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Items: 36

1.

A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release.

Ubonprasert S, Jaroensuk J, Pornthanakasem W, Kamonsutthipaijit N, Wongpituk P, Mee-Udorn P, Rungrotmongkol T, Ketchart O, Chitnumsub P, Leartsakulpanich U, Chaiyen P, Maenpuen S.

J Biol Chem. 2019 Jul 5;294(27):10490-10502. doi: 10.1074/jbc.RA119.007454. Epub 2019 May 22.

PMID:
31118236
2.

Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine.

Jaruwat A, Riangrungroj P, Ubonprasert S, Sae-Ueng U, Kuaprasert B, Yuthavong Y, Leartsakulpanich U, Chitnumsub P.

Arch Biochem Biophys. 2019 May 30;667:6-13. doi: 10.1016/j.abb.2019.04.002. Epub 2019 Apr 16.

PMID:
31002765
3.

Application of WST-8 based colorimetric NAD(P)H detection for quantitative dehydrogenase assays.

Chamchoy K, Pakotiprapha D, Pumirat P, Leartsakulpanich U, Boonyuen U.

BMC Biochem. 2019 Apr 8;20(1):4. doi: 10.1186/s12858-019-0108-1.

4.

Characterization of Plasmodium knowlesi dihydrofolate reductase-thymidylate synthase and sensitivity to antifolates.

Ittarat W, Pornthanakasem W, Mungthin M, Suwandittakul N, Leelayoova S, Tarnchompoo B, Yuthavong Y, Kongkasuriyachai D, Leartsakulpanich U.

Parasitol Int. 2018 Dec;67(6):787-792. doi: 10.1016/j.parint.2018.08.004. Epub 2018 Aug 14.

PMID:
30114522
5.

Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold.

Schwertz G, Witschel MC, Rottmann M, Leartsakulpanich U, Chitnumsub P, Jaruwat A, Amornwatcharapong W, Ittarat W, Schäfer A, Aponte RA, Trapp N, Chaiyen P, Diederich F.

ChemMedChem. 2018 May 8;13(9):931-943. doi: 10.1002/cmdc.201800053. Epub 2018 Apr 14.

PMID:
29655285
6.

Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs.

Schwertz G, Frei MS, Witschel MC, Rottmann M, Leartsakulpanich U, Chitnumsub P, Jaruwat A, Ittarat W, Schäfer A, Aponte RA, Trapp N, Mark K, Chaiyen P, Diederich F.

Chemistry. 2017 Oct 12;23(57):14345-14357. doi: 10.1002/chem.201703244. Epub 2017 Oct 2.

PMID:
28967982
7.

Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior.

Amornwatcharapong W, Maenpuen S, Chitnumsub P, Leartsakulpanich U, Chaiyen P.

Arch Biochem Biophys. 2017 Sep 15;630:91-100. doi: 10.1016/j.abb.2017.07.017. Epub 2017 Jul 29.

PMID:
28760597
8.

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures.

Schwertz G, Witschel MC, Rottmann M, Bonnert R, Leartsakulpanich U, Chitnumsub P, Jaruwat A, Ittarat W, Schäfer A, Aponte RA, Charman SA, White KL, Kundu A, Sadhukhan S, Lloyd M, Freiberg GM, Srikumaran M, Siggel M, Zwyssig A, Chaiyen P, Diederich F.

J Med Chem. 2017 Jun 22;60(12):4840-4860. doi: 10.1021/acs.jmedchem.7b00008. Epub 2017 Jun 13.

PMID:
28537728
9.

Characterization of Plasmodium falciparum ATP-dependent DNA helicase RuvB3.

Limudomporn P, Moonsom S, Leartsakulpanich U, Suntornthiticharoen P, Petmitr S, Weinfeld M, Chavalitshewinkoon-Petmitr P.

Malar J. 2016 Nov 3;15(1):526.

10.

Role of Plasmodium vivax Dihydropteroate Synthase Polymorphisms in Sulfa Drug Resistance.

Pornthanakasem W, Riangrungroj P, Chitnumsub P, Ittarat W, Kongkasuriyachai D, Uthaipibull C, Yuthavong Y, Leartsakulpanich U.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4453-63. doi: 10.1128/AAC.01835-15. Print 2016 Aug.

11.

Biochemical and functional characterization of Plasmodium falciparum DNA polymerase δ.

Vasuvat J, Montree A, Moonsom S, Leartsakulpanich U, Petmitr S, Focher F, Wright GE, Chavalitshewinkoon-Petmitr P.

Malar J. 2016 Feb 24;15:116. doi: 10.1186/s12936-016-1166-0.

12.

Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.

Witschel MC, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, Tonazzi S, Schwertz G, Stelzer F, Mietzner T, McNamara C, Thater F, Freymond C, Jaruwat A, Pinthong C, Riangrungroj P, Oufir M, Hamburger M, Mäser P, Sanz-Alonso LM, Charman S, Wittlin S, Yuthavong Y, Chaiyen P, Diederich F.

J Med Chem. 2015 Apr 9;58(7):3117-30. doi: 10.1021/jm501987h. Epub 2015 Mar 18.

PMID:
25785478
13.

Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase.

Maenpuen S, Amornwatcharapong W, Krasatong P, Sucharitakul J, Palfey BA, Yuthavong Y, Chitnumsub P, Leartsakulpanich U, Chaiyen P.

J Biol Chem. 2015 Mar 27;290(13):8656-65. doi: 10.1074/jbc.M114.612275. Epub 2015 Feb 12.

14.

Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control.

Chitnumsub P, Jaruwat A, Riangrungroj P, Ittarat W, Noytanom K, Oonanant W, Vanichthanankul J, Chuankhayan P, Maenpuen S, Chen CJ, Chaiyen P, Yuthavong Y, Leartsakulpanich U.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3177-86. doi: 10.1107/S1399004714023128. Epub 2014 Nov 22.

15.

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities.

Chitnumsub P, Ittarat W, Jaruwat A, Noytanom K, Amornwatcharapong W, Pornthanakasem W, Chaiyen P, Yuthavong Y, Leartsakulpanich U.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1517-27. doi: 10.1107/S1399004714005598. Epub 2014 May 23.

16.

Antifolate Agents Against Wild and Mutant Strains of Plasmodium falciparum.

Shaikh MS, Rana J, Gaikwad D, Leartsakulpanich U, Ambre PK, Pissurlenkar RR, Coutinho EC.

Indian J Pharm Sci. 2014 Mar;76(2):116-24.

17.

Rational design of InhA inhibitors in the class of diphenyl ether derivatives as potential anti-tubercular agents using molecular dynamics simulations.

Kamsri P, Koohatammakun N, Srisupan A, Meewong P, Punkvang A, Saparpakorn P, Hannongbua S, Wolschann P, Prueksaaroon S, Leartsakulpanich U, Pungpo P.

SAR QSAR Environ Res. 2014;25(6):473-88. doi: 10.1080/1062936X.2014.898690. Epub 2014 Apr 30.

PMID:
24785640
18.

Molecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug target.

Suksangpleng T, Leartsakulpanich U, Moonsom S, Siribal S, Boonyuen U, Wright GE, Chavalitshewinkoon-Petmitr P.

Malar J. 2014 Apr 17;13:149. doi: 10.1186/1475-2875-13-149.

19.

Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition.

Pinthong C, Maenpuen S, Amornwatcharapong W, Yuthavong Y, Leartsakulpanich U, Chaiyen P.

FEBS J. 2014 Jun;281(11):2570-83. doi: 10.1111/febs.12803. Epub 2014 Apr 28.

20.

Expression of a secretory α-glucosidase II from Apis cerana indica in Pichia pastoris and its characterization.

Kaewmuangmoon J, Kilaso M, Leartsakulpanich U, Kimura K, Kimura A, Chanchao C.

BMC Biotechnol. 2013 Feb 18;13:16. doi: 10.1186/1472-6750-13-16.

21.

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization.

Pornthanakasem W, Kongkasuriyachai D, Uthaipibull C, Yuthavong Y, Leartsakulpanich U.

Malar J. 2012 Nov 22;11:387. doi: 10.1186/1475-2875-11-387.

22.

Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay.

Sopitthummakhun K, Thongpanchang C, Vilaivan T, Yuthavong Y, Chaiyen P, Leartsakulpanich U.

Malar J. 2012 Jun 12;11:194. doi: 10.1186/1475-2875-11-194.

23.

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene.

Tirakarn S, Riangrungroj P, Kongsaeree P, Imwong M, Yuthavong Y, Leartsakulpanich U.

Parasitol Int. 2012 Jun;61(2):324-32. doi: 10.1016/j.parint.2011.12.004. Epub 2012 Jan 2.

24.

Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax.

Chanama M, Chanama S, Shaw PJ, Chitnumsub P, Leartsakulpanich U, Yuthavong Y.

Mol Biol Rep. 2011 Feb;38(2):1029-37. doi: 10.1007/s11033-010-0199-7. Epub 2010 Jun 25.

PMID:
20577818
25.

Characterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial target.

Maenpuen S, Sopitthummakhun K, Yuthavong Y, Chaiyen P, Leartsakulpanich U.

Mol Biochem Parasitol. 2009 Nov;168(1):63-73. doi: 10.1016/j.molbiopara.2009.06.010. Epub 2009 Jul 8.

PMID:
19591881
26.

Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues.

Sopitthummakhun K, Maenpuen S, Yuthavong Y, Leartsakulpanich U, Chaiyen P.

FEBS J. 2009 Aug;276(15):4023-36. doi: 10.1111/j.1742-4658.2009.07111.x. Epub 2009 Jun 22.

27.

Avian influenza A/H5N1 neuraminidase expressed in yeast with a functional head domain.

Yongkiettrakul S, Boonyapakron K, Jongkaewwattana A, Wanitchang A, Leartsakulpanich U, Chitnumsub P, Eurwilaichitr L, Yuthavong Y.

J Virol Methods. 2009 Mar;156(1-2):44-51. doi: 10.1016/j.jviromet.2008.10.025. Epub 2008 Dec 11.

PMID:
19038288
28.

Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase.

Leartsakulpanich U, Kongkasuriyachai D, Imwong M, Chotivanich K, Yuthavong Y.

Parasitol Int. 2008 Jun;57(2):223-8. Epub 2007 Nov 12.

PMID:
18096429
29.

Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.

Japrung D, Leartsakulpanich U, Chusacultanachai S, Yuthavong Y.

Antimicrob Agents Chemother. 2007 Dec;51(12):4356-60. Epub 2007 Sep 17.

30.

Folate metabolism as a source of molecular targets for antimalarials.

Yuthavong Y, Kamchonwongpaisan S, Leartsakulpanich U, Chitnumsub P.

Future Microbiol. 2006 Jun;1(1):113-25. Review.

PMID:
17661690
31.

Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.

Bunyarataphan S, Leartsakulpanich U, Taweechai S, Tarnchompoo B, Kamchonwongpaisan S, Yuthavong Y.

Antimicrob Agents Chemother. 2006 Nov;50(11):3631-7. Epub 2006 Sep 5.

32.

Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.

Kongsaeree P, Khongsuk P, Leartsakulpanich U, Chitnumsub P, Tarnchompoo B, Walkinshaw MD, Yuthavong Y.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13046-51. Epub 2005 Aug 31.

33.

Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure.

Imwong M, Pukrittayakamee S, Rénia L, Letourneur F, Charlieu JP, Leartsakulpanich U, Looareesuwan S, White NJ, Snounou G.

Antimicrob Agents Chemother. 2003 May;47(5):1514-21.

34.

Molecular characterization of dihydrofolate reductase in relation to antifolate resistance in Plasmodium vivax.

Leartsakulpanich U, Imwong M, Pukrittayakamee S, White NJ, Snounou G, Sirawaraporn W, Yuthavong Y.

Mol Biochem Parasitol. 2002 Jan;119(1):63-73.

PMID:
11755187
36.

Electrochemical and spectroscopic properties of the iron-sulfur flavoprotein from Methanosarcina thermophila.

Becker DF, Leartsakulpanich U, Surerus KK, Ferry JG, Ragsdale SW.

J Biol Chem. 1998 Oct 9;273(41):26462-9.

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