Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 93

1.

Senolytics improve physical function and increase lifespan in old age.

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL.

Nat Med. 2018 Jul 9. doi: 10.1038/s41591-018-0092-9. [Epub ahead of print]

PMID:
29988130
2.

Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations.

Schafer MJ, Haak AJ, Tschumperlin DJ, LeBrasseur NK.

Curr Rheumatol Rep. 2018 Jan 26;20(1):3. doi: 10.1007/s11926-018-0712-x. Review.

PMID:
29374361
3.

Biology of premature ageing in survivors of cancer.

Cupit-Link MC, Kirkland JL, Ness KK, Armstrong GT, Tchkonia T, LeBrasseur NK, Armenian SH, Ruddy KJ, Hashmi SK.

ESMO Open. 2017 Dec 18;2(5):e000250. doi: 10.1136/esmoopen-2017-000250. eCollection 2017. Review.

4.

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.

Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, Quarles EK, Robbins PD, Ladiges WC, LeBrasseur NK, Niedernhofer LJ.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12706. Epub 2017 Dec 31.

5.

Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Nov 7;23(11):1384. doi: 10.1038/nm1117-1384c.

PMID:
29117174
6.

Plasma Sphingolipids are Associated With Gait Parameters in the Mayo Clinic Study of Aging.

Wennberg AMV, Schafer MJ, LeBrasseur NK, Savica R, Bui HH, Hagen CE, Hollman JH, Petersen RC, Mielke MM.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):960-965. doi: 10.1093/gerona/glx139.

PMID:
28977376
7.

Targeting cellular senescence prevents age-related bone loss in mice.

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S.

Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Erratum in: Nat Med. 2017 Nov 7;23 (11):1384.

8.

Functional not chronologic age: Frailty index predicts outcomes in advanced ovarian cancer.

Kumar A, Langstraat CL, DeJong SR, McGree ME, Bakkum-Gamez JN, Weaver AL, LeBrasseur NK, Cliby WA.

Gynecol Oncol. 2017 Oct;147(1):104-109. doi: 10.1016/j.ygyno.2017.07.126. Epub 2017 Jul 19.

PMID:
28734497
9.

Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women.

Justice JN, Gregory H, Tchkonia T, LeBrasseur NK, Kirkland JL, Kritchevsky SB, Nicklas BJ.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):939-945. doi: 10.1093/gerona/glx134.

PMID:
28658942
10.

Physical Resilience: Opportunities and Challenges in Translation.

LeBrasseur NK.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):978-979. doi: 10.1093/gerona/glx028. No abstract available.

11.

The Impact of Frailty on Patient-Centered Outcomes Following Aortic Valve Replacement.

Kotajarvi BR, Schafer MJ, Atkinson EJ, Traynor MM, Bruce CJ, Greason KL, Suri RM, Miller JD, LeBrasseur NK.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):917-921. doi: 10.1093/gerona/glx038.

12.

Relationship between pre-transplant physical function and outcomes after kidney transplant.

Lorenz EC, Cheville AL, Amer H, Kotajarvi BR, Stegall MD, Petterson TM, Kremers WK, Cosio FG, LeBrasseur NK.

Clin Transplant. 2017 May;31(5). doi: 10.1111/ctr.12952. Epub 2017 Apr 17. Erratum in: Clin Transplant. 2017 Aug;31(8):.

13.

A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition.

Krishnan A, Abdullah TS, Mounajjed T, Hartono S, McConico A, White T, LeBrasseur N, Lanza I, Nair S, Gores G, Charlton M.

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G666-G680. doi: 10.1152/ajpgi.00213.2016. Epub 2017 Feb 23.

14.

Cellular senescence mediates fibrotic pulmonary disease.

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK.

Nat Commun. 2017 Feb 23;8:14532. doi: 10.1038/ncomms14532.

15.

Disease drivers of aging.

Hodes RJ, Sierra F, Austad SN, Epel E, Neigh GN, Erlandson KM, Schafer MJ, LeBrasseur NK, Wiley C, Campisi J, Sehl ME, Scalia R, Eguchi S, Kasinath BS, Halter JB, Cohen HJ, Demark-Wahnefried W, Ahles TA, Barzilai N, Hurria A, Hunt PW.

Ann N Y Acad Sci. 2016 Dec;1386(1):45-68. doi: 10.1111/nyas.13299. Review.

16.

Direct ortho-Arylation of Pyridinecarboxylic Acids: Overcoming the Deactivating Effect of sp2-Nitrogen.

Johnston AJ, Ling KB, Sale D, Lebrasseur N, Larrosa I.

Org Lett. 2016 Dec 2;18(23):6094-6097. Epub 2016 Nov 18.

PMID:
27934340
17.

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver.

Zhou D, Hlady RA, Schafer MJ, White TA, Liu C, Choi JH, Miller JD, Roberts LR, LeBrasseur NK, Robertson KD.

Epigenetics. 2017 Jan 2;12(1):55-69. doi: 10.1080/15592294.2016.1261239. Epub 2016 Nov 18. Erratum in: Epigenetics. 2017 Apr 3;12 (4):304-305.

18.

Identification of Senescent Cells in the Bone Microenvironment.

Farr JN, Fraser DG, Wang H, Jaehn K, Ogrodnik MB, Weivoda MM, Drake MT, Tchkonia T, LeBrasseur NK, Kirkland JL, Bonewald LF, Pignolo RJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Nov;31(11):1920-1929. doi: 10.1002/jbmr.2892. Epub 2016 Oct 24.

19.

Cellular senescence: Implications for metabolic disease.

Schafer MJ, Miller JD, LeBrasseur NK.

Mol Cell Endocrinol. 2017 Nov 5;455:93-102. doi: 10.1016/j.mce.2016.08.047. Epub 2016 Aug 31. Review.

PMID:
27591120
20.

CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis.

Tomita K, Freeman BL, Bronk SF, LeBrasseur NK, White TA, Hirsova P, Ibrahim SH.

Sci Rep. 2016 Jun 28;6:28786. doi: 10.1038/srep28786.

21.

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease.

Schafer MJ, Atkinson EJ, Vanderboom PM, Kotajarvi B, White TA, Moore MM, Bruce CJ, Greason KL, Suri RM, Khosla S, Miller JD, Bergen HR 3rd, LeBrasseur NK.

Cell Metab. 2016 Jun 14;23(6):1207-1215. doi: 10.1016/j.cmet.2016.05.023.

22.

An autonomous chemically fuelled small-molecule motor.

Wilson MR, Solà J, Carlone A, Goldup SM, Lebrasseur N, Leigh DA.

Nature. 2016 Jun 9;534(7606):235-40. doi: 10.1038/nature18013.

PMID:
27279219
23.

Energetic interventions for healthspan and resiliency with aging.

Huffman DM, Schafer MJ, LeBrasseur NK.

Exp Gerontol. 2016 Dec 15;86:73-83. doi: 10.1016/j.exger.2016.05.012. Epub 2016 May 31. Review.

24.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

25.

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization.

Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):3-15. Epub 2016 Jan 24.

26.

Targeting senescent cells enhances adipogenesis and metabolic function in old age.

Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL.

Elife. 2015 Dec 19;4:e12997. doi: 10.7554/eLife.12997.

27.

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2.

28.

Cellular Senescence and the Biology of Aging, Disease, and Frailty.

LeBrasseur NK, Tchkonia T, Kirkland JL.

Nestle Nutr Inst Workshop Ser. 2015;83:11-8. doi: 10.1159/000382054. Epub 2015 Oct 20. Review.

29.

Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay.

Bergen HR 3rd, Farr JN, Vanderboom PM, Atkinson EJ, White TA, Singh RJ, Khosla S, LeBrasseur NK.

Skelet Muscle. 2015 Jul 15;5:21. doi: 10.1186/s13395-015-0047-5. eCollection 2015.

30.

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

Palmer AK, Tchkonia T, LeBrasseur NK, Chini EN, Xu M, Kirkland JL.

Diabetes. 2015 Jul;64(7):2289-98. doi: 10.2337/db14-1820. Review.

31.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL.

Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22.

32.

Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction.

McGee-Lawrence ME, White TA, LeBrasseur NK, Westendorf JJ.

Mol Cell Endocrinol. 2015 Jul 15;410:42-51. doi: 10.1016/j.mce.2015.02.001. Epub 2015 Feb 7. Review.

33.

Shear wave elastography of passive skeletal muscle stiffness: influences of sex and age throughout adulthood.

Eby SF, Cloud BA, Brandenburg JE, Giambini H, Song P, Chen S, LeBrasseur NK, An KN.

Clin Biomech (Bristol, Avon). 2015 Jan;30(1):22-7. doi: 10.1016/j.clinbiomech.2014.11.011. Epub 2014 Nov 29.

34.

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.

Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ.

J Hepatol. 2015 May;62(5):1156-63. doi: 10.1016/j.jhep.2014.11.033. Epub 2014 Nov 28.

35.

Body composition during childhood and adolescence: relations to bone strength and microstructure.

Farr JN, Amin S, LeBrasseur NK, Atkinson EJ, Achenbach SJ, McCready LK, Joseph Melton L 3rd, Khosla S.

J Clin Endocrinol Metab. 2014 Dec;99(12):4641-8. doi: 10.1210/jc.2014-1113.

36.

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL.

Aging (Albany NY). 2014 Jul;6(7):575-86.

37.

Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice.

Murthy V, Gao Y, Geng L, LeBrasseur NK, White TA, Parks RJ, Brimijoin S.

Vaccine. 2014 Jul 16;32(33):4155-62. doi: 10.1016/j.vaccine.2014.05.067. Epub 2014 Jun 2.

38.

Regenerating skeletal muscle in the face of aging and disease.

Jasuja R, LeBrasseur NK.

Am J Phys Med Rehabil. 2014 Nov;93(11 Suppl 3):S88-96. doi: 10.1097/PHM.0000000000000118. Review.

PMID:
24879554
39.

Determinants of gait speed in COPD.

Karpman C, DePew ZS, LeBrasseur NK, Novotny PJ, Benzo RP.

Chest. 2014 Jul;146(1):104-110. doi: 10.1378/chest.13-2017.

40.

Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles.

List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ.

Endocrinology. 2014 May;155(5):1793-805. doi: 10.1210/en.2013-2086. Epub 2014 Feb 11.

41.

Myostatin and sarcopenia: opportunities and challenges - a mini-review.

White TA, LeBrasseur NK.

Gerontology. 2014;60(4):289-93. doi: 10.1159/000356740. Epub 2014 Jan 17. Review.

42.

Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice.

Murthy V, Gao Y, Geng L, LeBrasseur N, White T, Brimijoin S.

J Mol Neurosci. 2014 Jul;53(3):409-16. doi: 10.1007/s12031-013-0130-5. Epub 2013 Oct 2.

43.

Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.

Akasaki Y, Ouchi N, Izumiya Y, Bernardo BL, Lebrasseur NK, Walsh K.

Aging Cell. 2014 Feb;13(1):80-91. doi: 10.1111/acel.12153. Epub 2013 Sep 17.

44.

Measuring gait speed in the out-patient clinic: methodology and feasibility.

Karpman C, Lebrasseur NK, Depew ZS, Novotny PJ, Benzo RP.

Respir Care. 2014 Apr;59(4):531-7. doi: 10.4187/respcare.02688. Epub 2013 Aug 27.

45.

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet.

Lanza IR, Blachnio-Zabielska A, Johnson ML, Schimke JM, Jakaitis DR, Lebrasseur NK, Jensen MD, Sreekumaran Nair K, Zabielski P.

Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1391-403. doi: 10.1152/ajpendo.00584.2012. Epub 2013 Apr 30. Erratum in: Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E1048.

46.

The A2b adenosine receptor modulates glucose homeostasis and obesity.

Johnston-Cox H, Koupenova M, Yang D, Corkey B, Gokce N, Farb MG, LeBrasseur N, Ravid K.

PLoS One. 2012;7(7):e40584. doi: 10.1371/journal.pone.0040584. Epub 2012 Jul 25.

47.

Skeletal muscle mass is associated with bone geometry and microstructure and serum insulin-like growth factor binding protein-2 levels in adult women and men.

Lebrasseur NK, Achenbach SJ, Melton LJ 3rd, Amin S, Khosla S.

J Bone Miner Res. 2012 Oct;27(10):2159-69. doi: 10.1002/jbmr.1666.

48.

A three-compartment chemically-driven molecular information ratchet.

Carlone A, Goldup SM, Lebrasseur N, Leigh DA, Wilson A.

J Am Chem Soc. 2012 May 23;134(20):8321-3. doi: 10.1021/ja302711z. Epub 2012 May 8.

PMID:
22524156
49.

Building muscle, browning fat and preventing obesity by inhibiting myostatin.

Lebrasseur NK.

Diabetologia. 2012 Jan;55(1):13-7. doi: 10.1007/s00125-011-2361-8. Epub 2011 Nov 6.

PMID:
22057197
50.

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM.

Nature. 2011 Nov 2;479(7372):232-6. doi: 10.1038/nature10600.

Supplemental Content

Loading ...
Support Center