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Toll-like receptor signalling has inverted U-shaped response over time with the Western environment.

Guo J, Song Y, Saiganesh A, Hales BJ, Bosco A, Le Souëf PN, Zhang G.

Allergy. 2020 Mar 14. doi: 10.1111/all.14277. [Epub ahead of print] No abstract available.


Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children.

Cuthbertson L, Oo SWC, Cox MJ, Khoo SK, Cox DW, Chidlow G, Franks K, Prastanti F, Borland ML, Gern JE, Smith DW, Bizzintino JA, Laing IA, Le Souëf PN, Moffatt MF, Cookson WOC.

PLoS One. 2019 Oct 17;14(10):e0223990. doi: 10.1371/journal.pone.0223990. eCollection 2019.


Testing the socioeconomic and environmental determinants of better child-health outcomes in Africa: a cross-sectional study among nations.

Bradshaw CJA, Otto SP, Mehrabi Z, Annamalay AA, Heft-Neal S, Wagner Z, Le Souëf PN.

BMJ Open. 2019 Sep 30;9(9):e029968. doi: 10.1136/bmjopen-2019-029968. Erratum in: BMJ Open. 2020 Feb 13;10(2):e029968corr1.


Western oropharyngeal and gut microbial profiles are associated with allergic conditions in Chinese immigrant children.

Guo J, Lv Q, Ariff A, Zhang X, Peacock CS, Song Y, Wen X, Saiganesh A, Melton PE, Dykes GA, Moses EK, LE Souëf PN, Lu F, Zhang G.

World Allergy Organ J. 2019 Aug 9;12(8):100051. doi: 10.1016/j.waojou.2019.100051. eCollection 2019 Aug.


Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children.

Leffler J, Read JF, Jones AC, Mok D, Hollams EM, Laing IA, Le Souef PN, Sly PD, Kusel MMH, de Klerk NH, Bosco A, Holt PG, Strickland DH.

Pediatr Allergy Immunol. 2019 Sep;30(6):646-653. doi: 10.1111/pai.13063. Epub 2019 May 22.


Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.

Khoo SK, Read J, Franks K, Zhang G, Bizzintino J, Coleman L, McCrae C, Öberg L, Troy NM, Prastanti F, Everard J, Oo S, Borland ML, Maciewicz RA, Le Souëf PN, Laing IA, Bosco A.

J Immunol. 2019 Mar 15;202(6):1845-1858. doi: 10.4049/jimmunol.1800178. Epub 2019 Feb 11.


Glutathione S-Transferase Genotype Protects against In Utero Tobacco-linked Lung Function Deficits.

Owens L, Laing IA, Murdzoska J, Zhang G, Turner SW, Le Souëf PN.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):462-470. doi: 10.1164/rccm.201807-1332OC.


Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort.

Owens L, Laing IA, Zhang G, Turner S, Le Souëf PN.

J Asthma Allergy. 2018 Aug 13;11:173-180. doi: 10.2147/JAA.S170285. eCollection 2018.


Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations.

Leffler J, Jones AC, Hollams EM, Prastanti F, Le Souëf PN, Holt PG, Bosco A, Laing IA, Strickland DH.

J Allergy Clin Immunol. 2018 Nov;142(5):1639-1641.e5. doi: 10.1016/j.jaci.2018.07.003. Epub 2018 Jul 21. No abstract available.


Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions.

Cox DW, Khoo SK, Zhang G, Lindsay K, Keil AD, Knight G, Gern JE, Laing IA, Bizzintino J, Le Souëf PN.

Eur Respir J. 2018 Aug 9;52(2). pii: 1800207. doi: 10.1183/13993003.00207-2018. Print 2018 Aug. No abstract available.


A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment.

Saiganesh A, Hales BJ, Li Y, Holt PG, Le Souëf PN, Zhang G.

Allergy. 2018 Oct;73(10):2092-2094. doi: 10.1111/all.13531. Epub 2018 Jul 11. No abstract available.


Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood.

Owens L, Laing IA, Zhang G, Turner S, Le Souëf PN.

Pediatr Pulmonol. 2018 Aug;53(8):1082-1088. doi: 10.1002/ppul.24062. Epub 2018 May 27.


Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies.

Belgrave DCM, Granell R, Turner SW, Curtin JA, Buchan IE, Le Souëf PN, Simpson A, Henderson AJ, Custovic A.

Lancet Respir Med. 2018 Jul;6(7):526-534. doi: 10.1016/S2213-2600(18)30099-7. Epub 2018 Apr 5.


Prospective Assessment of Rhinovirus Symptoms and Species Recurrence in Children With and Without an Acute Wheezing Exacerbation.

Lethbridge R, Prastanti F, Robertson C, Oo S, Khoo SK, Le Souëf PN, Laing IA.

Viral Immunol. 2018 May;31(4):299-305. doi: 10.1089/vim.2017.0152. Epub 2018 Feb 15.


The Western environment reduces innate immune cytokine production in Chinese immigrants.

Saiganesh A, Hales BJ, Chen S, Filipovska-Naumovska E, Pereira G, Garand M, Kollmann TR, Currie AJ, Le Souëf PN, Zhang G.

J Allergy Clin Immunol. 2018 Apr;141(4):1504-1507.e3. doi: 10.1016/j.jaci.2017.11.031. Epub 2017 Dec 21. No abstract available.


Genetic Variants in the IL-4/IL-13 Pathway Influence Measles Vaccine Responses and Vaccine Failure in Children from Mozambique.

Clifford HD, Hayden CM, Khoo SK, Naniche D, Mandomando IM, Zhang G, Richmond P, Le Souëf PN.

Viral Immunol. 2017 Sep;30(7):472-478. doi: 10.1089/vim.2017.0014. Epub 2017 Jun 8.


Infant lung function predicts asthma persistence and remission in young adults.

Owens L, Laing IA, Zhang G, Le Souëf PN.

Respirology. 2017 Feb;22(2):289-294. doi: 10.1111/resp.12901. Epub 2016 Sep 16.


Immunodominant T-Cell Epitopes in the VP1 Capsid Protein of Rhinovirus Species A and C.

Gaido CM, Stone S, Chopra A, Thomas WR, Le Souëf PN, Hales BJ.

J Virol. 2016 Nov 14;90(23):10459-10471. doi: 10.1128/JVI.01701-16. Print 2016 Dec 1.


Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique.

Annamalay AA, Lanaspa M, Khoo SK, Madrid L, Acácio S, Zhang G, Laing IA, Gern J, Goldblatt J, Bizzintino J, Lehmann D, Le Souëf PN, Bassat Q.

Trop Med Int Health. 2016 Sep;21(9):1171-80. doi: 10.1111/tmi.12743. Epub 2016 Jul 26.


Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV.

Annamalay AA, Abbott S, Sikazwe C, Khoo SK, Bizzintino J, Zhang G, Laing I, Chidlow GR, Smith DW, Gern J, Goldblatt J, Lehmann D, Green RJ, Le Souëf PN.

J Clin Virol. 2016 Aug;81:58-63. doi: 10.1016/j.jcv.2016.06.002. Epub 2016 Jun 4.


Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia.

Zhang G, Wang K, Schultz E, Khoo SK, Zhang X, Annamalay A, Laing IA, Hales BJ, Goldblatt J, Le Souëf PN.

Environ Mol Mutagen. 2016 Jan;57(1):65-73. doi: 10.1002/em.21989. Epub 2015 Dec 16.


Longitudinal assessment of airway responsiveness from 1 month to 18 years in the PIAF birth cohort.

Cox DW, Mullane D, Zhang GC, Turner SW, Hayden CM, Goldblatt J, Landau LI, Le Souëf PN.

Eur Respir J. 2015 Dec;46(6):1654-61. doi: 10.1183/13993003.00397-2015. Epub 2015 Oct 22.


Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil.

Fawkner-Corbett DW, Khoo SK, Duarte CM, Bezerra PG, Bochkov YA, Gern JE, Le Souef PN, McNamara PS.

J Med Virol. 2016 Jan;88(1):58-63. doi: 10.1002/jmv.24300.


Lower anti-echovirus antibody responses in children presenting to hospital with asthma exacerbations.

Iwasaki J, Chai LY, Khoo SK, Bizzintino J, Laing IA, Le Souëf PN, Thomas WR, Hales BJ.

Clin Exp Allergy. 2015 Oct;45(10):1523-30. doi: 10.1111/cea.12501.


Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection.

Iwasaki J, Smith WA, Khoo SK, Bizzintino J, Zhang G, Cox DW, Laing IA, Le Souëf PN, Thomas WR, Hales BJ.

J Allergy Clin Immunol. 2014 Jul;134(1):25-32. doi: 10.1016/j.jaci.2014.03.014. Epub 2014 Apr 24.


Rhinovirus and the developing lung.

Cox DW, Le Souëf PN.

Paediatr Respir Rev. 2014 Sep;15(3):268-74. doi: 10.1016/j.prrv.2014.03.002. Epub 2014 Mar 27. Review.


Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop.

Bousquet J, Gern JE, Martinez FD, Anto JM, Johnson CC, Holt PG, Lemanske RF Jr, Le Souëf PN, Tepper RS, von Mutius ER, Arshad SH, Bacharier LB, Becker A, Belanger K, Bergström A, Bernstein DI, Cabana MD, Carroll KN, Castro M, Cooper PJ, Gillman MW, Gold DR, Henderson J, Heinrich J, Hong SJ, Jackson DJ, Keil T, Kozyrskyj AL, Lødrup Carlsen KC, Miller RL, Momas I, Morgan WJ, Noel P, Ownby DR, Pinart M, Ryan PH, Schwaninger JM, Sears MR, Simpson A, Smit HA, Stern DA, Subbarao P, Valenta R, Wang X, Weiss ST, Wood R, Wright AL, Wright RJ, Togias A, Gergen PJ.

J Allergy Clin Immunol. 2014 Jun;133(6):1535-46. doi: 10.1016/j.jaci.2014.01.018. Epub 2014 Mar 15.


Impact of CD14 promoter variants on measles vaccine responses and vaccine failure in children from Australia and Mozambique.

Clifford HD, Hayden CM, Khoo SK, Naniche D, Mandomando IM, Zhang G, Richmond P, Le Souëf PN.

Tissue Antigens. 2013 Dec;82(6):420-2. doi: 10.1111/tan.12226. Epub 2013 Oct 21. No abstract available.


Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions.

Cox DW, Bizzintino J, Ferrari G, Khoo SK, Zhang G, Whelan S, Lee WM, Bochkov YA, Geelhoed GC, Goldblatt J, Gern JE, Laing IA, Le Souëf PN.

Am J Respir Crit Care Med. 2013 Dec 1;188(11):1358-64. doi: 10.1164/rccm.201303-0498OC.


Reduced infant lung function, active smoking, and wheeze in 18-year-old individuals.

Mullane D, Turner SW, Cox DW, Goldblatt J, Landau LI, le Souëf PN.

JAMA Pediatr. 2013 Apr;167(4):368-73. doi: 10.1001/jamapediatrics.2013.633. Erratum in: JAMA Pediatr. 2013 Sep;167(9):873. Cox, Des [corrected to Cox, Des W].


Usefulness of parental response to questions about adherence to prescribed inhaled corticosteroids in young children.

Schultz A, Sly PD, Zhang G, Venter A, Devadason SG, le Souëf PN.

Arch Dis Child. 2012 Dec;97(12):1092-6. doi: 10.1136/archdischild-2012-302312. Epub 2012 Oct 25.


Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique.

Clifford HD, Hayden CM, Khoo SK, Naniche D, Mandomando IM, Zhang G, Richmond P, Le Souëf PN.

Vaccine. 2012 Sep 21;30(43):6180-5. doi: 10.1016/j.vaccine.2012.07.063. Epub 2012 Aug 4.


TLR3 and RIG-I gene variants: associations with functional effects on receptor expression and responses to measles virus and vaccine in vaccinated infants.

Clifford HD, Yerkovich ST, Khoo SK, Zhang G, Upham J, Le Souëf PN, Richmond P, Hayden CM.

Hum Immunol. 2012 Jun;73(6):677-85. doi: 10.1016/j.humimm.2012.03.004. Epub 2012 Apr 12.


The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial.

Guinovart C, Dobaño C, Bassat Q, Nhabomba A, Quintó L, Manaca MN, Aguilar R, Rodríguez MH, Barbosa A, Aponte JJ, Mayor AG, Renom M, Moraleda C, Roberts DJ, Schwarzer E, Le Souëf PN, Schofield L, Chitnis CE, Doolan DL, Alonso PL.

PLoS One. 2012;7(3):e32362. doi: 10.1371/journal.pone.0032362. Epub 2012 Mar 7.


CD46 measles virus receptor polymorphisms influence receptor protein expression and primary measles vaccine responses in naive Australian children.

Clifford HD, Hayden CM, Khoo SK, Zhang G, Le Souëf PN, Richmond P.

Clin Vaccine Immunol. 2012 May;19(5):704-10. doi: 10.1128/CVI.05652-11. Epub 2012 Feb 22.


Incentive device improves spacer technique but not clinical outcome in preschool children with asthma.

Schultz A, Sly PD, Zhang G, Venter A, Le Souëf PN, Devadason SG.

J Paediatr Child Health. 2012 Jan;48(1):52-6. doi: 10.1111/j.1440-1754.2011.02190.x. Epub 2011 Nov 1.


Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine.

Clifford HD, Yerkovich ST, Khoo SK, Zhang G, Upham J, Le Souëf PN, Richmond P, Hayden CM.

Immunogenetics. 2012 Mar;64(3):219-28. doi: 10.1007/s00251-011-0574-0. Epub 2011 Sep 23.


Symptomatic viral infection is associated with impaired response to treatment in children with acute asthma.

Rueter K, Bizzintino J, Martin AC, Zhang G, Hayden CM, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN.

J Pediatr. 2012 Jan;160(1):82-7. doi: 10.1016/j.jpeds.2011.06.025. Epub 2011 Aug 19.


SLAM and DC-SIGN measles receptor polymorphisms and their impact on antibody and cytokine responses to measles vaccine.

Clifford HD, Richmond P, Khoo SK, Zhang G, Yerkovich ST, Le Souëf PN, Hayden CM.

Vaccine. 2011 Jul 26;29(33):5407-13. doi: 10.1016/j.vaccine.2011.05.068. Epub 2011 Jun 7.


Regulatory role of IL10 genetic variations in determining allergen-induced T(H)2 cytokine responses in children.

Hayden CM, Zhang G, Judge PK, Khoo SK, Laing IA, Turner SW, Goldblatt J, Holt PG, Le Souëf PN.

J Allergy Clin Immunol. 2011 Jul;128(1):237-239.e8. doi: 10.1016/j.jaci.2011.02.032. Epub 2011 Mar 24. No abstract available.


Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes.

Zhang G, Hayden CM, Goldblatt J, Holt P, Le Souëf PN.

ISRN Allergy. 2011 Dec 28;2011:405813. doi: 10.5402/2011/405813. Print 2011.


Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children.

Schultz A, Le Souëf TJ, Venter A, Zhang G, Devadason SG, Le Souëf PN.

Pediatrics. 2010 Dec;126(6):e1493-8. doi: 10.1542/peds.2010-1377. Epub 2010 Nov 15.


The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma.

Schultz EN, Devadason SG, Khoo SK, Zhang G, Bizzintino JA, Martin AC, Goldblatt J, Laing IA, Le Souëf PN, Hayden CM.

J Asthma. 2010 Nov;47(9):1049-56. doi: 10.1080/02770903.2010.508856.


Association between human rhinovirus C and severity of acute asthma in children.

Bizzintino J, Lee WM, Laing IA, Vang F, Pappas T, Zhang G, Martin AC, Khoo SK, Cox DW, Geelhoed GC, McMinn PC, Goldblatt J, Gern JE, Le Souëf PN.

Eur Respir J. 2011 May;37(5):1037-42. doi: 10.1183/09031936.00092410. Epub 2010 Aug 6.


Validation of methodology for recording breathing and simulating drug delivery through spacers and valved holding chambers.

Schultz A, Le Souëf TJ, Looi K, Zhang G, Le Souëf PN, Devadason SG.

J Aerosol Med Pulm Drug Deliv. 2010 Oct;23(5):311-22. doi: 10.1089/jamp.2008.0733.


Asthma: time to confront some inconvenient truths.

Hancox RJ, Le Souëf PN, Anderson GP, Reddel HK, Chang AB, Beasley R.

Respirology. 2010 Feb;15(2):194-201. doi: 10.1111/j.1440-1843.2009.01700.x. Review.


In utero smoke exposure and role of maternal and infant glutathione s-transferase genes on airway responsiveness and lung function in infancy.

Murdzoska J, Devadason SG, Khoo SK, Landau LI, Young S, Goldblatt J, Zhang G, Le Souëf PN, Hayden CM.

Am J Respir Crit Care Med. 2010 Jan 1;181(1):64-71. doi: 10.1164/rccm.200812-1887OC. Epub 2009 Oct 22.


The importance of environment on respiratory genotype/phenotype relationships in the Inuit.

Candelaria PV, Backer V, Khoo SK, Bizzintino JA, Hayden CM, Baynam G, Laing IA, Zhang G, Porsbjerg C, Goldblatt J, Le Souëf PN; Greenlandic Study Population Group.

Allergy. 2010 Feb;65(2):229-37. doi: 10.1111/j.1398-9995.2009.02145.x. Epub 2009 Oct 1.


The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze.

Schultz A, Devadason SG, Savenije OE, Sly PD, Le Souëf PN, Brand PL.

Acta Paediatr. 2010 Jan;99(1):56-60. doi: 10.1111/j.1651-2227.2009.01508.x.


Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.

Bizzintino JA, Khoo SK, Zhang G, Martin AC, Rueter K, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN, Hayden CM.

Prostaglandins Leukot Essent Fatty Acids. 2009 Jul;81(1):9-15. doi: 10.1016/j.plefa.2009.05.022. Epub 2009 Jun 12.


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