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Items: 45

1.

Analysis of the polycystin complex (PCC) in human urinary exosome-like vesicles (ELVs).

Lea WA, McGreal K, Sharma M, Parnell SC, Zelenchuk L, Charlesworth MC, Madden BJ, Johnson KL, McCormick DJ, Hogan MC, Ward CJ.

Sci Rep. 2020 Jan 30;10(1):1500. doi: 10.1038/s41598-020-58087-3.

2.

Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis.

Lyu H, Petukhov PA, Banta PR, Jadhav A, Lea WA, Cheng Q, Arnér ESJ, Simeonov A, Thatcher GRJ, Angelucci F, Williams DL.

ACS Infect Dis. 2020 Mar 13;6(3):393-405. doi: 10.1021/acsinfecdis.9b00354. Epub 2020 Jan 24.

PMID:
31939288
3.

Human-Specific Abnormal Alternative Splicing of Wild-Type PKD1 Induces Premature Termination of Polycystin-1.

Lea WA, Parnell SC, Wallace DP, Calvet JP, Zelenchuk LV, Alvarez NS, Ward CJ.

J Am Soc Nephrol. 2018 Oct;29(10):2482-2492. doi: 10.1681/ASN.2018040442. Epub 2018 Sep 5.

4.

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.

Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Cheng Q, Arnér ESJ, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F.

ACS Chem Biol. 2018 Aug 17;13(8):2190-2202. doi: 10.1021/acschembio.8b00349. Epub 2018 Jun 11.

5.

A new epitope-tagged Pkhd1 allele sheds light on fibrocystin signaling.

Lea WA, Ward CJ.

Kidney Int. 2017 Nov;92(5):1041-1043. doi: 10.1016/j.kint.2017.05.026.

PMID:
29055424
6.

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.

Martinez NJ, Rai G, Yasgar A, Lea WA, Sun H, Wang Y, Luci DK, Yang SM, Nishihara K, Takeda S, Mohiuddin, Earnshaw I, Okada T, Mori K, Wilson K, Riggins GJ, Xia M, Grimaldi M, Jadhav A, Maloney DJ, Simeonov A.

PLoS One. 2016 Nov 8;11(11):e0166506. doi: 10.1371/journal.pone.0166506. eCollection 2016.

7.

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.

Martinez NJ, Rai G, Yasgar A, Lea WA, Sun H, Wang Y, Luci DK, Yang SM, Nishihara K, Takeda S, Sagor M, Earnshaw I, Okada T, Mori K, Wilson K, Riggins GJ, Xia M, Grimaldi M, Jadhav A, Maloney DJ, Simeonov A.

PLoS One. 2016 Aug 29;11(8):e0161486. doi: 10.1371/journal.pone.0161486. eCollection 2016. Erratum in: PLoS One. 2016 Nov 8;11(11):e0166506.

8.

Chaperonin-Based Biolayer Interferometry To Assess the Kinetic Stability of Metastable, Aggregation-Prone Proteins.

Lea WA, O'Neil PT, Machen AJ, Naik S, Chaudhri T, McGinn-Straub W, Tischer A, Auton MT, Burns JR, Baldwin MR, Khar KR, Karanicolas J, Fisher MT.

Biochemistry. 2016 Sep 6;55(35):4885-908. doi: 10.1021/acs.biochem.6b00293. Epub 2016 Aug 19.

9.

Discovery of a novel general anesthetic chemotype using high-throughput screening.

McKinstry-Wu AR, Bu W, Rai G, Lea WA, Weiser BP, Liang DF, Simeonov A, Jadhav A, Maloney DJ, Eckenhoff RG.

Anesthesiology. 2015 Feb;122(2):325-33. doi: 10.1097/ALN.0000000000000505.

10.

Biochemical assays for the discovery of TDP1 inhibitors.

Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y.

Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14.

11.

Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.

Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R.

J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22.

12.

Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.

Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA, Popovici-Muller J, DeLaBarre B, Artin E, Thorne N, Auld DS, Li Z, Dang L, Boxer MB, Simeonov A.

J Biol Chem. 2014 May 16;289(20):13717-25. doi: 10.1074/jbc.M113.511030. Epub 2014 Mar 25.

13.

Discovery of Novel General Anesthetics Using Apoferritin as a Surrogate System.

Rai G, Bu W, Lea WA, Liang D, Weiser B, Setola V, Austin CP, Simeonov A, Jadhav A, Eckenhoff R, Maloney DJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2013 May 8].

14.

Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A.

Nguyen JB, Pool CD, Wong CY, Treger RS, Williams DL, Cappello M, Lea WA, Simeonov A, Vermeire JJ, Modis Y.

Chem Biol. 2013 Aug 22;20(8):991-1001. doi: 10.1016/j.chembiol.2013.06.011. Epub 2013 Jul 25.

15.

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions.

Seidel SA, Dijkman PM, Lea WA, van den Bogaart G, Jerabek-Willemsen M, Lazic A, Joseph JS, Srinivasan P, Baaske P, Simeonov A, Katritch I, Melo FA, Ladbury JE, Schreiber G, Watts A, Braun D, Duhr S.

Methods. 2013 Mar;59(3):301-15. doi: 10.1016/j.ymeth.2012.12.005. Epub 2012 Dec 24. Review.

16.

High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase.

McCoy ES, Lea WA, Mott BT, Maloney DJ, Jadhav A, Simeonov A, Zylka MJ.

J Biomol Screen. 2013 Apr;18(4):481-9. doi: 10.1177/1087057112468613. Epub 2012 Nov 27.

17.

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

Thorne N, Shen M, Lea WA, Simeonov A, Lovell S, Auld DS, Inglese J.

Chem Biol. 2012 Aug 24;19(8):1060-72. doi: 10.1016/j.chembiol.2012.07.015.

18.

Discovery of a novel noniminosugar acid α glucosidase chaperone series.

Xiao J, Westbroek W, Motabar O, Lea WA, Hu X, Velayati A, Zheng W, Southall N, Gustafson AM, Goldin E, Sidransky E, Liu K, Simeonov A, Tamargo RJ, Ribes A, Matalonga L, Ferrer M, Marugan JJ.

J Med Chem. 2012 Sep 13;55(17):7546-59. doi: 10.1021/jm3005543. Epub 2012 Aug 17.

19.

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.

Patnaik S, Zheng W, Choi JH, Motabar O, Southall N, Westbroek W, Lea WA, Velayati A, Goldin E, Sidransky E, Leister W, Marugan JJ.

J Med Chem. 2012 Jun 28;55(12):5734-48. doi: 10.1021/jm300063b. Epub 2012 Jun 8.

20.

Non-iminosugar glucocerebrosidase small molecule chaperones.

Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E.

Medchemcomm. 2012 Jan;3(1):56-60. Epub 2011 Oct 24.

21.

Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase.

Lea WA, Simeonov A.

PLoS One. 2012;7(4):e36219. doi: 10.1371/journal.pone.0036219. Epub 2012 Apr 30.

22.

Fluorescence polarization assays in small molecule screening.

Lea WA, Simeonov A.

Expert Opin Drug Discov. 2011 Jan;6(1):17-32. doi: 10.1517/17460441.2011.537322.

23.

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP.

J Med Chem. 2011 Feb 24;54(4):1033-58. doi: 10.1021/jm1008902. Epub 2011 Jan 20.

24.

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1.

25.

A high-throughput approach for identification of novel general anesthetics.

Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG.

PLoS One. 2009 Sep 24;4(9):e7150. doi: 10.1371/journal.pone.0007150.

26.

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.

Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, Williams DL, Thomas CJ.

J Med Chem. 2009 Oct 22;52(20):6474-83. doi: 10.1021/jm901021k.

27.

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A.

Mol Cancer Ther. 2009 Jan;8(1):240-8. doi: 10.1158/1535-7163.MCT-08-0878.

28.

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.

Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A.

Assay Drug Dev Technol. 2008 Aug;6(4):551-5. doi: 10.1089/adt.2008.149.

29.

Comparison between electroglottography and electromagnetic glottography.

Titze IR, Story BH, Burnett GC, Holzrichter JF, Ng LC, Lea WA.

J Acoust Soc Am. 2000 Jan;107(1):581-8.

PMID:
10641666
30.

Speech articulator measurements using low power EM-wave sensors.

Holzrichter JF, Burnett GC, Ng LC, Lea WA.

J Acoust Soc Am. 1998 Jan;103(1):622-5.

PMID:
9440346
31.

Evaluating speech-recognition work.

Lea WA.

J Acoust Soc Am. 1970 Jun;47(6):1612-4. No abstract available.

PMID:
5426313
32.

TOPICAL AND INTRALESIONAL ADMINISTRATION OF TRIAMCINOLONE ACETONIDE: ADVANTAGES IN DERMATOLOGIC THERAPY.

LEA WA Jr.

J Am Geriatr Soc. 1963 Oct;11:987-92. No abstract available.

PMID:
14073673
33.

Coexisting heart disease, sclerema neonatorum, and possible protozoan infection. Report of a case.

STINSON JC, LEA WA Jr, WOOD HL, CRAMM CJ Jr.

JAMA. 1962 Sep 8;181:899-901. No abstract available.

PMID:
13917254
34.

Cutaneous larva migrans associated with Loeffler's syndrome, report of a case.

FALCONER HS, LEA WA Jr.

Tex State J Med. 1961 May;57:373-6. No abstract available.

PMID:
13697996
35.

A rapid technic for demonstrating melanin in fresh tissue.

STINSON JC, LEA WA Jr, SUNBURY TR, FORD HC.

J Invest Dermatol. 1959 Nov;33:223-4. No abstract available.

36.

Distribution of lipids and free amino acids in psoriatic scale.

CORNISH HH, BLOCK WD, LEA WA Jr.

J Invest Dermatol. 1959 Jan;32(1):43-7. No abstract available.

37.

Serum uric acid levels in psoriasis.

LEA WA Jr, CURTIS AC, BERNSTEIN IA.

J Invest Dermatol. 1958 Nov;31(5):269-71. No abstract available.

38.

The irritating and sensitizing capacity of epoxy resins.

LEA WA Jr, BLOCK WD, CORNISH HH.

AMA Arch Derm. 1958 Sep;78(3):304-8. No abstract available.

PMID:
13570681
39.

Gamma globulin in the treatment of herpes zoster.

LEA WA Jr, TAYLOR WB.

Tex State J Med. 1958 Aug;54(8):594-6. No abstract available.

PMID:
13580917
40.

Mycological flora of the healthy external auditory canal: a study of 120 human subjects.

LEA WA Jr, SCHUSTER DS, HARRELL ER.

J Invest Dermatol. 1958 Aug;31(2):137-8. No abstract available.

41.

Nitrogen balance and sulfur excretion studies in psoriasis.

BLOCK WD, LEA WA Jr, CURTIS AC, CANNON EF.

J Invest Dermatol. 1958 Jun;30(6):287-93. No abstract available.

42.

Electrophoretic studies in psoriasis.

SCHUSTER DS, LEA WA Jr, BLOCK WD, CURTIS AC.

AMA Arch Derm. 1958 Jun;77(6):713-4. No abstract available.

PMID:
13544606
43.

Studies on serum lipids, proteins, and lipoproteins in psoriasis.

LEA WA Jr, CORNISH HH, BLOCK WD.

J Invest Dermatol. 1958 Apr;30(4):181-5. No abstract available.

44.

Rouges and rashes.

LEA WA Jr, HACKETT AM.

Am J Nurs. 1958 Jan;58(1):82-6. No abstract available.

PMID:
13487665
45.

Ecthyma contagiosum (orf) in sheep and man; a summary of the literature and report of three cases.

TAYLOR WB, LEA WA Jr.

J Mich State Med Soc. 1957 Jul;56(7):871-4. No abstract available.

PMID:
13449585

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