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Items: 1 to 50 of 69


Unveiling the multi-step solubilization mechanism of sub-micron size vesicles by detergents.

Dalgarno PA, Juan-Colás J, Hedley GJ, Piñeiro L, Novo M, Perez-Gonzalez C, Samuel IDW, Leake MC, Johnson S, Al-Soufi W, Penedo JC, Quinn SD.

Sci Rep. 2019 Sep 9;9(1):12897. doi: 10.1038/s41598-019-49210-0.


Towards mapping the 3D genome through high speed single-molecule tracking of functional transcription factors in single living cells.

Wollman AJM, Hedlund EG, Shashkova S, Leake MC.

Methods. 2019 Jun 26. pii: S1046-2023(18)30473-0. doi: 10.1016/j.ymeth.2019.06.021. [Epub ahead of print]


Single-Organelle Quantification Reveals Stoichiometric and Structural Variability of Carboxysomes Dependent on the Environment.

Sun Y, Wollman AJM, Huang F, Leake MC, Liu LN.

Plant Cell. 2019 Jul;31(7):1648-1664. doi: 10.1105/tpc.18.00787. Epub 2019 May 2.


Single-molecule live cell imaging of Rep reveals the dynamic interplay between an accessory replicative helicase and the replisome.

Syeda AH, Wollman AJM, Hargreaves AL, Howard JAL, Brüning JG, McGlynn P, Leake MC.

Nucleic Acids Res. 2019 Jul 9;47(12):6287-6298. doi: 10.1093/nar/gkz298.


Correction: Transcription factor clusters regulate genes in eukaryotic cells.

Wollman AJ, Shashkova S, Hedlund EG, Friemann R, Hohmann S, Leake MC.

Elife. 2019 Feb 6;8. pii: e45804. doi: 10.7554/eLife.45804.


Staphylococcus aureus toxin LukSF dissociates from its membrane receptor target to enable renewed ligand sequestration.

Haapasalo K, Wollman AJM, de Haas CJC, van Kessel KPM, van Strijp JAG, Leake MC.

FASEB J. 2019 Mar;33(3):3807-3824. doi: 10.1096/fj.201801910R. Epub 2018 Dec 3.


ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance.

Pu Y, Li Y, Jin X, Tian T, Ma Q, Zhao Z, Lin SY, Chen Z, Li B, Yao G, Leake MC, Lo CJ, Bai F.

Mol Cell. 2019 Jan 3;73(1):143-156.e4. doi: 10.1016/j.molcel.2018.10.022. Epub 2018 Nov 21.


Single-molecule imaging of DNA gyrase activity in living Escherichia coli.

Stracy M, Wollman AJM, Kaja E, Gapinski J, Lee JE, Leek VA, McKie SJ, Mitchenall LA, Maxwell A, Sherratt DJ, Leake MC, Zawadzki P.

Nucleic Acids Res. 2019 Jan 10;47(1):210-220. doi: 10.1093/nar/gky1143.


High-Speed Single-Molecule Tracking of CXCL13 in the B-Follicle.

Miller H, Cosgrove J, Wollman AJM, Taylor E, Zhou Z, O'Toole PJ, Coles MC, Leake MC.

Front Immunol. 2018 May 22;9:1073. doi: 10.3389/fimmu.2018.01073. eCollection 2018.


The case for biophysics super-groups in physics departments.

Hoogenboom BW, Leake MC.

Phys Biol. 2018 Jul 6;15(6):060201. doi: 10.1088/1478-3975/aaca0a.


Molecular coordination of Staphylococcus aureus cell division.

Lund VA, Wacnik K, Turner RD, Cotterell BE, Walther CG, Fenn SJ, Grein F, Wollman AJ, Leake MC, Olivier N, Cadby A, Mesnage S, Jones S, Foster SJ.

Elife. 2018 Feb 21;7. pii: e32057. doi: 10.7554/eLife.32057.


Characterising Maturation of GFP and mCherry of Genomically Integrated Fusions in Saccharomyces cerevisiae.

Shashkova S, Wollman AJ, Hohmann S, Leake MC.

Bio Protoc. 2018 Jan 20;8(2):e2710. doi: 10.21769/BioProtoc.2710.


Corrigendum to "Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation" [Biochim. Biophys. Acta 1837(6) (2014) 811-824 DOI: 10.1016/j.bbabio.2014.01.020].

Llorente-Garcia I, Lenn T, Erhardt H, Harriman OL, Liu LN, Robson A, Chiu SW, Matthews S, Willis NJ, Bray CD, Lee SH, Shin JY, Bustamante C, Liphardt J, Friedrich T, Mullineaux CW, Leake MC.

Biochim Biophys Acta Bioenerg. 2018 Feb;1859(2):164. doi: 10.1016/j.bbabio.2017.11.005. Epub 2017 Nov 22. No abstract available.


Single-molecule techniques in biophysics: a review of the progress in methods and applications.

Miller H, Zhou Z, Shepherd J, Wollman AJM, Leake MC.

Rep Prog Phys. 2018 Feb;81(2):024601. doi: 10.1088/1361-6633/aa8a02.


The yeast Mig1 transcriptional repressor is dephosphorylated by glucose-dependent and -independent mechanisms.

Shashkova S, Wollman AJM, Leake MC, Hohmann S.

FEMS Microbiol Lett. 2017 Aug 1;364(14). doi: 10.1093/femsle/fnx133.


Transcription factor clusters regulate genes in eukaryotic cells.

Wollman AJ, Shashkova S, Hedlund EG, Friemann R, Hohmann S, Leake MC.

Elife. 2017 Aug 25;6. pii: e27451. doi: 10.7554/eLife.27451. Erratum in: Elife. 2019 Feb 06;8:.


Imaging the cell.

Carrascosa JL, Leake MC.

Biophys Rev. 2017 Aug;9(4):295-296. doi: 10.1007/s12551-017-0280-8. Epub 2017 Aug 3. No abstract available.


Single-molecule fluorescence microscopy review: shedding new light on old problems.

Shashkova S, Leake MC.

Biosci Rep. 2017 Jul 21;37(4). pii: BSR20170031. doi: 10.1042/BSR20170031. Print 2017 Aug 31. Review.


An experimental study of the putative mechanism of a synthetic autonomous rotary DNA nanomotor.

Dunn KE, Leake MC, Wollman AJ, Trefzer MA, Johnson S, Tyrrell AM.

R Soc Open Sci. 2017 Mar 22;4(3):160767. doi: 10.1098/rsos.160767. eCollection 2017 Mar.


Frequent exchange of the DNA polymerase during bacterial chromosome replication.

Beattie TR, Kapadia N, Nicolas E, Uphoff S, Wollman AJ, Leake MC, Reyes-Lamothe R.

Elife. 2017 Mar 31;6. pii: e21763. doi: 10.7554/eLife.21763.


Biophysics of Infection. Preface.

Leake MC.

Adv Exp Med Biol. 2016;915:v. No abstract available.


Using Fluorescence Recovery After Photobleaching (FRAP) to Study Dynamics of the Structural Maintenance of Chromosome (SMC) Complex In Vivo.

Badrinarayanan A, Leake MC.

Methods Mol Biol. 2016;1431:37-46. doi: 10.1007/978-1-4939-3631-1_4.


Single-Molecule Narrow-Field Microscopy of Protein-DNA Binding Dynamics in Glucose Signal Transduction of Live Yeast Cells.

Wollman AJ, Leake MC.

Methods Mol Biol. 2016;1431:5-15. doi: 10.1007/978-1-4939-3631-1_2.


New Advances in Chromosome Architecture.

Leake MC.

Methods Mol Biol. 2016;1431:1-3. doi: 10.1007/978-1-4939-3631-1_1.


Force Spectroscopy in Studying Infection.

Zhou Z, Leake MC.

Adv Exp Med Biol. 2016;915:307-27. doi: 10.1007/978-3-319-32189-9_19. Review.


Designing a Single-Molecule Biophysics Tool for Characterising DNA Damage for Techniques that Kill Infectious Pathogens Through DNA Damage Effects.

Miller H, Wollman AJ, Leake MC.

Adv Exp Med Biol. 2016;915:115-27. doi: 10.1007/978-3-319-32189-9_9. Review.


Single-Molecule Observation of DNA Replication Repair Pathways in E. coli.

Wollman AJ, Syeda AH, McGlynn P, Leake MC.

Adv Exp Med Biol. 2016;915:5-16. doi: 10.1007/978-3-319-32189-9_2. Review.


The Biophysics of Infection.

Leake MC.

Adv Exp Med Biol. 2016;915:1-3. doi: 10.1007/978-3-319-32189-9_1.


Single-molecule studies of the dynamics and interactions of bacterial OXPHOS complexes.

Lenn T, Leake MC.

Biochim Biophys Acta. 2016 Mar;1857(3):224-31. doi: 10.1016/j.bbabio.2015.10.008. Epub 2015 Oct 21.


Probing DNA interactions with proteins using a single-molecule toolbox: inside the cell, in a test tube and in a computer.

Wollman AJ, Miller H, Zhou Z, Leake MC.

Biochem Soc Trans. 2015 Apr;43(2):139-45. doi: 10.1042/BST20140253. Review.


From Animaculum to single molecules: 300 years of the light microscope.

Wollman AJ, Nudd R, Hedlund EG, Leake MC.

Open Biol. 2015 Apr;5(4):150019. doi: 10.1098/rsob.150019. Review.


Superresolution imaging of single DNA molecules using stochastic photoblinking of minor groove and intercalating dyes.

Miller H, Zhou Z, Wollman AJ, Leake MC.

Methods. 2015 Oct 15;88:81-8. doi: 10.1016/j.ymeth.2015.01.010. Epub 2015 Jan 27.


Localisation and interactions of the Vipp1 protein in cyanobacteria.

Bryan SJ, Burroughs NJ, Shevela D, Yu J, Rupprecht E, Liu LN, Mastroianni G, Xue Q, Llorente-Garcia I, Leake MC, Eichacker LA, Schneider D, Nixon PJ, Mullineaux CW.

Mol Microbiol. 2014 Oct 13. doi: 10.1111/mmi.12826. [Epub ahead of print]


Independent mobility of proteins and lipids in the plasma membrane of Escherichia coli.

Nenninger A, Mastroianni G, Robson A, Lenn T, Xue Q, Leake MC, Mullineaux CW.

Mol Microbiol. 2014 Jun;92(5):1142-53. doi: 10.1111/mmi.12619. Epub 2014 Apr 30.


Analytical tools for single-molecule fluorescence imaging in cellulo.

Leake MC.

Phys Chem Chem Phys. 2014 Jul 7;16(25):12635-47. doi: 10.1039/c4cp00219a.


Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation.

Llorente-Garcia I, Lenn T, Erhardt H, Harriman OL, Liu LN, Robson A, Chiu SW, Matthews S, Willis NJ, Bray CD, Lee SH, Shin JY, Bustamante C, Liphardt J, Friedrich T, Mullineaux CW, Leake MC.

Biochim Biophys Acta. 2014 Jun;1837(6):811-24. doi: 10.1016/j.bbabio.2014.01.020. Epub 2014 Feb 7. Erratum in: Biochim Biophys Acta. 2017 Nov 22;:.


Positioning of chemosensory proteins and FtsZ through the Rhodobacter sphaeroides cell cycle.

Chiu SW, Roberts MA, Leake MC, Armitage JP.

Mol Microbiol. 2013 Oct;90(2):322-37. doi: 10.1111/mmi.12366. Epub 2013 Sep 9.


The physics of life: one molecule at a time.

Leake MC.

Philos Trans R Soc Lond B Biol Sci. 2012 Dec 24;368(1611):20120248. doi: 10.1098/rstb.2012.0248. Print 2013 Feb 5.


Inferring diffusion in single live cells at the single-molecule level.

Robson A, Burrage K, Leake MC.

Philos Trans R Soc Lond B Biol Sci. 2012 Dec 24;368(1611):20120029. doi: 10.1098/rstb.2012.0029. Print 2013 Feb 5. Review.


In vivo architecture and action of bacterial structural maintenance of chromosome proteins.

Badrinarayanan A, Reyes-Lamothe R, Uphoff S, Leake MC, Sherratt DJ.

Science. 2012 Oct 26;338(6106):528-31. doi: 10.1126/science.1227126.


Single molecule experimentation in biological physics: exploring the living component of soft condensed matter one molecule at a time.

Harriman OL, Leake MC.

J Phys Condens Matter. 2011 Dec 21;23(50):503101. doi: 10.1088/0953-8984/23/50/503101. Epub 2011 Nov 9.


Functioning nanomachines seen in real-time in living bacteria using single-molecule and super-resolution fluorescence imaging.

Chiu SW, Leake MC.

Int J Mol Sci. 2011;12(4):2518-42. doi: 10.3390/ijms12042518. Epub 2011 Apr 15. Review.


Shining the spotlight on functional molecular complexes: The new science of single-molecule cell biology.

Leake MC.

Commun Integr Biol. 2010 Sep;3(5):415-8. doi: 10.4161/cib.3.5.12657.


Signal-dependent turnover of the bacterial flagellar switch protein FliM.

Delalez NJ, Wadhams GH, Rosser G, Xue Q, Brown MT, Dobbie IM, Berry RM, Leake MC, Armitage JP.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11347-51. doi: 10.1073/pnas.1000284107. Epub 2010 May 24.


Stoichiometry and architecture of active DNA replication machinery in Escherichia coli.

Reyes-Lamothe R, Sherratt DJ, Leake MC.

Science. 2010 Apr 23;328(5977):498-501. doi: 10.1126/science.1185757.


Millisecond timescale slimfield imaging and automated quantification of single fluorescent protein molecules for use in probing complex biological processes.

Plank M, Wadhams GH, Leake MC.

Integr Biol (Camb). 2009 Oct;1(10):602-12. doi: 10.1039/b907837a. Epub 2009 Aug 4.


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