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Items: 30

1.

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.

Alexandrou AJ, Milnes JT, Sun SZ, Fermini B, Kim SC, Jenkinson S, Leishman DJ, Witchel HJ, Hancox JC, Leaney JL.

J Physiol Pharmacol. 2014 Aug;65(4):511-23.

2.

Ophthalmological consequences of cyanotic congenital heart disease: vascular parameters and nerve fibre layer.

Cordina R, Leaney J, Golzan M, Grieve S, Celermajer DS, Graham SL.

Clin Exp Ophthalmol. 2015 Mar;43(2):115-23. doi: 10.1111/ceo.12401. Epub 2014 Sep 20.

PMID:
25077803
3.

Severe alkali burns from beer line cleaners warrant mandatory safety guidelines.

Samarawickrama C, Leaney J, Watson S.

Med J Aust. 2014 Jul 21;201(2):90. No abstract available.

PMID:
25045982
4.

Widespread endotheliopathy in adults with cyanotic congenital heart disease.

Cordina RL, Nakhla S, O'Meagher S, Leaney J, Graham S, Celermajer DS.

Cardiol Young. 2015 Mar;25(3):511-9. doi: 10.1017/S1047951114000262. Epub 2014 Mar 25.

PMID:
24666694
5.
6.

Spontaneous retinal venous pulsatility in patients with cyanotic congenital heart disease.

Mojtaba Golzan S, Leaney J, Cordina R, Avolio A, Celermajer DS, Graham SL.

Heart Vessels. 2012 Nov;27(6):618-23. doi: 10.1007/s00380-011-0201-x. Epub 2011 Nov 17.

PMID:
22089147
7.

Dynamic association between intraocular pressure and spontaneous pulsations of retinal veins.

Golzan SM, Graham SL, Leaney J, Avolio A.

Curr Eye Res. 2011 Jan;36(1):53-9. doi: 10.3109/02713683.2010.530731.

PMID:
21174598
8.

Dichoptic suppression of mfVEP amplitude: effect of retinal eccentricity and simulated unilateral visual impairment.

Leaney J, Klistorner A, Arvind H, Graham SL.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6549-55. doi: 10.1167/iovs.10-5769. Epub 2010 Jul 29.

PMID:
20671270
9.

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.

Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC.

J Pharmacol Toxicol Methods. 2010 Mar-Apr;61(2):178-91. doi: 10.1016/j.vascn.2010.02.007. Epub 2010 Feb 19.

PMID:
20172036
10.

Identifying preperimetric functional loss in glaucoma: a blue-on-yellow multifocal visual evoked potentials study.

Arvind H, Graham S, Leaney J, Grigg J, Goldberg I, Billson F, Klistorner A.

Ophthalmology. 2009 Jun;116(6):1134-41. doi: 10.1016/j.ophtha.2008.12.041. Epub 2009 Apr 23.

PMID:
19395037
11.

Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model.

Steidl-Nichols JV, Hanton G, Leaney J, Liu RC, Leishman D, McHarg A, Wallis R.

J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):9-22. Epub 2007 Jul 3.

PMID:
17707659
12.

Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro.

Lightbown ID, Johnson M, Davis A, Leaney J, Leishman DJ.

J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):194-202. Epub 2007 May 24.

PMID:
17583537
13.

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.

Duncan RS, McPate MJ, Ridley JM, Gao Z, James AF, Leishman DJ, Leaney JL, Witchel HJ, Hancox JC.

Biochem Pharmacol. 2007 Aug 1;74(3):425-37. Epub 2007 May 3.

14.

hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656.

Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC.

Biochem Biophys Res Commun. 2006 Dec 8;351(1):273-80. Epub 2006 Oct 23.

PMID:
17056009
15.

Differential phosphoinositide binding to components of the G protein-gated K+ channel.

Thomas AM, Brown SG, Leaney JL, Tinker A.

J Membr Biol. 2006 May;211(1):43-53. Epub 2006 Sep 18.

PMID:
16988861
16.

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin.

Alexandrou AJ, Duncan RS, Sullivan A, Hancox JC, Leishman DJ, Witchel HJ, Leaney JL.

Br J Pharmacol. 2006 Apr;147(8):905-16.

17.

Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.

Duncan RS, Ridley JM, Dempsey CE, Leishman DJ, Leaney JL, Hancox JC, Witchel HJ.

Biochem Biophys Res Commun. 2006 Mar 10;341(2):500-6. Epub 2006 Jan 13.

PMID:
16446155
18.

Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.

Perry M, Stansfeld PJ, Leaney J, Wood C, de Groot MJ, Leishman D, Sutcliffe MJ, Mitcheson JS.

Mol Pharmacol. 2006 Feb;69(2):509-19. Epub 2005 Nov 16.

PMID:
16291873
19.

PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells.

Brown SG, Thomas A, Dekker LV, Tinker A, Leaney JL.

Am J Physiol Cell Physiol. 2005 Sep;289(3):C543-56. Epub 2005 Apr 27.

20.

Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined by G protein cycle.

Leaney JL, Benians A, Brown S, Nobles M, Kelly D, Tinker A.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C182-91. Epub 2004 Mar 10.

22.

Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels.

Benians A, Leaney JL, Tinker A.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6239-44. Epub 2003 Apr 28.

23.

The dynamics of formation and action of the ternary complex revealed in living cells using a G-protein-gated K+ channel as a biosensor.

Benians A, Leaney JL, Milligan G, Tinker A.

J Biol Chem. 2003 Mar 21;278(12):10851-8. Epub 2003 Jan 14.

24.

A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits.

Leaney JL, Benians A, Graves FM, Tinker A.

J Biol Chem. 2002 Aug 9;277(32):28803-9. Epub 2002 Jun 4.

25.
28.

The molecular assembly of ATP-sensitive potassium channels. Determinants on the pore forming subunit.

Giblin JP, Leaney JL, Tinker A.

J Biol Chem. 1999 Aug 6;274(32):22652-9.

29.

A swelling-activated chloride current in rat sympathetic neurones.

Leaney JL, Marsh SJ, Brown DA.

J Physiol. 1997 Jun 15;501 ( Pt 3):555-64.

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