satyanarayana M, Jimmidi RK, Arya P, Leber B, Lin J, Culmsee C, Yi J, Andrews DW.

Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5. doi: 10.1016/j.chembiol.2017.03.011. Epub 2017 Apr 6.


Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study.

Lindheim L, Bashir M, Münzker J, Trummer C, Zachhuber V, Leber B, Horvath A, Pieber TR, Gorkiewicz G, Stadlbauer V, Obermayer-Pietsch B.

PLoS One. 2017 Jan 3;12(1):e0168390. doi: 10.1371/journal.pone.0168390. eCollection 2017.


MicroRNAs 223-3p and 93-5p in patients with chronic kidney disease before and after renal transplantation.

Ulbing M, Kirsch AH, Leber B, Lemesch S, Münzker J, Schweighofer N, Hofer D, Trummer O, Rosenkranz AR, Müller H, Eller K, Stadlbauer V, Obermayer-Pietsch B.

Bone. 2017 Feb;95:115-123. doi: 10.1016/j.bone.2016.11.016. Epub 2016 Nov 17.


Mode of renal replacement therapy determines endotoxemia and neutrophil dysfunction in chronic kidney disease.

Lemesch S, Ribitsch W, Schilcher G, Spindelböck W, Hafner-Gießauf H, Marsche G, Pasterk L, Payerl D, Schmerböck B, Tawdrous M, Rosenkranz AR, Stiegler P, Kager G, Hallström S, Oettl K, Eberhard K, Horvath A, Leber B, Stadlbauer V.

Sci Rep. 2016 Oct 4;6:34534. doi: 10.1038/srep34534.


Laboratory Investigation of Myeloproliferative Neoplasms (MPNs):  Recommendations of the Canadian Mpn Group.

Busque L, Porwit A, Day R, Olney HJ, Leber B, Éthier V, Sirhan S, Foltz L, Prchal J, Kamel-Reid S, Karsan A, Gupta V.

Am J Clin Pathol. 2016 Oct;146(4):408-22. doi: 10.1093/ajcp/aqw131. Review.


Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis.

Horvath A, Leber B, Schmerboeck B, Tawdrous M, Zettel G, Hartl A, Madl T, Stryeck S, Fuchs D, Lemesch S, Douschan P, Krones E, Spindelboeck W, Durchschein F, Rainer F, Zollner G, Stauber RE, Fickert P, Stiegler P, Stadlbauer V.

Aliment Pharmacol Ther. 2016 Nov;44(9):926-935. doi: 10.1111/apt.13788. Epub 2016 Sep 4.


Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells.

Oppermann S, Lam AJ, Tung S, Shi Y, McCaw L, Wang G, Ylanko J, Leber B, Andrews D, Spaner DE.

Oncotarget. 2016 Nov 8;7(45):72608-72621. doi: 10.18632/oncotarget.11618.


High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.

Oppermann S, Ylanko J, Shi Y, Hariharan S, Oakes CC, Brauer PM, Zúñiga-Pflücker JC, Leber B, Spaner DE, Andrews DW.

Blood. 2016 Aug 18;128(7):934-47. doi: 10.1182/blood-2015-12-687814. Epub 2016 Jun 13.


Patient-related factors independently impact overall survival in patients with myelodysplastic syndromes: an MDS-CAN prospective study.

Buckstein R, Wells RA, Zhu N, Leitch HA, Nevill TJ, Yee KW, Leber B, Sabloff M, St Hilaire E, Kumar R, Geddes M, Shamy A, Storring J, Kew A, Elemary M, Levitt M, Lenis M, Mamedov A, Zhang L, Rockwood K, Alibhai SM.

Br J Haematol. 2016 Jul;174(1):88-101. doi: 10.1111/bjh.14033. Epub 2016 Mar 15.


Triple Therapy with First Generation Protease Inhibitors for Hepatitis C Markedly Impairs Function of Neutrophil Granulocytes.

Spindelboeck W, Horvath A, Tawdrous M, Schmerböck B, Zettel G, Posch A, Streit A, Jurse P, Lemesch S, Horn M, Wuensch G, Stiegler P, Stauber RE, Leber B, Stadlbauer V.

PLoS One. 2016 Mar 3;11(3):e0150299. doi: 10.1371/journal.pone.0150299. eCollection 2016.


Small molecules reveal an alternative mechanism of Bax activation.

Brahmbhatt H, Uehling D, Al-Awar R, Leber B, Andrews D.

Biochem J. 2016 Apr 15;473(8):1073-83. doi: 10.1042/BCJ20160118. Epub 2016 Feb 25.


Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression.

Pasterk L, Lemesch S, Leber B, Trieb M, Curcic S, Stadlbauer V, Schuligoi R, Schicho R, Heinemann A, Marsche G.

Sci Rep. 2016 Feb 24;6:22104. doi: 10.1038/srep22104.


Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study.

Stadlbauer V, Leber B, Lemesch S, Trajanoski S, Bashir M, Horvath A, Tawdrous M, Stojakovic T, Fauler G, Fickert P, Högenauer C, Klymiuk I, Stiegler P, Lamprecht M, Pieber TR, Tripolt NJ, Sourij H.

PLoS One. 2015 Oct 28;10(10):e0141399. doi: 10.1371/journal.pone.0141399. eCollection 2015.


Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects.

Lamprecht M, Bogner S, Steinbauer K, Schuetz B, Greilberger JF, Leber B, Wagner B, Zinser E, Petek T, Wallner-Liebmann S, Oberwinkler T, Bachl N, Schippinger G.

J Int Soc Sports Nutr. 2015 Oct 20;12:40. doi: 10.1186/s12970-015-0101-z. eCollection 2015.


Evolving Therapeutic Options for Polycythemia Vera: Perspectives of the Canadian Myeloproliferative Neoplasms Group.

Sirhan S, Busque L, Foltz L, Grewal K, Hamm C, Laferriere N, Laneuville P, Leber B, Liew E, Olney HJ, Prchal J, Porwit A, Gupta V.

Clin Lymphoma Myeloma Leuk. 2015 Dec;15(12):715-27. doi: 10.1016/j.clml.2015.07.650. Epub 2015 Aug 7.


Immunohistochemical and radiological characterization of wound healing in porcine liver after radiofrequency ablation.

Stadlbauer V, Lang-Olip I, Leber B, Mayrhauser U, Koestenbauer S, Tawdrous M, Moche M, Sereinigg M, Seider D, Iberer F, Wiederstein-Grasser I, Portugaller RH, Stiegler P.

Histol Histopathol. 2016 Jan;31(1):115-29. doi: 10:14670/HH-11-667. Epub 2015 Sep 11.


Effect of Lactobacillus casei Shirota supplementation on trimethylamine-N-oxide levels in patients with metabolic syndrome: An open-label, randomized study.

Tripolt NJ, Leber B, Triebl A, Köfeler H, Stadlbauer V, Sourij H.

Atherosclerosis. 2015 Sep;242(1):141-4. doi: 10.1016/j.atherosclerosis.2015.05.005. Epub 2015 Jul 8.


Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia.

Lin HX, Sjaarda J, Dyck J, Stringer R, Hillis C, Harvey M, Carter R, Ainsworth P, Leber B, Pare G, Sadikovic B.

Eur J Haematol. 2016 Apr;96(4):360-6. doi: 10.1111/ejh.12597. Epub 2015 Jul 3.


Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond.

Brahmbhatt H, Oppermann S, Osterlund EJ, Leber B, Andrews DW.

Clin Cancer Res. 2015 Jun 15;21(12):2671-6. doi: 10.1158/1078-0432.CCR-14-0959. Epub 2015 Apr 2. Review.


Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations.

Salci KR, Lee JH, Laronde S, Dingwall S, Kushwah R, Fiebig-Comyn A, Leber B, Foley R, Dal Cin A, Bhatia M.

Stem Cells. 2015 Jun;33(6):1839-49. doi: 10.1002/stem.1994.

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