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Items: 37

1.

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.

Nicolai S, Wegrecki M, Cheng TY, Bourgeois EA, Cotton RN, Mayfield JA, Monnot GC, Le Nours J, Van Rhijn I, Rossjohn J, Moody DB, de Jong A.

Sci Immunol. 2020 Jan 3;5(43). pii: eaax5430. doi: 10.1126/sciimmunol.aax5430. Epub 2020 Jan 3.

PMID:
31901073
2.

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J.

Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900.

PMID:
31857486
3.

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors.

Almeida CF, Sundararaj S, Le Nours J, Praveena T, Cao B, Burugupalli S, Smith DGM, Patel O, Brigl M, Pellicci DG, Williams SJ, Uldrich AP, Godfrey DI, Rossjohn J.

Nat Commun. 2019 Nov 20;10(1):5242. doi: 10.1038/s41467-019-12941-9.

4.

A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.

Reinink P, Shahine A, Gras S, Cheng TY, Farquhar R, Lopez K, Suliman SA, Reijneveld JF, Le Nours J, Tan LL, León SR, Jimenez J, Calderon R, Lecca L, Murray MB, Rossjohn J, Moody DB, Van Rhijn I.

J Immunol. 2019 Dec 15;203(12):3395-3406. doi: 10.4049/jimmunol.1900872. Epub 2019 Nov 6.

PMID:
31694911
5.

Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.

Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Pryce R, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascón JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR.

Cell Chem Biol. 2018 Jul 19;25(7):925. doi: 10.1016/j.chembiol.2018.06.008. No abstract available.

6.

Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.

Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Pryce R, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascón JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR.

Cell Chem Biol. 2018 May 17;25(5):571-584.e8. doi: 10.1016/j.chembiol.2018.02.009. Epub 2018 Mar 22. Erratum in: Cell Chem Biol. 2018 Jul 19;25(7):925.

7.

Unconventional T Cell Targets for Cancer Immunotherapy.

Godfrey DI, Le Nours J, Andrews DM, Uldrich AP, Rossjohn J.

Immunity. 2018 Mar 20;48(3):453-473. doi: 10.1016/j.immuni.2018.03.009. Review.

8.

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

Wun KS, Reijneveld JF, Cheng TY, Ladell K, Uldrich AP, Le Nours J, Miners KL, McLaren JE, Grant EJ, Haigh OL, Watkins TS, Suliman S, Iwany S, Jimenez J, Calderon R, Tamara KL, Leon SR, Murray MB, Mayfield JA, Altman JD, Purcell AW, Miles JJ, Godfrey DI, Gras S, Price DA, Van Rhijn I, Moody DB, Rossjohn J.

Nat Immunol. 2018 Apr;19(4):397-406. doi: 10.1038/s41590-018-0065-7. Epub 2018 Mar 12.

9.

Mucosal-associated invariant T cell receptor recognition of small molecules presented by MR1.

Awad W, Le Nours J, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Immunol Cell Biol. 2018 Jul;96(6):588-597. doi: 10.1111/imcb.12017. Epub 2018 Feb 27. Review.

PMID:
29393543
10.

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function.

Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1204-E1213. doi: 10.1073/pnas.1716669115. Epub 2018 Jan 19.

11.

Molecular recognition of microbial lipid-based antigens by T cells.

Gras S, Van Rhijn I, Shahine A, Le Nours J.

Cell Mol Life Sci. 2018 May;75(9):1623-1639. doi: 10.1007/s00018-018-2749-4. Epub 2018 Jan 16. Review.

12.

Molecular features of lipid-based antigen presentation by group 1 CD1 molecules.

Le Nours J, Shahine A, Gras S.

Semin Cell Dev Biol. 2018 Dec;84:48-57. doi: 10.1016/j.semcdb.2017.11.002. Epub 2017 Nov 10. Review.

PMID:
29113870
13.

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.

Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J.

Nat Commun. 2016 Oct 27;7:13257. doi: 10.1038/ncomms13257.

14.

CD1a on Langerhans cells controls inflammatory skin disease.

Kim JH, Hu Y, Yongqing T, Kim J, Hughes VA, Le Nours J, Marquez EA, Purcell AW, Wan Q, Sugita M, Rossjohn J, Winau F.

Nat Immunol. 2016 Oct;17(10):1159-66. doi: 10.1038/ni.3523. Epub 2016 Aug 22.

15.

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.

Le Nours J, Praveena T, Pellicci DG, Gherardin NA, Ross FJ, Lim RT, Besra GS, Keshipeddy S, Richardson SK, Howell AR, Gras S, Godfrey DI, Rossjohn J, Uldrich AP.

Nat Commun. 2016 Feb 15;7:10570. doi: 10.1038/ncomms10570.

16.

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.

Gherardin NA, Keller AN, Woolley RE, Le Nours J, Ritchie DS, Neeson PJ, Birkinshaw RW, Eckle SBG, Waddington JN, Liu L, Fairlie DP, Uldrich AP, Pellicci DG, McCluskey J, Godfrey DI, Rossjohn J.

Immunity. 2016 Jan 19;44(1):32-45. doi: 10.1016/j.immuni.2015.12.005. Epub 2016 Jan 12.

17.

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells.

Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB.

J Immunol. 2015 Sep 15;195(6):2540-51. doi: 10.4049/jimmunol.1501019. Epub 2015 Aug 7.

18.

The molecular bases of δ/αβ T cell-mediated antigen recognition.

Pellicci DG, Uldrich AP, Le Nours J, Ross F, Chabrol E, Eckle SB, de Boer R, Lim RT, McPherson K, Besra G, Howell AR, Moretta L, McCluskey J, Heemskerk MH, Gras S, Rossjohn J, Godfrey DI.

J Exp Med. 2014 Dec 15;211(13):2599-615. doi: 10.1084/jem.20141764. Epub 2014 Dec 1.

19.

EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit.

Ng NM, Littler DR, Paton AW, Le Nours J, Rossjohn J, Paton JC, Beddoe T.

Structure. 2013 Nov 5;21(11):2003-13. doi: 10.1016/j.str.2013.08.024. Epub 2013 Oct 3.

20.

CD1d-lipid antigen recognition by the γδ TCR.

Uldrich AP, Le Nours J, Pellicci DG, Gherardin NA, McPherson KG, Lim RT, Patel O, Beddoe T, Gras S, Rossjohn J, Godfrey DI.

Nat Immunol. 2013 Nov;14(11):1137-45. doi: 10.1038/ni.2713. Epub 2013 Sep 29.

PMID:
24076636
21.

Structural basis of subtilase cytotoxin SubAB assembly.

Le Nours J, Paton AW, Byres E, Troy S, Herdman BP, Johnson MD, Paton JC, Rossjohn J, Beddoe T.

J Biol Chem. 2013 Sep 20;288(38):27505-16. doi: 10.1074/jbc.M113.462622. Epub 2013 Aug 6.

22.

Cloning, expression, purification and preliminary X-ray diffraction studies of a novel AB₅ toxin.

Ng N, Littler D, Le Nours J, Paton AW, Paton JC, Rossjohn J, Beddoe T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug;69(Pt 8):912-5. doi: 10.1107/S1744309113018927. Epub 2013 Jul 27.

23.

Recognition of vitamin B metabolites by mucosal-associated invariant T cells.

Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J.

Nat Commun. 2013;4:2142. doi: 10.1038/ncomms3142.

PMID:
23846752
24.

MR1 presents microbial vitamin B metabolites to MAIT cells.

Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O'Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J.

Nature. 2012 Nov 29;491(7426):717-23. doi: 10.1038/nature11605. Epub 2012 Oct 10.

PMID:
23051753
25.

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor.

Patel O, Pellicci DG, Gras S, Sandoval-Romero ML, Uldrich AP, Mallevaey T, Clarke AJ, Le Nours J, Theodossis A, Cardell SL, Gapin L, Godfrey DI, Rossjohn J.

Nat Immunol. 2012 Sep;13(9):857-63. doi: 10.1038/ni.2372. Epub 2012 Jul 22.

PMID:
22820603
26.

Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.

Le Nours J, Bulloch EM, Zhang Z, Greenwood DR, Middleditch MJ, Dickson JM, Baker EN.

J Biol Chem. 2011 Nov 25;286(47):40706-16. doi: 10.1074/jbc.M111.291138. Epub 2011 Sep 28.

27.

Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors.

Pellicci DG, Clarke AJ, Patel O, Mallevaey T, Beddoe T, Le Nours J, Uldrich AP, McCluskey J, Besra GS, Porcelli SA, Gapin L, Godfrey DI, Rossjohn J.

Nat Immunol. 2011 Jul 31;12(9):827-33. doi: 10.1038/ni.2076.

28.

Activity of three β-1,4-galactanases on small chromogenic substrates.

Torpenholt S, Le Nours J, Christensen U, Jahn M, Withers S, Ostergaard PR, Borchert TV, Poulsen JC, Lo Leggio L.

Carbohydr Res. 2011 Sep 27;346(13):2028-33. doi: 10.1016/j.carres.2011.05.017. Epub 2011 May 27.

PMID:
21696710
29.

Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability.

Crellin PK, Vivian JP, Scoble J, Chow FM, West NP, Brammananth R, Proellocks NI, Shahine A, Le Nours J, Wilce MC, Britton WJ, Coppel RL, Rossjohn J, Beddoe T.

J Biol Chem. 2010 Sep 24;285(39):30050-60. doi: 10.1074/jbc.M110.150094. Epub 2010 Jul 23.

30.

Structure, biological functions and applications of the AB5 toxins.

Beddoe T, Paton AW, Le Nours J, Rossjohn J, Paton JC.

Trends Biochem Sci. 2010 Jul;35(7):411-8. doi: 10.1016/j.tibs.2010.02.003. Epub 2010 Mar 2. Review.

31.

Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase.

Scoble J, McAlister AD, Fulton Z, Troy S, Byres E, Vivian JP, Brammananth R, Wilce MC, Le Nours J, Zaker-Tabrizi L, Coppel RL, Crellin PK, Rossjohn J, Beddoe T.

J Mol Biol. 2010 Apr 23;398(1):26-39. doi: 10.1016/j.jmb.2010.02.021. Epub 2010 Feb 25.

PMID:
20188740
32.

Crystal structure of a Legionella pneumophila ecto -triphosphate diphosphohydrolase, a structural and functional homolog of the eukaryotic NTPDases.

Vivian JP, Riedmaier P, Ge H, Le Nours J, Sansom FM, Wilce MC, Byres E, Dias M, Schmidberger JW, Cowan PJ, d'Apice AJ, Hartland EL, Rossjohn J, Beddoe T.

Structure. 2010 Feb 10;18(2):228-38. doi: 10.1016/j.str.2009.11.014.

33.

Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling.

Le Nours J, De Maria L, Welner D, Jørgensen CT, Christensen LL, Borchert TV, Larsen S, Lo Leggio L.

Proteins. 2009 Jun;75(4):977-89. doi: 10.1002/prot.22310.

PMID:
19089956
34.

The structure and characterization of a modular endo-beta-1,4-mannanase from Cellulomonas fimi.

Le Nours J, Anderson L, Stoll D, Stålbrand H, Lo Leggio L.

Biochemistry. 2005 Sep 27;44(38):12700-8.

PMID:
16171384
35.

The structure of endo-beta-1,4-galactanase from Bacillus licheniformis in complex with two oligosaccharide products.

Ryttersgaard C, Le Nours J, Lo Leggio L, Jørgensen CT, Christensen LL, Bjørnvad M, Larsen S.

J Mol Biol. 2004 Jul 30;341(1):107-17.

PMID:
15312766
36.

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.

Hansen M, Le Nours J, Johansson E, Antal T, Ullrich A, Löffler M, Larsen S.

Protein Sci. 2004 Apr;13(4):1031-42.

37.

Structure of two fungal beta-1,4-galactanases: searching for the basis for temperature and pH optimum.

Le Nours J, Ryttersgaard C, Lo Leggio L, Østergaard PR, Borchert TV, Christensen LL, Larsen S.

Protein Sci. 2003 Jun;12(6):1195-204.

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