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Items: 1 to 50 of 122


Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography.

Chen X, Winters C, Crocker V, Lazarou M, Sousa AA, Leapman RD, Reese TS.

Front Neuroanat. 2018 Dec 7;12:107. doi: 10.3389/fnana.2018.00107. eCollection 2018.


SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets.

Pokrovskaya ID, Joshi S, Tobin M, Desai R, Aronova MA, Kamykowski JA, Zhang G, Whiteheart SW, Leapman RD, Storrie B.

Blood Adv. 2018 Nov 13;2(21):2947-2958. doi: 10.1182/bloodadvances.2018019158.


Biological serial block face scanning electron microscopy at improved z-resolution based on Monte Carlo model.

He Q, Hsueh M, Zhang G, Joy DC, Leapman RD.

Sci Rep. 2018 Aug 28;8(1):12985. doi: 10.1038/s41598-018-31231-w.


Dotted Core-Shell Nanoparticles for T1 -Weighted MRI of Tumors.

Shen Z, Song J, Zhou Z, Yung BC, Aronova MA, Li Y, Dai Y, Fan W, Liu Y, Li Z, Ruan H, Leapman RD, Lin L, Niu G, Chen X, Wu A.

Adv Mater. 2018 Jul 4:e1803163. doi: 10.1002/adma.201803163. [Epub ahead of print]


Comparison of 3D cellular imaging techniques based on scanned electron probes: Serial block face SEM vs. Axial bright-field STEM tomography.

McBride EL, Rao A, Zhang G, Hoyne JD, Calco GN, Kuo BC, He Q, Prince AA, Pokrovskaya ID, Storrie B, Sousa AA, Aronova MA, Leapman RD.

J Struct Biol. 2018 Jun;202(3):216-228. doi: 10.1016/j.jsb.2018.01.012. Epub 2018 Feb 1.


Cells containing aragonite crystals mediate responses to gravity in Trichoplax adhaerens (Placozoa), an animal lacking neurons and synapses.

Mayorova TD, Smith CL, Hammar K, Winters CA, Pivovarova NB, Aronova MA, Leapman RD, Reese TS.

PLoS One. 2018 Jan 17;13(1):e0190905. doi: 10.1371/journal.pone.0190905. eCollection 2018.


Application of EELS and EFTEM to the life sciences enabled by the contributions of Ondrej Krivanek.

Leapman RD.

Ultramicroscopy. 2017 Sep;180:180-187. doi: 10.1016/j.ultramic.2017.01.002. Epub 2017 Mar 1.


PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

Sweeney AM, Fleming KE, McCauley JP, Rodriguez MF, Martin ET, Sousa AA, Leapman RD, Scimemi A.

Sci Rep. 2017 Mar 3;7:43606. doi: 10.1038/srep43606.


Tri-stimuli-responsive biodegradable theranostics for mild hyperthermia enhanced chemotherapy.

Lu N, Huang P, Fan W, Wang Z, Liu Y, Wang S, Zhang G, Hu J, Liu W, Niu G, Leapman RD, Lu G, Chen X.

Biomaterials. 2017 May;126:39-48. doi: 10.1016/j.biomaterials.2017.02.025. Epub 2017 Feb 23.


β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.

Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J.

Nat Commun. 2017 Feb 1;8:14295. doi: 10.1038/ncomms14295.


Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures.

Yadav S, Williamson JK, Aronova MA, Prince AA, Pokrovskaya ID, Leapman RD, Storrie B.

Platelets. 2017 Jun;28(4):400-408. doi: 10.1080/09537104.2016.1235685. Epub 2016 Oct 18.


Physicochemical characterization of ferumoxytol, heparin and protamine nanocomplexes for improved magnetic labeling of stem cells.

Bryant LH Jr, Kim SJ, Hobson M, Milo B, Kovacs ZI, Jikaria N, Lewis BK, Aronova MA, Sousa AA, Zhang G, Leapman RD, Frank JA.

Nanomedicine. 2017 Feb;13(2):503-513. doi: 10.1016/j.nano.2016.07.011. Epub 2016 Aug 9.


Compressed Sensing Electron Tomography for Determining Biological Structure.

Guay MD, Czaja W, Aronova MA, Leapman RD.

Sci Rep. 2016 Jun 13;6:27614. doi: 10.1038/srep27614.


Biointeractions of ultrasmall glutathione-coated gold nanoparticles: effect of small size variations.

Sousa AA, Hassan SA, Knittel LL, Balbo A, Aronova MA, Brown PH, Schuck P, Leapman RD.

Nanoscale. 2016 Mar 28;8(12):6577-88. doi: 10.1039/c5nr07642k.


STEM tomography reveals that the canalicular system and α-granules remain separate compartments during early secretion stages in blood platelets.

Pokrovskaya ID, Aronova MA, Kamykowski JA, Prince AA, Hoyne JD, Calco GN, Kuo BC, He Q, Leapman RD, Storrie B.

J Thromb Haemost. 2016 Mar;14(3):572-84. doi: 10.1111/jth.13225. Epub 2016 Feb 4.


PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density.

Chen X, Levy JM, Hou A, Winters C, Azzam R, Sousa AA, Leapman RD, Nicoll RA, Reese TS.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6983-92. doi: 10.1073/pnas.1517045112. Epub 2015 Nov 24.


Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States.

Chen RJ, Zhang G, Garfield SH, Shi YJ, Chen KG, Robey PG, Leapman RD.

PLoS One. 2015 Nov 13;10(11):e0142554. doi: 10.1371/journal.pone.0142554. eCollection 2015.


Combining quantitative 2D and 3D image analysis in the serial block face SEM: application to secretory organelles of pancreatic islet cells.

Shomorony A, Pfeifer CR, Aronova MA, Zhang G, Cai T, Xu H, Notkins AL, Leapman RD.

J Microsc. 2015 Aug;259(2):155-164. doi: 10.1111/jmi.12276. Epub 2015 Jul 2.


Quantitative analysis of mouse pancreatic islet architecture by serial block-face SEM.

Pfeifer CR, Shomorony A, Aronova MA, Zhang G, Cai T, Xu H, Notkins AL, Leapman RD.

J Struct Biol. 2015 Jan;189(1):44-52. doi: 10.1016/j.jsb.2014.10.013. Epub 2014 Nov 8.


Self-organized Mn2+-Block Copolymer Complexes and Their Use for In Vivo MR Imaging of Biological Processes.

Pothayee N, Chen DY, Aronova MA, Qian C, Bouraoud N, Dodd S, Leapman RD, Koretsky AP.

J Mater Chem B. 2014;2(40):7055-7064.


Passive diffusion as a mechanism underlying ribbon synapse vesicle release and resupply.

Graydon CW, Zhang J, Oesch NW, Sousa AA, Leapman RD, Diamond JS.

J Neurosci. 2014 Jul 2;34(27):8948-62. doi: 10.1523/JNEUROSCI.1022-14.2014.


Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance.

Bhirde AA, Chikkaveeraiah BV, Srivatsan A, Niu G, Jin AJ, Kapoor A, Wang Z, Patel S, Patel V, Gorbach AM, Leapman RD, Gutkind JS, Hight Walker AR, Chen X.

ACS Nano. 2014 May 27;8(5):4177-89. doi: 10.1021/nn501223q. Epub 2014 Apr 11.


A structural framework for a near-minimal form of life: mass and compositional analysis of the helical mollicute Spiroplasma melliferum BC3.

Trachtenberg S, Schuck P, Phillips TM, Andrews SB, Leapman RD.

PLoS One. 2014 Feb 21;9(2):e87921. doi: 10.1371/journal.pone.0087921. eCollection 2014.


Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy.

Huang P, Lin J, Li W, Rong P, Wang Z, Wang S, Wang X, Sun X, Aronova M, Niu G, Leapman RD, Nie Z, Chen X.

Angew Chem Int Ed Engl. 2013 Dec 23;52(52):13958-13964. doi: 10.1002/anie.201308986. Epub 2013 Dec 6.


Cryo-electron tomography of the magnetotactic vibrio Magnetovibrio blakemorei: insights into the biomineralization of prismatic magnetosomes.

Abreu F, Sousa AA, Aronova MA, Kim Y, Cox D, Leapman RD, Andrade LR, Kachar B, Bazylinski DA, Lins U.

J Struct Biol. 2013 Feb;181(2):162-8. doi: 10.1016/j.jsb.2012.12.002. Epub 2012 Dec 12.


Elemental mapping by electron energy loss spectroscopy in biology.

Aronova MA, Leapman RD.

Methods Mol Biol. 2013;950:209-26. doi: 10.1007/978-1-62703-137-0_13.


Mass mapping of amyloid fibrils in the electron microscope using STEM imaging.

Sousa AA, Leapman RD.

Methods Mol Biol. 2013;950:195-207. doi: 10.1007/978-1-62703-137-0_12.


Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM.

Norlin N, Hellberg M, Filippov A, Sousa AA, Gröbner G, Leapman RD, Almqvist N, Antzutkin ON.

J Struct Biol. 2012 Oct;180(1):174-89. doi: 10.1016/j.jsb.2012.06.010. Epub 2012 Jun 28.


Development and application of STEM for the biological sciences.

Sousa AA, Leapman RD.

Ultramicroscopy. 2012 Dec;123:38-49. doi: 10.1016/j.ultramic.2012.04.005. Epub 2012 May 18. Review.


Direct visualization of CaMKII at postsynaptic densities by electron microscopy tomography.

Fera A, Dosemeci A, Sousa AA, Yang C, Leapman RD, Reese TS.

J Comp Neurol. 2012 Dec 15;520(18):4218-25. doi: 10.1002/cne.23151.


Nuclear mapping of nanodrug delivery systems in dynamic cellular environments.

Bhirde AA, Kapoor A, Liu G, Iglesias-Bartolome R, Jin A, Zhang G, Xing R, Lee S, Leapman RD, Gutkind JS, Chen X.

ACS Nano. 2012 Jun 26;6(6):4966-72. doi: 10.1021/nn300516g. Epub 2012 May 2.


Synthesis, characterization, and direct intracellular imaging of ultrasmall and uniform glutathione-coated gold nanoparticles.

Sousa AA, Morgan JT, Brown PH, Adams A, Jayasekara MP, Zhang G, Ackerson CJ, Kruhlak MJ, Leapman RD.

Small. 2012 Jul 23;8(14):2277-86. doi: 10.1002/smll.201200071. Epub 2012 Apr 20.


Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.

Xing R, Zhang F, Xie J, Aronova M, Zhang G, Guo N, Huang X, Sun X, Liu G, Bryant LH, Bhirde A, Liang A, Hou Y, Leapman RD, Sun S, Chen X.

Nanoscale. 2011 Dec;3(12):4943-5. doi: 10.1039/c1nr11242b. Epub 2011 Nov 7.


Combining portable Raman probes with nanotubes for theranostic applications.

Bhirde AA, Liu G, Jin A, Iglesias-Bartolome R, Sousa AA, Leapman RD, Gutkind JS, Lee S, Chen X.

Theranostics. 2011;1:310-21. Epub 2011 Jul 4.


Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles.

Cai T, Hirai H, Zhang G, Zhang M, Takahashi N, Kasai H, Satin LS, Leapman RD, Notkins AL.

Diabetologia. 2011 Sep;54(9):2347-57. doi: 10.1007/s00125-011-2221-6. Epub 2011 Jul 6.


Effect of the charge state (z = -1, 0, +1) on the nuclear magnetic resonance of monodisperse Au25[S(CH2)2Ph]18(z) clusters.

Venzo A, Antonello S, Gascón JA, Guryanov I, Leapman RD, Perera NV, Sousa A, Zamuner M, Zanella A, Maran F.

Anal Chem. 2011 Aug 15;83(16):6355-62. doi: 10.1021/ac2012653. Epub 2011 Jul 27.


PSD-95 is required to sustain the molecular organization of the postsynaptic density.

Chen X, Nelson CD, Li X, Winters CA, Azzam R, Sousa AA, Leapman RD, Gainer H, Sheng M, Reese TS.

J Neurosci. 2011 Apr 27;31(17):6329-38. doi: 10.1523/JNEUROSCI.5968-10.2011.


Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice.

Bhirde AA, Patel S, Sousa AA, Patel V, Molinolo AA, Ji Y, Leapman RD, Gutkind JS, Rusling JF.

Nanomedicine (Lond). 2010 Dec;5(10):1535-46. doi: 10.2217/nnm.10.90.


EELS characterization of radiolytic products in frozen samples.

Aronova MA, Sousa AA, Leapman RD.

Micron. 2011 Apr;42(3):252-6. doi: 10.1016/j.micron.2010.10.009. Epub 2010 Nov 3.


Dual-axis electron tomography of biological specimens: Extending the limits of specimen thickness with bright-field STEM imaging.

Sousa AA, Azari AA, Zhang G, Leapman RD.

J Struct Biol. 2011 Apr;174(1):107-14. doi: 10.1016/j.jsb.2010.10.017. Epub 2010 Nov 3.


Limitations of beam damage in electron spectroscopic tomography of embedded cells.

Aronova MA, Sousa AA, Zhang G, Leapman RD.

J Microsc. 2010 Sep 1;239(3):223-32. doi: 10.1111/j.1365-2818.2010.03376.x.


Nanoparticles: Dissected with electrons.

Leapman RD.

Nat Nanotechnol. 2010 Jul;5(7):480-1. doi: 10.1038/nnano.2010.131. No abstract available.


Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast.

Fukunaga M, Li TQ, van Gelderen P, de Zwart JA, Shmueli K, Yao B, Lee J, Maric D, Aronova MA, Zhang G, Leapman RD, Schenck JF, Merkle H, Duyn JH.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3834-9. doi: 10.1073/pnas.0911177107. Epub 2010 Feb 3.


Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes.

Bhirde AA, Sousa AA, Patel V, Azari AA, Gutkind JS, Leapman RD, Rusling JF.

Nanomedicine (Lond). 2009 Oct;4(7):763-72. doi: 10.2217/nnm.09.56.


Nanoscale 3D cellular imaging by axial scanning transmission electron tomography.

Hohmann-Marriott MF, Sousa AA, Azari AA, Glushakova S, Zhang G, Zimmerberg J, Leapman RD.

Nat Methods. 2009 Oct;6(10):729-31. doi: 10.1038/nmeth.1367. Epub 2009 Aug 30.


Influence of melanosome dynamics on melanoma drug sensitivity.

Chen KG, Leapman RD, Zhang G, Lai B, Valencia JC, Cardarelli CO, Vieira WD, Hearing VJ, Gottesman MM.

J Natl Cancer Inst. 2009 Sep 16;101(18):1259-71. doi: 10.1093/jnci/djp259. Epub 2009 Aug 24.


Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors.

Sarin H, Kanevsky AS, Wu H, Sousa AA, Wilson CM, Aronova MA, Griffiths GL, Leapman RD, Vo HQ.

J Transl Med. 2009 Jun 23;7:51. doi: 10.1186/1479-5876-7-51.


Determining molecular mass distributions and compositions of functionalized dendrimer nanoparticles.

Sousa AA, Aronova MA, Wu H, Sarin H, Griffiths G, Leapman RD.

Nanomedicine (Lond). 2009 Jun;4(4):391-9. doi: 10.2217/nnm.09.14.


Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure.

Paravastu AK, Qahwash I, Leapman RD, Meredith SC, Tycko R.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7443-8. doi: 10.1073/pnas.0812033106. Epub 2009 Apr 17.

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