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Items: 1 to 50 of 140

1.

EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC.

Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein R, Knauf JA, Rätsch G, Fagin JA.

Cancer Discov. 2018 Oct 10. pii: CD-18-0606. doi: 10.1158/2159-8290.CD-18-0606. [Epub ahead of print]

PMID:
30305285
2.

Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells.

Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, Lozano G, Chiao P, Maitra A, Leach SD, Kolls JK, Vilar E, Wang TC, Bailey JM, McAllister F.

Gastroenterology. 2018 Jul;155(1):210-223.e3. doi: 10.1053/j.gastro.2018.03.041. Epub 2018 Mar 29.

PMID:
29604293
3.

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms.

Lowery MA, Wong W, Jordan EJ, Lee JW, Kemel Y, Vijai J, Mandelker D, Zehir A, Capanu M, Salo-Mullen E, Arnold AG, Yu KH, Varghese AM, Kelsen DP, Brenner R, Kaufmann E, Ravichandran V, Mukherjee S, Berger MF, Hyman DM, Klimstra DS, Abou-Alfa GK, Tjan C, Covington C, Maynard H, Allen PJ, Askan G, Leach SD, Iacobuzio-Donahue CA, Robson ME, Offit K, Stadler ZK, O'Reilly EM.

J Natl Cancer Inst. 2018 Oct 1;110(10):1067-1074. doi: 10.1093/jnci/djy024.

PMID:
29506128
4.

Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas.

Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, Humar A, Husain SZ, Leach SD, Gittes GK, Esni F.

Sci Rep. 2017 Dec 13;7(1):17539. doi: 10.1038/s41598-017-17884-z.

5.

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

Balachandran VP, Łuksza M, Zhao JN, Makarov V, Moral JA, Remark R, Herbst B, Askan G, Bhanot U, Senbabaoglu Y, Wells DK, Cary CIO, Grbovic-Huezo O, Attiyeh M, Medina B, Zhang J, Loo J, Saglimbeni J, Abu-Akeel M, Zappasodi R, Riaz N, Smoragiewicz M, Kelley ZL, Basturk O; Australian Pancreatic Cancer Genome Initiative; Garvan Institute of Medical Research; Prince of Wales Hospital; Royal North Shore Hospital; University of Glasgow; St Vincent’s Hospital; QIMR Berghofer Medical Research Institute; University of Melbourne, Centre for Cancer Research; University of Queensland, Institute for Molecular Bioscience; Bankstown Hospital; Liverpool Hospital; Royal Prince Alfred Hospital, Chris O’Brien Lifehouse; Westmead Hospital; Fremantle Hospital; St John of God Healthcare; Royal Adelaide Hospital; Flinders Medical Centre; Envoi Pathology; Princess Alexandria Hospital; Austin Hospital; Johns Hopkins Medical Institutes; ARC-Net Centre for Applied Research on Cancer, Gönen M, Levine AJ, Allen PJ, Fearon DT, Merad M, Gnjatic S, Iacobuzio-Donahue CA, Wolchok JD, DeMatteo RP, Chan TA, Greenbaum BD, Merghoub T, Leach SD.

Nature. 2017 Nov 23;551(7681):512-516. doi: 10.1038/nature24462. Epub 2017 Nov 8.

6.

Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.

Mandelker D, Zhang L, Kemel Y, Stadler ZK, Joseph V, Zehir A, Pradhan N, Arnold A, Walsh MF, Li Y, Balakrishnan AR, Syed A, Prasad M, Nafa K, Carlo MI, Cadoo KA, Sheehan M, Fleischut MH, Salo-Mullen E, Trottier M, Lipkin SM, Lincoln A, Mukherjee S, Ravichandran V, Cambria R, Galle J, Abida W, Arcila ME, Benayed R, Shah R, Yu K, Bajorin DF, Coleman JA, Leach SD, Lowery MA, Garcia-Aguilar J, Kantoff PW, Sawyers CL, Dickler MN, Saltz L, Motzer RJ, O'Reilly EM, Scher HI, Baselga J, Klimstra DS, Solit DB, Hyman DM, Berger MF, Ladanyi M, Robson ME, Offit K.

JAMA. 2017 Sep 5;318(9):825-835. doi: 10.1001/jama.2017.11137.

7.

Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype.

Lowery MA, Jordan EJ, Basturk O, Ptashkin RN, Zehir A, Berger MF, Leach T, Herbst B, Askan G, Maynard H, Glassman D, Covington C, Schultz N, Abou-Alfa GK, Harding JJ, Klimstra DS, Hechtman JF, Hyman DM, Allen PJ, Jarnagin WR, Balachandran VP, Varghese AM, Schattner MA, Yu KH, Saltz LB, Solit DB, Iacobuzio-Donahue CA, Leach SD, O'Reilly EM.

Clin Cancer Res. 2017 Oct 15;23(20):6094-6100. doi: 10.1158/1078-0432.CCR-17-0899. Epub 2017 Jul 28.

8.

PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk.

Sinha S, Fu YY, Grimont A, Ketcham M, Lafaro K, Saglimbeni JA, Askan G, Bailey JM, Melchor JP, Zhong Y, Joo MG, Grbovic-Huezo O, Yang IH, Basturk O, Baker L, Park Y, Kurtz RC, Tuveson D, Leach SD, Pasricha PJ.

Cancer Res. 2017 Apr 15;77(8):1868-1879. doi: 10.1158/0008-5472.CAN-16-0899-T. Epub 2017 Apr 6.

9.

Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer.

Zhong Y, Macgregor-Das A, Saunders T, Whittle MC, Makohon-Moore A, Kohutek ZA, Poling J, Herbst BT, Javier BM, Cope L, Leach SD, Hingorani SR, Iacobuzio-Donahue CA.

Clin Cancer Res. 2017 Mar 15;23(6):1607-1620. doi: 10.1158/1078-0432.CCR-15-1615. Epub 2016 Sep 16.

10.

New insights in the development of pancreatic cancer.

Sinha S, Leach SD.

Curr Opin Gastroenterol. 2016 Jul 21. [Epub ahead of print]

11.

A pancreatic exocrine-like cell regulatory circuit operating in the upper stomach of the sea urchin Strongylocentrotus purpuratus larva.

Perillo M, Wang YJ, Leach SD, Arnone MI.

BMC Evol Biol. 2016 May 26;16(1):117. doi: 10.1186/s12862-016-0686-0.

12.

p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.

Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds AB, Goggins M, Younes M, Iacobuzio-Donahue CA, Leach SD, Bailey JM.

Cancer Res. 2016 Jun 1;76(11):3351-63. doi: 10.1158/0008-5472.CAN-15-2268. Epub 2016 Mar 31.

13.

Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions.

Choi E, Hendley AM, Bailey JM, Leach SD, Goldenring JR.

Gastroenterology. 2016 Apr;150(4):918-30.e13. doi: 10.1053/j.gastro.2015.11.049. Epub 2015 Dec 8.

14.

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells.

Bailey JM, Hendley AM, Lafaro KJ, Pruski MA, Jones NC, Alsina J, Younes M, Maitra A, McAllister F, Iacobuzio-Donahue CA, Leach SD.

Oncogene. 2016 Aug 11;35(32):4282-8. doi: 10.1038/onc.2015.441. Epub 2015 Nov 23.

PMID:
26592447
15.

Emerging strategies for cancer immunoprevention.

Roeser JC, Leach SD, McAllister F.

Oncogene. 2015 Dec 10;34(50):6029-39. doi: 10.1038/onc.2015.98. Epub 2015 Sep 14. Review.

PMID:
26364615
16.

Ablation of Dicer leads to widespread perturbation of signaling pathways.

Sahasrabuddhe NA, Huang TC, Kumar P, Yang Y, Ghosh B, Leach SD, Chaerkady R, Pandey A.

Biochem Biophys Res Commun. 2015 Jul 31;463(3):389-94. doi: 10.1016/j.bbrc.2015.05.077. Epub 2015 May 30.

17.

Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish.

Wang YJ, Park JT, Parsons MJ, Leach SD.

Dev Dyn. 2015 Jun;244(6):724-35. doi: 10.1002/dvdy.24271. Epub 2015 May 22.

18.

Interleukin interrupted: a new strategy for the treatment of pancreatic cancer.

Leach SD.

J Exp Med. 2015 Mar 9;212(3):284. doi: 10.1084/jem.2123insight1. No abstract available.

19.

Organoid models of human and mouse ductal pancreatic cancer.

Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA.

Cell. 2015 Jan 15;160(1-2):324-38. doi: 10.1016/j.cell.2014.12.021. Epub 2014 Dec 31.

20.

p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.

Hendley AM, Provost E, Bailey JM, Wang YJ, Cleveland MH, Blake D, Bittman RW, Roeser JC, Maitra A, Reynolds AB, Leach SD.

Dev Biol. 2015 Mar 1;399(1):41-53. doi: 10.1016/j.ydbio.2014.12.010. Epub 2014 Dec 16.

21.

Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia.

Wang YJ, McAllister F, Bailey JM, Scott SG, Hendley AM, Leach SD, Ghosh B.

PLoS One. 2014 Nov 18;9(11):e113127. doi: 10.1371/journal.pone.0113127. eCollection 2014.

22.

Targeting IL-17 for pancreatic cancer prevention.

McAllister F, Leach SD.

Oncotarget. 2014 Oct 30;5(20):9530-1. No abstract available.

23.

The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer.

Provost E, Bailey JM, Aldrugh S, Liu S, Iacobuzio-Donahue C, Leach SD.

Zebrafish. 2014 Dec;11(6):551-9. doi: 10.1089/zeb.2014.1024.

24.

Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey.

Park JT, Johnson N, Liu S, Levesque M, Wang YJ, Ho H, Huso D, Maitra A, Parsons MJ, Prescott JD, Leach SD.

Oncogene. 2015 May 21;34(21):2801-6. doi: 10.1038/onc.2014.223. Epub 2014 Jul 28.

25.

Annotation of the zebrafish genome through an integrated transcriptomic and proteomic analysis.

Kelkar DS, Provost E, Chaerkady R, Muthusamy B, Manda SS, Subbannayya T, Selvan LD, Wang CH, Datta KK, Woo S, Dwivedi SB, Renuse S, Getnet D, Huang TC, Kim MS, Pinto SM, Mitchell CJ, Madugundu AK, Kumar P, Sharma J, Advani J, Dey G, Balakrishnan L, Syed N, Nanjappa V, Subbannayya Y, Goel R, Prasad TS, Bafna V, Sirdeshmukh R, Gowda H, Wang C, Leach SD, Pandey A.

Mol Cell Proteomics. 2014 Nov;13(11):3184-98. doi: 10.1074/mcp.M114.038299. Epub 2014 Jul 24.

26.

Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer.

Schiavone M, Rampazzo E, Casari A, Battilana G, Persano L, Moro E, Liu S, Leach SD, Tiso N, Argenton F.

Dis Model Mech. 2014 Jul;7(7):883-94. doi: 10.1242/dmm.014969. Epub 2014 May 30.

27.

A draft map of the human proteome.

Kim MS, Pinto SM, Getnet D, Nirujogi RS, Manda SS, Chaerkady R, Madugundu AK, Kelkar DS, Isserlin R, Jain S, Thomas JK, Muthusamy B, Leal-Rojas P, Kumar P, Sahasrabuddhe NA, Balakrishnan L, Advani J, George B, Renuse S, Selvan LD, Patil AH, Nanjappa V, Radhakrishnan A, Prasad S, Subbannayya T, Raju R, Kumar M, Sreenivasamurthy SK, Marimuthu A, Sathe GJ, Chavan S, Datta KK, Subbannayya Y, Sahu A, Yelamanchi SD, Jayaram S, Rajagopalan P, Sharma J, Murthy KR, Syed N, Goel R, Khan AA, Ahmad S, Dey G, Mudgal K, Chatterjee A, Huang TC, Zhong J, Wu X, Shaw PG, Freed D, Zahari MS, Mukherjee KK, Shankar S, Mahadevan A, Lam H, Mitchell CJ, Shankar SK, Satishchandra P, Schroeder JT, Sirdeshmukh R, Maitra A, Leach SD, Drake CG, Halushka MK, Prasad TS, Hruban RH, Kerr CL, Bader GD, Iacobuzio-Donahue CA, Gowda H, Pandey A.

Nature. 2014 May 29;509(7502):575-81. doi: 10.1038/nature13302.

28.

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia.

McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, Sears CL, Pardoll DM, Leach SD.

Cancer Cell. 2014 May 12;25(5):621-37. doi: 10.1016/j.ccr.2014.03.014.

29.

Regulation of PPAR-alpha pathway by Dicer revealed through proteomic analysis.

Sahasrabuddhe NA, Huang TC, Ahmad S, Kim MS, Yang Y, Ghosh B, Leach SD, Gowda H, Somani BL, Chaerkady R, Pandey A.

J Proteomics. 2014 Aug 28;108:306-15. doi: 10.1016/j.jprot.2014.04.027. Epub 2014 Apr 24.

PMID:
24769236
30.

A red-shifted fluorescent substrate for aldehyde dehydrogenase.

Minn I, Wang H, Mease RC, Byun Y, Yang X, Wang J, Leach SD, Pomper MG.

Nat Commun. 2014 Apr 23;5:3662. doi: 10.1038/ncomms4662.

31.

TAILOR: transgene activation and inactivation using lox and rox in zebrafish.

Park JT, Leach SD.

PLoS One. 2013 Dec 31;8(12):e85218. doi: 10.1371/journal.pone.0085218. eCollection 2013.

32.

Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas.

Matsuda H, Parsons MJ, Leach SD.

PLoS One. 2013 Sep 17;8(9):e74350. doi: 10.1371/journal.pone.0074350. eCollection 2013.

33.

DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer.

Bailey JM, Alsina J, Rasheed ZA, McAllister FM, Fu YY, Plentz R, Zhang H, Pasricha PJ, Bardeesy N, Matsui W, Maitra A, Leach SD.

Gastroenterology. 2014 Jan;146(1):245-56. doi: 10.1053/j.gastro.2013.09.050. Epub 2013 Oct 2.

34.

Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation.

Borden P, Houtz J, Leach SD, Kuruvilla R.

Cell Rep. 2013 Jul 25;4(2):287-301. doi: 10.1016/j.celrep.2013.06.019. Epub 2013 Jul 11.

35.

Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development.

Provost E, Weier CA, Leach SD.

Zebrafish. 2013 Jun;10(2):161-9. doi: 10.1089/zeb.2013.0884. Epub 2013 May 22.

36.

Sphere-forming assays for assessment of benign and malignant pancreatic stem cells.

Wang YJ, Bailey JM, Rovira M, Leach SD.

Methods Mol Biol. 2013;980:281-90. doi: 10.1007/978-1-62703-287-2_15.

PMID:
23359160
37.

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells.

Choi SM, Kim Y, Shim JS, Park JT, Wang RH, Leach SD, Liu JO, Deng C, Ye Z, Jang YY.

Hepatology. 2013 Jun;57(6):2458-68. doi: 10.1002/hep.26237.

38.

Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia.

Maitra A, Leach SD.

Cancer Cell. 2012 Dec 11;22(6):701-3. doi: 10.1016/j.ccr.2012.11.015.

39.

Signaling pathways mediating epithelial- mesenchymal crosstalk in pancreatic cancer: Hedgehog, Notch and TGFβ.

Bailey JM, Leach SD.

In: Grippo PJ, Munshi HG, editors. Pancreatic Cancer and Tumor Microenvironment. Trivandrum (India): Transworld Research Network; 2012. Chapter 7.

40.

Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development.

Provost E, Wehner KA, Zhong X, Ashar F, Nguyen E, Green R, Parsons MJ, Leach SD.

Development. 2012 Sep;139(17):3232-41. doi: 10.1242/dev.077107.

41.

Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cells.

Cleveland MH, Sawyer JM, Afelik S, Jensen J, Leach SD.

Semin Cell Dev Biol. 2012 Aug;23(6):711-9. doi: 10.1016/j.semcdb.2012.06.008. Epub 2012 Jun 26. Review.

42.

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function.

Yamazoe S, Shestopalov IA, Provost E, Leach SD, Chen JK.

Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6908-11. doi: 10.1002/anie.201201690. Epub 2012 Jun 11.

43.

Regulation of lipid metabolism by Dicer revealed through SILAC mice.

Huang TC, Sahasrabuddhe NA, Kim MS, Getnet D, Yang Y, Peterson JM, Ghosh B, Chaerkady R, Leach SD, Marchionni L, Wong GW, Pandey A.

J Proteome Res. 2012 Apr 6;11(4):2193-205. doi: 10.1021/pr2009884. Epub 2012 Feb 28.

44.

EMT and dissemination precede pancreatic tumor formation.

Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ.

Cell. 2012 Jan 20;148(1-2):349-61. doi: 10.1016/j.cell.2011.11.025.

45.

Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system.

Liu S, Leach SD.

Methods Cell Biol. 2011;105:367-81. doi: 10.1016/B978-0-12-381320-6.00015-1.

46.

p53: Guardian of pancreatic epithelial identity.

Ghosh B, Leach SD.

Cell Cycle. 2011 Jun 1;10(11):1717. Epub 2011 Jun 1. No abstract available.

47.

Zebrafish models for cancer.

Liu S, Leach SD.

Annu Rev Pathol. 2011;6:71-93. doi: 10.1146/annurev-pathol-011110-130330. Review.

PMID:
21261518
48.

Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway.

Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A, Mendell JT.

Genes Dev. 2010 Dec 15;24(24):2754-9. doi: 10.1101/gad.1950610.

49.

The role of PET scanning in pancreatic cancer.

Serrano OK, Chaudhry MA, Leach SD.

Adv Surg. 2010;44:313-25. Review.

PMID:
20919529
50.

Pisces and cancer: the stars align.

Leach SD.

Zebrafish. 2009 Dec;6(4):317. doi: 10.1089/zeb.2009.9988. No abstract available.

PMID:
20047464

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