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Items: 1 to 50 of 113

1.

Long-term Engineered Cultures of Primary Mouse Hepatocytes for Strain and Species Comparison Studies During Drug Development.

Ware BR, Brown GE, Soldatow VY, LeCluyse EL, Khetani SR.

Gene Expr. 2019 Jul 24. doi: 10.3727/105221619X15638857793317. [Epub ahead of print]

PMID:
31340881
2.

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.

Holman NS, Church RJ, Nautiyal M, Rose KA, Thacker SE, Otieno MA, Wolf KK, LeCluyse E, Watkins PB, Mosedale M.

Toxicol Sci. 2019 Aug 1;170(2):499-508. doi: 10.1093/toxsci/kfz112.

PMID:
31093666
3.

Advancing nonclinical innovation and safety in pharmaceutical testing.

Baker EJ, Beck NA, Berg EL, Clayton-Jeter HD, Chandrasekera PC, Curley JL, Donzanti BA, Ewart LC, Gunther JM, Kenna JG, LeCluyse EL, Liebman MN, Pugh CL, Watkins PB, Sullivan KM.

Drug Discov Today. 2019 Feb;24(2):624-628. doi: 10.1016/j.drudis.2018.11.011. Epub 2018 Nov 20. Review.

4.

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.

Mosedale M, Eaddy JS, Trask OJ Jr, Holman NS, Wolf KK, LeCluyse E, Ware BR, Khetani SR, Lu J, Brock WJ, Roth SE, Watkins PB.

Toxicol Sci. 2018 Jan 1;161(1):149-158. doi: 10.1093/toxsci/kfx206.

5.

Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification.

Tikunov AP, Shim YS, Bhattarai N, Siler SQ, Soldatow V, LeCluyse EL, McDunn JE, Watkins PB, Macdonald JM.

Toxicol In Vitro. 2017 Dec;45(Pt 1):119-127. doi: 10.1016/j.tiv.2017.08.021. Epub 2017 Sep 1.

PMID:
28867505
6.
7.

Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues.

Norona LM, Nguyen DG, Gerber DA, Presnell SC, LeCluyse EL.

Toxicol Sci. 2016 Dec;154(2):354-367. Epub 2016 Sep 7.

8.

Responding to State Licensure Board Investigations.

Singleton JM, Lecluyse EM.

J Med Pract Manage. 2016 Sep;32(1):21-24.

PMID:
30452839
9.

Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.

Soldatow V, Peffer RC, Trask OJ, Cowie DE, Andersen ME, LeCluyse E, Deisenroth C.

Toxicol In Vitro. 2016 Oct;36:224-237. doi: 10.1016/j.tiv.2016.08.006. Epub 2016 Aug 12.

PMID:
27530964
10.

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Holman NS, Mosedale M, Wolf KK, LeCluyse EL, Watkins PB.

Toxicol Sci. 2016 Jun;151(2):365-75. doi: 10.1093/toxsci/kfw047. Epub 2016 Mar 8.

11.

Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity.

Rose KA, Holman NS, Green AM, Andersen ME, LeCluyse EL.

J Pharm Sci. 2016 Feb;105(2):950-964. doi: 10.1016/S0022-3549(15)00192-6.

12.

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.

Wetmore BA, Wambaugh JF, Allen B, Ferguson SS, Sochaski MA, Setzer RW, Houck KA, Strope CL, Cantwell K, Judson RS, LeCluyse E, Clewell HJ, Thomas RS, Andersen ME.

Toxicol Sci. 2015 Nov;148(1):121-36. doi: 10.1093/toxsci/kfv171. Epub 2015 Aug 6.

13.

Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing.

Lu J, Einhorn S, Venkatarangan L, Miller M, Mann DA, Watkins PB, LeCluyse E.

Toxicol Sci. 2015 Sep;147(1):39-54. doi: 10.1093/toxsci/kfv117. Epub 2015 Jun 18.

PMID:
26092927
14.

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABAA receptor antagonist NP260.

Harrill AH, Eaddy JS, Rose K, Cullen JM, Ramanathan L, Wanaski S, Collins S, Ho Y, Watkins PB, Lecluyse EL.

Toxicol Appl Pharmacol. 2014 Jun 1;277(2):131-7. doi: 10.1016/j.taap.2014.03.015. Epub 2014 Mar 31.

PMID:
24699182
15.

A micropatterned hepatocyte coculture model for assessment of liver toxicity using high-content imaging analysis.

Trask OJ Jr, Moore A, LeCluyse EL.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):16-27. doi: 10.1089/adt.2013.525. Epub 2014 Jan 20.

PMID:
24444127
16.

Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin.

Choi K, Pfund WP, Andersen ME, Thomas RS, Clewell HJ, LeCluyse EL.

Tissue Eng Part C Methods. 2014 Aug;20(8):641-51. doi: 10.1089/ten.TEC.2013.0562. Epub 2014 Mar 4.

PMID:
24294911
17.

A map of the PPARα transcription regulatory network for primary human hepatocytes.

McMullen PD, Bhattacharya S, Woods CG, Sun B, Yarborough K, Ross SM, Miller ME, McBride MT, LeCluyse EL, Clewell RA, Andersen ME.

Chem Biol Interact. 2014 Feb 25;209:14-24. doi: 10.1016/j.cbi.2013.11.006. Epub 2013 Nov 22.

18.

Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).

Pedersen JM, Matsson P, Bergström CA, Hoogstraate J, Norén A, LeCluyse EL, Artursson P.

Toxicol Sci. 2013 Dec;136(2):328-43. doi: 10.1093/toxsci/kft197. Epub 2013 Sep 6.

19.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.

20.

Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system.

Ukairo O, McVay M, Krzyzewski S, Aoyama S, Rose K, Andersen ME, Khetani SR, Lecluyse EL.

J Biochem Mol Toxicol. 2013 Oct;27(10):471-8. doi: 10.1002/jbt.21512. Epub 2013 Aug 5.

PMID:
23918466
21.

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

Harrill JA, Hukkanen RR, Lawson M, Martin G, Gilger B, Soldatow V, Lecluyse EL, Budinsky RA, Rowlands JC, Thomas RS.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13.

PMID:
23859880
22.

In vitro models for liver toxicity testing.

Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I.

Toxicol Res (Camb). 2013 Jan 1;2(1):23-39. Epub 2012 Nov 23.

23.

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro.

Dash A, Simmers MB, Deering TG, Berry DJ, Feaver RE, Hastings NE, Pruett TL, LeCluyse EL, Blackman BR, Wamhoff BR.

Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1053-63. doi: 10.1152/ajpcell.00331.2012. Epub 2013 Mar 13.

24.

Long-term stability of primary rat hepatocytes in micropatterned cocultures.

Ukairo O, Kanchagar C, Moore A, Shi J, Gaffney J, Aoyama S, Rose K, Krzyzewski S, McGeehan J, Andersen ME, Khetani SR, Lecluyse EL.

J Biochem Mol Toxicol. 2013 Mar;27(3):204-12. doi: 10.1002/jbt.21469. Epub 2013 Jan 11.

PMID:
23315828
25.

A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes.

Smith CM, Nolan CK, Edwards MA, Hatfield JB, Stewart TW, Ferguson SS, Lecluyse EL, Sahi J.

J Pharm Sci. 2012 Oct;101(10):3989-4002. doi: 10.1002/jps.23262. Epub 2012 Jul 17.

PMID:
22806329
26.

Organotypic liver culture models: meeting current challenges in toxicity testing.

LeCluyse EL, Witek RP, Andersen ME, Powers MJ.

Crit Rev Toxicol. 2012 Jul;42(6):501-48. doi: 10.3109/10408444.2012.682115. Epub 2012 May 15. Review.

27.

Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Black MB, Budinsky RA, Dombkowski A, Cukovic D, LeCluyse EL, Ferguson SS, Thomas RS, Rowlands JC.

Toxicol Sci. 2012 May;127(1):199-215. doi: 10.1093/toxsci/kfs069. Epub 2012 Feb 1.

PMID:
22298810
28.

Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity.

Martinez SM, Bradford BU, Soldatow VY, Kosyk O, Sandot A, Witek R, Kaiser R, Stewart T, Amaral K, Freeman K, Black C, LeCluyse EL, Ferguson SS, Rusyn I.

Toxicol Appl Pharmacol. 2010 Dec 15;249(3):208-16. doi: 10.1016/j.taap.2010.09.012. Epub 2010 Sep 24.

29.

Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.

Budinsky RA, LeCluyse EL, Ferguson SS, Rowlands JC, Simon T.

Toxicol Sci. 2010 Nov;118(1):224-35. doi: 10.1093/toxsci/kfq238. Epub 2010 Aug 12.

PMID:
20705892
30.

Isolation and culture of primary hepatocytes from resected human liver tissue.

Lecluyse EL, Alexandre E.

Methods Mol Biol. 2010;640:57-82. doi: 10.1007/978-1-60761-688-7_3.

PMID:
20645046
31.

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS.

Toxicol Sci. 2010 Oct;117(2):348-58. doi: 10.1093/toxsci/kfq220. Epub 2010 Jul 16. Erratum in: Toxicol Sci. 2014 Feb;137(2):499. Dosage error in article text.

32.

Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals.

Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA, Judson RS, LeCluyse EL, Martin MT, Reif DM, Ferguson SS.

J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):329-46. doi: 10.1080/10937404.2010.483949.

PMID:
20574906
33.

Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.

Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL.

J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58. doi: 10.1002/jbt.20264.

PMID:
19202563
34.

Primary human hepatocyte culture for HCV study.

Zhu H, Elyar J, Foss R, Hemming A, Hall E, Lecluyse EL, Liu C.

Methods Mol Biol. 2009;510:373-82. doi: 10.1007/978-1-59745-394-3_28.

PMID:
19009276
35.

Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.

Govindarajan R, Endres CJ, Whittington D, LeCluyse E, Pastor-Anglada M, Tse CM, Unadkat JD.

Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G570-80. doi: 10.1152/ajpgi.00542.2007. Epub 2008 Jul 17.

36.

Hepatic stem cells and hepatoblasts: identification, isolation, and ex vivo maintenance.

Wauthier E, Schmelzer E, Turner W, Zhang L, LeCluyse E, Ruiz J, Turner R, Furth ME, Kubota H, Lozoya O, Barbier C, McClelland R, Yao HL, Moss N, Bruce A, Ludlow J, Reid LM.

Methods Cell Biol. 2008;86:137-225. doi: 10.1016/S0091-679X(08)00008-3. No abstract available.

PMID:
18442648
37.

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations.

Hewitt NJ, Lecluyse EL, Ferguson SS.

Xenobiotica. 2007 Oct-Nov;37(10-11):1196-224. Review.

PMID:
17968743
38.

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

Hewitt NJ, Lechón MJ, Houston JB, Hallifax D, Brown HS, Maurel P, Kenna JG, Gustavsson L, Lohmann C, Skonberg C, Guillouzo A, Tuschl G, Li AP, LeCluyse E, Groothuis GM, Hengstler JG.

Drug Metab Rev. 2007;39(1):159-234. Review.

PMID:
17364884
39.
40.

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.

Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H.

J Pharmacol Exp Ther. 2007 Jan;320(1):72-80. Epub 2006 Oct 13.

41.

Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel.

Shi D, Yang J, Yang D, LeCluyse EL, Black C, You L, Akhlaghi F, Yan B.

J Pharmacol Exp Ther. 2006 Dec;319(3):1477-84. Epub 2006 Sep 11.

PMID:
16966469
42.

Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol.

Tang M, Mukundan M, Yang J, Charpentier N, LeCluyse EL, Black C, Yang D, Shi D, Yan B.

J Pharmacol Exp Ther. 2006 Dec;319(3):1467-76. Epub 2006 Aug 30.

PMID:
16943252
43.

Human PXR forms a tryptophan zipper-mediated homodimer.

Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR.

Biochemistry. 2006 Jul 18;45(28):8579-89.

44.

Cloning, tissue expression, and regulation of beagle dog CYP4A genes.

Graham RA, Goodwin B, Merrihew RV, Krol WL, Lecluyse EL.

Toxicol Sci. 2006 Aug;92(2):356-67. Epub 2006 May 4.

PMID:
16675513
45.

Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes.

Graham RA, Tyler LO, Krol WL, Silver IS, Webster LO, Clark P, Chen L, Banks T, LeCluyse EL.

J Biochem Mol Toxicol. 2006;20(2):69-78.

PMID:
16615094
46.

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.

Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H.

J Pharmacol Exp Ther. 2006 Jun;317(3):1200-9. Epub 2006 Mar 2.

PMID:
16513849
47.

Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells.

Smith CM, Graham RA, Krol WL, Silver IS, Negishi M, Wang H, Lecluyse EL.

J Pharmacol Exp Ther. 2005 Dec;315(3):1256-64. Epub 2005 Aug 31.

PMID:
16135700
48.
49.

Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers.

Smith CM, Faucette SR, Wang H, LeCluyse EL.

J Biochem Mol Toxicol. 2005;19(2):96-108.

PMID:
15849716
50.

Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes.

Drobná Z, Waters SB, Walton FS, LeCluyse EL, Thomas DJ, Stýblo M.

Toxicol Appl Pharmacol. 2004 Dec 1;201(2):166-77.

PMID:
15541756

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