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Items: 1 to 50 of 81

1.

RecBCD coordinates repair of two ends at a DNA double-strand break, preventing aberrant chromosome amplification.

White MA, Azeroglu B, Lopez-Vernaza MA, Hasan AMM, Leach DRF.

Nucleic Acids Res. 2018 Jul 27;46(13):6670-6682. doi: 10.1093/nar/gky463.

2.

Replication Fork Breakage and Restart in Escherichia coli.

Michel B, Sinha AK, Leach DRF.

Microbiol Mol Biol Rev. 2018 Jun 13;82(3). pii: e00013-18. doi: 10.1128/MMBR.00013-18. Print 2018 Sep. Review.

PMID:
29898897
3.

Dynamics of RecA-mediated repair of replication-dependent DNA breaks.

Amarh V, White MA, Leach DRF.

J Cell Biol. 2018 Jul 2;217(7):2299-2307. doi: 10.1083/jcb.201803020. Epub 2018 May 22.

4.

Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome.

Sinha AK, Possoz C, Durand A, Desfontaines JM, Barre FX, Leach DRF, Michel B.

PLoS Genet. 2018 Mar 9;14(3):e1007256. doi: 10.1371/journal.pgen.1007256. eCollection 2018 Mar.

5.

Division-induced DNA double strand breaks in the chromosome terminus region of Escherichia coli lacking RecBCD DNA repair enzyme.

Sinha AK, Durand A, Desfontaines JM, Iurchenko I, Auger H, Leach DRF, Barre FX, Michel B.

PLoS Genet. 2017 Oct 2;13(10):e1006895. doi: 10.1371/journal.pgen.1006895. eCollection 2017 Oct.

6.

RecG controls DNA amplification at double-strand breaks and arrested replication forks.

Azeroglu B, Leach DRF.

FEBS Lett. 2017 Apr;591(8):1101-1113. doi: 10.1002/1873-3468.12583. Epub 2017 Feb 28. Review.

7.

RecG Directs DNA Synthesis during Double-Strand Break Repair.

Azeroglu B, Mawer JS, Cockram CA, White MA, Hasan AM, Filatenkova M, Leach DR.

PLoS Genet. 2016 Feb 12;12(2):e1005799. doi: 10.1371/journal.pgen.1005799. eCollection 2016 Feb.

8.

Long inverted repeat transiently stalls DNA replication by forming hairpin structures on both leading and lagging strands.

Lai PJ, Lim CT, Le HP, Katayama T, Leach DR, Furukohri A, Maki H.

Genes Cells. 2016 Feb;21(2):136-45. doi: 10.1111/gtc.12326. Epub 2016 Jan 6.

9.

Prevent and Cure: RPA Cooperates with Mre11-Sae2 in DNA Secondary Structure Repair.

Leach DR.

Mol Cell. 2015 Nov 5;60(3):344-5. doi: 10.1016/j.molcel.2015.10.036.

10.

A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex.

Lim CT, Lai PJ, Leach DR, Maki H, Furukohri A.

Nucleic Acids Res. 2015 Nov 16;43(20):9804-16. doi: 10.1093/nar/gkv855. Epub 2015 Aug 28.

11.

Quantitative genomic analysis of RecA protein binding during DNA double-strand break repair reveals RecBCD action in vivo.

Cockram CA, Filatenkova M, Danos V, El Karoui M, Leach DR.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4735-42. doi: 10.1073/pnas.1424269112. Epub 2015 Aug 10.

12.

Chromosomal directionality of DNA mismatch repair in Escherichia coli.

Hasan AM, Leach DR.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9388-93. doi: 10.1073/pnas.1505370112. Epub 2015 Jul 13.

13.

A perfect palindrome in the Escherichia coli chromosome forms DNA hairpins on both leading- and lagging-strands.

Azeroglu B, Lincker F, White MA, Jain D, Leach DR.

Nucleic Acids Res. 2014 Dec 1;42(21):13206-13. doi: 10.1093/nar/gku1136. Epub 2014 Nov 11.

14.

Repair on the go: E. coli maintains a high proliferation rate while repairing a chronic DNA double-strand break.

Darmon E, Eykelenboom JK, Lopez-Vernaza MA, White MA, Leach DR.

PLoS One. 2014 Oct 29;9(10):e110784. doi: 10.1371/journal.pone.0110784. eCollection 2014.

15.

Branch migration prevents DNA loss during double-strand break repair.

Mawer JS, Leach DR.

PLoS Genet. 2014 Aug 7;10(8):e1004485. doi: 10.1371/journal.pgen.1004485. eCollection 2014 Aug.

16.

Expansion of CAG repeats in Escherichia coli is controlled by single-strand DNA exonucleases of both polarities.

Jackson A, Okely EA, Leach DR.

Genetics. 2014 Oct;198(2):509-17. doi: 10.1534/genetics.114.168245. Epub 2014 Jul 31.

17.

Bacterial genome instability.

Darmon E, Leach DR.

Microbiol Mol Biol Rev. 2014 Mar;78(1):1-39. doi: 10.1128/MMBR.00035-13. Review.

18.

Pulsed-field gel electrophoresis of bacterial chromosomes.

Mawer JS, Leach DR.

Methods Mol Biol. 2013;1054:187-94. doi: 10.1007/978-1-62703-565-1_12.

PMID:
23913293
19.

WITHDRAWN: Symmetries and Asymmetries Associated with Non-Random Segregation of Sister DNA Strands in Escherichia coli.

Lopez-Vernaza MA, Leach DR.

Semin Cell Dev Biol. 2013 May 18. pii: S1084-9521(13)00077-3. doi: 10.1016/j.semcdb.2013.05.011. [Epub ahead of print]

PMID:
23692810
20.

Symmetries and asymmetries associated with non-random segregation of sister DNA strands in Escherichia coli.

Lopez-Vernaza MA, Leach DR.

Semin Cell Dev Biol. 2013 Aug-Sep;24(8-9):610-7. doi: 10.1016/j.semcdb.2013.05.010. Epub 2013 May 15. Review.

21.

DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG·CTG trinucleotide repeat.

Blackwood JK, Okely EA, Zahra R, Eykelenboom JK, Leach DR.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22582-6. doi: 10.1073/pnas.1012906108. Epub 2010 Dec 13.

22.

E. coli SbcCD and RecA control chromosomal rearrangement induced by an interrupted palindrome.

Darmon E, Eykelenboom JK, Lincker F, Jones LH, White M, Okely E, Blackwood JK, Leach DR.

Mol Cell. 2010 Jul 9;39(1):59-70. doi: 10.1016/j.molcel.2010.06.011.

23.

Overexpression of the single-stranded DNA-binding protein (SSB) stabilises CAG*CTG triplet repeats in an orientation dependent manner.

Andreoni F, Darmon E, Poon WC, Leach DR.

FEBS Lett. 2010 Jan 4;584(1):153-8. doi: 10.1016/j.febslet.2009.11.042.

24.

Holliday junctions, heteroduplex DNA and map expansion: a commentary on 'A mechanism for gene conversion in fungi' by Robin Holliday.

Leach DR.

Genet Res. 2007 Dec;89(5-6):281-3. doi: 10.1017/S0016672308009488. No abstract available.

PMID:
18976516
25.

Non-random segregation of sister chromosomes in Escherichia coli.

White MA, Eykelenboom JK, Lopez-Vernaza MA, Wilson E, Leach DR.

Nature. 2008 Oct 30;455(7217):1248-50. doi: 10.1038/nature07282.

PMID:
18972020
26.

SbcCD causes a double-strand break at a DNA palindrome in the Escherichia coli chromosome.

Eykelenboom JK, Blackwood JK, Okely E, Leach DR.

Mol Cell. 2008 Mar 14;29(5):644-51. doi: 10.1016/j.molcel.2007.12.020.

27.

Novel roles for selected genes in meiotic DNA processing.

Jordan PW, Klein F, Leach DR.

PLoS Genet. 2007 Dec;3(12):e222.

28.

SbcCD regulation and localization in Escherichia coli.

Darmon E, Lopez-Vernaza MA, Helness AC, Borking A, Wilson E, Thacker Z, Wardrope L, Leach DR.

J Bacteriol. 2007 Sep;189(18):6686-94. Epub 2007 Jul 20.

29.

Perspectives on the development of a therapeutic HER-2 cancer vaccine.

Renard V, Leach DR.

Vaccine. 2007 Sep 27;25 Suppl 2:B17-23. Epub 2007 Jun 18. Review.

PMID:
17630057
30.
31.

Linked foreign T-cell help activates self-reactive CTL and inhibits tumor growth.

Steinaa L, Rasmussen PB, Wegener AM, Sonderbye L, Leach DR, Rygaard J, Mouritsen S, Gautam AM.

J Immunol. 2005 Jul 1;175(1):329-34.

32.

Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex.

de Jager M, Trujillo KM, Sung P, Hopfner KP, Carney JP, Tainer JA, Connelly JC, Leach DR, Kanaar R, Wyman C.

J Mol Biol. 2004 Jun 11;339(4):937-49.

PMID:
15165861
33.

Repair of DNA covalently linked to protein.

Connelly JC, Leach DR.

Mol Cell. 2004 Feb 13;13(3):307-16. Review.

34.

HER-2 DNA and protein vaccines containing potent Th cell epitopes induce distinct protective and therapeutic antitumor responses in HER-2 transgenic mice.

Renard V, Sonderbye L, Ebbehøj K, Rasmussen PB, Gregorius K, Gottschalk T, Mouritsen S, Gautam A, Leach DR.

J Immunol. 2003 Aug 1;171(3):1588-95.

35.

Nucleolytic processing of a protein-bound DNA end by the E. coli SbcCD (MR) complex.

Connelly JC, de Leau ES, Leach DR.

DNA Repair (Amst). 2003 Jul 16;2(7):795-807.

PMID:
12826280
36.

Tethering on the brink: the evolutionarily conserved Mre11-Rad50 complex.

Connelly JC, Leach DR.

Trends Biochem Sci. 2002 Aug;27(8):410-8. Review.

PMID:
12151226
37.

Recombination at double-strand breaks and DNA ends: conserved mechanisms from phage to humans.

Cromie GA, Connelly JC, Leach DR.

Mol Cell. 2001 Dec;8(6):1163-74. Review.

38.

Recombinational repair of chromosomal DNA double-strand breaks generated by a restriction endonuclease.

Cromie GA, Leach DR.

Mol Microbiol. 2001 Aug;41(4):873-83. Erratum in: Mol Microbiol. 2003 Jun;48(5):1427.

39.

Control of crossing over.

Cromie GA, Leach DR.

Mol Cell. 2000 Oct;6(4):815-26.

40.
41.

Palindromes as substrates for multiple pathways of recombination in Escherichia coli.

Cromie GA, Millar CB, Schmidt KH, Leach DR.

Genetics. 2000 Feb;154(2):513-22.

42.

Two opposing effects of mismatch repair on CTG repeat instability in Escherichia coli.

Schmidt KH, Abbott CM, Leach DR.

Mol Microbiol. 2000 Jan;35(2):463-71.

43.

DNA cleavage and degradation by the SbcCD protein complex from Escherichia coli.

Connelly JC, de Leau ES, Leach DR.

Nucleic Acids Res. 1999 Feb 15;27(4):1039-46.

44.
45.
46.

Replication strand preference for deletions associated with DNA palindromes.

Pinder DJ, Blake CE, Lindsey JC, Leach DR.

Mol Microbiol. 1998 May;28(4):719-27.

47.
48.

Secondary structures in d(CGG) and d(CCG) repeat tracts.

Darlow JM, Leach DR.

J Mol Biol. 1998 Jan 9;275(1):3-16. Review.

PMID:
9451434
49.

Repair by recombination of DNA containing a palindromic sequence.

Leach DR, Okely EA, Pinder DJ.

Mol Microbiol. 1997 Nov;26(3):597-606.

50.

Overexpression, purification, and characterization of the SbcCD protein from Escherichia coli.

Connelly JC, de Leau ES, Okely EA, Leach DR.

J Biol Chem. 1997 Aug 8;272(32):19819-26.

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