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Items: 20

1.

Hachimoji DNA and RNA: A genetic system with eight building blocks.

Hoshika S, Leal NA, Kim MJ, Kim MS, Karalkar NB, Kim HJ, Bates AM, Watkins NE Jr, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia J Jr, Georgiadis MM, Benner SA.

Science. 2019 Feb 22;363(6429):884-887. doi: 10.1126/science.aat0971.

PMID:
30792304
2.

"Skinny" and "Fat" DNA: Two New Double Helices.

Hoshika S, Singh I, Switzer C, Molt RW Jr, Leal NA, Kim MJ, Kim MS, Kim HJ, Georgiadis MM, Benner SA.

J Am Chem Soc. 2018 Sep 19;140(37):11655-11660. doi: 10.1021/jacs.8b05042. Epub 2018 Sep 10.

PMID:
30148365
3.

A Survey of the Regulatory Requirements for BCS-Based Biowaivers for Solid Oral Dosage Forms by Participating Regulators and Organisations of the International Generic Drug Regulators Programme.

Van Oudtshoorn JE, García-Arieta A, Santos GML, Crane C, Rodrigues C, Simon C, Kim JM, Park SA, Okada Y, Kuribayashi R, Pfäffli C, Nolting A, Lojero IOC, Martínez ZR, Hung WY, Braddy AC, Leal NA, Triana DG, Clarke M, Bachmann P.

J Pharm Pharm Sci. 2018;21(1):27-37. doi: 10.18433/J3X93K. Review.

4.

Synthesis and Enzymology of 2'-Deoxy-7-deazaisoguanosine Triphosphate and Its Complement: A Second Generation Pair in an Artificially Expanded Genetic Information System.

Karalkar NB, Leal NA, Kim MS, Bradley KM, Benner SA.

ACS Synth Biol. 2016 Jul 15;5(7):672-8. doi: 10.1021/acssynbio.5b00276. Epub 2016 Feb 25.

PMID:
26914388
5.

Transcription, reverse transcription, and analysis of RNA containing artificial genetic components.

Leal NA, Kim HJ, Hoshika S, Kim MJ, Carrigan MA, Benner SA.

ACS Synth Biol. 2015 Apr 17;4(4):407-13. doi: 10.1021/sb500268n. Epub 2014 Aug 19.

PMID:
25137127
6.

Ribonucleosides for an artificially expanded genetic information system.

Kim HJ, Leal NA, Hoshika S, Benner SA.

J Org Chem. 2014 Apr 4;79(7):3194-9. doi: 10.1021/jo402665d. Epub 2014 Mar 18.

7.

Directed evolution of polymerases to accept nucleotides with nonstandard hydrogen bond patterns.

Laos R, Shaw R, Leal NA, Gaucher E, Benner S.

Biochemistry. 2013 Aug 6;52(31):5288-94. doi: 10.1021/bi400558c. Epub 2013 Jul 23.

PMID:
23815560
8.

Conversion strategy using an expanded genetic alphabet to assay nucleic acids.

Yang Z, Durante M, Glushakova LG, Sharma N, Leal NA, Bradley KM, Chen F, Benner SA.

Anal Chem. 2013 May 7;85(9):4705-12. doi: 10.1021/ac400422r. Epub 2013 Apr 17.

9.

Labeled nucleoside triphosphates with reversibly terminating aminoalkoxyl groups.

Hutter D, Kim MJ, Karalkar N, Leal NA, Chen F, Guggenheim E, Visalakshi V, Olejnik J, Gordon S, Benner SA.

Nucleosides Nucleotides Nucleic Acids. 2010 Nov;29(11):879-95. doi: 10.1080/15257770.2010.536191.

10.

Artificial genetic systems: self-avoiding DNA in PCR and multiplexed PCR.

Hoshika S, Chen F, Leal NA, Benner SA.

Angew Chem Int Ed Engl. 2010 Jul 26;49(32):5554-7. doi: 10.1002/anie.201001977. No abstract available.

11.

Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection.

Chen F, Gaucher EA, Leal NA, Hutter D, Havemann SA, Govindarajan S, Ortlund EA, Benner SA.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1948-53. doi: 10.1073/pnas.0908463107. Epub 2010 Jan 11.

12.

2'-deoxy-1-methylpseudocytidine, a stable analog of 2'-deoxy-5-methylisocytidine.

Kim HJ, Leal NA, Benner SA.

Bioorg Med Chem. 2009 May 15;17(10):3728-32. doi: 10.1016/j.bmc.2009.03.047. Epub 2009 Mar 27.

13.

Self-Avoiding Molecular Recognition Systems (SAMRS).

Hoshika S, Chen F, Leal NA, Benner SA.

Nucleic Acids Symp Ser (Oxf). 2008;(52):129-30. doi: 10.1093/nass/nrn066.

PMID:
18776287
14.

In vivo expression of human ATP:cob(I)alamin adenosyltransferase (ATR) using recombinant adeno-associated virus (rAAV) serotypes 2 and 8.

Erger KE, Conlon TJ, Leal NA, Zori R, Bobik TA, Flotte TR.

J Gene Med. 2007 Jun;9(6):462-9.

PMID:
17471589
15.

PduL is an evolutionarily distinct phosphotransacylase involved in B12-dependent 1,2-propanediol degradation by Salmonella enterica serovar typhimurium LT2.

Liu Y, Leal NA, Sampson EM, Johnson CL, Havemann GD, Bobik TA.

J Bacteriol. 2007 Mar;189(5):1589-96. Epub 2006 Dec 8.

16.

Dynamic assembly of primers on nucleic acid templates.

Leal NA, Sukeda M, Benner SA.

Nucleic Acids Res. 2006;34(17):4702-10. Epub 2006 Sep 8.

17.

Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase.

Leal NA, Olteanu H, Banerjee R, Bobik TA.

J Biol Chem. 2004 Nov 12;279(46):47536-42. Epub 2004 Aug 30.

19.

Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant.

Leal NA, Park SD, Kima PE, Bobik TA.

J Biol Chem. 2003 Mar 14;278(11):9227-34. Epub 2003 Jan 3.

20.

Functional genomic, biochemical, and genetic characterization of the Salmonella pduO gene, an ATP:cob(I)alamin adenosyltransferase gene.

Johnson CL, Pechonick E, Park SD, Havemann GD, Leal NA, Bobik TA.

J Bacteriol. 2001 Mar;183(5):1577-84.

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