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The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion.

Kuhlen L, Johnson S, Zeitler A, Bäurle S, Deme JC, Caesar JJE, Debo R, Fisher J, Wagner S, Lea SM.

Nat Commun. 2020 Mar 10;11(1):1296. doi: 10.1038/s41467-020-15071-9.


Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.

Reichhardt MP, Loimaranta V, Lea SM, Johnson S.

Life Sci Alliance. 2020 Feb 25;3(4). pii: e201900502. doi: 10.26508/lsa.201900502. Print 2020 Apr.


An inhibitor of complement C5 provides structural insights into activation.

Reichhardt MP, Johnson S, Tang T, Morgan T, Tebeka N, Popitsch N, Deme JC, Jore MM, Lea SM.

Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):362-370. doi: 10.1073/pnas.1909973116. Epub 2019 Dec 23.


Type 9 secretion system structures reveal a new protein transport mechanism.

Lauber F, Deme JC, Lea SM, Berks BC.

Nature. 2018 Dec;564(7734):77-82. doi: 10.1038/s41586-018-0693-y. Epub 2018 Nov 7.


Structural Insights into Notch Receptor-Ligand Interactions.

Handford PA, Korona B, Suckling R, Redfield C, Lea SM.

Adv Exp Med Biol. 2018;1066:33-46. doi: 10.1007/978-3-319-89512-3_2. Review.


Author Correction: Structure of the core of the type III secretion system export apparatus.

Kuhlen L, Abrusci P, Johnson S, Gault J, Deme J, Caesar J, Dietsche T, Mebrhatu MT, Ganief T, Macek B, Wagner S, Robinson CV, Lea SM.

Nat Struct Mol Biol. 2018 Aug;25(8):743. doi: 10.1038/s41594-018-0095-8.


Structure of the core of the type III secretion system export apparatus.

Kuhlen L, Abrusci P, Johnson S, Gault J, Deme J, Caesar J, Dietsche T, Mebrhatu MT, Ganief T, Macek B, Wagner S, Robinson CV, Lea SM.

Nat Struct Mol Biol. 2018 Jul;25(7):583-590. doi: 10.1038/s41594-018-0086-9. Epub 2018 Jul 2. Erratum in: Nat Struct Mol Biol. 2018 Aug;25(8):743.


Structure-based design of chimeric antigens for multivalent protein vaccines.

Hollingshead S, Jongerius I, Exley RM, Johnson S, Lea SM, Tang CM.

Nat Commun. 2018 Mar 13;9(1):1051. doi: 10.1038/s41467-018-03146-7.


Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.

Roversi P, Johnson S, Preston SG, Nunn MA, Paesen GC, Austyn JM, Nuttall PA, Lea SM.

Sci Rep. 2017 Nov 22;7(1):16057. doi: 10.1038/s41598-017-16413-2.


On the state of crystallography at the dawn of the electron microscopy revolution.

Higgins MK, Lea SM.

Curr Opin Struct Biol. 2017 Oct;46:95-101. doi: 10.1016/ Epub 2017 Jul 4. Review.


Structural Basis for Mitotic Centrosome Assembly in Flies.

Feng Z, Caballe A, Wainman A, Johnson S, Haensele AFM, Cottee MA, Conduit PT, Lea SM, Raff JW.

Cell. 2017 Jun 1;169(6):1078-1089.e13. doi: 10.1016/j.cell.2017.05.030.


Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

Suckling RJ, Korona B, Whiteman P, Chillakuri C, Holt L, Handford PA, Lea SM.

EMBO J. 2017 Aug 1;36(15):2204-2215. doi: 10.15252/embj.201796632. Epub 2017 Jun 1.


FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

Csincsi ÁI, Szabó Z, Bánlaki Z, Uzonyi B, Cserhalmi M, Kárpáti É, Tortajada A, Caesar JJE, Prohászka Z, Jokiranta TS, Lea SM, Rodríguez de Córdoba S, Józsi M.

J Immunol. 2017 Jul 1;199(1):292-303. doi: 10.4049/jimmunol.1600483. Epub 2017 May 22.


A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase.

Huang Q, Alcock F, Kneuper H, Deme JC, Rollauer SE, Lea SM, Berks BC, Palmer T.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1958-E1967. doi: 10.1073/pnas.1615056114. Epub 2017 Feb 21.


A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.

Cottee MA, Johnson S, Raff JW, Lea SM.

Biol Open. 2017 Mar 15;6(3):381-389. doi: 10.1242/bio.024661.


Different modes of variation for each BG lineage suggest different functions.

Chattaway J, Ramirez-Valdez RA, Chappell PE, Caesar JJ, Lea SM, Kaufman J.

Open Biol. 2016 Sep;6(9). pii: 160188. doi: 10.1098/rsob.160188.


A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding.

Berry JL, Xu Y, Ward PN, Lea SM, Matthews SJ, Pelicic V.

Structure. 2016 Jun 7;24(6):926-34. doi: 10.1016/j.str.2016.04.001. Epub 2016 May 5.


Structural basis for therapeutic inhibition of complement C5.

Jore MM, Johnson S, Sheppard D, Barber NM, Li YI, Nunn MA, Elmlund H, Lea SM.

Nat Struct Mol Biol. 2016 May;23(5):378-86. doi: 10.1038/nsmb.3196. Epub 2016 Mar 28.


Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.

Weisshuhn PC, Sheppard D, Taylor P, Whiteman P, Lea SM, Handford PA, Redfield C.

Structure. 2016 Apr 5;24(4):555-566. doi: 10.1016/j.str.2016.02.010. Epub 2016 Mar 17.


Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle.

Grabarczyk DB, Chappell PE, Johnson S, Stelzl LS, Lea SM, Berks BC.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7166-75. doi: 10.1073/pnas.1506386112. Epub 2015 Dec 11.


Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS.

McDowell MA, Marcoux J, McVicker G, Johnson S, Fong YH, Stevens R, Bowman LA, Degiacomi MT, Yan J, Wise A, Friede ME, Benesch JL, Deane JE, Tang CM, Robinson CV, Lea SM.

Mol Microbiol. 2016 Feb;99(4):749-66. doi: 10.1111/mmi.13267. Epub 2015 Dec 23.


Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.

Chappell PE, Garner LI, Yan J, Metcalfe C, Hatherley D, Johnson S, Robinson CV, Lea SM, Brown MH.

Structure. 2015 Aug 4;23(8):1426-1436. doi: 10.1016/j.str.2015.05.019. Epub 2015 Jul 2.


The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.

Cottee MA, Muschalik N, Johnson S, Leveson J, Raff JW, Lea SM.

Elife. 2015 May 23;4:e07236. doi: 10.7554/eLife.07236.


Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding.

Chappell P, Meziane el K, Harrison M, Magiera Ł, Hermann C, Mears L, Wrobel AG, Durant C, Nielsen LL, Buus S, Ternette N, Mwangi W, Butter C, Nair V, Ahyee T, Duggleby R, Madrigal A, Roversi P, Lea SM, Kaufman J.

Elife. 2015 Apr 10;4:e05345. doi: 10.7554/eLife.05345.


Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.

Csincsi ÁI, Kopp A, Zöldi M, Bánlaki Z, Uzonyi B, Hebecker M, Caesar JJ, Pickering MC, Daigo K, Hamakubo T, Lea SM, Goicoechea de Jorge E, Józsi M.

J Immunol. 2015 May 15;194(10):4963-73. doi: 10.4049/jimmunol.1403121. Epub 2015 Apr 8.


Mechanism of thiosulfate oxidation in the SoxA family of cysteine-ligated cytochromes.

Grabarczyk DB, Chappell PE, Eisel B, Johnson S, Lea SM, Berks BC.

J Biol Chem. 2015 Apr 3;290(14):9209-21. doi: 10.1074/jbc.M114.618025. Epub 2015 Feb 11.


Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility.

Caesar JJ, Lavender H, Ward PN, Exley RM, Eaton J, Chittock E, Malik TH, Goiecoechea De Jorge E, Pickering MC, Tang CM, Lea SM.

Elife. 2014 Dec 23;3. doi: 10.7554/eLife.04008.


Crystal structure of the Bacillus subtilis phosphodiesterase PhoD reveals an iron and calcium-containing active site.

Rodriguez F, Lillington J, Johnson S, Timmel CR, Lea SM, Berks BC.

J Biol Chem. 2014 Nov 7;289(45):30889-99. doi: 10.1074/jbc.M114.604892. Epub 2014 Sep 12.


A complex iron-calcium cofactor catalyzing phosphotransfer chemistry.

Yong SC, Roversi P, Lillington J, Rodriguez F, Krehenbrink M, Zeldin OB, Garman EF, Lea SM, Berks BC.

Science. 2014 Sep 5;345(6201):1170-1173. doi: 10.1126/science.1254237.


Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).

Watson R, Wearmouth E, McLoughlin AC, Jackson A, Ward S, Bertram P, Bennaceur K, Barker CE, Pappworth IY, Kavanagh D, Lea SM, Atkinson JP, Goodship TH, Marchbank KJ.

Mol Immunol. 2015 Feb;63(2):287-96. doi: 10.1016/j.molimm.2014.07.017. Epub 2014 Aug 21.


Investigating the structure of the factor B vWF-A domain/CD55 protein-protein complex using DEER spectroscopy: successes and pitfalls.

Lovett JE, Abbott RJ, Roversi P, Johnson S, Caesar JJ, Doria M, Jeschke G, Timmel CR, Lea SM.

Mol Phys. 2013 Oct;111(18-19):2865-2872. Epub 2013 Oct 9.


Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.

Taylor P, Takeuchi H, Sheppard D, Chillakuri C, Lea SM, Haltiwanger RS, Handford PA.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7290-5. doi: 10.1073/pnas.1319683111. Epub 2014 May 6.


Structural biology of Tat protein transport.

Berks BC, Lea SM, Stansfeld PJ.

Curr Opin Struct Biol. 2014 Aug;27:32-7. doi: 10.1016/ Epub 2014 Apr 5. Review.


Building a secreting nanomachine: a structural overview of the T3SS.

Abrusci P, McDowell MA, Lea SM, Johnson S.

Curr Opin Struct Biol. 2014 Apr;25:111-7. doi: 10.1016/ Epub 2014 Apr 1. Review.


Identification and characterization of the 'missing' terminal enzyme for siroheme biosynthesis in α-proteobacteria.

Bali S, Rollauer S, Roversi P, Raux-Deery E, Lea SM, Warren MJ, Ferguson SJ.

Mol Microbiol. 2014 Apr;92(1):153-63. doi: 10.1111/mmi.12542. Epub 2014 Mar 13.


The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.

Conduit PT, Feng Z, Richens JH, Baumbach J, Wainman A, Bakshi SD, Dobbelaere J, Johnson S, Lea SM, Raff JW.

Dev Cell. 2014 Mar 31;28(6):659-69. doi: 10.1016/j.devcel.2014.02.013. Epub 2014 Mar 20.


Polymorphisms in the human inhibitory signal-regulatory protein α do not affect binding to its ligand CD47.

Hatherley D, Lea SM, Johnson S, Barclay AN.

J Biol Chem. 2014 Apr 4;289(14):10024-8. doi: 10.1074/jbc.M114.550558. Epub 2014 Feb 18.


Functional analysis of the interdependence between DNA uptake sequence and its cognate ComP receptor during natural transformation in Neisseria species.

Berry JL, Cehovin A, McDowell MA, Lea SM, Pelicic V.

PLoS Genet. 2013;9(12):e1004014. doi: 10.1371/journal.pgen.1004014. Epub 2013 Dec 19.


Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates.

van der Veen S, Johnson S, Jongerius I, Malik T, Genovese A, Santini L, Staunton D, Ufret-Vincenty RL, Pickering MC, Lea SM, Tang CM.

Infect Immun. 2014 Mar;82(3):1157-63. doi: 10.1128/IAI.01183-13. Epub 2013 Dec 30.


Structural analysis uncovers lipid-binding properties of Notch ligands.

Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM.

Cell Rep. 2013 Nov 27;5(4):861-7. doi: 10.1016/j.celrep.2013.10.029. Epub 2013 Nov 14.


Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly.

Cottee MA, Muschalik N, Wong YL, Johnson CM, Johnson S, Andreeva A, Oegema K, Lea SM, Raff JW, van Breugel M.

Elife. 2013 Sep 17;2:e01071. doi: 10.7554/eLife.01071.


Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein.

Jongerius I, Lavender H, Tan L, Ruivo N, Exley RM, Caesar JJ, Lea SM, Johnson S, Tang CM.

PLoS Pathog. 2013;9(8):e1003528. doi: 10.1371/journal.ppat.1003528. Epub 2013 Aug 1.


Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi.

Caesar JJ, Wallich R, Kraiczy P, Zipfel PF, Lea SM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):629-33. doi: 10.1107/S1744309113012748. Epub 2013 May 23.


ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family.

Caesar JJ, Johnson S, Kraiczy P, Lea SM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):624-8. doi: 10.1107/S1744309113013249. Epub 2013 May 23.


Structural basis for recognition of the pore-forming toxin intermedilysin by human complement receptor CD59.

Johnson S, Brooks NJ, Smith RA, Lea SM, Bubeck D.

Cell Rep. 2013 May 30;3(5):1369-77. doi: 10.1016/j.celrep.2013.04.029. Epub 2013 May 9.


Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury.

Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, Paesen GC, Lissina O, Boland W, Ploss K, Caesar JJ, Leonhartsberger S, Lea SM, Nunn MA.

J Biol Chem. 2013 Jun 28;288(26):18789-802. doi: 10.1074/jbc.M112.420331. Epub 2013 Apr 26.


Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution.

Hatherley D, Lea SM, Johnson S, Barclay AN.

Structure. 2013 May 7;21(5):820-32. doi: 10.1016/j.str.2013.03.008. Epub 2013 Apr 18.


Dimerization of complement factor H-related proteins modulates complement activation in vivo.

Goicoechea de Jorge E, Caesar JJ, Malik TH, Patel M, Colledge M, Johnson S, Hakobyan S, Morgan BP, Harris CL, Pickering MC, Lea SM.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90. doi: 10.1073/pnas.1219260110. Epub 2013 Mar 4.


Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.

Malito E, Faleri A, Lo Surdo P, Veggi D, Maruggi G, Grassi E, Cartocci E, Bertoldi I, Genovese A, Santini L, Romagnoli G, Borgogni E, Brier S, Lo Passo C, Domina M, Castellino F, Felici F, van der Veen S, Johnson S, Lea SM, Tang CM, Pizza M, Savino S, Norais N, Rappuoli R, Bottomley MJ, Masignani V.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3304-9. doi: 10.1073/pnas.1222845110. Epub 2013 Feb 8.

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