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Items: 37


PmrC (EptA) and CptA Negatively Affect Outer Membrane Vesicle Production in Citrobacter rodentium.

Sinha A, Nyongesa S, Viau C, Gruenheid S, Veyrier FJ, Le Moual H.

J Bacteriol. 2019 Mar 13;201(7). pii: e00454-18. doi: 10.1128/JB.00454-18. Print 2019 Apr 1.


The Virulence Effect of CpxRA in Citrobacter rodentium Is Independent of the Auxiliary Proteins NlpE and CpxP.

Giannakopoulou N, Mendis N, Zhu L, Gruenheid S, Faucher SP, Le Moual H.

Front Cell Infect Microbiol. 2018 Sep 18;8:320. doi: 10.3389/fcimb.2018.00320. eCollection 2018.


Sex-hormone-driven innate antibodies protect females and infants against EPEC infection.

Zeng Z, Surewaard BGJ, Wong CHY, Guettler C, Petri B, Burkhard R, Wyss M, Le Moual H, Devinney R, Thompson GC, Blackwood J, Joffe AR, McCoy KD, Jenne CN, Kubes P.

Nat Immunol. 2018 Oct;19(10):1100-1111. doi: 10.1038/s41590-018-0211-2. Epub 2018 Sep 24.


Systematic Analysis of Two-Component Systems in Citrobacter rodentium Reveals Positive and Negative Roles in Virulence.

Thomassin JL, Leclerc JM, Giannakopoulou N, Zhu L, Salmon K, Portt A, Daigle F, Le Moual H, Gruenheid S.

Infect Immun. 2017 Jan 26;85(2). pii: e00654-16. doi: 10.1128/IAI.00654-16. Print 2017 Feb.


Microbiota-derived metabolites modulate tissue homeostasis: relevance to the oral cavity?

Le Moual H.

Oral Dis. 2016 Jul;22(5):350-2. doi: 10.1111/odi.12477. Epub 2016 Apr 26. No abstract available.


Antimicrobial Peptide Conformation as a Structural Determinant of Omptin Protease Specificity.

Brannon JR, Thomassin JL, Gruenheid S, Le Moual H.

J Bacteriol. 2015 Nov;197(22):3583-91. doi: 10.1128/JB.00469-15. Epub 2015 Sep 8.


Inhibition of outer membrane proteases of the omptin family by aprotinin.

Brannon JR, Burk DL, Leclerc JM, Thomassin JL, Portt A, Berghuis AM, Gruenheid S, Le Moual H.

Infect Immun. 2015 Jun;83(6):2300-11. doi: 10.1128/IAI.00136-15. Epub 2015 Mar 30.


The CpxRA two-component system is essential for Citrobacter rodentium virulence.

Thomassin JL, Giannakopoulou N, Zhu L, Gross J, Salmon K, Leclerc JM, Daigle F, Le Moual H, Gruenheid S.

Infect Immun. 2015 May;83(5):1919-28. doi: 10.1128/IAI.00194-15. Epub 2015 Feb 23.


Host defense peptide resistance contributes to colonization and maximal intestinal pathology by Crohn's disease-associated adherent-invasive Escherichia coli.

McPhee JB, Small CL, Reid-Yu SA, Brannon JR, Le Moual H, Coombes BK.

Infect Immun. 2014 Aug;82(8):3383-93. doi: 10.1128/IAI.01888-14. Epub 2014 May 27.


Enterohemorrhagic Escherichia coli OmpT regulates outer membrane vesicle biogenesis.

Premjani V, Tilley D, Gruenheid S, Le Moual H, Samis JA.

FEMS Microbiol Lett. 2014 Jun;355(2):185-92. doi: 10.1111/1574-6968.12463. Epub 2014 May 29.


Both group 4 capsule and lipopolysaccharide O-antigen contribute to enteropathogenic Escherichia coli resistance to human α-defensin 5.

Thomassin JL, Lee MJ, Brannon JR, Sheppard DC, Gruenheid S, Le Moual H.

PLoS One. 2013 Dec 4;8(12):e82475. doi: 10.1371/journal.pone.0082475. eCollection 2013.


Role of uropathogenic Escherichia coli OmpT in the resistance against human cathelicidin LL-37.

Brannon JR, Thomassin JL, Desloges I, Gruenheid S, Le Moual H.

FEMS Microbiol Lett. 2013 Aug;345(1):64-71. doi: 10.1111/1574-6968.12185. Epub 2013 Jun 13.


Enterohemorrhagic and enteropathogenic Escherichia coli evolved different strategies to resist antimicrobial peptides.

Thomassin JL, Brannon JR, Kaiser J, Gruenheid S, Le Moual H.

Gut Microbes. 2012 Nov-Dec;3(6):556-61. doi: 10.4161/gmic.21656. Epub 2012 Aug 16. Review.


Resistance to antimicrobial peptides in Gram-negative bacteria.

Gruenheid S, Le Moual H.

FEMS Microbiol Lett. 2012 May;330(2):81-9. doi: 10.1111/j.1574-6968.2012.02528.x. Epub 2012 Mar 12. Review.


OmpT outer membrane proteases of enterohemorrhagic and enteropathogenic Escherichia coli contribute differently to the degradation of human LL-37.

Thomassin JL, Brannon JR, Gibbs BF, Gruenheid S, Le Moual H.

Infect Immun. 2012 Feb;80(2):483-92. doi: 10.1128/IAI.05674-11. Epub 2011 Dec 5.


Absence of PmrAB-mediated phosphoethanolamine modifications of Citrobacter rodentium lipopolysaccharide affects outer membrane integrity.

Viau C, Le Sage V, Ting DK, Gross J, Le Moual H.

J Bacteriol. 2011 May;193(9):2168-76. doi: 10.1128/JB.01449-10. Epub 2011 Mar 4.


An outer membrane protease of the omptin family prevents activation of the Citrobacter rodentium PhoPQ two-component system by antimicrobial peptides.

Le Sage V, Zhu L, Lepage C, Portt A, Viau C, Daigle F, Gruenheid S, Le Moual H.

Mol Microbiol. 2009 Oct;74(1):98-111. doi: 10.1111/j.1365-2958.2009.06854.x. Epub 2009 Aug 24.


The prpZ gene cluster encoding eukaryotic-type Ser/Thr protein kinases and phosphatases is repressed by oxidative stress and involved in Salmonella enterica serovar Typhi survival in human macrophages.

Faucher SP, Viau C, Gros PP, Daigle F, Le Moual H.

FEMS Microbiol Lett. 2008 Apr;281(2):160-6. doi: 10.1111/j.1574-6968.2008.01094.x. Epub 2008 Feb 27.


Activation of the bacterial sensor kinase PhoQ by acidic pH.

Prost LR, Daley ME, Le Sage V, Bader MW, Le Moual H, Klevit RE, Miller SI.

Mol Cell. 2007 Apr 27;26(2):165-74.


Dimerization and DNA binding of the Salmonella enterica PhoP response regulator are phosphorylation independent.

Perron-Savard P, De Crescenzo G, Le Moual H.

Microbiology. 2005 Dec;151(Pt 12):3979-87.


Recognition of antimicrobial peptides by a bacterial sensor kinase.

Bader MW, Sanowar S, Daley ME, Schneider AR, Cho U, Xu W, Klevit RE, Le Moual H, Miller SI.

Cell. 2005 Aug 12;122(3):461-72.


Conformational changes in the cytoplasmic domain of the Escherichia coli aspartate receptor upon adaptive methylation.

Le Moual H, Quang T, Koshland DE Jr.

Biochemistry. 1998 Oct 20;37(42):14852-9.


Methylation of the Escherichia coli chemotaxis receptors: intra- and interdimer mechanisms.

Le Moual H, Quang T, Koshland DE Jr.

Biochemistry. 1997 Oct 28;36(43):13441-8.


Evidence that Asn542 of neprilysin (EC is involved in binding of the P2' residue of substrates and inhibitors.

Dion N, Le Moual H, Fournié-Zaluski MC, Roques BP, Crine P, Boileau G.

Biochem J. 1995 Oct 15;311 ( Pt 2):623-7.


Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11.

Le Moual H, Dion N, Roques BP, Crine P, Boileau G.

Eur J Biochem. 1994 Apr 1;221(1):475-80.


Substitution of potential metal-coordinating amino acid residues in the zinc-binding site of endopeptidase-24.11.

Le Moual H, Roques BP, Crine P, Boileau G.

FEBS Lett. 1993 Jun 14;324(2):196-200.


Charge polarity reversal inverses the specificity of neutral endopeptidase-24.11.

Beaumont A, Barbe B, Le Moual H, Boileau G, Crine P, Fournié-Zaluski MC, Roques BP.

J Biol Chem. 1992 Feb 5;267(4):2138-41.


Identification of two arginine residues involved in the binding of substrate to neutral endopeptidase 24-11.

Le Moual H, Beaumont A, Roques BP, Crine P, Boileau G.

Matrix Suppl. 1992;1:99. No abstract available.


Identification of Glu 646 of neutral endopeptidase 24-11 as a zinc binding residue.

Le Moual H, Crine P, Boileau G.

Matrix Suppl. 1992;1:100. No abstract available.


Identification of glutamic acid 646 as a zinc-coordinating residue in endopeptidase-24.11.

Le Moual H, Devault A, Roques BP, Crine P, Boileau G.

J Biol Chem. 1991 Aug 25;266(24):15670-4.


Evidence that both arginine 102 and arginine 747 are involved in substrate binding to neutral endopeptidase (EC

Beaumont A, Le Moual H, Boileau G, Crine P, Roques BP.

J Biol Chem. 1991 Jan 5;266(1):214-20.


Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

Devault A, Lazure C, Nault C, Le Moual H, Seidah NG, Chrétien M, Kahn P, Powell J, Mallet J, Beaumont A, et al.

EMBO J. 1987 May;6(5):1317-22. Erratum in: EMBO J 1987 Aug;6(8):2506.

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