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Items: 1 to 50 of 51

1.

A Simple, Universal, and Cost-Efficient Digital PCR Method for the Targeted Analysis of Copy Number Variations.

Cassinari K, Quenez O, Joly-Hélas G, Beaussire L, Le Meur N, Castelain M, Goldenberg A, Guerrot AM, Brehin AC, Deleuze JF, Boland A, Rovelet-Lecrux A, Campion D, Saugier-Veber P, Gruchy N, Frebourg T, Nicolas G, Sarafan-Vasseur N, Chambon P.

Clin Chem. 2019 Jul 10. pii: clinchem.2019.304246. doi: 10.1373/clinchem.2019.304246. [Epub ahead of print]

PMID:
31292136
2.

queryMed: Semantic Web functions for linking pharmacological and medical knowledge to data.

Rivault Y, Dameron O, Le Meur N.

Bioinformatics. 2019 Jan 18. doi: 10.1093/bioinformatics/btz034. [Epub ahead of print]

PMID:
30657867
3.

16p13.11 microduplication in 45 new patients: refined clinical significance and genotype-phenotype correlations.

Allach El Khattabi L, Heide S, Caberg JH, Andrieux J, Doco Fenzy M, Vincent-Delorme C, Callier P, Chantot-Bastaraud S, Afenjar A, Boute-Benejean O, Cordier MP, Faivre L, Francannet C, Gerard M, Goldenberg A, Masurel-Paulet A, Mosca-Boidron AL, Marle N, Moncla A, Le Meur N, Mathieu-Dramard M, Plessis G, Lesca G, Rossi M, Edery P, Delahaye-Duriez A, De Pontual L, Tabet AC, Lebbar A, Suiro L, Ioos C, Natiq A, Chafai Elalaoui S, Missirian C, Receveur A, François-Fiquet C, Garnier P, Yardin C, Laroche C, Vago P, Sanlaville D, Dupont JM, Benzacken B, Pipiras E.

J Med Genet. 2018 Oct 4. pii: jmedgenet-2018-105389. doi: 10.1136/jmedgenet-2018-105389. [Epub ahead of print]

PMID:
30287593
4.

Categorical state sequence analysis and regression tree to identify determinants of care trajectory in chronic disease: Example of end-stage renal disease.

Le Meur N, Vigneau C, Lefort M, Lebbah S, Jais JP, Daugas E, Bayat S.

Stat Methods Med Res. 2019 Jun;28(6):1731-1740. doi: 10.1177/0962280218774811. Epub 2018 May 9.

5.

MED13L-related intellectual disability: involvement of missense variants and delineation of the phenotype.

Smol T, Petit F, Piton A, Keren B, Sanlaville D, Afenjar A, Baker S, Bedoukian EC, Bhoj EJ, Bonneau D, Boudry-Labis E, Bouquillon S, Boute-Benejean O, Caumes R, Chatron N, Colson C, Coubes C, Coutton C, Devillard F, Dieux-Coeslier A, Doco-Fenzy M, Ewans LJ, Faivre L, Fassi E, Field M, Fournier C, Francannet C, Genevieve D, Giurgea I, Goldenberg A, Green AK, Guerrot AM, Heron D, Isidor B, Keena BA, Krock BL, Kuentz P, Lapi E, Le Meur N, Lesca G, Li D, Marey I, Mignot C, Nava C, Nesbitt A, Nicolas G, Roche-Lestienne C, Roscioli T, Satre V, Santani A, Stefanova M, Steinwall Larsen S, Saugier-Veber P, Picker-Minh S, Thuillier C, Verloes A, Vieville G, Wenzel M, Willems M, Whalen S, Zarate YA, Ziegler A, Manouvrier-Hanu S, Kalscheuer VM, Gerard B, Ghoumid J.

Neurogenetics. 2018 May;19(2):93-103. doi: 10.1007/s10048-018-0541-0. Epub 2018 Mar 6.

PMID:
29511999
6.

Does the edge effect impact on the measure of spatial accessibility to healthcare providers?

Gao F, Kihal W, Le Meur N, Souris M, Deguen S.

Int J Health Geogr. 2017 Dec 11;16(1):46. doi: 10.1186/s12942-017-0119-3.

7.

[The use of administrative health databases in infectious disease epidemiology and public health].

Fonteneau L, Le Meur N, Cohen-Akenine A, Pessel C, Brouard C, Delon F, Desjeux G, Durand J, Kirchgesner J, Lapidus N, Lemaitre M, Tala S, Thiébaut A, Watier L, Rudant J, Guillon-Grammatico L.

Rev Epidemiol Sante Publique. 2017 Oct;65 Suppl 4:S174-S182. doi: 10.1016/j.respe.2017.03.131. Epub 2017 Jun 16. French.

PMID:
28624133
8.

Facilitating access to the renal transplant waiting list does not increase the number of transplantations: comparative study of two French regions.

Lefort M, Vigneau C, Laurent A, Lebbah S, Le Meur N, Jais JP, Daugas E, Bayat S.

Clin Kidney J. 2016 Dec;9(6):849-857. Epub 2016 Sep 9.

9.

Xq28 duplication including MECP2 in six unreported affected females: what can we learn for diagnosis and genetic counselling?

El Chehadeh S, Touraine R, Prieur F, Reardon W, Bienvenu T, Chantot-Bastaraud S, Doco-Fenzy M, Landais E, Philippe C, Marle N, Callier P, Mosca-Boidron AL, Mugneret F, Le Meur N, Goldenberg A, Guerrot AM, Chambon P, Satre V, Coutton C, Jouk PS, Devillard F, Dieterich K, Afenjar A, Burglen L, Moutard ML, Addor MC, Lebon S, Martinet D, Alessandri JL, Doray B, Miguet M, Devys D, Saugier-Veber P, Drunat S, Aral B, Kremer V, Rondeau S, Tabet AC, Thevenon J, Thauvin-Robinet C, Perreton N, Des Portes V, Faivre L.

Clin Genet. 2017 Apr;91(4):576-588. doi: 10.1111/cge.12898. Epub 2017 Feb 16.

PMID:
27761913
10.

Assessment of the spatial accessibility to health professionals at French census block level.

Gao F, Kihal W, Le Meur N, Souris M, Deguen S.

Int J Equity Health. 2016 Aug 2;15(1):125. doi: 10.1186/s12939-016-0411-z.

11.

Pregnancy outcomes in prenatally diagnosed 47, XXX and 47, XYY syndromes: a 30-year French, retrospective, multicentre study.

Gruchy N, Blondeel E, Le Meur N, Joly-Hélas G, Chambon P, Till M, Herbaux M, Vigouroux-Castera A, Coussement A, Lespinasse J, Amblard F, Jimenez Pocquet M, Lebel-Roy C, Carré-Pigeon F, Flori E, Mugneret F, Jaillard S, Yardin C, Harbuz R, Collonge-Rame MA, Vago P, Valduga M, Leporrier N, Vialard F.

Prenat Diagn. 2016 Jun;36(6):523-9. doi: 10.1002/pd.4817. Epub 2016 May 10.

PMID:
27018091
12.

Health insurance database for post-discharge surveillance of surgical site infection following arthroplasty.

Le Meur N, Grammatico-Guillon L, Wang S, Astagneau P.

J Hosp Infect. 2016 Feb;92(2):140-6. doi: 10.1016/j.jhin.2015.10.006. Epub 2015 Oct 26.

PMID:
26679729
13.

A French multicenter study of over 700 patients with 22q11 deletions diagnosed using FISH or aCGH.

Poirsier C, Besseau-Ayasse J, Schluth-Bolard C, Toutain J, Missirian C, Le Caignec C, Bazin A, de Blois MC, Kuentz P, Catty M, Choiset A, Plessis G, Basinko A, Letard P, Flori E, Jimenez M, Valduga M, Landais E, Lallaoui H, Cartault F, Lespinasse J, Martin-Coignard D, Callier P, Pebrel-Richard C, Portnoi MF, Busa T, Receveur A, Amblard F, Yardin C, Harbuz R, Prieur F, Le Meur N, Pipiras E, Kleinfinger P, Vialard F, Doco-Fenzy M.

Eur J Hum Genet. 2016 Jun;24(6):844-51. doi: 10.1038/ejhg.2015.219. Epub 2015 Oct 28.

14.
15.

Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells.

Nizard P, Ezan F, Bonnier D, Le Meur N, Langouët S, Baffet G, Arlot-Bonnemains Y, Théret N.

BMC Genomics. 2014 Dec 23;15:1169. doi: 10.1186/1471-2164-15-1169.

16.

Pregnancy outcomes of prenatally diagnosed Turner syndrome: a French multicenter retrospective study including a series of 975 cases.

Gruchy N, Vialard F, Blondeel E, Le Meur N, Joly-Hélas G, Chambon P, Till M, Herbaut-Graux M, Vigouroux-Castera A, Coussement A, Lespinasse J, Amblard F, Jimenez M, Lebel Roy Camille L, Carré-Pigeon F, Flori E, Mugneret F, Jaillard S, Yardin C, Harbuz R, Collonge Rame M, Vago P, Valduga M, Leporrier N.

Prenat Diagn. 2014 Dec;34(12):1133-8. doi: 10.1002/pd.4439. Epub 2014 Jul 22.

PMID:
24961405
17.

Clinical assessment of five patients with BRWD3 mutation at Xq21.1 gives further evidence for mild to moderate intellectual disability and macrocephaly.

Grotto S, Drouin-Garraud V, Ounap K, Puusepp-Benazzouz H, Schuurs-Hoeijmakers J, Le Meur N, Chambon P, Fehrenbach S, van Bokhoven H, Frébourg T, de Brouwer AP, Saugier-Veber P.

Eur J Med Genet. 2014 Apr;57(5):200-6. doi: 10.1016/j.ejmg.2013.12.012. Epub 2014 Jan 22.

PMID:
24462886
18.

A French collaborative survey of 272 fetuses with 22q11.2 deletion: ultrasound findings, fetal autopsies and pregnancy outcomes.

Besseau-Ayasse J, Violle-Poirsier C, Bazin A, Gruchy N, Moncla A, Girard F, Till M, Mugneret F, Coussement A, Pelluard F, Jimenez M, Vago P, Portnoï MF, Dupont C, Beneteau C, Amblard F, Valduga M, Bresson JL, Carré-Pigeon F, Le Meur N, Tapia S, Yardin C, Receveur A, Lespinasse J, Pipiras E, Beaujard MP, Teboul P, Brisset S, Catty M, Nowak E, Douet Guilbert N, Lallaoui H, Bouquillon S, Gatinois V, Joly-Helas G, Prieur F, Cartault F, Martin D, Kleinfinger P, Molina Gomes D, Doco-Fenzy M, Vialard F.

Prenat Diagn. 2014 May;34(5):424-30. doi: 10.1002/pd.4321. Epub 2014 Feb 12.

PMID:
24395195
19.

Measuring the evolution of ontology complexity: the gene ontology case study.

Dameron O, Bettembourg C, Le Meur N.

PLoS One. 2013 Oct 11;8(10):e75993. doi: 10.1371/journal.pone.0075993. eCollection 2013.

20.

A statistical procedure to create a neighborhood socioeconomic index for health inequalities analysis.

Lalloué B, Monnez JM, Padilla C, Kihal W, Le Meur N, Zmirou-Navier D, Deguen S.

Int J Equity Health. 2013 Mar 28;12:21. doi: 10.1186/1475-9276-12-21.

21.

Computational methods for evaluation of cell-based data assessment--Bioconductor.

Le Meur N.

Curr Opin Biotechnol. 2013 Feb;24(1):105-11. doi: 10.1016/j.copbio.2012.09.003. Epub 2012 Oct 10. Review.

PMID:
23062230
22.

Toward new insights on the white blood cell differential by flow cytometry: a proof of concept study on the sepsis model.

Roussel M, Gros A, Gacouin A, Le Meur N, Le Tulzo Y, Fest T.

Cytometry B Clin Cytom. 2012 Nov;82(6):345-52. doi: 10.1002/cyto.b.21027. Epub 2012 May 9.

23.

Analyzing biological data using R: methods for graphs and networks.

Le Meur N, Gentleman R.

Methods Mol Biol. 2012;804:343-73. doi: 10.1007/978-1-61779-361-5_19.

PMID:
22144163
24.

Pregnancy outcomes in 188 French cases of prenatally diagnosed Klinefelter syndrome.

Gruchy N, Vialard F, Decamp M, Choiset A, Rossi A, Le Meur N, Moirot H, Yardin C, Bonnet-Dupeyron MN, Lespinasse J, Herbaut-Graux M, Till M, Layet V, Leporrier N.

Hum Reprod. 2011 Sep;26(9):2570-5. doi: 10.1093/humrep/der193. Epub 2011 Jul 5.

PMID:
21733853
25.

RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.

Gilot D, Le Meur N, Giudicelli F, Le Vée M, Lagadic-Gossmann D, Théret N, Fardel O.

PLoS One. 2011 Mar 29;6(3):e18261. doi: 10.1371/journal.pone.0018261.

26.

Development of a nonfluorescent multiplex semiquantitative polymerase chain reaction to confirm rearrangements detected by array-comparative genomic hybridization.

Huin V, Drouot N, Chambon P, Le Meur N, Frébourg T, Tosi M, Saugier-Veber P.

Genet Test Mol Biomarkers. 2011 Jul-Aug;15(7-8):469-74. doi: 10.1089/gtmb.2010.0144. Epub 2011 Mar 17.

PMID:
21413874
27.

MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations.

Le Meur N, Holder-Espinasse M, Jaillard S, Goldenberg A, Joriot S, Amati-Bonneau P, Guichet A, Barth M, Charollais A, Journel H, Auvin S, Boucher C, Kerckaert JP, David V, Manouvrier-Hanu S, Saugier-Veber P, Frébourg T, Dubourg C, Andrieux J, Bonneau D.

J Med Genet. 2010 Jan;47(1):22-9. doi: 10.1136/jmg.2009.069732. Epub 2009 Jul 9.

28.

Modeling synthetic lethality.

Le Meur N, Gentleman R.

Genome Biol. 2008;9(9):R135. doi: 10.1186/gb-2008-9-9-r135. Epub 2008 Sep 12.

29.

M@IA: a modular open-source application for microarray workflow and integrative datamining.

Le Béchec A, Zindy P, Sierocinski T, Petritis D, Bihouée A, Le Meur N, Léger J, Théret N.

In Silico Biol. 2008;8(1):63-9.

PMID:
18430991
30.

Using flowViz to visualize flow cytometry data.

Sarkar D, Le Meur N, Gentleman R.

Bioinformatics. 2008 Mar 15;24(6):878-9. doi: 10.1093/bioinformatics/btn021. Epub 2008 Feb 1.

31.

Data quality assessment of ungated flow cytometry data in high throughput experiments.

Le Meur N, Rossini A, Gasparetto M, Smith C, Brinkman RR, Gentleman R.

Cytometry A. 2007 Jun;71(6):393-403.

32.

Contrasting gene expression profiles in two canine models of atrial fibrillation.

Cardin S, Libby E, Pelletier P, Le Bouter S, Shiroshita-Takeshita A, Le Meur N, Léger J, Demolombe S, Ponton A, Glass L, Nattel S.

Circ Res. 2007 Feb 16;100(3):425-33. Epub 2007 Jan 18.

PMID:
17234964
33.

Transcriptome profiling uncovers metabolic and regulatory processes occurring during the transition from desiccation-sensitive to desiccation-tolerant stages in Medicago truncatula seeds.

Buitink J, Leger JJ, Guisle I, Vu BL, Wuillème S, Lamirault G, Le Bars A, Le Meur N, Becker A, Küster H, Leprince O.

Plant J. 2006 Sep;47(5):735-50.

34.

Data standards for flow cytometry.

Spidlen J, Gentleman RC, Haaland PD, Langille M, Le Meur N, Ochs MF, Schmitt C, Smith CA, Treister AS, Brinkman RR.

OMICS. 2006 Summer;10(2):209-14. Review.

35.

Cellular gene expression survey of PseudoRabies Virus (PRV) infected Human Embryonic Kidney cells (HEK-293).

Blanchard Y, Le Meur N, Le Cunff M, Blanchard P, Léger J, Jestin A.

Vet Res. 2006 Sep-Oct;37(5):705-23. Epub 2006 Jul 6.

36.

Simple detection of genomic microdeletions and microduplications using QMPSF in patients with idiopathic mental retardation.

Saugier-Veber P, Goldenberg A, Drouin-Garraud V, de La Rochebrochard C, Layet V, Drouot N, Le Meur N, Gilbert-Du-Ssardier B, Joly-Hélas G, Moirot H, Rossi A, Tosi M, Frébourg T.

Eur J Hum Genet. 2006 Sep;14(9):1009-17. Epub 2006 Jun 14.

37.

Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer.

Le Jan S, Le Meur N, Cazes A, Philippe J, Le Cunff M, Léger J, Corvol P, Germain S.

FEBS Lett. 2006 Jun 12;580(14):3395-400. Epub 2006 May 11.

38.

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.

Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerrière A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D.

Nat Genet. 2006 Jan;38(1):24-6. Epub 2005 Dec 20.

PMID:
16369530
39.

Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line.

Troadec MB, Glaise D, Lamirault G, Le Cunff M, Guérin E, Le Meur N, Détivaud L, Zindy P, Leroyer P, Guisle I, Duval H, Gripon P, Théret N, Boudjema K, Guguen-Guillouzo C, Brissot P, Léger JJ, Loréal O.

Genomics. 2006 Jan;87(1):93-103. Epub 2005 Dec 1.

40.

Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man.

Lamirault G, Gaborit N, Le Meur N, Chevalier C, Lande G, Demolombe S, Escande D, Nattel S, Léger JJ, Steenman M.

J Mol Cell Cardiol. 2006 Jan;40(1):173-84. Epub 2005 Oct 19.

PMID:
16242148
41.

Gene expression profiling in human cardiovascular disease.

Steenman M, Lamirault G, Le Meur N, Léger JJ.

Clin Chem Lab Med. 2005;43(7):696-701. Review.

PMID:
16207127
42.

Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.

Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S.

Circulation. 2005 Jul 26;112(4):471-81. Epub 2005 Jul 18.

PMID:
16027256
43.

Profiling dendritic cell maturation with dedicated microarrays.

McIlroy D, Tanguy-Royer S, Le Meur N, Guisle I, Royer PJ, Léger J, Meflah K, Grégoire M.

J Leukoc Biol. 2005 Sep;78(3):794-803. Epub 2005 Jun 16.

PMID:
15961579
44.

Molecular characterization of a 14q deletion in a boy with features of Holt-Oram syndrome.

Le Meur N, Goldenberg A, Michel-Adde C, Drouin-Garraud V, Blaysat G, Marret S, Amara SA, Moirot H, Joly-Hélas G, Mace B, Kleinfinger P, Saugier-Veber P, Frébourg T, Rossi A.

Am J Med Genet A. 2005 May 1;134(4):439-42.

PMID:
15810003
45.

Distinct molecular portraits of human failing hearts identified by dedicated cDNA microarrays.

Steenman M, Lamirault G, Le Meur N, Le Cunff M, Escande D, Léger JJ.

Eur J Heart Fail. 2005 Mar 2;7(2):157-65.

46.

DNA chip technology in cardiovascular research.

Lamirault G, Steenman M, Le Meur N, Demolombe S, Trochu JN, Léger JJ.

Arch Mal Coeur Vaiss. 2004 Dec;97(12):1251-5. Review.

PMID:
15669368
47.

A dynamic, web-accessible resource to process raw microarray scan data into consolidated gene expression values: importance of replication.

Le Meur N, Lamirault G, Bihouée A, Steenman M, Bédrine-Ferran H, Teusan R, Ramstein G, Léger JJ.

Nucleic Acids Res. 2004 Oct 8;32(18):5349-58. Print 2004.

48.

Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability.

Killian A, Le Meur N, Sesboüé R, Bourguignon J, Bougeard G, Gautherot J, Bastard C, Frébourg T, Flaman JM.

Oncogene. 2004 Nov 11;23(53):8597-602.

PMID:
15467761
49.

Transcriptome variations in human CaCo-2 cells: a model for enterocyte differentiation and its link to iron absorption.

Bédrine-Ferran H, Le Meur N, Gicquel I, Le Cunff M, Soriano N, Guisle I, Mottier S, Monnier A, Teusan R, Fergelot P, Le Gall JY, Léger J, Mosser J.

Genomics. 2004 May;83(5):772-89.

PMID:
15081108
50.

Complete germline deletion of the STK11 gene in a family with Peutz-Jeghers syndrome.

Le Meur N, Martin C, Saugier-Veber P, Joly G, Lemoine F, Moirot H, Rossi A, Bachy B, Cabot A, Joly P, Frébourg T.

Eur J Hum Genet. 2004 May;12(5):415-8.

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