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Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala.

Ostroff LE, Santini E, Sears R, Deane Z, Kanadia RN, LeDoux JE, Lhakhang T, Tsirigos A, Heguy A, Klann E.

Elife. 2019 Dec 11;8. pii: e51607. doi: 10.7554/eLife.51607.


A brainstem-central amygdala circuit underlies defensive responses to learned threats.

Gu Y, Piper WT, Branigan LA, Vazey EM, Aston-Jones G, Lin L, LeDoux JE, Sears RM.

Mol Psychiatry. 2019 Nov 22. doi: 10.1038/s41380-019-0599-6. [Epub ahead of print]


Chemogenetic Inhibition Reveals That Processing Relative But Not Absolute Threat Requires Basal Amygdala.

Campese VD, Kim IT, Hou M, Gupta S, Draus C, Kurpas B, Burke K, LeDoux JE.

J Neurosci. 2019 Oct 23;39(43):8510-8516. doi: 10.1523/JNEUROSCI.2530-18.2019. Epub 2019 Sep 6.


Understanding the Higher-Order Approach to Consciousness.

Brown R, Lau H, LeDoux JE.

Trends Cogn Sci. 2019 Sep;23(9):754-768. doi: 10.1016/j.tics.2019.06.009. Epub 2019 Jul 30. Review.


Viewpoints: Approaches to defining and investigating fear.

Mobbs D, Adolphs R, Fanselow MS, Barrett LF, LeDoux JE, Ressler K, Tye KM.

Nat Neurosci. 2019 Aug;22(8):1205-1216. doi: 10.1038/s41593-019-0456-6. No abstract available.


Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation.

Junod A, Opendak M, LeDoux JE, Sullivan RM.

Front Behav Neurosci. 2019 Jun 25;13:130. doi: 10.3389/fnbeh.2019.00130. eCollection 2019.


A principled method to identify individual differences and behavioral shifts in signaled active avoidance.

Krypotos AM, Moscarello JM, Sears RM, LeDoux JE, Galatzer-Levy I.

Learn Mem. 2018 Oct 15;25(11):564-568. doi: 10.1101/lm.047399.118. Print 2018 Nov.


Addendum: Preventing the return of fear in humans using reconsolidation update mechanisms.

Schiller D, Monfils MH, Raio CM, Johnson DC, LeDoux JE, Phelps EA.

Nature. 2018 Oct;562(7727):E21. doi: 10.1038/s41586-018-0405-7. No abstract available.


β-Adrenergic enhancement of neuronal excitability in the lateral amygdala is developmentally gated.

Fink AE, LeDoux JE.

J Neurophysiol. 2018 May 1;119(5):1658-1664. doi: 10.1152/jn.00853.2017. Epub 2018 Jan 17.


Elevating the Role of Subjective Experience in the Clinic: Response to Fanselow and Pennington.

Pine DS, LeDoux JE.

Am J Psychiatry. 2017 Nov 1;174(11):1121-1122. doi: 10.1176/appi.ajp.2017.17070818r. No abstract available.


Noradrenergic Regulation of Central Amygdala in Aversive Pavlovian-to-Instrumental Transfer.

Campese VD, Soroeta JM, Vazey EM, Aston-Jones G, LeDoux JE, Sears RM.

eNeuro. 2017 Oct 24;4(5). pii: ENEURO.0224-17.2017. doi: 10.1523/ENEURO.0224-17.2017. eCollection 2017 Sep-Oct.


Pavlovian Extinction and Recovery Effects in Aversive Pavlovian to Instrumental Transfer.

Campese VD, Kim IT, Rojas G, LeDoux JE.

Front Behav Neurosci. 2017 Sep 25;11:179. doi: 10.3389/fnbeh.2017.00179. eCollection 2017.


Characterization of the amplificatory effect of norepinephrine in the acquisition of Pavlovian threat associations.

Díaz-Mataix L, Piper WT, Schiff HC, Roberts CH, Campese VD, Sears RM, LeDoux JE.

Learn Mem. 2017 Aug 16;24(9):432-439. doi: 10.1101/lm.044412.116. Print 2017 Sep.


Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory.

Huynh TN, Santini E, Mojica E, Fink AE, Hall BS, Fetcho RN, Grosenick L, Deisseroth K, LeDoux JE, Liston C, Klann E.

Mol Psychiatry. 2018 Jun;23(6):1394-1401. doi: 10.1038/mp.2017.99. Epub 2017 May 2.


Active Avoidance: Neural Mechanisms and Attenuation of Pavlovian Conditioned Responding.

Boeke EA, Moscarello JM, LeDoux JE, Phelps EA, Hartley CA.

J Neurosci. 2017 May 3;37(18):4808-4818. doi: 10.1523/JNEUROSCI.3261-16.2017. Epub 2017 Apr 13.


Semantics, Surplus Meaning, and the Science of Fear.

LeDoux JE.

Trends Cogn Sci. 2017 May;21(5):303-306. doi: 10.1016/j.tics.2017.02.004. Epub 2017 Mar 16.


A higher-order theory of emotional consciousness.

LeDoux JE, Brown R.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E2016-E2025. doi: 10.1073/pnas.1619316114. Epub 2017 Feb 15.


Updating of aversive memories after temporal error detection is differentially modulated by mTOR across development.

Tallot L, Diaz-Mataix L, Perry RE, Wood K, LeDoux JE, Mouly AM, Sullivan RM, Doyère V.

Learn Mem. 2017 Feb 15;24(3):115-122. doi: 10.1101/lm.043083.116. Print 2017 Mar.


Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation.

Ostroff LE, Botsford B, Gindina S, Cowansage KK, LeDoux JE, Klann E, Hoeffer C.

J Neurosci. 2017 Feb 15;37(7):1862-1872. doi: 10.1523/JNEUROSCI.3301-16.2017. Epub 2017 Jan 13.


Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control.

Dallérac G, Graupner M, Knippenberg J, Martinez RC, Tavares TF, Tallot L, El Massioui N, Verschueren A, Höhn S, Bertolus JB, Reyes A, LeDoux JE, Schafe GE, Diaz-Mataix L, Doyère V.

Nat Commun. 2017 Jan 9;8:13920. doi: 10.1038/ncomms13920.


Primary auditory cortex regulates threat memory specificity.

Wigestrand MB, Schiff HC, Fyhn M, LeDoux JE, Sears RM.

Learn Mem. 2016 Dec 15;24(1):55-58. doi: 10.1101/lm.044362.116. Print 2017 Jan.


Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework.

LeDoux JE, Pine DS.

Am J Psychiatry. 2016 Nov 1;173(11):1083-1093. Epub 2016 Sep 9. Review.


β-Adrenergic Receptors Regulate the Acquisition and Consolidation Phases of Aversive Memory Formation Through Distinct, Temporally Regulated Signaling Pathways.

Schiff HC, Johansen JP, Hou M, Bush DE, Smith EK, Klein JE, LeDoux JE, Sears RM.

Neuropsychopharmacology. 2017 Mar;42(4):895-903. doi: 10.1038/npp.2016.238. Epub 2016 Oct 20.


The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm.

LeDoux JE, Moscarello J, Sears R, Campese V.

Mol Psychiatry. 2017 Jan;22(1):24-36. doi: 10.1038/mp.2016.166. Epub 2016 Oct 18. Review.


Translational Approaches Targeting Reconsolidation.

Kroes MC, Schiller D, LeDoux JE, Phelps EA.

Curr Top Behav Neurosci. 2016;28:197-230. doi: 10.1007/7854_2015_5008. Review.


Evaluation of ambiguous associations in the amygdala by learning the structure of the environment.

Madarasz TJ, Diaz-Mataix L, Akhand O, Ycu EA, LeDoux JE, Johansen JP.

Nat Neurosci. 2016 Jul;19(7):965-72. doi: 10.1038/nn.4308. Epub 2016 May 23.


The Neural Foundations of Reaction and Action in Aversive Motivation.

Campese VD, Sears RM, Moscarello JM, Diaz-Mataix L, Cain CK, LeDoux JE.

Curr Top Behav Neurosci. 2016;27:171-95. doi: 10.1007/7854_2015_401. Review.


Modulation of instrumental responding by a conditioned threat stimulus requires lateral and central amygdala.

Campese VD, Gonzaga R, Moscarello JM, LeDoux JE.

Front Behav Neurosci. 2015 Oct 30;9:293. doi: 10.3389/fnbeh.2015.00293. eCollection 2015.


Active avoidance requires a serial basal amygdala to nucleus accumbens shell circuit.

Ramirez F, Moscarello JM, LeDoux JE, Sears RM.

J Neurosci. 2015 Feb 25;35(8):3470-7. doi: 10.1523/JNEUROSCI.1331-14.2015.


Novelty-facilitated extinction: providing a novel outcome in place of an expected threat diminishes recovery of defensive responses.

Dunsmoor JE, Campese VD, Ceceli AO, LeDoux JE, Phelps EA.

Biol Psychiatry. 2015 Aug 1;78(3):203-9. doi: 10.1016/j.biopsych.2014.12.008. Epub 2014 Dec 16.


Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation.

Johansen JP, Diaz-Mataix L, Hamanaka H, Ozawa T, Ycu E, Koivumaa J, Kumar A, Hou M, Deisseroth K, Boyden ES, LeDoux JE.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5584-92. doi: 10.1073/pnas.1421304111. Epub 2014 Dec 8.


Heterogeneity in signaled active avoidance learning: substantive and methodological relevance of diversity in instrumental defensive responses to threat cues.

Galatzer-Levy IR, Moscarello J, Blessing EM, Klein J, Cain CK, LeDoux JE.

Front Syst Neurosci. 2014 Sep 24;8:179. doi: 10.3389/fnsys.2014.00179. eCollection 2014.


Medial amygdala lesions selectively block aversive pavlovian-instrumental transfer in rats.

McCue MG, LeDoux JE, Cain CK.

Front Behav Neurosci. 2014 Sep 18;8:329. doi: 10.3389/fnbeh.2014.00329. eCollection 2014.


Lesions of lateral or central amygdala abolish aversive Pavlovian-to-instrumental transfer in rats.

Campese VD, Kim J, Lázaro-Muñoz G, Pena L, LeDoux JE, Cain CK.

Front Behav Neurosci. 2014 May 7;8:161. doi: 10.3389/fnbeh.2014.00161. eCollection 2014.


Extinction resistant changes in the human auditory association cortex following threat learning.

Apergis-Schoute AM, Schiller D, LeDoux JE, Phelps EA.

Neurobiol Learn Mem. 2014 Sep;113:109-14. doi: 10.1016/j.nlm.2014.01.016. Epub 2014 Feb 11.


Coming to terms with fear.

LeDoux JE.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2871-8. doi: 10.1073/pnas.1400335111. Epub 2014 Feb 5. Review.


Molecular mechanisms of threat learning in the lateral nucleus of the amygdala.

Sears RM, Schiff HC, LeDoux JE.

Prog Mol Biol Transl Sci. 2014;122:263-304. doi: 10.1016/B978-0-12-420170-5.00010-6. Review.


Synapses lacking astrocyte appear in the amygdala during consolidation of Pavlovian threat conditioning.

Ostroff LE, Manzur MK, Cain CK, Ledoux JE.

J Comp Neurol. 2014 Jun 15;522(9):2152-63. doi: 10.1002/cne.23523.


Development of an aversive Pavlovian-to-instrumental transfer task in rat.

Campese V, McCue M, Lázaro-Muñoz G, Ledoux JE, Cain CK.

Front Behav Neurosci. 2013 Nov 26;7:176. doi: 10.3389/fnbeh.2013.00176. eCollection 2013.


Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.

Sears RM, Fink AE, Wigestrand MB, Farb CR, de Lecea L, Ledoux JE.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20260-5. doi: 10.1073/pnas.1320325110. Epub 2013 Nov 25.


Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement.

Schiller D, Kanen JW, LeDoux JE, Monfils MH, Phelps EA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20040-5. doi: 10.1073/pnas.1320322110. Epub 2013 Nov 25.


The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association.

Debiec J, Diaz-Mataix L, Bush DE, Doyère V, LeDoux JE.

Learn Mem. 2013 Nov 19;20(12):695-9. doi: 10.1101/lm.031609.113.


Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory.

Cowansage KK, Bush DE, Josselyn SA, Klann E, Ledoux JE.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16645-50. doi: 10.1073/pnas.1304665110. Epub 2013 Sep 23.


Memory reconsolidation.

Alberini CM, Ledoux JE.

Curr Biol. 2013 Sep 9;23(17):R746-50. doi: 10.1016/j.cub.2013.06.046.


Active vs. reactive threat responding is associated with differential c-Fos expression in specific regions of amygdala and prefrontal cortex.

Martinez RC, Gupta N, Lázaro-Muñoz G, Sears RM, Kim S, Moscarello JM, LeDoux JE, Cain CK.

Learn Mem. 2013 Jul 18;20(8):446-52. doi: 10.1101/lm.031047.113.


Heterogeneity in threat extinction learning: substantive and methodological considerations for identifying individual difference in response to stress.

Galatzer-Levy IR, Bonanno GA, Bush DE, Ledoux JE.

Front Behav Neurosci. 2013 May 29;7:55. doi: 10.3389/fnbeh.2013.00055. eCollection 2013.


The slippery slope of fear.

LeDoux JE.

Trends Cogn Sci. 2013 Apr;17(4):155-6. doi: 10.1016/j.tics.2013.02.004. Epub 2013 Mar 13.


Detection of a temporal error triggers reconsolidation of amygdala-dependent memories.

Díaz-Mataix L, Ruiz Martinez RC, Schafe GE, LeDoux JE, Doyère V.

Curr Biol. 2013 Mar 18;23(6):467-72. doi: 10.1016/j.cub.2013.01.053. Epub 2013 Feb 28.


Active avoidance learning requires prefrontal suppression of amygdala-mediated defensive reactions.

Moscarello JM, LeDoux JE.

J Neurosci. 2013 Feb 27;33(9):3815-23. doi: 10.1523/JNEUROSCI.2596-12.2013.


Chronic antidepressant treatment impairs the acquisition of fear extinction.

Burghardt NS, Sigurdsson T, Gorman JM, McEwen BS, LeDoux JE.

Biol Psychiatry. 2013 Jun 1;73(11):1078-86. doi: 10.1016/j.biopsych.2012.10.012. Epub 2012 Dec 20.

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