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Items: 33


Convergence of recent GWAS data for suicidality with previous blood biomarkers: independent reproducibility using independent methodologies in independent cohorts.

Niculescu AB, Le-Niculescu H.

Mol Psychiatry. 2019 Aug 5. doi: 10.1038/s41380-019-0465-6. [Epub ahead of print] Review.


Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs.

Le-Niculescu H, Roseberry K, Levey DF, Rogers J, Kosary K, Prabha S, Jones T, Judd S, McCormick MA, Wessel AR, Williams A, Phalen PL, Mamdani F, Sequeira A, Kurian SM, Niculescu AB.

Mol Psychiatry. 2019 Mar 12. doi: 10.1038/s41380-019-0370-z. [Epub ahead of print]


Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs.

Niculescu AB, Le-Niculescu H, Levey DF, Roseberry K, Soe KC, Rogers J, Khan F, Jones T, Judd S, McCormick MA, Wessel AR, Williams A, Kurian SM, White FA.

Mol Psychiatry. 2019 Apr;24(4):501-522. doi: 10.1038/s41380-018-0345-5. Epub 2019 Feb 12.


Assessing Risk of Future Suicidality in Emergency Department Patients.

Brucker K, Duggan C, Niezer J, Roseberry K, Le-Niculescu H, Niculescu AB, Kline JA.

Acad Emerg Med. 2019 Apr;26(4):376-383. doi: 10.1111/acem.13562. Epub 2018 Oct 30.


Precision medicine for suicidality: from universality to subtypes and personalization.

Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, Niculescu EM, Niezer JO, Williams A, Graham DL, Jones TJ, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian SM, Shekhar A, Schork NJ, Sandusky GE, Salomon DR.

Mol Psychiatry. 2017 Sep;22(9):1250-1273. doi: 10.1038/mp.2017.128. Epub 2017 Aug 15.


Dissecting Suicidality Using a Combined Genomic and Clinical Approach.

Niculescu AB, Le-Niculescu H.

Neuropsychopharmacology. 2017 Jan;42(1):360. doi: 10.1038/npp.2016.228. No abstract available.


Mood, stress and longevity: convergence on ANK3.

Rangaraju S, Levey DF, Nho K, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, Niculescu AB.

Mol Psychiatry. 2016 Aug;21(8):1037-49. doi: 10.1038/mp.2016.65. Epub 2016 May 24.


Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment.

Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB.

Mol Psychiatry. 2016 Jun;21(6):768-85. doi: 10.1038/mp.2016.31. Epub 2016 Apr 5.


Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.

Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR.

Mol Psychiatry. 2015 Nov;20(11):1266-85. doi: 10.1038/mp.2015.112. Epub 2015 Aug 18.


Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions.

Niculescu AB, Levey D, Le-Niculescu H, Niculescu E, Kurian SM, Salomon D.

Mol Psychiatry. 2015 Mar;20(3):286-8. doi: 10.1038/mp.2014.180. Epub 2015 Jan 13.


Genetic risk prediction and neurobiological understanding of alcoholism.

Levey DF, Le-Niculescu H, Frank J, Ayalew M, Jain N, Kirlin B, Learman R, Winiger E, Rodd Z, Shekhar A, Schork N, Kiefer F, Wodarz N, Müller-Myhsok B, Dahmen N; GESGA Consortium, Nöthen M, Sherva R, Farrer L, Smith AH, Kranzler HR, Rietschel M, Gelernter J, Niculescu AB.

Transl Psychiatry. 2014 May 20;4:e391. doi: 10.1038/tp.2014.29. Erratum in: Transl Psychiatry. 2014;4:e456. Kiefe, F [corrected to Kiefer, F].


Discovery and validation of blood biomarkers for suicidality.

Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB 3rd.

Mol Psychiatry. 2013 Dec;18(12):1249-64. doi: 10.1038/mp.2013.95. Epub 2013 Aug 20.


Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.

Ayalew M, Le-Niculescu H, Levey DF, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon D, Schork NJ, Fanous AH, O'Donovan MC, Niculescu AB.

Mol Psychiatry. 2012 Sep;17(9):887-905. doi: 10.1038/mp.2012.37. Epub 2012 May 15.


Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms.

Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M, Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA, Niculescu AB.

Transl Psychiatry. 2011 May 24;1:e9. doi: 10.1038/tp.2011.9.


Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.

Le-Niculescu H, Case NJ, Hulvershorn L, Patel SD, Bowker D, Gupta J, Bell R, Edenberg HJ, Tsuang MT, Kuczenski R, Geyer MA, Rodd ZA, Niculescu AB.

Transl Psychiatry. 2011 Apr 26;1:e4. doi: 10.1038/tp.2011.1.


Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness).

Le-Niculescu H, Patel SD, Niculescu AB.

Curr Opin Pharmacol. 2010 Oct;10(5):594-600. doi: 10.1016/j.coph.2010.08.008. Review.


Coming to grips with complex disorders: genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics.

Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon FJ, Nurnberger JI Jr, Niculescu AB 3rd.

Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):850-77. doi: 10.1002/ajmg.b.31087.


The P-value illusion: how to improve (psychiatric) genetic studies.

Niculescu AB, Le-Niculescu H.

Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):847-9. doi: 10.1002/ajmg.b.31076.


Convergent Functional Genomics: what we have learned and can learn about genes, pathways, and mechanisms.

Niculescu AB, Le-Niculescu H.

Neuropsychopharmacology. 2010 Jan;35(1):355-6. doi: 10.1038/npp.2009.107. No abstract available.


Identification of blood biomarkers for psychosis using convergent functional genomics.

Kurian SM, Le-Niculescu H, Patel SD, Bertram D, Davis J, Dike C, Yehyawi N, Lysaker P, Dustin J, Caligiuri M, Lohr J, Lahiri DK, Nurnberger JI Jr, Faraone SV, Geyer MA, Tsuang MT, Schork NJ, Salomon DR, Niculescu AB.

Mol Psychiatry. 2011 Jan;16(1):37-58. doi: 10.1038/mp.2009.117. Epub 2009 Nov 24.


Evidence for genetic association of RORB with bipolar disorder.

McGrath CL, Glatt SJ, Sklar P, Le-Niculescu H, Kuczenski R, Doyle AE, Biederman J, Mick E, Faraone SV, Niculescu AB, Tsuang MT.

BMC Psychiatry. 2009 Nov 12;9:70. doi: 10.1186/1471-244X-9-70.


Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms.

Le-Niculescu H, Patel SD, Bhat M, Kuczenski R, Faraone SV, Tsuang MT, McMahon FJ, Schork NJ, Nurnberger JI Jr, Niculescu AB 3rd.

Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):155-81. doi: 10.1002/ajmg.b.30887.


Identifying blood biomarkers for mood disorders using convergent functional genomics.

Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, Tsuang MT, Salomon DR, Nurnberger JI Jr, Niculescu AB.

Mol Psychiatry. 2009 Feb;14(2):156-74. doi: 10.1038/mp.2008.11. Epub 2008 Feb 26. Erratum in: Mol Psychiatry. 2009 Dec;14(12):1143.


Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism.

Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S, Tan J, Rodd ZA, Paulus M, Geyer MA, Edenberg HJ, Glatt SJ, Faraone SV, Nurnberger JI, Kuczenski R, Tsuang MT, Niculescu AB.

Am J Med Genet B Neuropsychiatr Genet. 2008 Mar 5;147B(2):134-66. doi: 10.1002/ajmg.b.30707.


Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers.

Le-Niculescu H, McFarland MJ, Mamidipalli S, Ogden CA, Kuczenski R, Kurian SM, Salomon DR, Tsuang MT, Nurnberger JI Jr, Niculescu AB.

Neurosci Biobehav Rev. 2007;31(6):897-903. Epub 2007 Jun 3. Review.


Towards understanding the schizophrenia code: an expanded convergent functional genomics approach.

Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE, Edenberg HJ, Kuczenski R, Geyer MA, Nurnberger JI Jr, Faraone SV, Tsuang MT, Niculescu AB.

Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5;144B(2):129-58.


Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach.

Rodd ZA, Bertsch BA, Strother WN, Le-Niculescu H, Balaraman Y, Hayden E, Jerome RE, Lumeng L, Nurnberger JI Jr, Edenberg HJ, McBride WJ, Niculescu AB.

Pharmacogenomics J. 2007 Aug;7(4):222-56. Epub 2006 Oct 10.


PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes.

Niculescu AB, Lulow LL, Ogden CA, Le-Niculescu H, Salomon DR, Schork NJ, Caligiuri MP, Lohr JB.

Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141B(6):653-62.


Convergent functional genomics: a Bayesian candidate gene identification approach for complex disorders.

Bertsch B, Ogden CA, Sidhu K, Le-Niculescu H, Kuczenski R, Niculescu AB.

Methods. 2005 Nov;37(3):274-9.


Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles.

Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG.

J Biol Chem. 2005 Jun 10;280(23):22012-20. Epub 2005 Mar 4.


Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection.

Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M.

Invest Ophthalmol Vis Sci. 2002 May;43(5):1631-5.


Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death.

Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M.

Mol Cell Biol. 1999 Jan;19(1):751-63.


The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein.

Lin P, Le-Niculescu H, Hofmeister R, McCaffery JM, Jin M, Hennemann H, McQuistan T, De Vries L, Farquhar MG.

J Cell Biol. 1998 Jun 29;141(7):1515-27.

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