Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 251

1.

Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple Orthosteric Binding Sites.

Gregory KJ, Giraldo J, Diao J, Christopoulos A, Leach K.

Mol Pharmacol. 2020 Jan;97(1):35-45. doi: 10.1124/mol.119.118091. Epub 2019 Nov 8.

PMID:
31704718
2.

Multiple Shape Coexistence in ^{110,112}Cd.

Garrett PE, Rodríguez TR, Varela AD, Green KL, Bangay J, Finlay A, Austin RAE, Ball GC, Bandyopadhyay DS, Bildstein V, Colosimo S, Cross DS, Demand GA, Finlay P, Garnsworthy AB, Grinyer GF, Hackman G, Jigmeddorj B, Jolie J, Kulp WD, Leach KG, Morton AC, Orce JN, Pearson CJ, Phillips AA, Radich AJ, Rand ET, Schumaker MA, Svensson CE, Sumithrarachchi C, Triambak S, Warr N, Wong J, Wood JL, Yates SW.

Phys Rev Lett. 2019 Oct 4;123(14):142502. doi: 10.1103/PhysRevLett.123.142502.

PMID:
31702191
3.

Direct Observation of Proton Emission in ^{11}Be.

Ayyad Y, Olaizola B, Mittig W, Potel G, Zelevinsky V, Horoi M, Beceiro-Novo S, Alcorta M, Andreoiu C, Ahn T, Anholm M, Atar L, Babu A, Bazin D, Bernier N, Bhattacharjee SS, Bowry M, Caballero-Folch R, Cortesi M, Dalitz C, Dunling E, Garnsworthy AB, Holl M, Kootte B, Leach KG, Randhawa JS, Saito Y, Santamaria C, Šiurytė P, Svensson CE, Umashankar R, Watwood N, Yates D.

Phys Rev Lett. 2019 Aug 23;123(8):082501. doi: 10.1103/PhysRevLett.123.082501.

PMID:
31491233
4.

Metabotropic glutamate receptor 5 (mGlu5 )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons.

Hellyer SD, Albold S, Sengmany K, Singh J, Leach K, Gregory KJ.

J Neurochem. 2019 Nov;151(3):301-315. doi: 10.1111/jnc.14844. Epub 2019 Aug 26.

PMID:
31376155
5.

L-Amino Acids Promote Calcitonin Release via a Calcium-Sensing Receptor: Gq/11-Mediated Pathway in Human C-Cells.

Mun HC, Leach KM, Conigrave AD.

Endocrinology. 2019 Jul 1;160(7):1590-1599. doi: 10.1210/en.2018-00860.

PMID:
31127815
6.

The Degradation Chemistry of GSK2879552: Salt Selection and Microenvironmental pH Modulation to Stabilize a Cyclopropyl Amine.

Campbell JM, Lee M, Clawson J, Kennedy-Gabb S, Bethune S, Janiga A, Kindon L, Leach KP.

J Pharm Sci. 2019 Sep;108(9):2858-2864. doi: 10.1016/j.xphs.2019.04.026. Epub 2019 May 2.

PMID:
31054890
7.

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5.

Chen ANY, Hellyer SD, Trinh PNH, Leach K, Gregory KJ.

Basic Clin Pharmacol Toxicol. 2019 Apr 14. doi: 10.1111/bcpt.13239. [Epub ahead of print]

PMID:
30983151
8.

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.

Sengmany K, Hellyer SD, Albold S, Wang T, Conn PJ, May LT, Christopoulos A, Leach K, Gregory KJ.

Neuropharmacology. 2019 May 1;149:83-96. doi: 10.1016/j.neuropharm.2019.02.005. Epub 2019 Feb 11.

PMID:
30763654
9.

Analysis of unstable degradation impurities of a benzodiazepine and their quantification without isolation using multiple linear regression.

Campbell JM, Grinias K, Facchine K, Igne B, Clawson J, Peterson J, Wolters A, Barry J, Watson S, Leach K.

J Pharm Biomed Anal. 2019 Apr 15;167:1-6. doi: 10.1016/j.jpba.2019.01.028. Epub 2019 Jan 17.

PMID:
30731352
10.

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5.

Trinh PNH, May LT, Leach K, Gregory KJ.

Clin Sci (Lond). 2018 Nov 2;132(21):2323-2338. doi: 10.1042/CS20180374. Print 2018 Nov 15. Review.

PMID:
30389826
11.

Induced Pluripotent Stem Cell-Derived Podocyte-Like Cells as Models for Assessing Mechanisms Underlying Heritable Disease Phenotype: Initial Studies Using Two Alport Syndrome Patient Lines Indicate Impaired Potassium Channel Activity.

Haynes JM, Selby JN, Vandekolk TH, Abad IPL, Ho JK, Lieuw WL, Leach K, Savige J, Saini S, Fisher CL, Ricardo SD.

J Pharmacol Exp Ther. 2018 Nov;367(2):335-347. doi: 10.1124/jpet.118.250142. Epub 2018 Aug 13.

PMID:
30104322
12.

Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity.

Diepenhorst NA, Leach K, Keller AN, Rueda P, Cook AE, Pierce TL, Nowell C, Pastoureau P, Sabatini M, Summers RJ, Charman WN, Sexton PM, Christopoulos A, Langmead CJ.

Br J Pharmacol. 2018 Nov;175(21):4095-4108. doi: 10.1111/bph.14344. Epub 2018 Jun 3.

13.

Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms.

Keller AN, Kufareva I, Josephs TM, Diao J, Mai VT, Conigrave AD, Christopoulos A, Gregory KJ, Leach K.

Mol Pharmacol. 2018 Jun;93(6):619-630. doi: 10.1124/mol.118.112086. Epub 2018 Apr 10.

14.

"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.

Hellyer SD, Albold S, Wang T, Chen ANY, May LT, Leach K, Gregory KJ.

Mol Pharmacol. 2018 May;93(5):504-514. doi: 10.1124/mol.117.111518. Epub 2018 Mar 7.

PMID:
29514854
15.

Dawning of the N=32 Shell Closure Seen through Precision Mass Measurements of Neutron-Rich Titanium Isotopes.

Leistenschneider E, Reiter MP, Ayet San Andrés S, Kootte B, Holt JD, Navrátil P, Babcock C, Barbieri C, Barquest BR, Bergmann J, Bollig J, Brunner T, Dunling E, Finlay A, Geissel H, Graham L, Greiner F, Hergert H, Hornung C, Jesch C, Klawitter R, Lan Y, Lascar D, Leach KG, Lippert W, McKay JE, Paul SF, Schwenk A, Short D, Simonis J, Somà V, Steinbrügge R, Stroberg SR, Thompson R, Wieser ME, Will C, Yavor M, Andreoiu C, Dickel T, Dillmann I, Gwinner G, Plaß WR, Scheidenberger C, Kwiatkowski AA, Dilling J.

Phys Rev Lett. 2018 Feb 9;120(6):062503. doi: 10.1103/PhysRevLett.120.062503.

PMID:
29481255
16.

The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk - A cross sectional study of UK farms.

Bradley AJ, Leach KA, Green MJ, Gibbons J, Ohnstad IC, Black DH, Payne B, Prout VE, Breen JE.

Int J Food Microbiol. 2018 Mar 23;269:36-45. doi: 10.1016/j.ijfoodmicro.2017.12.022. Epub 2017 Dec 19.

PMID:
29421356
17.

A pilot survey of farm animal welfare in Serbia, a country preparing for EU accession.

Phythian CJ, Mullan S, Butterworth A, Lambton S, Ilić J, Burazerović J, Burazerović E, Leach KA.

Vet Med Sci. 2017 Oct 23;3(4):208-226. doi: 10.1002/vms3.72. eCollection 2017 Nov.

18.

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K.

PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017.

19.

Sugar Transporters in Plants: New Insights and Discoveries.

Julius BT, Leach KA, Tran TM, Mertz RA, Braun DM.

Plant Cell Physiol. 2017 Sep 1;58(9):1442-1460. doi: 10.1093/pcp/pcx090. Review.

PMID:
28922744
20.

NEOPLASIA IN SNAKES AT ZOO ATLANTA DURING 1992-2012.

Page-Karjian A, Hahne M, Leach K, Murphy H, Lock B, Rivera S.

J Zoo Wildl Med. 2017 Jun;48(2):521-524. doi: 10.1638/2016-0101R1.1.

PMID:
28749281
21.

Sucrose transporter2 contributes to maize growth, development, and crop yield.

Leach KA, Tran TM, Slewinski TL, Meeley RB, Braun DM.

J Integr Plant Biol. 2017 Jun;59(6):390-408. doi: 10.1111/jipb.12527. Epub 2017 Apr 14.

PMID:
28206710
22.

AHDB Dairy Mastitis Control Plan.

Bradley A, Breen J, Leach K, Gibbons J, Armstrong D, Green M.

Vet Rec. 2017 Feb 11;180(6):154-155. doi: 10.1136/vr.j680. No abstract available.

PMID:
28183899
23.

Molecular insights into allosteric modulation of Class C G protein-coupled receptors.

Leach K, Gregory KJ.

Pharmacol Res. 2017 Feb;116:105-118. doi: 10.1016/j.phrs.2016.12.006. Epub 2016 Dec 11. Review.

PMID:
27965032
24.

Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation.

Hellyer S, Leach K, Gregory KJ.

Curr Opin Pharmacol. 2017 Feb;32:49-55. doi: 10.1016/j.coph.2016.10.007. Epub 2016 Nov 11. Review.

PMID:
27842256
25.

Sucrose Transporter ZmSut1 Expression and Localization Uncover New Insights into Sucrose Phloem Loading.

Baker RF, Leach KA, Boyer NR, Swyers MJ, Benitez-Alfonso Y, Skopelitis T, Luo A, Sylvester A, Jackson D, Braun DM.

Plant Physiol. 2016 Nov;172(3):1876-1898. Epub 2016 Sep 12.

26.

Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.

Shatz W, Hass PE, Mathieu M, Kim HS, Leach K, Zhou M, Crawford Y, Shen A, Wang K, Chang DP, Maia M, Crowell SR, Dickmann L, Scheer JM, Kelley RF.

Mol Pharm. 2016 Sep 6;13(9):2996-3003. doi: 10.1021/acs.molpharmaceut.6b00345. Epub 2016 Jun 14.

PMID:
27244474
27.

Soluble Sugar and Starch Extraction and Quantification from Maize (Zea mays) Leaves.

Leach KA, Braun DM.

Curr Protoc Plant Biol. 2016 May;1(1):139-161. doi: 10.1002/cppb.20018.

PMID:
31725991
28.

Genomic DNA Isolation from Maize (Zea mays) Leaves Using a Simple, High-Throughput Protocol.

Leach KA, McSteen PC, Braun DM.

Curr Protoc Plant Biol. 2016 May;1(1):15-27. doi: 10.1002/cppb.20000.

PMID:
31725985
29.

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.

Leach K, Gregory KJ, Kufareva I, Khajehali E, Cook AE, Abagyan R, Conigrave AD, Sexton PM, Christopoulos A.

Cell Res. 2016 May;26(5):574-92. doi: 10.1038/cr.2016.36. Epub 2016 Mar 22.

30.

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.

Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A.

Nature. 2016 Mar 17;531(7594):335-40. doi: 10.1038/nature17188. Epub 2016 Mar 9.

31.

Evidence-Based Practice Guideline: Changing the Practice of Physical Restraint Use in Acute Care.

Lach HW, Leach KM, Butcher HK.

J Gerontol Nurs. 2016 Feb;42(2):17-26. doi: 10.3928/00989134-20160113-04.

PMID:
26820185
32.

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.

Rueda P, Harley E, Lu Y, Stewart GD, Fabb S, Diepenhorst N, Cremers B, Rouillon MH, Wehrle I, Geant A, Lamarche G, Leach K, Charman WN, Christopoulos A, Summers RJ, Sexton PM, Langmead CJ.

PLoS One. 2016 Jan 19;11(1):e0146846. doi: 10.1371/journal.pone.0146846. eCollection 2016.

33.

Recycling manure as cow bedding: Potential benefits and risks for UK dairy farms.

Leach KA, Archer SC, Breen JE, Green MJ, Ohnstad IC, Tuer S, Bradley AJ.

Vet J. 2015 Nov;206(2):123-30. doi: 10.1016/j.tvjl.2015.08.013. Epub 2015 Aug 12. Review.

PMID:
26388545
34.

Bright Fraction of Single-Walled Carbon Nanotubes through Correlated Fluorescence and Topography Measurements.

Nogaj LJ, Smyder JA, Leach KE, Tu X, Zheng M, Krauss TD.

J Phys Chem Lett. 2015 Jul 16;6(14):2816-21. doi: 10.1021/acs.jpclett.5b01032. Epub 2015 Jul 6.

PMID:
26266867
35.

Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.

Khajehali E, Malone DT, Glass M, Sexton PM, Christopoulos A, Leach K.

Mol Pharmacol. 2015 Aug;88(2):368-79. doi: 10.1124/mol.115.099192. Epub 2015 Jun 4.

PMID:
26044547
36.

Expertly validated models and phylogenetically-controlled analysis suggests responses to climate change are related to species traits in the order lagomorpha.

Leach K, Kelly R, Cameron A, Montgomery WI, Reid N.

PLoS One. 2015 Apr 15;10(4):e0122267. doi: 10.1371/journal.pone.0122267. eCollection 2015.

37.

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR.

Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038/ncomms7734.

PMID:
25828455
38.

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias.

Leach K, Conigrave AD, Sexton PM, Christopoulos A.

Trends Pharmacol Sci. 2015 Apr;36(4):215-25. doi: 10.1016/j.tips.2015.02.004. Epub 2015 Mar 9. Review.

PMID:
25765207
39.

Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization.

Brennan SC, Mun HC, Leach K, Kuchel PW, Christopoulos A, Conigrave AD.

Endocrinology. 2015 Apr;156(4):1330-42. doi: 10.1210/en.2014-1771. Epub 2015 Jan 21.

PMID:
25607893
40.

Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir.

Zhang X, Wang R, Piotrowski M, Zhang H, Leach KL.

Toxicol In Vitro. 2015 Feb;29(1):251-8.

PMID:
25448811
41.

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.

Cook AE, Mistry SN, Gregory KJ, Furness SG, Sexton PM, Scammells PJ, Conigrave AD, Christopoulos A, Leach K.

Br J Pharmacol. 2015 Jan;172(1):185-200. doi: 10.1111/bph.12937. Epub 2014 Dec 1.

42.

In-trap spectroscopy of charge-bred radioactive ions.

Lennarz A, Grossheim A, Leach KG, Alanssari M, Brunner T, Chaudhuri A, Chowdhury U, Crespo López-Urrutia JR, Gallant AT, Holl M, Kwiatkowski AA, Lassen J, Macdonald TD, Schultz BE, Seeraji S, Simon MC, Andreoiu C, Dilling J, Frekers D.

Phys Rev Lett. 2014 Aug 22;113(8):082502. Epub 2014 Aug 21.

PMID:
25192092
43.

Breakdown of the isobaric multiplet mass equation for the A = 20 and 21 multiplets.

Gallant AT, Brodeur M, Andreoiu C, Bader A, Chaudhuri A, Chowdhury U, Grossheim A, Klawitter R, Kwiatkowski AA, Leach KG, Lennarz A, Macdonald TD, Schultz BE, Lassen J, Heggen H, Raeder S, Teigelhöfer A, Brown BA, Magilligan A, Holt JD, Menéndez J, Simonis J, Schwenk A, Dilling J.

Phys Rev Lett. 2014 Aug 22;113(8):082501. Epub 2014 Aug 19.

PMID:
25192091
44.

Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor.

Goolam MA, Ward JH, Avlani VA, Leach K, Christopoulos A, Conigrave AD.

FEBS Lett. 2014 Sep 17;588(18):3340-6. doi: 10.1016/j.febslet.2014.07.022. Epub 2014 Jul 28.

45.
46.

Efficient molecular marker design using the MaizeGDB Mo17 SNPs and Indels track.

Settles AM, Bagadion AM, Bai F, Zhang J, Barron B, Leach K, Mudunkothge JS, Hoffner C, Bihmidine S, Finefield E, Hibbard J, Dieter E, Malidelis IA, Gustin JL, Karoblyte V, Tseung CW, Braun DM.

G3 (Bethesda). 2014 Apr 17;4(6):1143-5. doi: 10.1534/g3.114.010454.

47.

Umbilical cord transection to induce fetal demise prior to second-trimester D&E abortion: in reply.

Tocce K, Leach KK, Teal SB.

Contraception. 2014 May;89(5):473-4. doi: 10.1016/j.contraception.2014.02.009. Epub 2014 Feb 26. No abstract available.

PMID:
24656554
48.

Reduced face aftereffects in autism are not due to poor attention.

Ewing L, Leach K, Pellicano E, Jeffery L, Rhodes G.

PLoS One. 2013 Nov 29;8(11):e81353. doi: 10.1371/journal.pone.0081353. eCollection 2013.

49.

Investigating the value dairy farmers place on a reduction of lameness in their herds using a willingness to pay approach.

Bennett RM, Barker ZE, Main DC, Whay HR, Leach KA.

Vet J. 2014 Jan;199(1):72-5. doi: 10.1016/j.tvjl.2013.09.068. Epub 2013 Oct 7.

PMID:
24268682
50.

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders.

Leach K, Sexton PM, Christopoulos A, Conigrave AD.

Br J Pharmacol. 2014 Mar;171(5):1142-55. doi: 10.1111/bph.12420. Review.

Supplemental Content

Support Center