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Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation.

Zhang W, Chuang YA, Na Y, Ye Z, Yang L, Lin R, Zhou J, Wu J, Qiu J, Savonenko A, Leahy DJ, Huganir R, Linden DJ, Worley PF.

Mol Cell. 2019 May 23. pii: S1097-2765(19)30357-0. doi: 10.1016/j.molcel.2019.05.004. [Epub ahead of print]


EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.

Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA.

Cell. 2017 Oct 19;171(3):683-695.e18. doi: 10.1016/j.cell.2017.09.017. Epub 2017 Oct 5.


BOC is a modifier gene in holoprosencephaly.

Hong M, Srivastava K, Kim S, Allen BL, Leahy DJ, Hu P, Roessler E, Krauss RS, Muenke M.

Hum Mutat. 2017 Nov;38(11):1464-1470. doi: 10.1002/humu.23286. Epub 2017 Jul 21.


Laser induced mortality of Anopheles stephensi mosquitoes.

Keller MD, Leahy DJ, Norton BJ, Johanson T, Mullen ER, Marvit M, Makagon A.

Sci Rep. 2016 Feb 18;6:20936. doi: 10.1038/srep20936.


A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.

Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M.

Nat Commun. 2016 Feb 4;7:10339. doi: 10.1038/ncomms10339.


Immunoaffinity Purification of Proteins.

Kavran JM, Leahy DJ.

Methods Enzymol. 2015;559:27-36. doi: 10.1016/bs.mie.2014.11.006. Epub 2015 Mar 29.


Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1.

Li W, Koutmou KS, Leahy DJ, Li M.

J Biol Chem. 2015 Jul 31;290(31):18904-13. doi: 10.1074/jbc.M115.658864. Epub 2015 Jun 11.


Structural basis of arc binding to synaptic proteins: implications for cognitive disease.

Zhang W, Wu J, Ward MD, Yang S, Chuang YA, Xiao M, Li R, Leahy DJ, Worley PF.

Neuron. 2015 Apr 22;86(2):490-500. doi: 10.1016/j.neuron.2015.03.030. Epub 2015 Apr 9.


Smoothened goes molecular: new pieces in the hedgehog signaling puzzle.

McCabe JM, Leahy DJ.

J Biol Chem. 2015 Feb 6;290(6):3500-7. doi: 10.1074/jbc.R114.617936. Epub 2014 Dec 17. Review.


Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.

Ward MD, Leahy DJ.

J Biol Chem. 2015 Jan 16;290(3):1570-9. doi: 10.1074/jbc.M114.612085. Epub 2014 Dec 2.


Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs.

Cleveland TE 4th, McCabe JM, Leahy DJ.

Protein Expr Purif. 2014 Dec;104:92-102. doi: 10.1016/j.pep.2014.09.012. Epub 2014 Sep 26.


How IGF-1 activates its receptor.

Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ.

Elife. 2014 Sep 25;3. pii: e03772. doi: 10.7554/eLife.03772.


Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.

Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA.

J Biol Chem. 2014 Nov 7;289(45):31361-72. doi: 10.1074/jbc.M114.597153. Epub 2014 Sep 23.


FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia.

Ma HS, Nguyen B, Duffield AS, Li L, Galanis A, Williams AB, Brown PA, Levis MJ, Leahy DJ, Small D.

Cancer Res. 2014 Sep 15;74(18):5206-17. doi: 10.1158/0008-5472.CAN-14-1028. Epub 2014 Jul 24.


Silver staining of SDS-polyacrylamide gel.

Kavran JM, Leahy DJ.

Methods Enzymol. 2014;541:169-76. doi: 10.1016/B978-0-12-420119-4.00014-8.


Coupling antibody to cyanogen bromide-activated sepharose.

Kavran JM, Leahy DJ.

Methods Enzymol. 2014;541:27-34. doi: 10.1016/B978-0-12-420119-4.00003-3.


The FRET signatures of noninteracting proteins in membranes: simulations and experiments.

King C, Sarabipour S, Byrne P, Leahy DJ, Hristova K.

Biophys J. 2014 Mar 18;106(6):1309-17. doi: 10.1016/j.bpj.2014.01.039.


An Fc domain protein-small molecule conjugate as an enhanced immunomodulator.

Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, Powell JD, Cole PA.

J Am Chem Soc. 2014 Mar 5;136(9):3370-3. doi: 10.1021/ja5006674. Epub 2014 Feb 24.


Single cell cloning of a stable mammalian cell line.

Longo PA, Kavran JM, Kim MS, Leahy DJ.

Methods Enzymol. 2014;536:165-72. doi: 10.1016/B978-0-12-420070-8.00014-3.


Lysis of mammalian and Sf9 cells.

Kavran JM, Leahy DJ.

Methods Enzymol. 2014;536:47-52. doi: 10.1016/B978-0-12-420070-8.00004-0.


Transient mammalian cell transfection with polyethylenimine (PEI).

Longo PA, Kavran JM, Kim MS, Leahy DJ.

Methods Enzymol. 2013;529:227-40. doi: 10.1016/B978-0-12-418687-3.00018-5.


Generating mammalian stable cell lines by electroporation.

A Longo P, Kavran JM, Kim MS, Leahy DJ.

Methods Enzymol. 2013;529:209-26. doi: 10.1016/B978-0-12-418687-3.00017-3.


Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor.

Wang Z, Raines LL, Hooy RM, Roberson H, Leahy DJ, Cole PA.

ACS Chem Biol. 2013 Nov 15;8(11):2372-6. doi: 10.1021/cb4005707. Epub 2013 Sep 6.


Piecing together the extracellular puzzle.

Leahy DJ.

Cell. 2013 Jul 3;154(1):23-5. doi: 10.1016/j.cell.2013.06.014.


Magic bullets from llamas.

Leahy DJ.

Structure. 2013 Jul 2;21(7):1072-3. doi: 10.1016/j.str.2013.06.008.


Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.

Han J, Ryu S, Moskowitz DM, Rothenberg D, Leahy DJ, Atzmon G, Barzilai N, Suh Y.

Mech Ageing Dev. 2013 Oct;134(10):478-85. doi: 10.1016/j.mad.2013.01.005. Epub 2013 Feb 1.


Dystroglycan organizes axon guidance cue localization and axonal pathfinding.

Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD.

Neuron. 2012 Dec 6;76(5):931-44. doi: 10.1016/j.neuron.2012.10.009.


Proteolytic processing of ErbB4 in breast cancer.

Hollmén M, Liu P, Kurppa K, Wildiers H, Reinvall I, Vandorpe T, Smeets A, Deraedt K, Vahlberg T, Joensuu H, Leahy DJ, Schöffski P, Elenius K.

PLoS One. 2012;7(6):e39413. doi: 10.1371/journal.pone.0039413. Epub 2012 Jun 22.


Structural basis for heteromeric assembly and perinuclear organization of keratin filaments.

Lee CH, Kim MS, Chung BM, Leahy DJ, Coulombe PA.

Nat Struct Mol Biol. 2012 Jun 17;19(7):707-15. doi: 10.1038/nsmb.2330.


A single ligand is sufficient to activate EGFR dimers.

Liu P, Cleveland TE 4th, Bouyain S, Byrne PO, Longo PA, Leahy DJ.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10861-6. doi: 10.1073/pnas.1201114109. Epub 2012 Jun 14.


Mechanistic insights into the activation of oncogenic forms of EGF receptor.

Wang Z, Longo PA, Tarrant MK, Kim K, Head S, Leahy DJ, Cole PA.

Nat Struct Mol Biol. 2011 Nov 20;18(12):1388-93. doi: 10.1038/nsmb.2168.


The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether.

Liu P, Bouyain S, Eigenbrot C, Leahy DJ.

Protein Sci. 2012 Jan;21(1):152-5. doi: 10.1002/pro.753. Epub 2011 Nov 14.


Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.

Kim MS, Saunders AM, Hamaoka BY, Beachy PA, Leahy DJ.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13112-7. doi: 10.1073/pnas.1109877108. Epub 2011 Jul 26.


Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor.

Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, Cole PA.

Science. 2010 Dec 17;330(6011):1689-92. doi: 10.1126/science.1196154. Epub 2010 Nov 18.


Interactions between Hedgehog proteins and their binding partners come into view.

Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C.

Genes Dev. 2010 Sep 15;24(18):2001-12. doi: 10.1101/gad.1951710. Review.


The ins and outs of EGFR asymmetry.

Leahy DJ.

Cell. 2010 Aug 20;142(4):513-5. doi: 10.1016/j.cell.2010.08.003.


All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ.

J Biol Chem. 2010 Aug 6;285(32):24584-90. doi: 10.1074/jbc.M110.131680. Epub 2010 Jun 1.


A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal.

Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD.

J Neurosci. 2010 Apr 21;30(16):5767-75. doi: 10.1523/JNEUROSCI.5061-09.2010.


Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response.

Williams EH, Pappano WN, Saunders AM, Kim MS, Leahy DJ, Beachy PA.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5869-74. doi: 10.1073/pnas.1001777107. Epub 2010 Mar 15.


In vitro enzymatic characterization of near full length EGFR in activated and inhibited states.

Qiu C, Tarrant MK, Boronina T, Longo PA, Kavran JM, Cole RN, Cole PA, Leahy DJ.

Biochemistry. 2009 Jul 21;48(28):6624-32. doi: 10.1021/bi900755n.


The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla.

McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ.

Nature. 2008 Oct 16;455(7215):979-83. doi: 10.1038/nature07358. Epub 2008 Sep 14.


Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+.

Mori MX, Vander Kooi CW, Leahy DJ, Yue DT.

Structure. 2008 Apr;16(4):607-20. doi: 10.1016/j.str.2008.01.011.


A molecular view of anti-ErbB monoclonal antibody therapy.

Leahy DJ.

Cancer Cell. 2008 Apr;13(4):291-3. doi: 10.1016/j.ccr.2008.03.010.


Mechanism of activation and inhibition of the HER4/ErbB4 kinase.

Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ.

Structure. 2008 Mar;16(3):460-7. doi: 10.1016/j.str.2007.12.016.


Functionally significant insulin-like growth factor I receptor mutations in centenarians.

Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3438-42. doi: 10.1073/pnas.0705467105. Epub 2008 Mar 3.


A monkey wrench in the kinase machine.

Leahy DJ.

Nat Struct Mol Biol. 2007 Dec;14(12):1120-1. No abstract available.


Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site.

Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ.

J Biol Chem. 2008 Feb 1;283(5):2734-40. Epub 2007 Nov 28.


Structural basis for ligand and heparin binding to neuropilin B domains.

Vander Kooi CW, Jusino MA, Perman B, Neau DB, Bellamy HD, Leahy DJ.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6152-7. Epub 2007 Apr 3.

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