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Items: 26


FGF19 Analog as a Surgical Factor Mimetic That Contributes to Metabolic Effects Beyond Glucose Homeostasis.

DePaoli AM, Zhou M, Kaplan DD, Hunt SC, Adams TD, Learned RM, Tian H, Ling L.

Diabetes. 2019 Jun;68(6):1315-1328. doi: 10.2337/db18-1305. Epub 2019 Mar 12.


Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis.

Zhou M, Learned RM, Rossi SJ, Tian H, DePaoli AM, Ling L.

J Lipid Res. 2019 Mar;60(3):550-565. doi: 10.1194/jlr.M089961. Epub 2019 Jan 24.


Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice.

Zhou M, Learned RM, Rossi SJ, DePaoli AM, Tian H, Ling L.

Hepatol Commun. 2017 Oct 16;1(10):1024-1042. doi: 10.1002/hep4.1108. eCollection 2017 Dec.


Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis.

Zhou M, Yang H, Learned RM, Tian H, Ling L.

Nat Commun. 2017 May 16;8:15433. doi: 10.1038/ncomms15433.


Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15.

Zhou M, Luo J, Chen M, Yang H, Learned RM, DePaoli AM, Tian H, Ling L.

J Hepatol. 2017 Jun;66(6):1182-1192. doi: 10.1016/j.jhep.2017.01.027. Epub 2017 Feb 9.


Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2-deficient mice.

Zhou M, Learned RM, Rossi SJ, DePaoli AM, Tian H, Ling L.

Hepatology. 2016 Mar;63(3):914-29. doi: 10.1002/hep.28257. Epub 2015 Nov 30.


A nontumorigenic variant of FGF19 treats cholestatic liver diseases.

Luo J, Ko B, Elliott M, Zhou M, Lindhout DA, Phung V, To C, Learned RM, Tian H, DePaoli AM, Ling L.

Sci Transl Med. 2014 Jul 30;6(247):247ra100. doi: 10.1126/scitranslmed.3009098.


Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19.

Zhou M, Wang X, Phung V, Lindhout DA, Mondal K, Hsu JY, Yang H, Humphrey M, Ding X, Arora T, Learned RM, DePaoli AM, Tian H, Ling L.

Cancer Res. 2014 Jun 15;74(12):3306-16. doi: 10.1158/0008-5472.CAN-14-0208. Epub 2014 Apr 11.


INT131: a selective modulator of PPAR gamma.

Motani A, Wang Z, Weiszmann J, McGee LR, Lee G, Liu Q, Staunton J, Fang Z, Fuentes H, Lindstrom M, Liu J, Biermann DH, Jaen J, Walker NP, Learned RM, Chen JL, Li Y.

J Mol Biol. 2009 Mar 13;386(5):1301-11.


T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties.

Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL.

J Biol Chem. 2008 Apr 4;283(14):9168-76. doi: 10.1074/jbc.M800104200. Epub 2008 Feb 7.


T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

Lee G, Elwood F, McNally J, Weiszmann J, Lindstrom M, Amaral K, Nakamura M, Miao S, Cao P, Learned RM, Chen JL, Li Y.

J Biol Chem. 2002 May 31;277(22):19649-57. Epub 2002 Mar 4.


Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells.

Medina JC, Roche D, Shan B, Learned RM, Frankmoelle WP, Clark DL, Rosen T, Jaen JC.

Bioorg Med Chem Lett. 1999 Jul 5;9(13):1843-6.


Identification of a nuclear receptor for bile acids.

Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B.

Science. 1999 May 21;284(5418):1362-5.


Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors.

Shan B, Medina JC, Santha E, Frankmoelle WP, Chou TC, Learned RM, Narbut MR, Stott D, Wu P, Jaen JC, Rosen T, Timmermans PB, Beckmann H.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5686-91.


Novel antineoplastic agents with efficacy against multidrug resistant tumor cells.

Medina JC, Shan B, Beckmann H, Farrell RP, Clark DL, Learned RM, Roche D, Li A, Baichwal V, Case C, Baeuerle PA, Rosen T, Jaen JC.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2653-6.


Molecular and genetic analysis of signal transduction in higher plants.

Learned RM.

Curr Opin Cell Biol. 1992 Apr;4(2):252-6. Review.


Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis.

Bell SP, Learned RM, Jantzen HM, Tjian R.

Science. 1988 Sep 2;241(4870):1192-7.


Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element.

Learned RM, Learned TK, Haltiner MM, Tjian RT.

Cell. 1986 Jun 20;45(6):847-57.


Regulation of human ribosomal RNA transcription.

Learned RM, Smale ST, Haltiner MM, Tjian R.

Proc Natl Acad Sci U S A. 1983 Jun;80(12):3558-62.


In vitro transcription of human ribosomal RNA genes by RNA polymerase I.

Learned RM, Tjian R.

J Mol Appl Genet. 1982;1(6):575-84.


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