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Items: 10


Vaccination reduces fentanyl distribution to the brain and fentanyl-induced toxicity in mice and rats: a potential role for a prophylactic vaccine against fentanyl-induced overdose.

Raleigh MD, Baruffaldi F, Peterson SJ, Le Naour M, Harmon TM, Vigliaturo JR, Pentel PR, Pravetoni M.

J Pharmacol Exp Ther. 2018 Nov 8. pii: jpet.118.253674. doi: 10.1124/jpet.118.253674. [Epub ahead of print]


Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.

Le Naour M, Lunzer MM, Powers MD, Kalyuzhny AE, Benneyworth MA, Thomas MJ, Portoghese PS.

J Med Chem. 2014 Aug 14;57(15):6383-92. doi: 10.1021/jm500159d. Epub 2014 Jul 18.


Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.

Le Naour M, Akgün E, Yekkirala A, Lunzer MM, Powers MD, Kalyuzhny AE, Portoghese PS.

J Med Chem. 2013 Jul 11;56(13):5505-13. doi: 10.1021/jm4005219. Epub 2013 Jun 20.


Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.

Pravetoni M, Le Naour M, Tucker AM, Harmon TM, Hawley TM, Portoghese PS, Pentel PR.

J Med Chem. 2013 Feb 14;56(3):915-23. doi: 10.1021/jm3013745. Epub 2013 Jan 15.


Effect of oxime ether incorporation in acyl indole derivatives on PPAR subtype selectivity.

Le Naour M, Leclerc V, Farce A, Caignard DH, Hennuyer N, Staels B, Audinot-Bouchez V, Boutin JA, Lonchampt M, Dacquet C, Ktorza A, Berthelot P, Lebegue N.

ChemMedChem. 2012 Dec;7(12):2179-93. doi: 10.1002/cmdc.201200316. Epub 2012 Oct 9.


Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats.

Pravetoni M, Raleigh MD, Le Naour M, Tucker AM, Harmon TM, Jones JM, Birnbaum AK, Portoghese PS, Pentel PR.

Vaccine. 2012 Jun 29;30(31):4617-24. doi: 10.1016/j.vaccine.2012.04.101. Epub 2012 May 11.


An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia.

Pravetoni M, Le Naour M, Harmon TM, Tucker AM, Portoghese PS, Pentel PR.

J Pharmacol Exp Ther. 2012 Apr;341(1):225-32. doi: 10.1124/jpet.111.189506. Epub 2012 Jan 18.


Opioid activity of spinally selective analogues of N-naphthoyl-β-naltrexamine in HEK-293 cells and mice.

Le Naour M, Lunzer MM, Powers MD, Portoghese PS.

J Med Chem. 2012 Jan 26;55(2):670-7. doi: 10.1021/jm200902v. Epub 2012 Jan 5.


[Apropos of the pharmacologic action of the bark of Combretodendron africanum (Welw) Exel and particularly on its abortive power and its disturber on the estral cycle].

Bouquet A, Debray MM, Dauguet JC, Girre A, Leclair JF, Le Naour M, Patay R.

Therapie. 1967 Mar-Apr;22(2):325-36. French. No abstract available.


[On a toxic and oxytocic Euphorbiaceae of the Ivory Coast: Mareya micrantha Muell. Arg].

Paris R, Patay R, Moury J, Le Naour M.

Ann Pharm Fr. 1966 Mar;24(3):173-6. French. No abstract available.


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