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Items: 1 to 50 of 84

1.

Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation.

Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G.

Sci Immunol. 2016 Jul 14;1(1):aaf8759. doi: 10.1126/sciimmunol.aaf8759. Epub 2016 Jun 23.

PMID:
28783676
2.

Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation.

Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G.

Sci Immunol. 2016 Jul 14;1(1). pii: aaf8759.

3.

Abrogation of renal allograft tolerance in MGH miniature swine: the role of intra-graft and peripheral factors in long-term tolerance.

Scalea JR, Okumi M, Villani V, Shimizu A, Nishimura H, Gillon BC, Torabi R, Cormack T, Moran S, LeGuern C, Sachs DH, Yamada K.

Am J Transplant. 2014 Sep;14(9):2001-10. doi: 10.1111/ajt.12816. Epub 2014 Aug 6.

4.

Primary vascularization of allografts governs their immunogenicity and susceptibility to tolerogenesis.

Kant CD, Akiyama Y, Tanaka K, Shea S, Connolly SE, Germana S, Winn HJ, LeGuern C, Tocco G, Benichou G.

J Immunol. 2013 Aug 15;191(4):1948-56. doi: 10.4049/jimmunol.1202092. Epub 2013 Jul 5.

5.

Expansion of polyreactive B cells cross-reactive to HLA and self in the blood of a patient with kidney graft rejection.

Porcheray F, DeVito J, Helou Y, Dargon I, Fraser JW, Nobecourt P, Ferdman J, Germana S, Girouard TC, Kawai T, Saidman SL, Wong W, Colvin RB, Leguern C, Zorn E.

Am J Transplant. 2012 Aug;12(8):2088-97. doi: 10.1111/j.1600-6143.2012.04053.x. Epub 2012 Apr 17.

6.

Regulatory T cells for tolerance therapy: revisiting the concept.

Leguern C.

Crit Rev Immunol. 2011;31(3):189-207. Review.

7.

Intracellular MHC class II controls regulatory tolerance to allogeneic transplants.

LeGuern C, Akiyama Y, Germana S, Tanaka K, Fernandez L, Iwamoto Y, Houser S, Benichou G.

J Immunol. 2010 Mar 1;184(5):2394-400. doi: 10.4049/jimmunol.0803664. Epub 2010 Jan 25.

8.
9.

Switching on immune regulation to prevent graft rejection.

LeGuern C.

Transplantation. 2005 May 27;79(10):1308-9. No abstract available.

PMID:
15912096
10.

Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity.

Matter-Reissmann UB, Sonntag KC, Gilli UO, Leguern C, Schneider MK, Seebach JD.

Xenotransplantation. 2004 Jan;11(1):43-52.

PMID:
14962292
11.

Histomorphometric comparison of cardiac allograft vasculopathy in miniature swine.

Houser SL, McMorrow IM, LeGuern C, Schwarze ML, Fuchimoto Y, Sachs DH, Madsen JC.

J Heart Lung Transplant. 2004 Jan;23(1):50-60.

PMID:
14734127
12.
13.

Regulation of T-cell functions by MHC class II self-presentation.

LeGuern C.

Trends Immunol. 2003 Dec;24(12):633-8. Review.

PMID:
14644136
14.

Engraftment of quiescent progenitors and conversion to full chimerism after nonmyelosuppressive conditioning and hematopoietic cell transplantation in miniature swine.

Lima B, Gleit ZL, Cameron AM, Germana S, Murphy MC, Consorti R, Chang Q, Down JD, LeGuern C, Sachs DH, Huang CA.

Biol Blood Marrow Transplant. 2003 Sep;9(9):571-82.

15.

Expression of MHC class II DQ alpha/beta heterodimers from recombinant polycistronic retroviral genomes.

Shimada H, Germana S, Hayashi H, Sachs DH, LeGuern C.

Surg Today. 2003;33(3):183-9.

PMID:
12658383
16.

Nonmyeloablative conditioning is sufficient to allow engraftment of EGFP-expressing bone marrow and subsequent acceptance of EGFP-transgenic skin grafts in mice.

Andersson G, Illigens BM, Johnson KW, Calderhead D, LeGuern C, Benichou G, White-Scharf ME, Down JD.

Blood. 2003 Jun 1;101(11):4305-12. Epub 2003 Feb 6.

17.

Gene therapy--its potential in surgery.

Gojo S, Yamamoto S, Patience C, LeGuern C, Cooper DK.

Ann R Coll Surg Engl. 2002 Sep;84(5):297-301. Review.

18.

MHC alloantigens elicit secondary, but not primary, indirect in vitro proliferative responses.

Haller GW, Lima B, Kunisaki SM, Germana S, Leguern C, Huang CA, Sachs DH.

J Immunol. 2002 Oct 1;169(7):3613-21.

19.

Expression of xenogeneic MHC class II molecules in HLA-DR(+) and -DR(-) cells: influence of retrovirus vector design and cellular context.

Denaro M, Kolber-Simonds D, Schad V, Muthukumar S, Germana S, White-Scharf ME, Banerjee PT, LeGuern C, Andersson G.

Xenotransplantation. 2002 Mar;9(2):115-24.

PMID:
11897004
20.

Modulation of the in vivo primate anti-Gal response through administration of anti-idiotypic antibodies.

McMorrow IM, Buhler L, Treter S, Neethling FA, Alwayn IP, Comrack CA, Kitamura H, Awwad M, DerSimonian H, Cooper DK, Sachs DH, LeGuern C.

Xenotransplantation. 2002 Mar;9(2):106-14.

PMID:
11897003
21.

New intra-renal graft genes associated with tolerance or rejection.

McMorrow IM, Narayan K, Sachs DH, LeGuern C.

Kidney Int. 2002 Jan;61(1 Suppl):S85-93.

22.

Paper alert. Immunology.

Elliott T, Bonneville M, Kruisbeek A, Walker PR, Essayan D, Glaichenhaus N, Vyakarnam A, Casanova JL, Liu Y, AuchinclossJr H, Waneck G, LeGuern C, Akdis C.

Curr Opin Immunol. 2001 Dec;13(6):625-34. No abstract available.

PMID:
11677080
23.

Persistence of dominant T cell clones in accepted solid organ transplants.

Baron C, McMorrow I, Sachs DH, LeGuern C.

J Immunol. 2001 Oct 15;167(8):4154-60.

24.

Immortalized bone-marrow derived pig endothelial cells.

Seebach JD, Schneider MK, Comrack CA, LeGuern A, Kolb SA, Knolle PA, Germana S, DerSimonian H, LeGuern C, Sachs DH.

Xenotransplantation. 2001 Feb;8(1):48-61.

PMID:
11208191
25.

A particular TCR beta variable region used by T cells infiltrating kidney transplants.

Baron C, Sachs DH, LeGuern C.

J Immunol. 2001 Feb 15;166(4):2589-96.

26.

Tolerance to solid organ transplants through transfer of MHC class II genes.

Sonntag KC, Emery DW, Yasumoto A, Haller G, Germana S, Sablinski T, Shimizu A, Yamada K, Shimada H, Arn S, Sachs DH, LeGuern C.

J Clin Invest. 2001 Jan;107(1):65-71.

27.

Assessment of transduction rates of porcine bone marrow.

Sonntag KC, Nebhard N, Haller GW, Yasumoto A, Sachs DH, LeGuern C.

J Hematother Stem Cell Res. 2000 Oct;9(5):721-6.

PMID:
11091496
28.

Regulated expression of an MHC class II gene from a promoter-inducible retrovirus.

Sonntag KC, Haller GW, Giauffret D, Germana S, Reeves SA, Levy J, Sachs DH, LeGuern C.

Hum Gene Ther. 2000 Sep 20;11(14):1961-9.

PMID:
11020796
29.

Injection of porcine anti-idiotypic antibodies to primate anti-Gal antibodies leads to active inhibition of serum cytotoxicity in a baboon.

B├╝hler L, Treter S, McMorrow I, Neethling FA, Alwayn I, Awwad M, Thall A, Cooper DK, LeGuern C, Sachs DH.

Transplant Proc. 2000 Aug;32(5):1102. No abstract available.

PMID:
10936379
30.
31.

Gene therapy and transplantation.

Gojo S, Cooper DK, Iacomini J, LeGuern C.

Transplantation. 2000 May 27;69(10):1995-9. Review.

PMID:
10852583
32.

Xenogeneic and allogeneic skin grafting after retrovirus-mediated SLA class II DR gene transfer in baboons.

Gojo S, Shimizu A, Ierino FL, Banerjee PT, Cooper DK, LeGuern C, Sachs DH.

Transplant Proc. 2000 Mar;32(2):289-90. No abstract available.

PMID:
10715420
33.

MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome.

Shimada H, Germana S, Sonntag KC, Banerjee P, Moore D, Sachs DH, LeGuern C.

Hum Gene Ther. 1999 Sep 20;10(14):2397-405.

PMID:
10515459
34.

Recombinant retrovirus vectors for the expression of MHC class II heterodimers.

Shimada H, Alexander RC, Germana S, Sachs DH, LeGuern C.

Surg Today. 1999;29(6):533-41.

PMID:
10385368
35.

HLA-G expression on porcine endothelial cells protects partially against direct human NK cytotoxicity but not against ADCC.

Seebach JD, Pazmany L, Waneck GL, Minja F, Germana S, LeGuern C, Sachs DH.

Transplant Proc. 1999 Jun;31(4):1864-5. No abstract available.

PMID:
10371975
36.

Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.

Ierino FL, Gojo S, Banerjee PT, Giovino M, Xu Y, Gere J, Kaynor C, Awwad M, Monroy R, Rembert J, Hatch T, Foley A, Kozlowski T, Yamada K, Neethling FA, Fishman J, Bailin M, Spitzer TR, Cooper DK, Cosimi AB, LeGuern C, Sachs DH.

Transplantation. 1999 Apr 27;67(8):1119-28.

PMID:
10232561
37.

Transfer of porcine MHC DRalpha into IEalpha-deficient murine bone marrow results in reduced IE-restricted Vbeta usage.

Emery DW, Shimada H, Germana S, Sachs DH, LeGuern C.

Transplantation. 1998 Oct 27;66(8):1081-8.

PMID:
9808495
38.

Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity.

Emery DW, Sablinski T, Shimada H, Germana S, Gianello P, Foley A, Shulman S, Arn S, Fishman J, Lorf T, Nickeleit V, Colvin RB, Sachs DH, LeGuern C.

Transplantation. 1997 Nov 27;64(10):1414-23.

PMID:
9392304
39.

HLA-Cw3 expression on porcine endothelial cells protects against xenogeneic cytotoxicity mediated by a subset of human NK cells.

Seebach JD, Comrack C, Germana S, LeGuern C, Sachs DH, DerSimonian H.

J Immunol. 1997 Oct 1;159(7):3655-61.

PMID:
9317166
40.

The mechanism of specific prolongation of class I-mismatched skin grafts induced by retroviral gene therapy.

Mayfield RS, Hayashi H, Sawada T, Bergen K, LeGuern C, Sykes M, Sachs DH, Iacomini J.

Eur J Immunol. 1997 May;27(5):1177-81.

PMID:
9174608
41.

Selective increase in CD4-positive graft-infiltrating mononuclear cells among the infiltrates in class I disparate kidney grafts undergoing rejection.

Giangrande I, Yamada K, Arn S, Lorf T, Sachs DH, LeGuern C.

Transplantation. 1997 Mar 15;63(5):722-8.

PMID:
9075845
42.

Tolerant cells infiltrating class I mismatched swine kidney allografts lack the CD4 single positive subset and down regulate TCR gene expression.

Giangrande I, Yamada K, Germana S, Sachs D, LeGuern C.

Transplant Proc. 1997 Feb-Mar;29(1-2):1164. No abstract available.

PMID:
9123254
43.

Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene.

Hayashi H, Mayfield RS, Sawada T, Germana S, Sykes M, Iacomini J, Sachs DH, LeGuern C.

Transplant Proc. 1997 Feb-Mar;29(1-2):1133. No abstract available.

PMID:
9123234
44.

Mechanism of tolerance following class II gene transduction of autologous swine bone marrow.

Yasumoto A, Yamada K, Sablinski T, LeGuern C, Sykes M, Sachs DH.

Transplant Proc. 1997 Feb-Mar;29(1-2):1132. No abstract available.

PMID:
9123233
45.

Retroviral vectors transfer functional MHC class II heterodimers into bone marrow: a genetic approach to tolerance induction.

Germana S, Shimada H, Sachs DH, LeGuern C.

Transplant Proc. 1997 Feb-Mar;29(1-2):1129. No abstract available.

PMID:
9123230
46.

Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine.

Blancho G, Gianello PR, Lorf T, Germana S, Giangrande I, Mourad G, Colvin RB, Sachs DH, LeGuern C.

Transplantation. 1997 Jan 15;63(1):26-33.

PMID:
9000656
47.

Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells.

Hayashi H, LeGuern C, Sachs DH, Sykes M.

Bone Marrow Transplant. 1996 Aug;18(2):285-92.

PMID:
8864436
48.

Culture and characterization of hematopoietic progenitor cells from miniature swine.

Emery DW, Sachs DH, LeGuern C.

Exp Hematol. 1996 Jul;24(8):927-35.

PMID:
8690052
49.

Miniature swine MHC class II heterodimers expressed through double-copy retroviral vectors.

Shimada H, Emery DW, Shafer G, Germana S, Sachs DH, LeGuern C.

Transplant Proc. 1996 Jun;28(3):1986-9. No abstract available.

PMID:
8658969
50.

Derivation of immortalized swine stromal cell lines.

Paguio CG, Germana S, LeGuern C, Jubinsky P, Sachs DH, Emery DW.

Transplant Proc. 1996 Apr;28(2):791. No abstract available.

PMID:
8623401

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