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Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review.

Bezerra GSN, Barbosa WL Júnior, Silva EDD, Leal NC, Medeiros ZM.

Braz J Infect Dis. 2019 Mar - Apr;23(2):111-120. doi: 10.1016/j.bjid.2019.04.001. Epub 2019 May 1. Review.


Retrospective Study of 18 Titanium Alloy Crowns Produced by Computer-Aided Design and Manufacturing in Dogs.

Mestrinho LA, Gordo I, Gawor J, Leal N, Niza M.

Front Vet Sci. 2019 Apr 5;6:97. doi: 10.3389/fvets.2019.00097. eCollection 2019.


Hachimoji DNA and RNA: A genetic system with eight building blocks.

Hoshika S, Leal NA, Kim MJ, Kim MS, Karalkar NB, Kim HJ, Bates AM, Watkins NE Jr, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia J Jr, Georgiadis MM, Benner SA.

Science. 2019 Feb 22;363(6429):884-887. doi: 10.1126/science.aat0971.


A single introduction of Yersinia pestis to Brazil during the 3rd plague pandemic.

Vogler AJ, Sahl JW, Leal NC, Sobreira M, Williamson CHD, Bollig MC, Birdsell DN, Rivera A, Thompson B, Nottingham R, Rezende AM, Keim P, Almeida AMP, Wagner DM.

PLoS One. 2019 Jan 9;14(1):e0209478. doi: 10.1371/journal.pone.0209478. eCollection 2019.


Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients.

Leal NS, Dentoni G, Schreiner B, Kämäräinen OP, Partanen N, Herukka SK, Koivisto AM, Hiltunen M, Rauramaa T, Leinonen V, Ankarcrona M.

Acta Neuropathol Commun. 2018 Oct 1;6(1):102. doi: 10.1186/s40478-018-0605-2.


Multidrug-resistant Acinetobacter baumannii clones persist on hospital inanimate surfaces.

Rocha IV, Xavier DE, Almeida KRH, Oliveira SR, Leal NC.

Braz J Infect Dis. 2018 Sep - Oct;22(5):438-441. doi: 10.1016/j.bjid.2018.08.004. Epub 2018 Sep 25.


"Skinny" and "Fat" DNA: Two New Double Helices.

Hoshika S, Singh I, Switzer C, Molt RW Jr, Leal NA, Kim MJ, Kim MS, Kim HJ, Georgiadis MM, Benner SA.

J Am Chem Soc. 2018 Sep 19;140(37):11655-11660. doi: 10.1021/jacs.8b05042. Epub 2018 Sep 10.


Occurrence of the vanA gene in Staphylococcus epidermidis from nasopharyngeal secretion of Health-Care Workers, Recife, Brazil.

Bezerra Neto AM, Rabelo MA, Lima JLDC, Loibman SO, Leal NC, Maciel MAV.

Rev Soc Bras Med Trop. 2018 May-Jun;51(3):304-309. doi: 10.1590/0037-8682-0159-2017.


Microscopic detection of Mycobacterium tuberculosis in direct or processed sputum smears.

Magalhães JLO, Lima JFDC, Araújo AA, Coutinho IO, Leal NC, Almeida AMP.

Rev Soc Bras Med Trop. 2018 Mar-Apr;51(2):237-239. doi: 10.1590/0037-8682-0238-2017.


Anti-arthritic properties of crude extract from Chenopodium ambrosioides L. leaves.

Pereira WS, da Silva GP, Vigliano MV, Leal NRF, Pinto FA, Fernandes DC, Santos SVM, Martino T, Nascimento JR, de Azevedo APS, Fonseca EN, Velozo LSM, Souza Neto LR, Bastos FF, Portari EA, Sabino KCC, Nascimento F, Coelho MGP.

J Pharm Pharmacol. 2018 Aug;70(8):1078-1091. doi: 10.1111/jphp.12926. Epub 2018 Apr 30.


Anti-inflammatory effect of diterpenes-enriched fractions from Pterodon polygalaeflorus through inhibition of macrophage migration and cytokine production.

Leal NRF, Vigliano MV, Pinto FA, de Sousa TV, Velozo LSM, Sabino KCC, Justo MDG, Coelho MGP.

J Pharm Pharmacol. 2018 Jun;70(6):808-820. doi: 10.1111/jphp.12889. Epub 2018 Mar 7.


TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer.

Filadi R, Leal NS, Schreiner B, Rossi A, Dentoni G, Pinho CM, Wiehager B, Cieri D, Calì T, Pizzo P, Ankarcrona M.

Curr Biol. 2018 Feb 5;28(3):369-382.e6. doi: 10.1016/j.cub.2017.12.047. Epub 2018 Jan 27.


A Survey of the Regulatory Requirements for BCS-Based Biowaivers for Solid Oral Dosage Forms by Participating Regulators and Organisations of the International Generic Drug Regulators Programme.

Van Oudtshoorn JE, García-Arieta A, Santos GML, Crane C, Rodrigues C, Simon C, Kim JM, Park SA, Okada Y, Kuribayashi R, Pfäffli C, Nolting A, Lojero IOC, Martínez ZR, Hung WY, Braddy AC, Leal NA, Triana DG, Clarke M, Bachmann P.

J Pharm Pharm Sci. 2018;21(1):27-37. doi: 10.18433/J3X93K.


Bionalytical validation study for the determination of unbound ambrisentan in human plasma using rapid equilibrium dialysis followed by ultra performance liquid chromatography coupled to mass spectrometry.

Garcia-Martínez S, Rico E, Casal E, Grisaleña A, Alcaraz E, King N, Leal N, Navarro I, Campanero MÁ.

J Pharm Biomed Anal. 2018 Feb 20;150:427-435. doi: 10.1016/j.jpba.2017.12.030. Epub 2017 Dec 16.


Model Informed Pediatric Development Applied to Bilastine: Ontogenic PK Model Development, Dose Selection for First Time in Children and PK Study Design.

Vozmediano V, Sologuren A, Lukas JC, Leal N, Rodriguez M.

Pharm Res. 2017 Dec;34(12):2720-2734. doi: 10.1007/s11095-017-2248-6. Epub 2017 Oct 2.


Genetic diversity and virulence potential of clinical and environmental Aeromonas spp. isolates from a diarrhea outbreak.

Silva LCAD, Leal-Balbino TC, Melo BST, Mendes-Marques CL, Rezende AM, Almeida AMP, Leal NC.

BMC Microbiol. 2017 Aug 18;17(1):179. doi: 10.1186/s12866-017-1089-0.


Rodents and other small mammal reservoirs in plague foci in northeastern Brazil.

Da Costa ECV, Sobreira M, Leal NC, De Almeida AMP.

J Infect Dev Ctries. 2017 Jun 1;11(5):426-430. doi: 10.3855/jidc.8271.


Ciprofloxacin-resistant and extended-spectrum β-lactamase-producing Escherichia coli ST410 strain carrying the mcr-1 gene associated with bloodstream infection.

Rocha IV, Andrade CADN, Campos TL, Rezende AM, Leal NC, Vidal CFL, Xavier DE.

Int J Antimicrob Agents. 2017 May;49(5):655-656. doi: 10.1016/j.ijantimicag.2017.03.001. Epub 2017 Mar 14. No abstract available.


High Frequency of OXA-253-Producing Acinetobacter baumannii in Different Hospitals in Recife, Brazil.

de Sá Cavalcanti FL, Mendes-Marques CL, Vasconcelos CR, de Lima Campos T, Rezende AM, Xavier DE, Leal NC, de-Melo-Neto OP, de Morais MM, Leal-Balbino TC.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01309-16. doi: 10.1128/AAC.01309-16. Print 2017 Jan.


How mechanical stresses modulate enamel demineralization in non-carious cervical lesions?

Leal NMS, Silva JL, Benigno MIM, Bemerguy EA, Meira JBC, Ballester RY.

J Mech Behav Biomed Mater. 2017 Feb;66:50-57. doi: 10.1016/j.jmbbm.2016.11.003. Epub 2016 Nov 4.


Biplot analysis of strawberry genotypes recommended for the State of Espírito Santo.

Costa AF, Teodoro PE, Bhering LL, Leal NR, Tardin FD, Daher RF.

Genet Mol Res. 2016 Aug 26;15(3). doi: 10.4238/gmr.15038919.


Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.

Estrada LD, Chamorro D, Yañez MJ, Gonzalez M, Leal N, von Bernhardi R, Dulcey AE, Marugan J, Ferrer M, Soto C, Zanlungo S, Inestrosa NC, Alvarez AR.

J Alzheimers Dis. 2016 Oct 4;54(3):1193-1205.


c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease.

Yáñez MJ, Belbin O, Estrada LD, Leal N, Contreras PS, Lleó A, Burgos PV, Zanlungo S, Alvarez AR.

Biochim Biophys Acta. 2016 Nov;1862(11):2158-2167. doi: 10.1016/j.bbadis.2016.08.016. Epub 2016 Aug 23.


Supervised physical therapy in women treated with radiotherapy for breast cancer.

Leal NF, Oliveira HF, Carrara HH.

Rev Lat Am Enfermagem. 2016 Aug 15;24:e2755. doi: 10.1590/1518-8345.0702.2755. English, Portuguese, Spanish.


Use of a Boari flap and renal descensus as treatment for proximal ureteral rupture in a cat.

Gordo I, Mestrinho LA, Minderico MM, Leal NM, Hamaide AJ.

J Am Vet Med Assoc. 2016 Aug 15;249(4):406-10. doi: 10.2460/javma.249.4.406.


Latex protein extracts from Calotropis procera with immunomodulatory properties protect against experimental infections with Listeria monocytogenes.

Nascimento DC, Ralph MT, Batista JE, Silva DM, Gomes-Filho MA, Alencar NM, Leal NC, Ramos MV, Lima-Filho JV.

Phytomedicine. 2016 Jun 15;23(7):745-53. doi: 10.1016/j.phymed.2016.03.012. Epub 2016 Apr 13.


Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production.

Leal NS, Schreiner B, Pinho CM, Filadi R, Wiehager B, Karlström H, Pizzo P, Ankarcrona M.

J Cell Mol Med. 2016 Sep;20(9):1686-95. doi: 10.1111/jcmm.12863. Epub 2016 May 20.


Occurrence and analysis of irp2 virulence gene in isolates of Klebsiella pneumoniae and Enterobacter spp. from microbiota and hospital and community-acquired infections.

Souza Lopes AC, Rodrigues JF, Cabral AB, da Silva ME, Leal NC, da Silveira VM, de Morais Júnior MA.

Microb Pathog. 2016 Jul;96:15-9. doi: 10.1016/j.micpath.2016.04.018. Epub 2016 Apr 29.


Synthesis and Enzymology of 2'-Deoxy-7-deazaisoguanosine Triphosphate and Its Complement: A Second Generation Pair in an Artificially Expanded Genetic Information System.

Karalkar NB, Leal NA, Kim MS, Bradley KM, Benner SA.

ACS Synth Biol. 2016 Jul 15;5(7):672-8. doi: 10.1021/acssynbio.5b00276. Epub 2016 Feb 25.


Viability of Yersinia pestis subcultures in agar stabs.

Leal NC, Sobreira M, Araújo AF, Magalhães JL, Vogler AJ, Bollig MC, Nottingham R, Keim P, Wagner DM, Almeida AM.

Lett Appl Microbiol. 2016 Jan;62(1):91-5. doi: 10.1111/lam.12519.


Double atrial septum or redundant Eustachian valve: procedural management during atrial septal defect occlusion.

Freixa X, Regueiro A, de Araujo GN, Leal N, Sabaté M.

EuroIntervention. 2015 Oct;11(6):e1-2. doi: 10.4244/EIJV11I6A141. No abstract available.


Characterization of epidemic clones of Listeria monocytogenes serotype 4b isolated from humans and meat products in Brazil.

Barbosa AV, Cerqueira Ade M, Rusak LA, Dos Reis CM, Leal NC, Hofer E, Vallim DC.

J Infect Dev Ctries. 2015 Sep 27;9(9):962-9. doi: 10.3855/jidc.5639.


[Computer-aided method and rapid prototyping for the personalized fabrication of a silicone bandage digital prosthesis].

Ventura Ferreira N, Leal N, Correia Sá I, Reis A, Marques M.

Acta Med Port. 2014 Nov-Dec;27(6):775-9. Epub 2014 Dec 30. Portuguese.


Transcription, reverse transcription, and analysis of RNA containing artificial genetic components.

Leal NA, Kim HJ, Hoshika S, Kim MJ, Carrigan MA, Benner SA.

ACS Synth Biol. 2015 Apr 17;4(4):407-13. doi: 10.1021/sb500268n. Epub 2014 Aug 19.


An engineering-based approach for design and fabrication of a customized nasal prosthesis.

Neto R, Costa-Ferreira A, Leal N, Machado M, Reis A.

Prosthet Orthot Int. 2015 Oct;39(5):422-8. doi: 10.1177/0309364614535232. Epub 2014 Jun 4.


EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.

Vargas LM, Leal N, Estrada LD, González A, Serrano F, Araya K, Gysling K, Inestrosa NC, Pasquale EB, Alvarez AR.

PLoS One. 2014 Mar 21;9(3):e92309. doi: 10.1371/journal.pone.0092309. eCollection 2014.


Ribonucleosides for an artificially expanded genetic information system.

Kim HJ, Leal NA, Hoshika S, Benner SA.

J Org Chem. 2014 Apr 4;79(7):3194-9. doi: 10.1021/jo402665d. Epub 2014 Mar 18.


Pre-multidrug-resistant Mycobacterium tuberculosis Beijing strain associated with disseminated tuberculosis in a pet dog.

Botelho A, Perdigão J, Canto A, Albuquerque T, Leal N, Macedo R, Portugal I, Cunha MV.

J Clin Microbiol. 2014 Jan;52(1):354-6. doi: 10.1128/JCM.02800-13. Epub 2013 Oct 23.


Antimicrobial resistance and detection of the mecA gene besides enterotoxin-encoding genes among coagulase-negative Staphylococci isolated from clam meat of Anomalocardia brasiliana.

Batista JE, Ferreira EL, Nascimento DC, Ventura RF, de Oliveira WL, Leal NC, Lima-Filho JV.

Foodborne Pathog Dis. 2013 Dec;10(12):1044-9. doi: 10.1089/fpd.2013.1576. Epub 2013 Oct 8.


Preservation of the native spleen in multivisceral transplantation.

Hernandez F, Andres AM, Encinas JL, Domínguez E, Gamez M, Murcia FJ, Leal N, Martinez L, Molina M, Ramos E, Sarria J, Martinez-Ojinaga E, Prieto G, Frauca E, Lopez-Santamaria M.

Pediatr Transplant. 2013 Sep;17(6):556-60. doi: 10.1111/petr.12124.


Directed evolution of polymerases to accept nucleotides with nonstandard hydrogen bond patterns.

Laos R, Shaw R, Leal NA, Gaucher E, Benner S.

Biochemistry. 2013 Aug 6;52(31):5288-94. doi: 10.1021/bi400558c. Epub 2013 Jul 23.


Tacrolimus dose individualization in "de novo" patients after 10 years of experience in liver transplantation: pharmacokinetic considerations and patient pathophysiology.

Valdivieso N, Oteo I, Valdivieso A, Lukas JC, Leal N, Gastaca M, de Urbina JO, Calvo R, Suarez E.

Int J Clin Pharmacol Ther. 2013 Jul;51(7):606-14. doi: 10.5414/CP201800.


Development of duplex-PCR for identification of Aeromonas species.

Mendes-Marques CL, Hofer E, Leal NC.

Rev Soc Bras Med Trop. 2013 May-Jun;46(3):355-7.


Conversion strategy using an expanded genetic alphabet to assay nucleic acids.

Yang Z, Durante M, Glushakova LG, Sharma N, Leal NA, Bradley KM, Chen F, Benner SA.

Anal Chem. 2013 May 7;85(9):4705-12. doi: 10.1021/ac400422r. Epub 2013 Apr 17.


The aquatic environment as a reservoir of Vibrio cholerae O1 in hydrographic basins of the state of Pernambuco, Brazil.

Mendes-Marques CL, Silveira Filho Vda M, da Costa AP, Nunes Mde L, da Silva Filho SV, Figueirôa ÂC, Hofer E, de Almeida AM, Leal NC.

ScientificWorldJournal. 2013;2013:746254. doi: 10.1155/2013/746254. Epub 2013 Feb 25.


Molecular characterization of Aeromonas spp. and Vibrio cholerae O1 isolated during a diarrhea outbreak.

Mendes-Marques CL, Nascimento LM, Theophilo GN, Hofer E, Melo Neto OP, Leal NC.

Rev Inst Med Trop Sao Paulo. 2012 Dec;54(6):299-304.


Genetic diversity of Yersinia pestis in Brazil.

Oliveira MB, Barros MP, Silveira-Filho VM, Araújo-Nepomuceno MR, Balbino VQ, Leal NC, Almeida AM, Leal-Balbino TC.

Genet Mol Res. 2012 Sep 25;11(3):3414-24. doi: 10.4238/2012.September.25.10.


Plague diagnosis STNPCR and MPCR kits assembly, reaction reproducibility, and reagent stability.

da Silva LC, Vasconcelos SS, Mendes-Marques CL, de Almeida AM, Leal NC.

Adv Exp Med Biol. 2012;954:143-7. doi: 10.1007/978-1-4614-3561-7_18. No abstract available.


Plague in Brazil: from now and then.

Tavares C, Aragão AI, Leal NC, Leal-Balbino TC, de Oliveira MB, de Oliveira Gonçalves Ferreira GM, de Almeida AM.

Adv Exp Med Biol. 2012;954:69-77. doi: 10.1007/978-1-4614-3561-7_10. No abstract available.


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