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Items: 9

1.

Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney.

Puranik AS, Leaf IA, Jensen MA, Hedayat AF, Saad A, Kim KW, Saadalla AM, Woollard JR, Kashyap S, Textor SC, Grande JP, Lerman A, Simari RD, Randolph GJ, Duffield JS, Lerman LO.

Sci Rep. 2018 Sep 17;8(1):13948. doi: 10.1038/s41598-018-31887-4.

2.

Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis.

Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS.

J Am Soc Nephrol. 2018 Jun;29(6):1690-1705. doi: 10.1681/ASN.2017121283. Epub 2018 May 8.

3.

What can target kidney fibrosis?

Leaf IA, Duffield JS.

Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i89-i97. doi: 10.1093/ndt/gfw388. Review.

PMID:
28391346
4.

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.

Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS.

J Clin Invest. 2017 Jan 3;127(1):321-334. doi: 10.1172/JCI87532. Epub 2016 Nov 21.

5.

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.

Aachoui Y, Kajiwara Y, Leaf IA, Mao D, Ting JP, Coers J, Aderem A, Buxbaum JD, Miao EA.

Cell Host Microbe. 2015 Sep 9;18(3):320-32. doi: 10.1016/j.chom.2015.07.016. Epub 2015 Aug 27.

6.

Caspase-11 protects against bacteria that escape the vacuole.

Aachoui Y, Leaf IA, Hagar JA, Fontana MF, Campos CG, Zak DE, Tan MH, Cotter PA, Vance RE, Aderem A, Miao EA.

Science. 2013 Feb 22;339(6122):975-8. doi: 10.1126/science.1230751. Epub 2013 Jan 24.

7.

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A.

Nat Immunol. 2010 Dec;11(12):1136-42. doi: 10.1038/ni.1960. Epub 2010 Nov 7.

8.

Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.

Warren SE, Armstrong A, Hamilton MK, Mao DP, Leaf IA, Miao EA, Aderem A.

J Immunol. 2010 Jul 15;185(2):818-21. doi: 10.4049/jimmunol.1000724. Epub 2010 Jun 18.

9.

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.

Miao EA, Mao DP, Yudkovsky N, Bonneau R, Lorang CG, Warren SE, Leaf IA, Aderem A.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3076-80. doi: 10.1073/pnas.0913087107. Epub 2010 Feb 1.

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