Sort by
Items per page

Send to

Choose Destination

Search results

Items: 23


Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans.

Caplan T, Polvi EJ, Xie JL, Buckhalter S, Leach MD, Robbins N, Cowen LE.

Cell Rep. 2018 May 22;23(8):2292-2298. doi: 10.1016/j.celrep.2018.04.084.


Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.

Xie JL, Bohovych I, Wong EOY, Lambert JP, Gingras AC, Khalimonchuk O, Cowen LE, Leach MD.

Microb Cell. 2017 Oct 2;4(10):342-361. doi: 10.15698/mic2017.10.594.


The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.

Xie JL, Qin L, Miao Z, Grys BT, Diaz JC, Ting K, Krieger JR, Tong J, Tan K, Leach MD, Ketela T, Moran MF, Krysan DJ, Boone C, Andrews BJ, Selmecki A, Ho Wong K, Robbins N, Cowen LE.

Nat Commun. 2017 Sep 11;8(1):499. doi: 10.1038/s41467-017-00547-y.


Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity.

Leach MD, Kim T, DiGregorio SE, Collins C, Zhang Z, Duennwald ML, Cowen LE.

G3 (Bethesda). 2017 Jan 5;7(1):95-108. doi: 10.1534/g3.116.035675.


Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues.

Xie JL, Grahl N, Sless T, Leach MD, Kim SH, Hogan DA, Robbins N, Cowen LE.

PLoS Genet. 2016 Oct 27;12(10):e1006405. doi: 10.1371/journal.pgen.1006405. eCollection 2016 Oct.


Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.

Leach MD, Farrer RA, Tan K, Miao Z, Walker LA, Cuomo CA, Wheeler RT, Brown AJ, Wong KH, Cowen LE.

Nat Commun. 2016 May 26;7:11704. doi: 10.1038/ncomms11704.


Functional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular States.

Diezmann S, Leach MD, Cowen LE.

PLoS One. 2015 Sep 14;10(9):e0137947. doi: 10.1371/journal.pone.0137947. eCollection 2015.


Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies.

Polvi EJ, Li X, O'Meara TR, Leach MD, Cowen LE.

Cell Mol Life Sci. 2015 Jun;72(12):2261-87. doi: 10.1007/s00018-015-1860-z. Epub 2015 Feb 21. Review.


Correction for Sandai et al., The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast Candida albicans.

Sandai D, Yin Z, Selway L, Stead D, Walker J, Leach MD, Bohovych I, Ene IV, Kastora S, Budge S, Munro CA, Odds FC, Gow NA, Brown AJ.

MBio. 2015 Jan 20;6(1). pii: e02489-14. doi: 10.1128/mBio.02489-14. No abstract available.


Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans.

Leach MD, Cowen LE.

Eukaryot Cell. 2014 Aug;13(8):1077-84. doi: 10.1128/EC.00138-14. Epub 2014 Jun 20.


Stress adaptation in a pathogenic fungus.

Brown AJ, Budge S, Kaloriti D, Tillmann A, Jacobsen MD, Yin Z, Ene IV, Bohovych I, Sandai D, Kastora S, Potrykus J, Ballou ER, Childers DS, Shahana S, Leach MD.

J Exp Biol. 2014 Jan 1;217(Pt 1):144-55. doi: 10.1242/jeb.088930. Review.


Surviving the heat of the moment: a fungal pathogens perspective.

Leach MD, Cowen LE.

PLoS Pathog. 2013 Mar;9(3):e1003163. doi: 10.1371/journal.ppat.1003163. Epub 2013 Mar 7. No abstract available.


Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.

Leach MD, Budge S, Walker L, Munro C, Cowen LE, Brown AJ.

PLoS Pathog. 2012 Dec;8(12):e1003069. doi: 10.1371/journal.ppat.1003069. Epub 2012 Dec 27.


The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans.

Sandai D, Yin Z, Selway L, Stead D, Walker J, Leach MD, Bohovych I, Ene IV, Kastora S, Budge S, Munro CA, Odds FC, Gow NA, Brown AJ.

MBio. 2012 Dec 11;3(6). pii: e00495-12. doi: 10.1128/mBio.00495-12. Erratum in: MBio. 2015;6(1). pii: e02489-14. doi: 10.1128/mBio.02489-14.


Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance.

Robbins N, Leach MD, Cowen LE.

Cell Rep. 2012 Oct 25;2(4):878-88. doi: 10.1016/j.celrep.2012.08.035. Epub 2012 Oct 4.


Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs.

Leach MD, Klipp E, Cowen LE, Brown AJ.

Nat Rev Microbiol. 2012 Oct;10(10):693-704. doi: 10.1038/nrmicro2875. Review.


Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans.

Leach MD, Tyc KM, Brown AJ, Klipp E.

PLoS One. 2012;7(3):e32467. doi: 10.1371/journal.pone.0032467. Epub 2012 Mar 20.


Posttranslational modifications of proteins in the pathobiology of medically relevant fungi.

Leach MD, Brown AJ.

Eukaryot Cell. 2012 Feb;11(2):98-108. doi: 10.1128/EC.05238-11. Epub 2011 Dec 9. Review.


Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans.

Leach MD, Stead DA, Argo E, MacCallum DM, Brown AJ.

Mol Microbiol. 2011 Mar;79(6):1574-93. doi: 10.1111/j.1365-2958.2011.07542.x. Epub 2011 Jan 26. Erratum in: Mol Microbiol. 2012 May;84(3):594.


The relevance of heat shock regulation in fungal pathogens of humans.

Brown AJ, Leach MD, Nicholls S.

Virulence. 2010 Jul-Aug;1(4):330-2. doi: 10.4161/viru.1.4.12364.


Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals.

Nicholls S, Leach MD, Priest CL, Brown AJ.

Mol Microbiol. 2009 Nov;74(4):844-61. doi: 10.1111/j.1365-2958.2009.06883.x. Epub 2009 Oct 8.


A discrete, stochastic model and correction method for bacterial source tracking.

Leach MD, Broschat SL, Call DR.

Environ Sci Technol. 2008 Jan 15;42(2):524-9.


Supplemental Content

Loading ...
Support Center