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Items: 1 to 50 of 89

1.

Toll-Like Receptor 8 Stability is Regulated by Ring Finger 216 in response to circulating MicroRNAs.

Evankovich J, Lear T, Baldwin C, Chen Y, White V, Villandre J, Londino J, Liu Y, McVerry B, Kitsios GD, Mallampalli RK, Chen BB.

Am J Respir Cell Mol Biol. 2019 Aug 6. doi: 10.1165/rcmb.2018-0373OC. [Epub ahead of print]

PMID:
31385713
2.

RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.

Lear T, Dunn SR, McKelvey AC, Mir A, Evankovich J, Chen BB, Liu Y.

Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C584-C592. doi: 10.1152/ajpcell.00193.2017. Epub 2017 Oct 4. Erratum in: Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C582.

3.

Post-translational modification of the interferon-gamma receptor alters its stability and signaling.

Londino JD, Gulick DL, Lear TB, Suber TL, Weathington NM, Masa LS, Chen BB, Mallampalli RK.

Biochem J. 2017 Oct 10;474(20):3543-3557. doi: 10.1042/BCJ20170548.

4.

Alpha-melanocyte stimulating hormone-induced anorexia in Japanese quail (Coturnix japonica) likely involves the ventromedial hypothalamus and paraventricular nucleus of the hypothalamus.

Lear T, Liu L, O'Donnell M, McConn BR, Denbow DM, Cline MA, Gilbert ER.

Gen Comp Endocrinol. 2017 Oct 1;252:97-102. doi: 10.1016/j.ygcen.2017.08.005. Epub 2017 Aug 4.

PMID:
28782535
5.

Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation.

Evankovich J, Lear T, Mckelvey A, Dunn S, Londino J, Liu Y, Chen BB, Mallampalli RK.

FASEB J. 2017 Sep;31(9):3894-3903. doi: 10.1096/fj.201700031R. Epub 2017 May 17.

6.

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.

McKelvey AC, Lear TB, Dunn SR, Evankovich J, Londino JD, Bednash JS, Zhang Y, McVerry BJ, Liu Y, Chen BB.

Elife. 2016 Nov 2;5. pii: e18496. doi: 10.7554/eLife.18496.

7.

Therapeutic targets in fibrotic pathways.

Lear T, Chen BB.

Cytokine. 2016 Dec;88:193-195. doi: 10.1016/j.cyto.2016.09.008. Epub 2016 Sep 19.

8.

Comparison of DMRT3 genotypes among American Saddlebred horses with reference to gait.

Regatieri IC, Eberth JE, Sarver F, Lear TL, Bailey E.

Anim Genet. 2016 Oct;47(5):603-5. doi: 10.1111/age.12458. Epub 2016 Jun 14.

PMID:
27295976
9.

Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4.

Lear T, McKelvey AC, Rajbhandari S, Dunn SR, Coon TA, Connelly W, Zhao JY, Kass DJ, Zhang Y, Liu Y, Chen BB.

J Exp Med. 2016 May 30;213(6):1029-46. doi: 10.1084/jem.20151229. Epub 2016 May 9.

10.

Crystal structure and interaction studies of the human FBxo3 ApaG domain.

Krzysiak TC, Chen BB, Lear T, Mallampalli RK, Gronenborn AM.

FEBS J. 2016 Jun;283(11):2091-101. doi: 10.1111/febs.13721. Epub 2016 Apr 22.

11.

The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.

Franz J, Jerome J, Lear T, Gong Q, Weathington NM.

J Immunol Res. 2015;2015:912713. doi: 10.1155/2015/912713. Epub 2015 Jun 11.

12.

The proinflammatory role of HECTD2 in innate immunity and experimental lung injury.

Coon TA, McKelvey AC, Lear T, Rajbhandari S, Dunn SR, Connelly W, Zhao JY, Han S, Liu Y, Weathington NM, McVerry BJ, Zhang Y, Chen BB.

Sci Transl Med. 2015 Jul 8;7(295):295ra109. doi: 10.1126/scitranslmed.aab3881.

13.

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase.

Han S, Lear TB, Jerome JA, Rajbhandari S, Snavely CA, Gulick DL, Gibson KF, Zou C, Chen BB, Mallampalli RK.

J Biol Chem. 2015 Jul 17;290(29):18124-33. doi: 10.1074/jbc.M115.645549. Epub 2015 Jun 2.

14.

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.

Liu Y, Lear T, Iannone O, Shiva S, Corey C, Rajbhandari S, Jerome J, Chen BB, Mallampalli RK.

J Biol Chem. 2015 May 8;290(19):11843-52. doi: 10.1074/jbc.M114.629931. Epub 2015 Mar 16.

15.

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.

Liu Y, Lear T, Zhao Y, Zhao J, Zou C, Chen BB, Mallampalli RK.

Cell Death Dis. 2015 Feb 5;6:e1630. doi: 10.1038/cddis.2014.585.

16.

Novel PDE4 inhibitors derived from Chinese medicine forsythia.

Coon TA, McKelvey AC, Weathington NM, Birru RL, Lear T, Leikauf GD, Chen BB.

PLoS One. 2014 Dec 30;9(12):e115937. doi: 10.1371/journal.pone.0115937. eCollection 2014.

17.

Speciation with gene flow in equids despite extensive chromosomal plasticity.

Jónsson H, Schubert M, Seguin-Orlando A, Ginolhac A, Petersen L, Fumagalli M, Albrechtsen A, Petersen B, Korneliussen TS, Vilstrup JT, Lear T, Myka JL, Lundquist J, Miller DC, Alfarhan AH, Alquraishi SA, Al-Rasheid KA, Stagegaard J, Strauss G, Bertelsen MF, Sicheritz-Ponten T, Antczak DF, Bailey E, Nielsen R, Willerslev E, Orlando L.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18655-60. doi: 10.1073/pnas.1412627111. Epub 2014 Dec 1.

18.

Copy number variation in the horse genome.

Ghosh S, Qu Z, Das PJ, Fang E, Juras R, Cothran EG, McDonell S, Kenney DG, Lear TL, Adelson DL, Chowdhary BP, Raudsepp T.

PLoS Genet. 2014 Oct 23;10(10):e1004712. doi: 10.1371/journal.pgen.1004712. eCollection 2014 Oct.

19.

Parascaris univalens--a victim of large-scale misidentification?

Nielsen MK, Wang J, Davis R, Bellaw JL, Lyons ET, Lear TL, Goday C.

Parasitol Res. 2014 Dec;113(12):4485-90. doi: 10.1007/s00436-014-4135-y. Epub 2014 Sep 18.

PMID:
25231078
20.

E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia.

Chen BB, Coon TA, Glasser JR, Zou C, Ellis B, Das T, McKelvey AC, Rajbhandari S, Lear T, Kamga C, Shiva S, Li C, Pilewski JM, Callio J, Chu CT, Ray A, Ray P, Tyurina YY, Kagan VE, Mallampalli RK.

Cell Rep. 2014 Apr 24;7(2):476-487. doi: 10.1016/j.celrep.2014.02.048. Epub 2014 Apr 3.

21.

Detection of two equine trisomies using SNP-CGH.

Holl HM, Lear TL, Nolen-Walston RD, Slack J, Brooks SA.

Mamm Genome. 2013 Jun;24(5-6):252-6. doi: 10.1007/s00335-013-9450-6. Epub 2013 Mar 21.

PMID:
23515943
22.

Inbreeding in the Thoroughbred horse.

Binns MM, Boehler DA, Bailey E, Lear TL, Cardwell JM, Lambert DH.

Anim Genet. 2012 Jun;43(3):340-2. doi: 10.1111/j.1365-2052.2011.02259.x. Epub 2011 Nov 8.

PMID:
22486509
23.

Disorders of sexual development in the domestic horse, Equus caballus.

Lear TL, McGee RB.

Sex Dev. 2012;6(1-3):61-71. doi: 10.1159/000334048. Epub 2011 Nov 17. Review.

PMID:
22095202
24.

Morphological and chemical influences on alumina-supported palladium catalysts active for the gas phase hydrogenation of crotonaldehyde.

McInroy AR, Uhl A, Lear T, Klapötke TM, Shaikhutdinov S, Schauermann S, Rupprechter G, Freund HJ, Lennon D.

J Chem Phys. 2011 Jun 7;134(21):214704. doi: 10.1063/1.3593472.

PMID:
21663372
25.

Equine disorders of sexual development in 17 mares including XX, SRY-negative, XY, SRY-negative and XY, SRY-positive genotypes.

Villagómez DA, Lear TL, Chenier T, Lee S, McGee RB, Cahill J, Foster RA, Reyes E, St John E, King WA.

Sex Dev. 2011;5(1):16-25. doi: 10.1159/000322811. Epub 2010 Dec 22.

PMID:
21196712
26.

Molecular heterogeneity of XY sex reversal in horses.

Raudsepp T, Durkin K, Lear TL, Das PJ, Avila F, Kachroo P, Chowdhary BP.

Anim Genet. 2010 Dec;41 Suppl 2:41-52. doi: 10.1111/j.1365-2052.2010.02101.x.

PMID:
21070275
27.

Genome sequence, comparative analysis, and population genetics of the domestic horse.

Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MC, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G, Hasegawa T, Hill EW, Jurka J, Kiialainen A, Lindgren G, Liu J, Magnani E, Mickelson JR, Murray J, Nergadze SG, Onofrio R, Pedroni S, Piras MF, Raudsepp T, Rocchi M, Røed KH, Ryder OA, Searle S, Skow L, Swinburne JE, Syvänen AC, Tozaki T, Valberg SJ, Vaudin M, White JR, Zody MC; Broad Institute Genome Sequencing Platform; Broad Institute Whole Genome Assembly Team, Lander ES, Lindblad-Toh K.

Science. 2009 Nov 6;326(5954):865-7. doi: 10.1126/science.1178158.

28.

Characterization of equine and other vertebrate TLR3, TLR7, and TLR8 genes.

Astakhova NM, Perelygin AA, Zharkikh AA, Lear TL, Coleman SJ, MacLeod JN, Brinton MA.

Immunogenetics. 2009 Jul;61(7):529-39. doi: 10.1007/s00251-009-0381-z. Epub 2009 Jul 1.

PMID:
19568743
29.

The effect of age and telomere length on immune function in the horse.

Katepalli MP, Adams AA, Lear TL, Horohov DW.

Dev Comp Immunol. 2008;32(12):1409-15. doi: 10.1016/j.dci.2008.06.007. Epub 2008 Jul 9.

PMID:
18619486
30.

Concerted evolution of vertebrate CCR2 and CCR5 genes and the origin of a recombinant equine CCR5/2 gene.

Perelygin AA, Zharkikh AA, Astakhova NM, Lear TL, Brinton MA.

J Hered. 2008 Sep-Oct;99(5):500-11. doi: 10.1093/jhered/esn029. Epub 2008 May 22.

PMID:
18502735
31.

Three autosomal chromosome translocations associated with repeated early embryonic loss (REEL) in the domestic horse (Equus caballus).

Lear TL, Lundquist J, Zent WW, Fishback WD Jr, Clark A.

Cytogenet Genome Res. 2008;120(1-2):117-22. doi: 10.1159/000118749. Epub 2008 Apr 30.

PMID:
18467834
32.

Equine clinical cytogenetics: the past and future.

Lear TL, Bailey E.

Cytogenet Genome Res. 2008;120(1-2):42-9. doi: 10.1159/000118739. Epub 2008 Apr 30. Review.

PMID:
18467824
33.

A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses.

Brooks SA, Lear TL, Adelson DL, Bailey E.

Cytogenet Genome Res. 2007;119(3-4):225-30. doi: 10.1159/000112065. Epub 2008 Feb 1.

PMID:
18253033
34.

The RSPO genes: chromosomal assignment in horse by FISH.

De Lorenzi L, Lear TL, Molteni L, Parma P.

Anim Genet. 2008 Feb;39(1):86-7. Epub 2007 Dec 12. No abstract available.

PMID:
18076742
35.

Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes.

Rios JJ, Perelygin AA, Long MT, Lear TL, Zharkikh AA, Brinton MA, Adelson DL.

BMC Genomics. 2007 Sep 7;8:313.

36.

Chromosomal assignments and sequences for the equine core circadian clock genes.

Murphy BA, Lear TL, Adelson DL, Fitzgerald BP.

Anim Genet. 2007 Feb;38(1):84-5. No abstract available.

PMID:
17257198
37.

Comparative analysis of vertebrate EIF2AK2 (PKR) genes and assignment of the equine gene to ECA15q24-q25 and the bovine gene to BTA11q12-q15.

Perelygin AA, Lear TL, Zharkikh AA, Brinton MA.

Genet Sel Evol. 2006 Sep-Oct;38(5):551-63. Epub 2006 Sep 6.

39.

Construction of a medium-density horse gene map.

Perrocheau M, Boutreux V, Chadi S, Mata X, Decaunes P, Raudsepp T, Durkin K, Incarnato D, Iannuzzi L, Lear TL, Hirota K, Hasegawa T, Zhu B, de Jong P, Cribiu EP, Chowdhary BP, Guérin G.

Anim Genet. 2006 Apr;37(2):145-55.

PMID:
16573529
40.

The application of infrared spectroscopy to probe the surface morphology of alumina-supported palladium catalysts.

Lear T, Marshall R, Lopez-Sanchez JA, Jackson SD, Klapötke TM, Bäumer M, Rupprechter G, Freund HJ, Lennon D.

J Chem Phys. 2005 Nov 1;123(17):174706. Erratum in: J Chem Phys. 2006 Feb 14;124(6):069901.

PMID:
16375556
41.

Genomic characterization of MHC class I genes of the horse.

Tallmadge RL, Lear TL, Antczak DF.

Immunogenetics. 2005 Nov;57(10):763-74. Epub 2005 Nov 8.

PMID:
16220348
42.

Structure of equine 2'-5'oligoadenylate synthetase (OAS) gene family and FISH mapping of OAS genes to ECA8p15-->p14 and BTA17q24-->q25.

Perelygin AA, Lear TL, Zharkikh AA, Brinton MA.

Cytogenet Genome Res. 2005;111(1):51-6.

PMID:
16093721
43.

A model high surface area alumina-supported palladium catalyst.

Lear T, Marshall R, Gibson EK, Schütt T, Klapötke TM, Rupprechter G, Freund HJ, Winfield JM, Lennon D.

Phys Chem Chem Phys. 2005 Feb 21;7(4):565-7.

PMID:
19787870
44.
45.

Natural killer cell receptors in the horse: evidence for the existence of multiple transcribed LY49 genes.

Takahashi T, Yawata M, Raudsepp T, Lear TL, Chowdhary BP, Antczak DF, Kasahara M.

Eur J Immunol. 2004 Mar;34(3):773-784. doi: 10.1002/eji.200324695.

46.

FISH analysis comparing genome organization in the domestic horse (Equus caballus) to that of the Mongolian wild horse (E. przewalskii).

Myka JL, Lear TL, Houck ML, Ryder OA, Bailey E.

Cytogenet Genome Res. 2003;102(1-4):222-5.

PMID:
14970707
47.

Homologous fission event(s) implicated for chromosomal polymorphisms among five species in the genus Equus.

Myka JL, Lear TL, Houck ML, Ryder OA, Bailey E.

Cytogenet Genome Res. 2003;102(1-4):217-21.

PMID:
14970706
48.

Genetic mapping of GBE1 and its association with glycogen storage disease IV in American Quarter horses.

Ward TL, Valberg SJ, Lear TL, Guérin G, Milenkovic D, Swinburne JE, Binns MM, Raudsepp T, Skow L, Chowdhary BP, Mickelson JR.

Cytogenet Genome Res. 2003;102(1-4):201-6.

PMID:
14970703
49.

The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes.

Chowdhary BP, Raudsepp T, Kata SR, Goh G, Millon LV, Allan V, Piumi F, Guérin G, Swinburne J, Binns M, Lear TL, Mickelson J, Murray J, Antczak DF, Womack JE, Skow LC.

Genome Res. 2003 Apr;13(4):742-51. Erratum in: Genome Res. 2003 Jun;13(6a):1258.

50.

Characterization of the beta2-microglobulin gene of the horse.

Tallmadge RL, Lear TL, Johnson AK, Guérin G, Millon LV, Carpenter SL, Antczak DF.

Immunogenetics. 2003 Jan;54(10):725-33. Epub 2002 Dec 5.

PMID:
12557059

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