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Items: 1 to 50 of 205

1.

A centralized communication network: Recent insights into the role of the cancer associated fibroblast in the development of drug resistance in tumors.

Leask A.

Semin Cell Dev Biol. 2019 Nov 7. pii: S1084-9521(18)30316-1. doi: 10.1016/j.semcdb.2019.10.016. [Epub ahead of print] Review.

PMID:
31708414
2.

Insights into Fibroblast Plasticity: CCN2 Is Required for Activation of Cancer-Associated Fibroblasts in a Murine Model of Melanoma.

Tsang M, Quesnel K, Vincent K, Hutchenreuther J, Postovit LM, Leask A.

Am J Pathol. 2019 Oct 11. pii: S0002-9440(19)30754-0. doi: 10.1016/j.ajpath.2019.09.006. [Epub ahead of print]

PMID:
31610176
3.
4.

Do drugs that target mTOR generate CCN2-mediated fibrogenic side effects?

Leask A.

J Cell Commun Signal. 2019 Sep;13(3):277-278. doi: 10.1007/s12079-019-00520-y. Epub 2019 May 22.

5.

Periostin and CCN2 Scaffolds Promote the Wound Healing Response in the Skin of Diabetic Mice.

Elliott CG, Wang J, Walker JT, Michelsons S, Dunmore-Buyze J, Drangova M, Leask A, Hamilton DW.

Tissue Eng Part A. 2019 Sep;25(17-18):1326-1339. doi: 10.1089/ten.TEA.2018.0268. Epub 2019 Feb 27.

PMID:
30572781
6.

Genetic manipulation of CCN2/CTGF unveils cell-specific ECM-remodeling effects in injured skeletal muscle.

Petrosino JM, Leask A, Accornero F.

FASEB J. 2019 Feb;33(2):2047-2057. doi: 10.1096/fj.201800622RR. Epub 2018 Sep 14.

PMID:
30216109
7.

Report on the 9th international workshop on the CCN family of genes, November 2-7, 2017, Saint-Malo, France.

Yeger H, Brigstock D, Fisher G, Lau L, Leask A, Perbal B.

J Cell Commun Signal. 2018 Sep;12(3):505-511. doi: 10.1007/s12079-018-0472-4. No abstract available.

8.

Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ.

Tang X, Muhammad H, McLean C, Miotla-Zarebska J, Fleming J, Didangelos A, Önnerfjord P, Leask A, Saklatvala J, Vincent TL.

Ann Rheum Dis. 2018 Sep;77(9):1372-1380. doi: 10.1136/annrheumdis-2018-212964. Epub 2018 Jun 20.

9.

Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma.

Hutchenreuther J, Vincent K, Norley C, Racanelli M, Gruber SB, Johnson TM, Fullen DR, Raskin L, Perbal B, Holdsworth DW, Postovit LM, Leask A.

Matrix Biol. 2018 Dec;74:52-61. doi: 10.1016/j.matbio.2018.06.003. Epub 2018 Jun 7.

PMID:
29885461
10.

A sticky wicket: Overexpression of integrin alpha 11 is sufficient for cardiac fibrosis.

Leask A.

Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.13025. Epub 2018 Jan 18. No abstract available.

PMID:
29282884
11.

Why target the tumor stroma in melanoma?

Hutchenreuther J, Leask A.

J Cell Commun Signal. 2018 Mar;12(1):113-118. doi: 10.1007/s12079-017-0419-1. Epub 2017 Nov 6. Review.

12.

Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts.

Murphy-Marshman H, Quensel K, Shi-Wen X, Barnfield R, Kelly J, Peidl A, Stratton RJ, Leask A.

PLoS One. 2017 Oct 19;12(10):e0186740. doi: 10.1371/journal.pone.0186740. eCollection 2017.

13.

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis.

Makino K, Makino T, Stawski L, Lipson KE, Leask A, Trojanowska M.

Arthritis Res Ther. 2017 Jun 13;19(1):134. doi: 10.1186/s13075-017-1356-3.

14.

Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis.

Kinashi H, Falke LL, Nguyen TQ, Bovenschen N, Aten J, Leask A, Ito Y, Goldschmeding R.

Kidney Int. 2017 Oct;92(4):850-863. doi: 10.1016/j.kint.2017.03.029. Epub 2017 May 23.

PMID:
28545716
15.

TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma.

Tellios N, Belrose JC, Tokarewicz AC, Hutnik C, Liu H, Leask A, Motolko M, Iijima M, Parapuram SK.

Sci Rep. 2017 Apr 11;7(1):812. doi: 10.1038/s41598-017-00845-x.

16.

Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex.

Ercan E, Han JM, Di Nardo A, Winden K, Han MJ, Hoyo L, Saffari A, Leask A, Geschwind DH, Sahin M.

J Exp Med. 2017 Mar 6;214(3):681-697. doi: 10.1084/jem.20160446. Epub 2017 Feb 9.

17.

CCN3: stopping that achy, breaky aorta.

Leask A.

J Cell Commun Signal. 2017 Mar;11(1):93-94. doi: 10.1007/s12079-016-0363-5. Epub 2016 Nov 12. Review.

18.

Studying the CCN Proteins in Fibrosis.

Hutchenreuther J, Leask A, Thompson K.

Methods Mol Biol. 2017;1489:423-429.

PMID:
27734394
19.

CCN2 in Skin Fibrosis.

Leask A.

Methods Mol Biol. 2017;1489:417-421.

PMID:
27734393
20.

A tale of two orgins: do myofibroblasts originate from different sources in wound healing and fibrosis?

Hutchenreuther J, Leask A.

Cell Tissue Res. 2016 Sep;365(3):507-9. doi: 10.1007/s00441-016-2419-5. Epub 2016 May 17. Review. No abstract available.

PMID:
27184951
21.

Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus.

Bedore J, Quesnel K, Quinonez D, Séguin CA, Leask A.

J Cell Commun Signal. 2016 Jun;10(2):137-42. doi: 10.1007/s12079-016-0329-7. Epub 2016 May 12.

22.

CCN6: a modulator of breast cancer progression.

Leask A.

J Cell Commun Signal. 2016 Jun;10(2):163-4. doi: 10.1007/s12079-016-0321-2. Epub 2016 Apr 16. Review.

23.

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.

Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori K, Suzuki A.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E71-80. doi: 10.1073/pnas.1517188113. Epub 2015 Dec 22.

24.

Canadian connective tissue conference London, Ontario: an editorial.

Leask A.

J Cell Commun Signal. 2015 Dec;9(4):301. doi: 10.1007/s12079-015-0310-x. Epub 2015 Nov 18. No abstract available.

25.

CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload.

Fontes MS, Kessler EL, van Stuijvenberg L, Brans MA, Falke LL, Kok B, Leask A, van Rijen HV, Vos MA, Goldschmeding R, van Veen TA.

J Mol Cell Cardiol. 2015 Nov;88:82-90. doi: 10.1016/j.yjmcc.2015.09.015. Epub 2015 Sep 26.

PMID:
26410398
26.

CCN2 Expression by Tumor Stroma Is Required for Melanoma Metastasis.

Hutchenreuther J, Vincent KM, Carter DE, Postovit LM, Leask A.

J Invest Dermatol. 2015 Nov;135(11):2805-2813. doi: 10.1038/jid.2015.279. Epub 2015 Jul 13.

27.

Matrix remodeling in systemic sclerosis.

Leask A.

Semin Immunopathol. 2015 Sep;37(5):559-63. doi: 10.1007/s00281-015-0508-2. Epub 2015 Jul 4. Review.

PMID:
26141607
28.

5Z-7-Oxozeanol Inhibits the Effects of TGFβ1 on Human Gingival Fibroblasts.

Kuk H, Hutchenreuther J, Murphy-Marshman H, Carter D, Leask A.

PLoS One. 2015 Apr 30;10(4):e0123689. doi: 10.1371/journal.pone.0123689. eCollection 2015.

29.

Fixing a hole: CCN2 closes chronic wounds.

Leask A.

J Cell Commun Signal. 2015 Sep;9(3):281-2. doi: 10.1007/s12079-015-0292-8. Epub 2015 Apr 22. No abstract available.

30.

Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling.

Accornero F, van Berlo JH, Correll RN, Elrod JW, Sargent MA, York A, Rabinowitz JE, Leask A, Molkentin JD.

Mol Cell Biol. 2015 Jun;35(12):2154-64. doi: 10.1128/MCB.00199-15. Epub 2015 Apr 13.

31.

Getting to the heart of the matter: new insights into cardiac fibrosis.

Leask A.

Circ Res. 2015 Mar 27;116(7):1269-76. doi: 10.1161/CIRCRESAHA.116.305381. Review.

PMID:
25814687
32.

Inflammatory microenvironment and tumor necrosis factor alpha as modulators of periostin and CCN2 expression in human non-healing skin wounds and dermal fibroblasts.

Elliott CG, Forbes TL, Leask A, Hamilton DW.

Matrix Biol. 2015 Apr;43:71-84. doi: 10.1016/j.matbio.2015.03.003. Epub 2015 Mar 14.

PMID:
25779637
33.

Erratum to: Thrombospondin 1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism.

Chen Y, Leask A, Abraham DJ, Kennedy L, Shi-Wen X, Denton CP, Black CM, Verjee LS, Eastwood M.

Fibrogenesis Tissue Repair. 2015 Mar 14;8:4. doi: 10.1186/s13069-015-0021-1. eCollection 2015.

34.

Yin and Yang revisited: CCN3 as an anti-fibrotic therapeutic?

Leask A.

J Cell Commun Signal. 2015 Mar;9(1):97-8. doi: 10.1007/s12079-015-0281-y. Epub 2015 Feb 22.

35.

Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism.

Parapuram SK, Thompson K, Tsang M, Hutchenreuther J, Bekking C, Liu S, Leask A.

Matrix Biol. 2015 Apr;43:35-41. doi: 10.1016/j.matbio.2015.01.017. Epub 2015 Jan 30.

PMID:
25644104
36.

CCN2 is required for recruitment of Sox2-expressing cells during cutaneous tissue repair.

Tsang M, Leask A.

J Cell Commun Signal. 2015 Dec;9(4):341-6. doi: 10.1007/s12079-014-0245-7. Epub 2014 Oct 18.

37.

Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice.

Pi L, Robinson PM, Jorgensen M, Oh SH, Brown AR, Weinreb PH, Trinh TL, Yianni P, Liu C, Leask A, Violette SM, Scott EW, Schultz GS, Petersen BE.

Hepatology. 2015 Feb;61(2):678-91. doi: 10.1002/hep.27425.

38.

Targeting the extracellular matrix: matricellular proteins regulate cell-extracellular matrix communication within distinct niches of the intervertebral disc.

Bedore J, Leask A, Séguin CA.

Matrix Biol. 2014 Jul;37:124-30. doi: 10.1016/j.matbio.2014.05.005. Epub 2014 May 27. Review.

39.

Monitoring collagen synthesis in fibroblasts using fluorescently labeled tRNA pairs.

Liu J, Pampillo M, Guo F, Liu S, Cooperman BS, Farrell I, Dahary D, Gan BS, O'Gorman DB, Smilansky Z, Babwah AV, Leask A.

J Cell Physiol. 2014 Sep;229(9):1121-9. doi: 10.1002/jcp.24630.

PMID:
24676899
40.

Conditional knockout of CTGF affects corneal wound healing.

Gibson DJ, Pi L, Sriram S, Mao C, Petersen BE, Scott EW, Leask A, Schultz GS.

Invest Ophthalmol Vis Sci. 2014 Apr 1;55(4):2062-70. doi: 10.1167/iovs.13-12735.

41.

Skin progenitor cells contribute to bleomycin-induced skin fibrosis.

Liu S, Herault Y, Pavlovic G, Leask A.

Arthritis Rheumatol. 2014 Mar;66(3):707-13. doi: 10.1002/art.38276.

42.

ALK5 inhibition blocks TGFβ-induced CCN1 expression in human foreskin fibroblasts.

Thompson K, Murphy-Marshman H, Leask A.

J Cell Commun Signal. 2014 Mar;8(1):59-63. doi: 10.1007/s12079-014-0229-7. Epub 2014 Feb 25.

43.

Report on the 7(th) international workshop on the CCN family of genes : October 16-19, 2013-Nice, France.

Perbal B, Trackman P, Castellot J, Brigstock D, Takigawa M, Lau L, Leask A.

J Cell Commun Signal. 2014 Mar;8(1):71-6. doi: 10.1007/s12079-014-0227-9. Epub 2014 Feb 20.

44.
45.
46.
47.

miR-218 regulates focal adhesion kinase-dependent TGFβ signaling in fibroblasts.

Guo F, Carter DE, Leask A.

Mol Biol Cell. 2014 Apr;25(7):1151-8. doi: 10.1091/mbc.E13-08-0451. Epub 2014 Feb 5.

48.

Activation of latent TGFβ by αvβ 1 integrin: of potential importance in myofibroblast activation in fibrosis.

Leask A, Hutchenreuther J.

J Cell Commun Signal. 2014 Jun;8(2):171-2. doi: 10.1007/s12079-014-0221-2. Epub 2014 Jan 24.

49.

CCN2 expression by fibroblasts is not required for cutaneous tissue repair.

Liu S, Thompson K, Leask A.

Wound Repair Regen. 2014 Jan-Feb;22(1):119-24. doi: 10.1111/wrr.12131.

PMID:
24393160
50.

CCN2 modulates hair follicle cycling in mice.

Liu S, Leask A.

Mol Biol Cell. 2013 Dec;24(24):3939-44. doi: 10.1091/mbc.E13-08-0472. Epub 2013 Oct 23.

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