Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 239

1.

Induced pluripotent stem cell derived podocyte like cells as models for assessing mechanisms underlying heritable disease phenotype: initial studies using two Alport syndrome patient lines indicate impaired potassium channel activity.

Haynes JM, Selby JN, Abad IP, Vandekolk T, Ho JK, Lieuw WL, Leach K, Savige J, Saini S, Fisher C, Ricardo S.

J Pharmacol Exp Ther. 2018 Aug 13. pii: jpet.118.250142. doi: 10.1124/jpet.118.250142. [Epub ahead of print]

2.

Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity.

Diepenhorst NA, Leach K, Keller AN, Rueda P, Cook AE, Pierce TL, Nowell C, Pastoureau P, Sabatini M, Summers RJ, Charman WN, Sexton PM, Christopoulos A, Langmead CJ.

Br J Pharmacol. 2018 May 1. doi: 10.1111/bph.14344. [Epub ahead of print]

PMID:
29714810
3.

Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms.

Keller AN, Kufareva I, Josephs TM, Diao J, Mai VT, Conigrave AD, Christopoulos A, Gregory KJ, Leach K.

Mol Pharmacol. 2018 Jun;93(6):619-630. doi: 10.1124/mol.118.112086. Epub 2018 Apr 10.

PMID:
29636377
4.

"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.

Hellyer SD, Albold S, Wang T, Chen ANY, May LT, Leach K, Gregory KJ.

Mol Pharmacol. 2018 May;93(5):504-514. doi: 10.1124/mol.117.111518. Epub 2018 Mar 7.

PMID:
29514854
5.

Dawning of the N=32 Shell Closure Seen through Precision Mass Measurements of Neutron-Rich Titanium Isotopes.

Leistenschneider E, Reiter MP, Ayet San Andrés S, Kootte B, Holt JD, Navrátil P, Babcock C, Barbieri C, Barquest BR, Bergmann J, Bollig J, Brunner T, Dunling E, Finlay A, Geissel H, Graham L, Greiner F, Hergert H, Hornung C, Jesch C, Klawitter R, Lan Y, Lascar D, Leach KG, Lippert W, McKay JE, Paul SF, Schwenk A, Short D, Simonis J, Somà V, Steinbrügge R, Stroberg SR, Thompson R, Wieser ME, Will C, Yavor M, Andreoiu C, Dickel T, Dillmann I, Gwinner G, Plaß WR, Scheidenberger C, Kwiatkowski AA, Dilling J.

Phys Rev Lett. 2018 Feb 9;120(6):062503. doi: 10.1103/PhysRevLett.120.062503.

PMID:
29481255
6.

The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk - A cross sectional study of UK farms.

Bradley AJ, Leach KA, Green MJ, Gibbons J, Ohnstad IC, Black DH, Payne B, Prout VE, Breen JE.

Int J Food Microbiol. 2018 Mar 23;269:36-45. doi: 10.1016/j.ijfoodmicro.2017.12.022. Epub 2017 Dec 19.

PMID:
29421356
7.

A pilot survey of farm animal welfare in Serbia, a country preparing for EU accession.

Phythian CJ, Mullan S, Butterworth A, Lambton S, Ilić J, Burazerović J, Burazerović E, Leach KA.

Vet Med Sci. 2017 Oct 23;3(4):208-226. doi: 10.1002/vms3.72. eCollection 2017 Nov.

8.

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K.

PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017.

9.

Sugar Transporters in Plants: New Insights and Discoveries.

Julius BT, Leach KA, Tran TM, Mertz RA, Braun DM.

Plant Cell Physiol. 2017 Sep 1;58(9):1442-1460. doi: 10.1093/pcp/pcx090. Review.

PMID:
28922744
10.

NEOPLASIA IN SNAKES AT ZOO ATLANTA DURING 1992-2012.

Page-Karjian A, Hahne M, Leach K, Murphy H, Lock B, Rivera S.

J Zoo Wildl Med. 2017 Jun;48(2):521-524. doi: 10.1638/2016-0101R1.1.

PMID:
28749281
11.

Sucrose transporter2 contributes to maize growth, development, and crop yield.

Leach KA, Tran TM, Slewinski TL, Meeley RB, Braun DM.

J Integr Plant Biol. 2017 Jun;59(6):390-408. doi: 10.1111/jipb.12527. Epub 2017 Apr 14.

PMID:
28206710
12.

AHDB Dairy Mastitis Control Plan.

Bradley A, Breen J, Leach K, Gibbons J, Armstrong D, Green M.

Vet Rec. 2017 Feb 11;180(6):154-155. doi: 10.1136/vr.j680. No abstract available.

PMID:
28183899
13.

Molecular insights into allosteric modulation of Class C G protein-coupled receptors.

Leach K, Gregory KJ.

Pharmacol Res. 2017 Feb;116:105-118. doi: 10.1016/j.phrs.2016.12.006. Epub 2016 Dec 11. Review.

PMID:
27965032
14.

Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation.

Hellyer S, Leach K, Gregory KJ.

Curr Opin Pharmacol. 2017 Feb;32:49-55. doi: 10.1016/j.coph.2016.10.007. Epub 2016 Nov 11. Review.

PMID:
27842256
15.

Sucrose Transporter ZmSut1 Expression and Localization Uncover New Insights into Sucrose Phloem Loading.

Baker RF, Leach KA, Boyer NR, Swyers MJ, Benitez-Alfonso Y, Skopelitis T, Luo A, Sylvester A, Jackson D, Braun DM.

Plant Physiol. 2016 Nov;172(3):1876-1898. Epub 2016 Sep 12.

16.

Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.

Shatz W, Hass PE, Mathieu M, Kim HS, Leach K, Zhou M, Crawford Y, Shen A, Wang K, Chang DP, Maia M, Crowell SR, Dickmann L, Scheer JM, Kelley RF.

Mol Pharm. 2016 Sep 6;13(9):2996-3003. doi: 10.1021/acs.molpharmaceut.6b00345. Epub 2016 Jun 14.

PMID:
27244474
17.

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.

Leach K, Gregory KJ, Kufareva I, Khajehali E, Cook AE, Abagyan R, Conigrave AD, Sexton PM, Christopoulos A.

Cell Res. 2016 May;26(5):574-92. doi: 10.1038/cr.2016.36. Epub 2016 Mar 22.

18.

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.

Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A.

Nature. 2016 Mar 17;531(7594):335-40. doi: 10.1038/nature17188. Epub 2016 Mar 9.

19.

Evidence-Based Practice Guideline: Changing the Practice of Physical Restraint Use in Acute Care.

Lach HW, Leach KM, Butcher HK.

J Gerontol Nurs. 2016 Feb;42(2):17-26. doi: 10.3928/00989134-20160113-04.

PMID:
26820185
20.

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.

Rueda P, Harley E, Lu Y, Stewart GD, Fabb S, Diepenhorst N, Cremers B, Rouillon MH, Wehrle I, Geant A, Lamarche G, Leach K, Charman WN, Christopoulos A, Summers RJ, Sexton PM, Langmead CJ.

PLoS One. 2016 Jan 19;11(1):e0146846. doi: 10.1371/journal.pone.0146846. eCollection 2016.

21.

Recycling manure as cow bedding: Potential benefits and risks for UK dairy farms.

Leach KA, Archer SC, Breen JE, Green MJ, Ohnstad IC, Tuer S, Bradley AJ.

Vet J. 2015 Nov;206(2):123-30. doi: 10.1016/j.tvjl.2015.08.013. Epub 2015 Aug 12. Review.

PMID:
26388545
22.

Bright Fraction of Single-Walled Carbon Nanotubes through Correlated Fluorescence and Topography Measurements.

Nogaj LJ, Smyder JA, Leach KE, Tu X, Zheng M, Krauss TD.

J Phys Chem Lett. 2015 Jul 16;6(14):2816-21. doi: 10.1021/acs.jpclett.5b01032. Epub 2015 Jul 6.

PMID:
26266867
23.

Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.

Khajehali E, Malone DT, Glass M, Sexton PM, Christopoulos A, Leach K.

Mol Pharmacol. 2015 Aug;88(2):368-79. doi: 10.1124/mol.115.099192. Epub 2015 Jun 4.

24.

Expertly validated models and phylogenetically-controlled analysis suggests responses to climate change are related to species traits in the order lagomorpha.

Leach K, Kelly R, Cameron A, Montgomery WI, Reid N.

PLoS One. 2015 Apr 15;10(4):e0122267. doi: 10.1371/journal.pone.0122267. eCollection 2015.

25.

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR.

Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038/ncomms7734.

PMID:
25828455
26.

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias.

Leach K, Conigrave AD, Sexton PM, Christopoulos A.

Trends Pharmacol Sci. 2015 Apr;36(4):215-25. doi: 10.1016/j.tips.2015.02.004. Epub 2015 Mar 9. Review.

PMID:
25765207
27.

Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization.

Brennan SC, Mun HC, Leach K, Kuchel PW, Christopoulos A, Conigrave AD.

Endocrinology. 2015 Apr;156(4):1330-42. doi: 10.1210/en.2014-1771. Epub 2015 Jan 21.

PMID:
25607893
28.

Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir.

Zhang X, Wang R, Piotrowski M, Zhang H, Leach KL.

Toxicol In Vitro. 2015 Feb;29(1):251-8.

PMID:
25448811
29.

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.

Cook AE, Mistry SN, Gregory KJ, Furness SG, Sexton PM, Scammells PJ, Conigrave AD, Christopoulos A, Leach K.

Br J Pharmacol. 2015 Jan;172(1):185-200. doi: 10.1111/bph.12937. Epub 2014 Dec 1.

30.

In-trap spectroscopy of charge-bred radioactive ions.

Lennarz A, Grossheim A, Leach KG, Alanssari M, Brunner T, Chaudhuri A, Chowdhury U, Crespo López-Urrutia JR, Gallant AT, Holl M, Kwiatkowski AA, Lassen J, Macdonald TD, Schultz BE, Seeraji S, Simon MC, Andreoiu C, Dilling J, Frekers D.

Phys Rev Lett. 2014 Aug 22;113(8):082502. Epub 2014 Aug 21.

PMID:
25192092
31.

Breakdown of the isobaric multiplet mass equation for the A = 20 and 21 multiplets.

Gallant AT, Brodeur M, Andreoiu C, Bader A, Chaudhuri A, Chowdhury U, Grossheim A, Klawitter R, Kwiatkowski AA, Leach KG, Lennarz A, Macdonald TD, Schultz BE, Lassen J, Heggen H, Raeder S, Teigelhöfer A, Brown BA, Magilligan A, Holt JD, Menéndez J, Simonis J, Schwenk A, Dilling J.

Phys Rev Lett. 2014 Aug 22;113(8):082501. Epub 2014 Aug 19.

PMID:
25192091
32.

Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor.

Goolam MA, Ward JH, Avlani VA, Leach K, Christopoulos A, Conigrave AD.

FEBS Lett. 2014 Sep 17;588(18):3340-6. doi: 10.1016/j.febslet.2014.07.022. Epub 2014 Jul 28.

33.
34.

Efficient molecular marker design using the MaizeGDB Mo17 SNPs and Indels track.

Settles AM, Bagadion AM, Bai F, Zhang J, Barron B, Leach K, Mudunkothge JS, Hoffner C, Bihmidine S, Finefield E, Hibbard J, Dieter E, Malidelis IA, Gustin JL, Karoblyte V, Tseung CW, Braun DM.

G3 (Bethesda). 2014 Apr 17;4(6):1143-5. doi: 10.1534/g3.114.010454.

35.

Umbilical cord transection to induce fetal demise prior to second-trimester D&E abortion: in reply.

Tocce K, Leach KK, Teal SB.

Contraception. 2014 May;89(5):473-4. doi: 10.1016/j.contraception.2014.02.009. Epub 2014 Feb 26. No abstract available.

PMID:
24656554
36.

Reduced face aftereffects in autism are not due to poor attention.

Ewing L, Leach K, Pellicano E, Jeffery L, Rhodes G.

PLoS One. 2013 Nov 29;8(11):e81353. doi: 10.1371/journal.pone.0081353. eCollection 2013.

37.

Investigating the value dairy farmers place on a reduction of lameness in their herds using a willingness to pay approach.

Bennett RM, Barker ZE, Main DC, Whay HR, Leach KA.

Vet J. 2014 Jan;199(1):72-5. doi: 10.1016/j.tvjl.2013.09.068. Epub 2013 Oct 7.

PMID:
24268682
38.

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders.

Leach K, Sexton PM, Christopoulos A, Conigrave AD.

Br J Pharmacol. 2014 Mar;171(5):1142-55. doi: 10.1111/bph.12420. Review.

39.

Umbilical cord transection to induce fetal demise prior to second-trimester D&E abortion.

Tocce K, Leach KK, Sheeder JL, Nielson K, Teal SB.

Contraception. 2013 Dec;88(6):712-6. doi: 10.1016/j.contraception.2013.08.001. Epub 2013 Aug 8.

PMID:
24034582
40.

The nurse's role in closing the diagnostic gap for people with dementia.

Leach K, Hicks A.

Br J Community Nurs. 2013 Sep;18(9):433-4, 436-40. Review.

PMID:
24005487
41.

Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.

Magee TV, Brown MF, Starr JT, Ackley DC, Abramite JA, Aubrecht J, Butler A, Crandon JL, Dib-Hajj F, Flanagan ME, Granskog K, Hardink JR, Huband MD, Irvine R, Kuhn M, Leach KL, Li B, Lin J, Luke DR, MacVane SH, Miller AA, McCurdy S, McKim JM Jr, Nicolau DP, Nguyen TT, Noe MC, O'Donnell JP, Seibel SB, Shen Y, Stepan AF, Tomaras AP, Wilga PC, Zhang L, Xu J, Chen JM.

J Med Chem. 2013 Jun 27;56(12):5079-93. doi: 10.1021/jm400416u. Epub 2013 Jun 18.

PMID:
23735048
42.

The role of nurses in commissioning services within primary care.

Leach K, Shepherd AB.

Br J Community Nurs. 2013 Apr;18(4):187-92.

PMID:
23574910
43.

Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter.

Zhang X, Scialis RJ, Feng B, Leach K.

Toxicol Sci. 2013 Jul;134(1):73-82. doi: 10.1093/toxsci/kft085. Epub 2013 Apr 5.

PMID:
23564645
44.

Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells.

Avlani VA, Ma W, Mun HC, Leach K, Delbridge L, Christopoulos A, Conigrave AD.

Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1097-104. doi: 10.1152/ajpendo.00054.2013. Epub 2013 Mar 26.

45.

Direct and indirect plant defenses are not suppressed by endosymbionts of a specialist root herbivore.

Robert CA, Frank DL, Leach KA, Turlings TC, Hibbard BE, Erb M.

J Chem Ecol. 2013 Apr;39(4):507-15. doi: 10.1007/s10886-013-0264-5. Epub 2013 Feb 26.

PMID:
23440444
46.

Collective structure in 94Zr and subshell effects in shape coexistence.

Chakraborty A, Peters EE, Crider BP, Andreoiu C, Bender PC, Cross DS, Demand GA, Garnsworthy AB, Garrett PE, Hackman G, Hadinia B, Ketelhut S, Kumar A, Leach KG, McEllistrem MT, Pore J, Prados-Estévez FM, Rand ET, Singh B, Tardiff ER, Wang ZM, Wood JL, Yates SW.

Phys Rev Lett. 2013 Jan 11;110(2):022504. Epub 2013 Jan 9.

PMID:
23383898
47.

Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators.

Leach K, Wen A, Cook AE, Sexton PM, Conigrave AD, Christopoulos A.

Endocrinology. 2013 Mar;154(3):1105-16. doi: 10.1210/en.2012-1887. Epub 2013 Jan 31.

PMID:
23372019
48.

Reducing lameness in dairy herds--overcoming some barriers.

Leach KA, Paul ES, Whay HR, Barker ZE, Maggs CM, Sedgwick AK, Main DC.

Res Vet Sci. 2013 Jun;94(3):820-5. doi: 10.1016/j.rvsc.2012.10.005. Epub 2012 Nov 16.

PMID:
23158851
49.

Promoting farmer engagement and activity in the control of dairy cattle lameness.

Whay HR, Barker ZE, Leach KA, Main DC.

Vet J. 2012 Sep;193(3):617-21. doi: 10.1016/j.tvjl.2012.06.041. Epub 2012 Aug 12.

PMID:
22892183
50.

The effects of early treatment for hindlimb lameness in dairy cows on four commercial UK farms.

Leach KA, Tisdall DA, Bell NJ, Main DC, Green LE.

Vet J. 2012 Sep;193(3):626-32. doi: 10.1016/j.tvjl.2012.06.043. Epub 2012 Aug 11.

PMID:
22884565

Supplemental Content

Support Center