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The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.

Castillo JJ, Jelinek D, Wei H, Gannon NP, Vaughan RA, Horwood LJ, Meaney FJ, Garcia-Smith R, Trujillo KA, Heidenreich RA, Meyre D, Orlando RA, LeBoeuf RC, Garver WS.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E183-E194. doi: 10.1152/ajpendo.00369.2016. Epub 2017 May 9.


Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages.

Tang C, Houston BA, Storey C, LeBoeuf RC.

J Lipid Res. 2016 May;57(5):848-57. doi: 10.1194/jlr.M065797. Epub 2016 Mar 17.


The Use of Kits in the Analysis of Tissue Lipids Requires Validation.

Rider T, LeBoeuf RC, Tso P, Jandacek RJ.

Lipids. 2016 Apr;51(4):497-504. doi: 10.1007/s11745-016-4134-0. Epub 2016 Mar 7.


Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice.

Tang C, Liu Y, Yang W, Storey C, McMillen TS, Houston BA, Heinecke JW, LeBoeuf RC.

J Lipid Res. 2016 Jan;57(1):100-8. doi: 10.1194/jlr.M064303. Epub 2015 Nov 3.


ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction.

Wei H, Tarling EJ, McMillen TS, Tang C, LeBoeuf RC.

J Lipid Res. 2015 Dec;56(12):2337-47. doi: 10.1194/jlr.M063354. Epub 2015 Oct 21.


Serum amyloid A and inflammation in diabetic kidney disease and podocytes.

Anderberg RJ, Meek RL, Hudkins KL, Cooney SK, Alpers CE, Leboeuf RC, Tuttle KR.

Lab Invest. 2015 Jun;95(6):697. doi: 10.1038/labinvest.2015.38. No abstract available.


Serum amyloid A and inflammation in diabetic kidney disease and podocytes.

Anderberg RJ, Meek RL, Hudkins KL, Cooney SK, Alpers CE, Leboeuf RC, Tuttle KR.

Lab Invest. 2015 Mar;95(3):250-62. doi: 10.1038/labinvest.2014.163. Epub 2014 Dec 22. Erratum in: Lab Invest. 2015 Jun;95(6):697.


Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.

Wu X, Davis RC, McMillen TS, Schaeffer V, Zhou Z, Qi H, Mazandarani PN, Alialy R, Hudkins KL, Lusis AJ, LeBoeuf RC.

Physiol Rep. 2014 Nov 26;2(11). pii: e12208. doi: 10.14814/phy2.12208. Print 2014 Nov 1.


Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.

Spiezio SH, Amon LM, McMillen TS, Vick CM, Houston BA, Caldwell M, Ogimoto K, Morton GJ, Kirk EA, Schwartz MW, Nadeau JH, LeBoeuf RC.

Mamm Genome. 2014 Dec;25(11-12):549-63. doi: 10.1007/s00335-014-9530-2. Epub 2014 Jul 8.


Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.

Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW.

Endocrinology. 2014 Sep;155(9):3409-20. doi: 10.1210/en.2014-1037. Epub 2014 Jun 10.


Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice.

Wei H, Averill MM, McMillen TS, Dastvan F, Mitra P, Subramanian S, Tang C, Chait A, Leboeuf RC.

Nutr Diabetes. 2014 Feb 24;4:e108. doi: 10.1038/nutd.2014.4.


Atherosclerosis and cardiac function assessment in low-density lipoprotein receptor-deficient mice undergoing body weight cycling.

McMillen TS, Minami E, Leboeuf RC.

Nutr Diabetes. 2013 Jun 24;3:e79. doi: 10.1038/nutd.2013.19.


Glomerular cell death and inflammation with high-protein diet and diabetes.

Meek RL, LeBoeuf RC, Saha SA, Alpers CE, Hudkins KL, Cooney SK, Anderberg RJ, Tuttle KR.

Nephrol Dial Transplant. 2013 Jul;28(7):1711-20. doi: 10.1093/ndt/gfs579. Epub 2013 Jan 12.


A single nucleotide polymorphism in the p27(Kip1) gene is associated with primary patency of lower extremity vein bypass grafts.

Conte MS, Owens CD, Belkin M, Creager MA, Edwards KL, Gasper WJ, Kenagy RD, LeBoeuf RC, Sobel M, Clowes A.

J Vasc Surg. 2013 May;57(5):1179-85.e1-2. doi: 10.1016/j.jvs.2012.11.040. Epub 2013 Jan 9.


Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.

Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC.

Mamm Genome. 2012 Oct;23(9-10):680-92. doi: 10.1007/s00335-012-9411-5. Epub 2012 Aug 15. Review.


Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice.

Wei H, Zhang WJ, McMillen TS, Leboeuf RC, Frei B.

Atherosclerosis. 2012 Aug;223(2):306-13. doi: 10.1016/j.atherosclerosis.2012.06.013. Epub 2012 Jun 16.


RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration.

Schaeffer V, Hansen KM, Morris DR, LeBoeuf RC, Abrass CK.

Am J Physiol Renal Physiol. 2012 Jul 1;303(1):F75-82. doi: 10.1152/ajprenal.00185.2012. Epub 2012 Apr 18.


Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice.

Pamir N, McMillen TS, Edgel KA, Kim F, LeBoeuf RC.

Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E961-71. doi: 10.1152/ajpendo.00447.2011. Epub 2012 Feb 7.


Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice.

Edgel KA, McMillen TS, Wei H, Pamir N, Houston BA, Caldwell MT, Mai PO, Oram JF, Tang C, Leboeuf RC.

Biochim Biophys Acta. 2012 Mar;1821(3):425-34. doi: 10.1016/j.bbalip.2011.11.012. Epub 2011 Dec 10.


S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation.

Averill MM, Barnhart S, Becker L, Li X, Heinecke JW, Leboeuf RC, Hamerman JA, Sorg C, Kerkhoff C, Bornfeldt KE.

Circulation. 2011 Mar 22;123(11):1216-26. doi: 10.1161/CIRCULATIONAHA.110.985523. Epub 2011 Mar 7.


Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci.

Nelson JD, LeBoeuf RC, Bomsztyk K.

Diabetes. 2011 Jan;60(1):127-37. doi: 10.2337/db09-1806. Epub 2010 Oct 7.


In vivo knockdown of nicotinic acetylcholine receptor α1 diminishes aortic atherosclerosis.

Zhang G, Marshall AL, Thomas AL, Kernan KA, Su Y, LeBoeuf RC, Dong XR, Tchao BN.

Atherosclerosis. 2011 Mar;215(1):34-42. doi: 10.1016/j.atherosclerosis.2010.07.057. Epub 2010 Aug 10.


Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys.

Tang C, Kanter JE, Bornfeldt KE, Leboeuf RC, Oram JF.

J Lipid Res. 2010 Jul;51(7):1719-28. doi: 10.1194/jlr.M003525. Epub 2009 Nov 23.


Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells.

Lee MY, Garvey SM, Baras AS, Lemmon JA, Gomez MF, Schoppee Bortz PD, Daum G, LeBoeuf RC, Wamhoff BR.

Hum Mol Genet. 2010 Feb 1;19(3):468-79. doi: 10.1093/hmg/ddp511. Epub 2009 Nov 19.


Tumor necrosis factor-alpha and lymphotoxin-alpha increase macrophage ABCA1 by gene expression and protein stabilization via different receptors.

Edgel KA, Leboeuf RC, Oram JF.

Atherosclerosis. 2010 Apr;209(2):387-92. doi: 10.1016/j.atherosclerosis.2009.10.019. Epub 2009 Oct 22.


beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice.

Harmon JS, Bogdani M, Parazzoli SD, Mak SS, Oseid EA, Berghmans M, Leboeuf RC, Robertson RP.

Endocrinology. 2009 Nov;150(11):4855-62. doi: 10.1210/en.2009-0708. Epub 2009 Oct 9.


A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis.

Zhang G, Kernan KA, Thomas A, Collins S, Song Y, Li L, Zhu W, Leboeuf RC, Eddy AA.

J Biol Chem. 2009 Oct 16;284(42):29050-64. doi: 10.1074/jbc.M109.010249. Epub 2009 Aug 18.


Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse.

Hsing LC, Kirk EA, McMillen TS, Hsiao SH, Caldwell M, Houston B, Rudensky AY, LeBoeuf RC.

J Autoimmun. 2010 Mar;34(2):96-104. doi: 10.1016/j.jaut.2009.07.003. Epub 2009 Aug 6.


Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status.

Pamir N, McMillen TS, Kaiyala KJ, Schwartz MW, LeBoeuf RC.

Endocrinology. 2009 Sep;150(9):4124-34. doi: 10.1210/en.2009-0137. Epub 2009 May 28.


Overexpression of apolipoprotein A5 in mice is not protective against body weight gain and aberrant glucose homeostasis.

Pamir N, McMillen TS, Li YI, Lai CM, Wong H, LeBoeuf RC.

Metabolism. 2009 Apr;58(4):560-7. doi: 10.1016/j.metabol.2008.11.018.


Diabetes-accelerated atherosclerosis and inflammation.

Kanter JE, Averill MM, Leboeuf RC, Bornfeldt KE.

Circ Res. 2008 Oct 10;103(8):e116-7. doi: 10.1161/CIRCRESAHA.108.182642. No abstract available.


Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase.

Li YI, Elmer G, Leboeuf RC.

Life Sci. 2008 Oct 10;83(15-16):557-62. doi: 10.1016/j.lfs.2008.08.003. Epub 2008 Aug 16.


Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies.

Hall TR, Bogdani M, Leboeuf RC, Kirk EA, Maziarz M, Banga JP, Oak S, Pennington CA, Hampe CS.

Immunology. 2008 Apr;123(4):547-54. Epub 2007 Nov 14.


Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research.

Katz R, Hamilton JA, Pownall HJ, Deckelbaum RJ, Hillard CJ, Leboeuf RC, Watkins PA.

J Mol Neurosci. 2007 Sep;33(1):146-50.


Mapping genes responsible for strain-specific iron phenotypes in murine chromosome substitution strains.

Ajioka RS, LeBoeuf RC, Gillespie RR, Amon LM, Kushner JP.

Blood Cells Mol Dis. 2007 Sep-Oct;39(2):199-205. Epub 2007 May 9.


Do glucose and lipids exert independent effects on atherosclerotic lesion initiation or progression to advanced plaques?

Kanter JE, Johansson F, LeBoeuf RC, Bornfeldt KE.

Circ Res. 2007 Mar 30;100(6):769-81. Review.


Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice.

McMillen TS, Heinecke JW, LeBoeuf RC.

Circulation. 2005 May 31;111(21):2798-804. Epub 2005 May 23.


Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.

Ladiges WC, Knoblaugh SE, Morton JF, Korth MJ, Sopher BL, Baskin CR, MacAuley A, Goodman AG, LeBoeuf RC, Katze MG.

Diabetes. 2005 Apr;54(4):1074-81.


Serum amyloid A and lipoprotein retention in murine models of atherosclerosis.

O'Brien KD, McDonald TO, Kunjathoor V, Eng K, Knopp EA, Lewis K, Lopez R, Kirk EA, Chait A, Wight TN, deBeer FC, LeBoeuf RC.

Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):785-90. Epub 2005 Feb 3.


Hyperlipidemia aggravates renal disease in B6.ROP Os/+ mice.

Mühlfeld AS, Spencer MW, Hudkins KL, Kirk E, LeBoeuf RC, Alpers CE.

Kidney Int. 2004 Oct;66(4):1393-402.


Hyperglycemia and hyperlipidemia act synergistically to induce renal disease in LDL receptor-deficient BALB mice.

Spencer MW, Mühlfeld AS, Segerer S, Hudkins KL, Kirk E, LeBoeuf RC, Alpers CE.

Am J Nephrol. 2004 Jan-Feb;24(1):20-31. Epub 2003 Dec 10.


Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherosclerosis associated with obesity.

Schreyer SA, Lystig TC, Vick CM, LeBoeuf RC.

Atherosclerosis. 2003 Nov;171(1):49-55.


The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE.

Diabetologia. 2003 Jan;46(1):71-9. Epub 2003 Jan 9.


Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice.

Shie FS, LeBoeuf RC, Jin LW.

Neuroreport. 2003 Jan 20;14(1):123-9. Erratum in: Neuroreport. 2004 Aug 26;15(12):1993. LeBoeur, Renée C [corrected to LeBoeuf, Renée C].


Renal injury in apolipoprotein E-deficient mice.

Wen M, Segerer S, Dantas M, Brown PA, Hudkins KL, Goodpaster T, Kirk E, LeBoeuf RC, Alpers CE.

Lab Invest. 2002 Aug;82(8):999-1006.


The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor.

Brown ML, Yui K, Smith JD, LeBoeuf RC, Weng W, Umeda PK, Li R, Song R, Gianturco SH, Bradley WA.

J Lipid Res. 2002 Aug;43(8):1181-91.


Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice.

Shie FS, Jin LW, Cook DG, Leverenz JB, LeBoeuf RC.

Neuroreport. 2002 Mar 25;13(4):455-9.


Accumulation of biglycan and perlecan, but not versican, in lesions of murine models of atherosclerosis.

Kunjathoor VV, Chiu DS, O'Brien KD, LeBoeuf RC.

Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):462-8.

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