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Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration.

Beloueche-Babari M, Casals Galobart T, Delgado-Goni T, Wantuch S, Parkes HG, Tandy D, Harker JA, Leach MO.

Br J Cancer. 2020 Jan 15. doi: 10.1038/s41416-019-0717-x. [Epub ahead of print]


Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells.

Delgado-Goñi T, Galobart TC, Wantuch S, Normantaite D, Leach MO, Whittaker SR, Beloueche-Babari M.

Br J Cancer. 2020 Jan;122(1):72-81. doi: 10.1038/s41416-019-0628-x. Epub 2019 Dec 10.


Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers: a case-controlled study (SIGNIFY).

Bancroft EK, Saya S, Brown E, Thomas S, Taylor N, Rothwell J, Pope J, Chamberlain A, Page E, Benafif S, Hanson H, Dias A, Mikropoulos C, Izatt L, Side L, Walker L, Donaldson A, Cook JA, Barwell J, Wiles V, Limb L, Eccles DM, Leach MO, Shanley S, Gilbert FJ, Gallagher D, Rajashanker B, Whitehouse RW, Koh DM, Sohaib SA, Evans DG, Eeles RA, Walker LG.

J Med Genet. 2019 Nov 12. pii: jmedgenet-2019-106407. doi: 10.1136/jmedgenet-2019-106407. [Epub ahead of print]


Supervised Machine-Learning Enables Segmentation and Evaluation of Heterogeneous Post-treatment Changes in Multi-Parametric MRI of Soft-Tissue Sarcoma.

Blackledge MD, Winfield JM, Miah A, Strauss D, Thway K, Morgan VA, Collins DJ, Koh DM, Leach MO, Messiou C.

Front Oncol. 2019 Oct 10;9:941. doi: 10.3389/fonc.2019.00941. eCollection 2019.


De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.

Andrejeva G, Gowan S, Lin G, Wong Te Fong AL, Shamsaei E, Parkes HG, Mui J, Raynaud FI, Asad Y, Vizcay-Barrena G, Nikitorowicz-Buniak J, Valenti M, Howell L, Fleck RA, Martin LA, Kirkin V, Leach MO, Chung YL.

Autophagy. 2019 Sep 13:1-17. doi: 10.1080/15548627.2019.1659608. [Epub ahead of print]


Utility of Multi-Parametric Quantitative Magnetic Resonance Imaging for Characterization and Radiotherapy Response Assessment in Soft-Tissue Sarcomas and Correlation With Histopathology.

Winfield JM, Miah AB, Strauss D, Thway K, Collins DJ, deSouza NM, Leach MO, Morgan VA, Giles SL, Moskovic E, Hayes A, Smith M, Zaidi SH, Henderson D, Messiou C.

Front Oncol. 2019 Apr 25;9:280. doi: 10.3389/fonc.2019.00280. eCollection 2019.


Post-radiotherapy apparent diffusion coefficient (ADC) in children and young adults with high-grade gliomas and diffuse intrinsic pontine gliomas.

Carceller F, Jerome NP, Fowkes LA, Khabra K, Mackinnon A, Bautista F, Marshall LV, Vaidya S, Mandeville H, Morgan V, Leach MO, Koh DM.

Pediatr Hematol Oncol. 2019 Mar;36(2):103-112. doi: 10.1080/08880018.2019.1592267. Epub 2019 Apr 12.


Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

Wilson M, Andronesi O, Barker PB, Bartha R, Bizzi A, Bolan PJ, Brindle KM, Choi IY, Cudalbu C, Dydak U, Emir UE, Gonzalez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Huppi PS, Hurd RE, Kantarci K, Kauppinen RA, Klomp DWJ, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjańska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Mullins PG, Murdoch JB, Nelson SJ, Noeske R, Öz G, Pan JW, Peet AC, Poptani H, Posse S, Ratai EM, Salibi N, Scheenen TWJ, Smith ICP, Soher BJ, Tkáč I, Vigneron DB, Howe FA.

Magn Reson Med. 2019 Aug;82(2):527-550. doi: 10.1002/mrm.27742. Epub 2019 Mar 28. Review.


Synthetic 4D-CT of the thorax for treatment plan adaptation on MR-guided radiotherapy systems.

Freedman JN, Bainbridge HE, Nill S, Collins DJ, Kachelrieß M, Leach MO, McDonald F, Oelfke U, Wetscherek A.

Phys Med Biol. 2019 May 23;64(11):115005. doi: 10.1088/1361-6560/ab0dbb.


Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.

Al-Saffar NMS, Troy H, Wong Te Fong AC, Paravati R, Jackson LE, Gowan S, Boult JKR, Robinson SP, Eccles SA, Yap TA, Leach MO, Chung YL.

Br J Cancer. 2018 Oct;119(9):1118-1128. doi: 10.1038/s41416-018-0242-3. Epub 2018 Oct 31.


Reproducibility of the lung anatomy under active breathing coordinator control: Dosimetric consequences for scanned proton treatments.

den Otter LA, Kaza E, Kierkels RGJ, Meijers A, Ubbels FJF, Leach MO, Collins DJ, Langendijk JA, Knopf AC.

Med Phys. 2018 Dec;45(12):5525-5534. doi: 10.1002/mp.13195. Epub 2018 Oct 19.


Circulating Growth and Sex Hormone Levels and Breast Tissue Composition in Young Nulliparous Women.

Denholm R, De Stavola BL, Hipwell JH, Doran SJ, Holly JMP, Folkerd E, Dowsett M, Leach MO, Hawkes DJ, Dos-Santos-Silva I.

Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1500-1508. doi: 10.1158/1055-9965.EPI-18-0036. Epub 2018 Sep 18.


Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma.

Baker LCJ, Sikka A, Price JM, Boult JKR, Lepicard EY, Box G, Jamin Y, Spinks TJ, Kramer-Marek G, Leach MO, Eccles SA, Box C, Robinson SP.

Front Oncol. 2018 Jul 23;8:271. doi: 10.3389/fonc.2018.00271. eCollection 2018.


Prospective multicentre evaluation and refinement of an analysis tool for magnetic resonance spectroscopy of childhood cerebellar tumours.

Manias KA, Harris LM, Davies NP, Natarajan K, MacPherson L, Foster K, Brundler MA, Hargrave DR, Payne GS, Leach MO, Morgan PS, Auer D, Jaspan T, Arvanitis TN, Grundy RG, Peet AC.

Pediatr Radiol. 2018 Oct;48(11):1630-1641. doi: 10.1007/s00247-018-4182-0. Epub 2018 Jul 30.


Super-resolution T2-weighted 4D MRI for image guided radiotherapy.

Freedman JN, Collins DJ, Gurney-Champion OJ, McClelland JR, Nill S, Oelfke U, Leach MO, Wetscherek A.

Radiother Oncol. 2018 Dec;129(3):486-493. doi: 10.1016/j.radonc.2018.05.015. Epub 2018 Jun 2.


Microstructure Characterization of Bone Metastases from Prostate Cancer with Diffusion MRI: Preliminary Findings.

Bailey C, Collins DJ, Tunariu N, Orton MR, Morgan VA, Feiweier T, Hawkes DJ, Leach MO, Alexander DC, Panagiotaki E.

Front Oncol. 2018 Feb 16;8:26. doi: 10.3389/fonc.2018.00026. eCollection 2018.


Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models.

Wong Te Fong AC, Thavasu P, Gagrica S, Swales KE, Leach MO, Cosulich SC, Chung YL, Banerji U.

Oncotarget. 2017 Dec 6;8(69):113874-113884. doi: 10.18632/oncotarget.23022. eCollection 2017 Dec 26.


Non-Invasive Prostate Cancer Characterization with Diffusion-Weighted MRI: Insight from In silico Studies of a Transgenic Mouse Model.

Hill DK, Heindl A, Zormpas-Petridis K, Collins DJ, Euceda LR, Rodrigues DN, Moestue SA, Jamin Y, Koh DM, Yuan Y, Bathen TF, Leach MO, Blackledge MD.

Front Oncol. 2017 Dec 1;7:290. doi: 10.3389/fonc.2017.00290. eCollection 2017.


MRI-based Assessment of 3D Intrafractional Motion of Head and Neck Cancer for Radiation Therapy.

Gurney-Champion OJ, McQuaid D, Dunlop A, Wong KH, Welsh LC, Riddell AM, Koh DM, Oelfke U, Leach MO, Nutting CM, Bhide SA, Harrington KJ, Panek R, Newbold KL.

Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):306-316. doi: 10.1016/j.ijrobp.2017.10.016. Epub 2017 Oct 16.


Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and neck cancer.

Wong KH, Panek R, Dunlop A, Mcquaid D, Riddell A, Welsh LC, Murray I, Koh DM, Leach MO, Bhide SA, Nutting CM, Oyen WJ, Harrington KJ, Newbold KL.

Eur J Nucl Med Mol Imaging. 2018 May;45(5):759-767. doi: 10.1007/s00259-017-3890-2. Epub 2017 Nov 21.


Growth Trajectories, Breast Size, and Breast-Tissue Composition in a British Prebirth Cohort of Young Women.

Denholm R, De Stavola B, Hipwell JH, Doran SJ, Busana MC, Leach MO, Hawkes DJ, Dos-Santos-Silva I.

Am J Epidemiol. 2018 Jun 1;187(6):1259-1268. doi: 10.1093/aje/kwx358.


Quantitative evaluation of contrast agent uptake in standard fat-suppressed dynamic contrast-enhanced MRI examinations of the breast.

Kousi E, Smith J, Ledger AE, Scurr E, Allen S, Wilson RM, O'Flynn E, Pope RJE, Leach MO, Schmidt MA.

Med Phys. 2018 Jan;45(1):287-296. doi: 10.1002/mp.12652. Epub 2017 Nov 30.


Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.

Jerome NP, Boult JKR, Orton MR, d'Arcy JA, Nerurkar A, Leach MO, Koh DM, Collins DJ, Robinson SP.

Eur Radiol. 2018 Apr;28(4):1642-1653. doi: 10.1007/s00330-017-5083-6. Epub 2017 Oct 16.


MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy.

Beloueche-Babari M, Wantuch S, Casals Galobart T, Koniordou M, Parkes HG, Arunan V, Chung YL, Eykyn TR, Smith PD, Leach MO.

Cancer Res. 2017 Nov 1;77(21):5913-5924. doi: 10.1158/0008-5472.CAN-16-2686. Epub 2017 Sep 18.


Accuracy of screening women at familial risk of breast cancer without a known gene mutation: Individual patient data meta-analysis.

Phi XA, Houssami N, Hooning MJ, Riedl CC, Leach MO, Sardanelli F, Warner E, Trop I, Saadatmand S, Tilanus-Linthorst MMA, Helbich TH, van den Heuvel ER, de Koning HJ, Obdeijn IM, de Bock GH.

Eur J Cancer. 2017 Nov;85:31-38. doi: 10.1016/j.ejca.2017.07.055. Review.


Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.

Shah A, Delgado-Goni T, Casals Galobart T, Wantuch S, Jamin Y, Leach MO, Robinson SP, Bamber J, Beloueche-Babari M.

Sci Rep. 2017 Aug 15;7(1):8215. doi: 10.1038/s41598-017-07864-8.


In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.

Al-Saffar NMS, Agliano A, Marshall LV, Jackson LE, Balarajah G, Sidhu J, Clarke PA, Jones C, Workman P, Pearson ADJ, Leach MO.

PLoS One. 2017 Jul 13;12(7):e0180263. doi: 10.1371/journal.pone.0180263. eCollection 2017.


Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy.

Agliano A, Balarajah G, Ciobota DM, Sidhu J, Clarke PA, Jones C, Workman P, Leach MO, Al-Saffar NMS.

Oncotarget. 2017 Jul 18;8(29):47969-47983. doi: 10.18632/oncotarget.18206.


Magnetic Resonance Imaging-Based Assessment of Breast Cancer-Related Lymphoedema Tissue Composition.

Borri M, Gordon KD, Hughes JC, Scurr ED, Koh DM, Leach MO, Mortimer PS, Schmidt MA.

Invest Radiol. 2017 Sep;52(9):554-561. doi: 10.1097/RLI.0000000000000386.


Breast MRI segmentation for density estimation: Do different methods give the same results and how much do differences matter?

Doran SJ, Hipwell JH, Denholm R, Eiben B, Busana M, Hawkes DJ, Leach MO, Silva IDS.

Med Phys. 2017 Sep;44(9):4573-4592. doi: 10.1002/mp.12320. Epub 2017 Jul 25.


T2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance-Guided Radiotherapy Treatment Planning.

Freedman JN, Collins DJ, Bainbridge H, Rank CM, Nill S, Kachelrieß M, Oelfke U, Leach MO, Wetscherek A.

Invest Radiol. 2017 Oct;52(10):563-573. doi: 10.1097/RLI.0000000000000381.


Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI.

Panek R, Welsh L, Baker LCJ, Schmidt MA, Wong KH, Riddell AM, Koh DM, Dunlop A, Mcquaid D, d'Arcy JA, Bhide SA, Harrington KJ, Nutting CM, Hopkinson G, Richardson C, Box C, Eccles SA, Leach MO, Robinson SP, Newbold KL.

Clin Cancer Res. 2017 Aug 1;23(15):4233-4241. doi: 10.1158/1078-0432.CCR-16-1209. Epub 2017 Mar 17.


Extracranial Soft-Tissue Tumors: Repeatability of Apparent Diffusion Coefficient Estimates from Diffusion-weighted MR Imaging.

Winfield JM, Tunariu N, Rata M, Miyazaki K, Jerome NP, Germuska M, Blackledge MD, Collins DJ, de Bono JS, Yap TA, deSouza NM, Doran SJ, Koh DM, Leach MO, Messiou C, Orton MR.

Radiology. 2017 Jul;284(1):88-99. doi: 10.1148/radiol.2017161965. Epub 2017 Mar 16.


Lung volume reproducibility under ABC control and self-sustained breath-holding.

Kaza E, Dunlop A, Panek R, Collins DJ, Orton M, Symonds-Tayler R, McQuaid D, Scurr E, Hansen V, Leach MO.

J Appl Clin Med Phys. 2017 Mar;18(2):154-162. doi: 10.1002/acm2.12034. Epub 2017 Feb 25.


Magnetic Resonance Spectroscopy to Study Glycolytic Metabolism During Autophagy.

Chung YL, Leach MO, Eykyn TR.

Methods Enzymol. 2017;588:133-153. doi: 10.1016/bs.mie.2016.09.078. Epub 2016 Nov 17.


A generalized framework unifying image registration and respiratory motion models and incorporating image reconstruction, for partial image data or full images.

McClelland JR, Modat M, Arridge S, Grimes H, D'Souza D, Thomas D, Connell DO, Low DA, Kaza E, Collins DJ, Leach MO, Hawkes DJ.

Phys Med Biol. 2017 Jun 7;62(11):4273-4292. doi: 10.1088/1361-6560/aa6070. Epub 2017 Feb 14.


Baseline results from the UK SIGNIFY study: a whole-body MRI screening study in TP53 mutation carriers and matched controls.

Saya S, Killick E, Thomas S, Taylor N, Bancroft EK, Rothwell J, Benafif S, Dias A, Mikropoulos C, Pope J, Chamberlain A, Gunapala R; SIGNIFY Study Steering Committee, Izatt L, Side L, Walker L, Tomkins S, Cook J, Barwell J, Wiles V, Limb L, Eccles D, Leach MO, Shanley S, Gilbert FJ, Hanson H, Gallagher D, Rajashanker B, Whitehouse RW, Koh DM, Sohaib SA, Evans DG, Eeles RA.

Fam Cancer. 2017 Jul;16(3):433-440. doi: 10.1007/s10689-017-9965-1.


A novel approach to evaluate spatial resolution of MRI clinical images for optimization and standardization of breast screening protocols.

Borri M, Scurr ED, Richardson C, Usher M, Leach MO, Schmidt MA.

Med Phys. 2016 Dec;43(12):6354.


Extended T2-IVIM model for correction of TE dependence of pseudo-diffusion volume fraction in clinical diffusion-weighted magnetic resonance imaging.

Jerome NP, d'Arcy JA, Feiweier T, Koh DM, Leach MO, Collins DJ, Orton MR.

Phys Med Biol. 2016 Dec 21;61(24):N667-N680. Epub 2016 Nov 28.


Blood transfusion during radical chemo-radiotherapy does not reduce tumour hypoxia in squamous cell cancer of the head and neck.

Welsh L, Panek R, Riddell A, Wong K, Leach MO, Tavassoli M, Rahman D, Schmidt M, Hurley T, Grove L, Richards T, Koh DM, Nutting C, Harrington K, Newbold K, Bhide S.

Br J Cancer. 2017 Jan 3;116(1):28-35. doi: 10.1038/bjc.2016.386. Epub 2016 Nov 24.


Diffusion-weighted Imaging as a Treatment Response Biomarker for Evaluating Bone Metastases in Prostate Cancer: A Pilot Study.

Perez-Lopez R, Mateo J, Mossop H, Blackledge MD, Collins DJ, Rata M, Morgan VA, Macdonald A, Sandhu S, Lorente D, Rescigno P, Zafeiriou Z, Bianchini D, Porta N, Hall E, Leach MO, de Bono JS, Koh DM, Tunariu N.

Radiology. 2017 Apr;283(1):168-177. doi: 10.1148/radiol.2016160646. Epub 2016 Nov 22.


Time-resolved angiography with stochastic trajectories for dynamic contrast-enhanced MRI in head and neck cancer: Are pharmacokinetic parameters affected?

Panek R, Schmidt MA, Borri M, Koh DM, Riddell A, Welsh L, Dunlop A, Powell C, Bhide SA, Nutting CM, Harrington KJ, Newbold KL, Leach MO.

Med Phys. 2016 Nov;43(11):6024.


Imaging biomarker roadmap for cancer studies.

O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC.

Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. doi: 10.1038/nrclinonc.2016.162. Epub 2016 Oct 11. Review.


T2-adjusted computed diffusion-weighted imaging: A novel method to enhance tumour visualisation.

Cheng L, Blackledge MD, Collins DJ, Orton MR, Jerome NP, Feiweier T, Rata M, Morgan V, Tunariu N, Leach MO, Koh DM.

Comput Biol Med. 2016 Dec 1;79:92-98. doi: 10.1016/j.compbiomed.2016.09.022. Epub 2016 Oct 1.


The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells.

Delgado-Goni T, Miniotis MF, Wantuch S, Parkes HG, Marais R, Workman P, Leach MO, Beloueche-Babari M.

Mol Cancer Ther. 2016 Dec;15(12):2987-2999. Epub 2016 Oct 7.


Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review.

Denholm R, De Stavola B, Hipwell JH, Doran SJ, Busana MC, Eng A, Jeffreys M, Leach MO, Hawkes D, Dos Santos Silva I.

Breast Cancer Res. 2016 Oct 12;18(1):102. Review.


Feasibility and applicability of diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in routine assessments of children with high-grade gliomas.

Carceller F, Jerome NP, Miyazaki K, Collins DJ, Orton MR, d'Arcy JA, Wallace T, Moreno L, Pearson AD, Zacharoulis S, Leach MO, Marshall LV, Koh DM.

Pediatr Blood Cancer. 2017 Feb;64(2):279-283. doi: 10.1002/pbc.26216. Epub 2016 Sep 12.


Validating a robust double-quantum-filtered (1) H MRS lactate measurement method in high-grade brain tumours.

Payne GS, Harris LM, Cairns GS, Messiou C, deSouza NM, Macdonald A, Saran F, Leach MO.

NMR Biomed. 2016 Oct;29(10):1420-6. doi: 10.1002/nbm.3587. Epub 2016 Aug 11.


Development of a temperature-controlled phantom for magnetic resonance quality assurance of diffusion, dynamic, and relaxometry measurements.

Jerome NP, Papoutsaki MV, Orton MR, Parkes HG, Winfield JM, Boss MA, Leach MO, deSouza NM, Collins DJ.

Med Phys. 2016 Jun;43(6):2998-3007. doi: 10.1118/1.4948997.


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