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Items: 1 to 50 of 69

1.

Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine's aversive effects in adolescent rats.

Harris AC, Muelken P, Swain Y, Palumbo M, Jain V, Goniewicz ML, Stepanov I, LeSage MG.

Drug Alcohol Depend. 2019 Oct 1;203:51-60. doi: 10.1016/j.drugalcdep.2019.05.023. Epub 2019 Aug 1.

PMID:
31404849
2.

Propylene glycol, a major electronic cigarette constituent, attenuates the adverse effects of high-dose nicotine as measured by intracranial self-stimulation in rats.

Harris AC, Muelken P, Haave Z, Swain Y, Smethells JR, LeSage MG.

Drug Alcohol Depend. 2018 Dec 1;193:162-168. doi: 10.1016/j.drugalcdep.2018.08.037. Epub 2018 Oct 18.

PMID:
30384324
3.

Status and Future Directions of Preclinical Behavioral Pharmacology in Tobacco Regulatory Science.

LeSage MG, Smethells JR, Harris AC.

Behav Anal (Wash D C). 2018 Aug;18(3):252-274. doi: 10.1037/bar0000113. Epub 2018 Jul 9.

4.

The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats.

Pentel PR, Raleigh MD, LeSage MG, Thisted T, Horrigan S, Biesova Z, Kalnik MW.

BMC Biotechnol. 2018 Jul 24;18(1):46. doi: 10.1186/s12896-018-0457-7.

5.

A Bayesian hierarchical model for demand curve analysis.

Ho YY, Nhu Vo T, Chu H, LeSage MG, Luo X, Le CT.

Stat Methods Med Res. 2018 Aug;27(8):2401-2412. doi: 10.1177/0962280216680651. Retraction in: Stat Methods Med Res. 2018 Dec;27(12):3839.

PMID:
29984638
6.

Substitutability of nicotine alone and an electronic cigarette liquid using a concurrent choice assay in rats: A behavioral economic analysis.

Smethells JR, Harris AC, Burroughs D, Hursh SR, LeSage MG.

Drug Alcohol Depend. 2018 Apr 1;185:58-66. doi: 10.1016/j.drugalcdep.2017.12.008. Epub 2018 Feb 5.

7.

Effects of nicotine-containing and "nicotine-free" e-cigarette refill liquids on intracranial self-stimulation in rats.

Harris AC, Muelken P, Smethells JR, Yershova K, Stepanov I, Olson TT, Kellar KJ, LeSage MG.

Drug Alcohol Depend. 2018 Apr 1;185:1-9. doi: 10.1016/j.drugalcdep.2017.11.032. Epub 2018 Feb 1.

8.

Locomotor activity does not predict individual differences in morphine self-administration in rats.

Swain Y, Muelken P, LeSage MG, Gewirtz JC, Harris AC.

Pharmacol Biochem Behav. 2018 Mar;166:48-56. doi: 10.1016/j.pbb.2018.01.008. Epub 2018 Feb 2.

9.

Consortium on Methods Evaluating Tobacco: Research Tools to Inform US Food and Drug Administration Regulation of Snus.

Berman ML, Bickel WK, Harris AC, LeSage MG, O'Connor RJ, Stepanov I, Shields PG, Hatsukami DK.

Nicotine Tob Res. 2018 Sep 25;20(11):1292-1300. doi: 10.1093/ntr/ntx228. Review.

10.

Similar precipitated withdrawal effects on intracranial self-stimulation during chronic infusion of an e-cigarette liquid or nicotine alone.

Harris AC, Muelken P, Smethells JR, Krueger M, LeSage MG.

Pharmacol Biochem Behav. 2017 Oct;161:1-5. doi: 10.1016/j.pbb.2017.08.011. Epub 2017 Sep 1.

11.

Self-Administration of Smokeless Tobacco Products in Rats.

LeSage MG, Burroughs D, Muelken P, Harris AC.

Tob Regul Sci. 2016 Oct;2(4):329-342. doi: 10.18001/TRS.2.4.5.

12.

Abuse liability assessment of an e-cigarette refill liquid using intracranial self-stimulation and self-administration models in rats.

LeSage MG, Staley M, Muelken P, Smethells JR, Stepanov I, Vogel RI, Pentel PR, Harris AC.

Drug Alcohol Depend. 2016 Nov 1;168:76-88. doi: 10.1016/j.drugalcdep.2016.08.628. Epub 2016 Sep 1.

13.

The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats.

Bunney PE, Burroughs D, Hernandez C, LeSage MG.

Physiol Behav. 2016 Feb 1;154:49-59. doi: 10.1016/j.physbeh.2015.11.002. Epub 2015 Nov 6.

14.

Correction: The Anti-(+)-Methamphetamine Monoclonal Antibody mAb7F9 Attenuates Acute (+)-Methamphetamine Effects on Intracranial Self-Stimulation in Rats.

Harris AC, LeSage MG, Shelley D, Perry JL, Pentel PR, Owens SM.

PLoS One. 2015 Sep 18;10(9):e0138959. doi: 10.1371/journal.pone.0138959. eCollection 2015. No abstract available.

15.

Effects of nicotine and minor tobacco alkaloids on intracranial-self-stimulation in rats.

Harris AC, Tally L, Muelken P, Banal A, Schmidt CE, Cao Q, LeSage MG.

Drug Alcohol Depend. 2015 Aug 1;153:330-4. doi: 10.1016/j.drugalcdep.2015.06.005. Epub 2015 Jun 9.

16.

Predictors of the nicotine reinforcement threshold, compensation, and elasticity of demand in a rodent model of nicotine reduction policy.

Grebenstein PE, Burroughs D, Roiko SA, Pentel PR, LeSage MG.

Drug Alcohol Depend. 2015 Jun 1;151:181-93. doi: 10.1016/j.drugalcdep.2015.03.030. Epub 2015 Apr 7.

17.

The anti-(+)-methamphetamine monoclonal antibody mAb7F9 attenuates acute (+)-methamphetamine effects on intracranial self-stimulation in rats.

Harris AC, LeSage MG, Shelley D, Perry JL, Pentel PR, Owens SM.

PLoS One. 2015 Mar 5;10(3):e0118787. doi: 10.1371/journal.pone.0118787. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138959.

18.

Animal models to assess the abuse liability of tobacco products: effects of smokeless tobacco extracts on intracranial self-stimulation.

Harris AC, Tally L, Schmidt CE, Muelken P, Stepanov I, Saha S, Vogel RI, LeSage MG.

Drug Alcohol Depend. 2015 Feb 1;147:60-7. doi: 10.1016/j.drugalcdep.2014.12.015. Epub 2014 Dec 23.

19.

Pharmacokinetic correlates of the effects of a heroin vaccine on heroin self-administration in rats.

Raleigh MD, Pentel PR, LeSage MG.

PLoS One. 2014 Dec 23;9(12):e115696. doi: 10.1371/journal.pone.0115696. eCollection 2014.

20.

Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats.

Pravetoni M, Pentel PR, Potter DN, Chartoff EH, Tally L, LeSage MG.

PLoS One. 2014 Jul 15;9(7):e101807. doi: 10.1371/journal.pone.0101807. eCollection 2014.

21.

Restraint stress attenuates nicotine's locomotor stimulant but not discriminative stimulus effects in rats.

Harris AC, Mattson C, Shelley D, LeSage MG.

Pharmacol Biochem Behav. 2014 Sep;124:92-100. doi: 10.1016/j.pbb.2014.05.012. Epub 2014 May 24.

22.

New directions in nicotine vaccine design and use.

Pentel PR, LeSage MG.

Adv Pharmacol. 2014;69:553-80. doi: 10.1016/B978-0-12-420118-7.00014-7. Review.

23.

Sex differences in nicotine self-administration in rats during progressive unit dose reduction: implications for nicotine regulation policy.

Grebenstein P, Burroughs D, Zhang Y, LeSage MG.

Pharmacol Biochem Behav. 2013 Dec;114-115:70-81. doi: 10.1016/j.pbb.2013.10.020. Epub 2013 Nov 4. Erratum in: Pharmacol Biochem Behav. 2014 Feb;117:157.

24.

Impact of tobacco regulation on animal research: new perspectives and opportunities.

Donny EC, Taylor TG, LeSage MG, Levin M, Buffalari DM, Joel D, Sved AF.

Nicotine Tob Res. 2012 Nov;14(11):1319-38. doi: 10.1093/ntr/nts162. Epub 2012 Sep 4. Review.

25.

The reinforcement threshold for nicotine as a target for tobacco control.

Sofuoglu M, LeSage MG.

Drug Alcohol Depend. 2012 Sep 1;125(1-2):1-7. doi: 10.1016/j.drugalcdep.2012.04.023. Epub 2012 May 21. Review.

26.

Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist.

LeSage MG, Shelley D, Pravetoni M, Pentel PR.

Pharmacol Biochem Behav. 2012 Jul;102(1):157-62. doi: 10.1016/j.pbb.2012.03.026. Epub 2012 Apr 4.

27.

Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats.

Harris AC, Stepanov I, Pentel PR, Lesage MG.

Psychopharmacology (Berl). 2012 Apr;220(3):565-76. doi: 10.1007/s00213-011-2514-y. Epub 2011 Sep 30.

28.

Combined active and passive immunization against nicotine: minimizing monoclonal antibody requirements using a target antibody concentration strategy.

Cornish KE, Harris AC, LeSage MG, Keyler DE, Burroughs D, Earley C, Pentel PR.

Int Immunopharmacol. 2011 Nov;11(11):1809-15. doi: 10.1016/j.intimp.2011.07.009. Epub 2011 Jul 28.

29.

A lack of association between severity of nicotine withdrawal and individual differences in compensatory nicotine self-administration in rats.

Harris AC, Pentel PR, Burroughs D, Staley MD, Lesage MG.

Psychopharmacology (Berl). 2011 Sep;217(2):153-66. doi: 10.1007/s00213-011-2273-9. Epub 2011 Apr 15.

30.

Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats.

Pravetoni M, Keyler DE, Raleigh MD, Harris AC, Lesage MG, Mattson CK, Pettersson S, Pentel PR.

Biochem Pharmacol. 2011 May 1;81(9):1164-70. doi: 10.1016/j.bcp.2011.02.004. Epub 2011 Feb 17.

31.

Nicotine reduction revisited: science and future directions.

Hatsukami DK, Perkins KA, Lesage MG, Ashley DL, Henningfield JE, Benowitz NL, Backinger CL, Zeller M.

Tob Control. 2010 Oct;19(5):e1-10. doi: 10.1136/tc.2009.035584. Review.

32.

Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats.

Harris AC, Mattson C, Lesage MG, Keyler DE, Pentel PR.

Pharmacol Biochem Behav. 2010 Aug;96(2):217-27. doi: 10.1016/j.pbb.2010.05.008. Epub 2010 May 18.

33.

Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA.

LeSage MG, Perry JL, Kotz CM, Shelley D, Corrigall WA.

Psychopharmacology (Berl). 2010 Apr;209(2):203-12. doi: 10.1007/s00213-010-1792-0. Epub 2010 Feb 24.

34.

Correlates of individual differences in compensatory nicotine self-administration in rats following a decrease in nicotine unit dose.

Harris AC, Pentel PR, LeSage MG.

Psychopharmacology (Berl). 2009 Sep;205(4):599-611. doi: 10.1007/s00213-009-1567-7. Epub 2009 May 28.

35.

Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats.

Roiko SA, Harris AC, LeSage MG, Keyler DE, Pentel PR.

Pharmacol Biochem Behav. 2009 Aug;93(2):105-11. doi: 10.1016/j.pbb.2009.04.011. Epub 2009 Apr 23.

36.
37.

Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats.

LeSage MG, Shelley D, Ross JT, Carroll FI, Corrigall WA.

Pharmacol Biochem Behav. 2009 Jan;91(3):461-7. doi: 10.1016/j.pbb.2008.08.024. Epub 2008 Sep 9.

38.

Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats.

Roiko SA, Harris AC, Keyler DE, Lesage MG, Zhang Y, Pentel PR.

J Pharmacol Exp Ther. 2008 Jun;325(3):985-93. doi: 10.1124/jpet.107.135111. Epub 2008 Feb 27.

PMID:
18305013
39.

Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction.

Harris AC, Burroughs D, Pentel PR, LeSage MG.

Exp Clin Psychopharmacol. 2008 Feb;16(1):86-97. doi: 10.1037/1064-1297.16.1.86.

PMID:
18266555
40.

Translational research in medication development for nicotine dependence.

Lerman C, LeSage MG, Perkins KA, O'Malley SS, Siegel SJ, Benowitz NL, Corrigall WA.

Nat Rev Drug Discov. 2007 Sep;6(9):746-62. Review.

PMID:
17690709
41.

Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats.

Lesage MG, Keyler DE, Burroughs D, Pentel PR.

Psychopharmacology (Berl). 2007 Oct;194(3):413-21. Epub 2007 Jul 7.

PMID:
17619178
42.
43.

Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats.

Ross JT, Corrigall WA, Heidbreder CA, LeSage MG.

Eur J Pharmacol. 2007 Mar 22;559(2-3):173-9. Epub 2007 Jan 19.

PMID:
17303116
44.

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats.

LeSage MG, Gustaf E, Dufek MB, Pentel PR.

Pharmacol Biochem Behav. 2006 Nov;85(3):575-83. Epub 2006 Dec 4.

45.

Vaccination against nicotine does not prevent nicotine-induced changes in fetal nicotinic receptor binding and c-fos mRNA expression in rats.

Pentel PR, Keyler DE, Chen Y, LeSage MG, Dufek MB, Le C, Leslie FM.

Neurotoxicol Teratol. 2006 Sep-Oct;28(5):589-96. Epub 2006 Aug 15.

PMID:
16996246
46.

Changes in maternal and fetal nicotine distribution after maternal administration of monoclonal nicotine-specific antibody to rats.

Keyler DE, Lesage MG, Dufek MB, Pentel PR.

Int Immunopharmacol. 2006 Nov;6(11):1665-72. Epub 2006 Aug 4.

47.

Erratum to Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies.

LeSage MG, Keyler DE, Pentel PR.

AAPS J. 2006 Sep;8(3):E622. doi: 10.1208/aapsj080370c. Epub 2006 Sep 1. No abstract available.

48.

Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats.

Skott M, Andreassen TT, Ulrich-Vinther M, Chen X, Keyler DE, LeSage MG, Pentel PR, Bechtold JE, Soballe K.

J Orthop Res. 2006 Jul;24(7):1472-9.

49.

Effects of nicotine withdrawal on performance under a progressive-ratio schedule of sucrose pellet delivery in rats.

LeSage MG, Burroughs D, Pentel PR.

Pharmacol Biochem Behav. 2006 Apr;83(4):585-91. Epub 2006 Apr 27.

PMID:
16643998
50.

Current status of immunologic approaches to treating tobacco dependence: vaccines and nicotine-specific antibodies.

LeSage MG, Keyler DE, Pentel PR.

AAPS J. 2006 Feb 24;8(1):E65-75. Review. Erratum in: AAPS J. 2006;8(3):E622. AAPS J. 2006 Sep;8(3):E622.

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