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Items: 38


Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages.

Janssen WJ, Danhorn T, Harris C, Mould KJ, Lee FF, Hedin BR, D'Alessandro A, Leach SM, Alper S.

G3 (Bethesda). 2020 Feb 6;10(2):555-567. doi: 10.1534/g3.119.400935.


Families and Schools Together (FAST) for improving outcomes for children and their families.

Valentine JC, Leach SM, Fowler AP, Stojda DK, Macdonald G.

Cochrane Database Syst Rev. 2019 Jul 31;7:CD012760. doi: 10.1002/14651858.CD012760.pub2. [Epub ahead of print] Review.


CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis.

Arends T, Dege C, Bortnick A, Danhorn T, Knapp JR, Jia H, Harmacek L, Fleenor CJ, Straign D, Walton K, Leach SM, Feeney AJ, Murre C, O'Connor BP, Hagman JR.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10927-10936. doi: 10.1073/pnas.1821301116. Epub 2019 May 13.


The Kinome of Human Alveolar Type II and Basal Cells, and Its Reprogramming in Lung Cancer.

Leach SM, Finigan J, Vasu VT, Mishra R, Ghosh M, Foster D, Mason R, Kosmider B, Farias Hesson E, Kern JA.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):481-491. doi: 10.1165/rcmb.2018-0283OC.


Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus.

Sang A, Danhorn T, Peterson JN, Rankin AL, O'Connor BP, Leach SM, Torres RM, Pelanda R.

Nat Commun. 2018 Sep 28;9(1):3973. doi: 10.1038/s41467-018-06293-z.


Whole Blood Gene Expression Profiling Predicts Severe Morbidity and Mortality in Cystic Fibrosis: A 5-Year Follow-Up Study.

Saavedra MT, Quon BS, Faino A, Caceres SM, Poch KR, Sanders LA, Malcolm KC, Nichols DP, Sagel SD, Taylor-Cousar JL, Leach SM, Strand M, Nick JA.

Ann Am Thorac Soc. 2018 May;15(5):589-598. doi: 10.1513/AnnalsATS.201707-527OC.


The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.

Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H.

J Allergy Clin Immunol. 2018 Oct;142(4):1173-1184. doi: 10.1016/j.jaci.2017.10.043. Epub 2017 Dec 24.


Gene expression profile data for mouse facial development.

Leach SM, Feng W, Williams T.

Data Brief. 2017 May 6;13:242-247. doi: 10.1016/j.dib.2017.05.003. eCollection 2017 Aug.


Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis.

McCubbrey AL, Barthel L, Mohning MP, Redente EF, Mould KJ, Thomas SM, Leach SM, Danhorn T, Gibbings SL, Jakubzick CV, Henson PM, Janssen WJ.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):66-78. doi: 10.1165/rcmb.2017-0154OC.


Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma.

Miller MA, Danhorn T, Cruickshank-Quinn CI, Leach SM, Jacobson S, Strand MJ, Reisdorph NA, Bowler RP, Petrache I, Kechris K.

PLoS One. 2017 Jun 2;12(6):e0178281. doi: 10.1371/journal.pone.0178281. eCollection 2017.


Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury.

Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):294-306. doi: 10.1165/rcmb.2017-0061OC.


Systems biology of facial development: contributions of ectoderm and mesenchyme.

Hooper JE, Feng W, Li H, Leach SM, Phang T, Siska C, Jones KL, Spritz RA, Hunter LE, Williams T.

Dev Biol. 2017 Jun 1;426(1):97-114. doi: 10.1016/j.ydbio.2017.03.025. Epub 2017 Mar 29.


Three Unique Interstitial Macrophages in the Murine Lung at Steady State.

Gibbings SL, Thomas SM, Atif SM, McCubbrey AL, Desch AN, Danhorn T, Leach SM, Bratton DL, Henson PM, Janssen WJ, Jakubzick CV.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):66-76. doi: 10.1165/rcmb.2016-0361OC.


Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing.

Chen Z, Gowan K, Leach SM, Viboolsittiseri SS, Mishra AK, Kadoishi T, Diener K, Gao B, Jones K, Wang JH.

BMC Genomics. 2016 Oct 21;17(1):823.


Sputum is a surrogate for bronchoalveolar lavage for monitoring Mycobacterium tuberculosis transcriptional profiles in TB patients.

Garcia BJ, Loxton AG, Dolganov GM, Van TT, Davis JL, de Jong BC, Voskuil MI, Leach SM, Schoolnik GK, Walzl G, Strong M, Walter ND.

Tuberculosis (Edinb). 2016 Sep;100:89-94. doi: 10.1016/ Epub 2016 Jul 25.


Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model.

Waugh KA, Leach SM, Moore BL, Bruno TC, Buhrman JD, Slansky JE.

J Immunol. 2016 Aug 15;197(4):1477-88. doi: 10.4049/jimmunol.1600589. Epub 2016 Jul 1.


Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR.

Munson DJ, Egelston CA, Chiotti KE, Parra ZE, Bruno TC, Moore BL, Nakano TA, Simons DL, Jimenez G, Yim JH, Rozanov DV, Falta MT, Fontenot AP, Reynolds PR, Leach SM, Borges VF, Kappler JW, Spellman PT, Lee PP, Slansky JE.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8272-7. doi: 10.1073/pnas.1606994113. Epub 2016 Jun 15.


Tolerance of Tumor-Specific T cells in Melanoma Metastases.

Waugh KA, Leach SM, Slansky JE.

J Clin Cell Immunol. 2016 Apr;7(2). pii: 409. Epub 2016 Apr 14. No abstract available.


Ly6C(+) monocyte efferocytosis and cross-presentation of cell-associated antigens.

Larson SR, Atif SM, Gibbings SL, Thomas SM, Prabagar MG, Danhorn T, Leach SM, Henson PM, Jakubzick CV.

Cell Death Differ. 2016 Jun;23(6):997-1003. doi: 10.1038/cdd.2016.24. Epub 2016 Mar 18.


Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity.

Chen Z, Elos MT, Viboolsittiseri SS, Gowan K, Leach SM, Rice M, Eder MD, Jones K, Wang JH.

J Hematol Oncol. 2016 Jan 7;9:2. doi: 10.1186/s13045-015-0230-5.


Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity.

Waugh KA, Leach SM, Slansky JE.

Vaccines (Basel). 2015 Sep 17;3(3):771-802. doi: 10.3390/vaccines3030771. Review.


Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages.

Gibbings SL, Goyal R, Desch AN, Leach SM, Prabagar M, Atif SM, Bratton DL, Janssen W, Jakubzick CV.

Blood. 2015 Sep 10;126(11):1357-66. doi: 10.1182/blood-2015-01-624809. Epub 2015 Jul 31.


Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex.

O'Connor BP, Danhorn T, De Arras L, Flatley BR, Marcus RA, Farias-Hesson E, Leach SM, Alper S.

PLoS Genet. 2015 Feb 6;11(2):e1004932. doi: 10.1371/journal.pgen.1004932. eCollection 2015 Feb.


Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.

Kim J, Vasu VT, Mishra R, Singleton KR, Yoo M, Leach SM, Farias-Hesson E, Mason RJ, Kang J, Ramamoorthy P, Kern JA, Heasley LE, Finigan JH, Tan AC.

Bioinformatics. 2014 Sep 1;30(17):2393-8. doi: 10.1093/bioinformatics/btu323. Epub 2014 May 7.


Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity.

De Arras L, Laws R, Leach SM, Pontis K, Freedman JH, Schwartz DA, Alper S.

Genetics. 2014 Jun;197(2):485-96. doi: 10.1534/genetics.113.160499. Epub 2013 Dec 20.


Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis.

Yang IV, Coldren CD, Leach SM, Seibold MA, Murphy E, Lin J, Rosen R, Neidermyer AJ, McKean DF, Groshong SD, Cool C, Cosgrove GP, Lynch DA, Brown KK, Schwarz MI, Fingerlin TE, Schwartz DA.

Thorax. 2013 Dec;68(12):1114-21. doi: 10.1136/thoraxjnl-2012-202943. Epub 2013 Jun 19.


The peripheral blood transcriptome identifies the presence and extent of disease in idiopathic pulmonary fibrosis.

Yang IV, Luna LG, Cotter J, Talbert J, Leach SM, Kidd R, Turner J, Kummer N, Kervitsky D, Brown KK, Boon K, Schwarz MI, Schwartz DA, Steele MP.

PLoS One. 2012;7(6):e37708. doi: 10.1371/journal.pone.0037708. Epub 2012 Jun 22.


Producing highly charged ions without solvent using laserspray ionization: a total solvent-free analysis approach at atmospheric pressure.

Wang B, Lietz CB, Inutan ED, Leach SM, Trimpin S.

Anal Chem. 2011 Jun 1;83(11):4076-84. doi: 10.1021/ac2000576. Epub 2011 May 12.


Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences.

Feng W, Leach SM, Tipney H, Phang T, Geraci M, Spritz RA, Hunter LE, Williams T.

PLoS One. 2009 Dec 16;4(12):e8066. doi: 10.1371/journal.pone.0008066.


Biomedical discovery acceleration, with applications to craniofacial development.

Leach SM, Tipney H, Feng W, Baumgartner WA, Kasliwal P, Schuyler RP, Williams T, Spritz RA, Hunter L.

PLoS Comput Biol. 2009 Mar;5(3):e1000215. doi: 10.1371/journal.pcbi.1000215. Epub 2009 Mar 27.


Leveraging existing biological knowledge in the identification of candidate genes for facial dysmorphology.

Tipney HJ, Leach SM, Feng W, Spritz R, Williams T, Hunter L.

BMC Bioinformatics. 2009 Feb 5;10 Suppl 2:S12. doi: 10.1186/1471-2105-10-S2-S12.


Predicting protein linkages in bacteria: which method is best depends on task.

Karimpour-Fard A, Leach SM, Gill RT, Hunter LE.

BMC Bioinformatics. 2008 Sep 24;9:397. doi: 10.1186/1471-2105-9-397.


The topology of the bacterial co-conserved protein network and its implications for predicting protein function.

Karimpour-Fard A, Leach SM, Hunter LE, Gill RT.

BMC Genomics. 2008 Jun 30;9:313. doi: 10.1186/1471-2164-9-313.


Improving protein function prediction methods with integrated literature data.

Gabow AP, Leach SM, Baumgartner WA, Hunter LE, Goldberg DS.

BMC Bioinformatics. 2008 Apr 15;9:198. doi: 10.1186/1471-2105-9-198.


Predicting the subcellular localization of human proteins using machine learning and exploratory data analysis.

Acquaah-Mensah GK, Leach SM, Guda C.

Genomics Proteomics Bioinformatics. 2006 May;4(2):120-33.


GEST: a gene expression search tool based on a novel Bayesian similarity metric.

Hunter L, Taylor RC, Leach SM, Simon R.

Bioinformatics. 2001;17 Suppl 1:S115-22.


Hypotensive effects of [D-Tyr27,36, D-Thr32]Neuropeptide Y (27-36).

Roscoe AK, Leach SM, Nyce JW, Wooles WR.

Peptides. 1995;16(8):1411-5.


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