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Items: 28


The translational regulator FMRP controls lipid and glucose metabolism in mice and humans.

Leboucher A, Pisani DF, Martinez-Gili L, Chilloux J, Bermudez-Martin P, Van Dijck A, Ganief T, Macek B, Becker JAJ, Le Merrer J, Kooy RF, Amri EZ, Khandjian EW, Dumas ME, Davidovic L.

Mol Metab. 2019 Mar;21:22-35. doi: 10.1016/j.molmet.2019.01.002. Epub 2019 Jan 14.


Back-translating behavioral intervention for autism spectrum disorders to mice with blunted reward restores social abilities.

Pujol CN, Pellissier LP, Clément C, Becker JAJ, Le Merrer J.

Transl Psychiatry. 2018 Sep 21;8(1):197. doi: 10.1038/s41398-018-0247-y.


LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.

Frantz MC, Pellissier LP, Pflimlin E, Loison S, Gandía J, Marsol C, Durroux T, Mouillac B, Becker JAJ, Le Merrer J, Valencia C, Villa P, Bonnet D, Hibert M.

J Med Chem. 2018 Oct 11;61(19):8670-8692. doi: 10.1021/acs.jmedchem.8b00697. Epub 2018 Sep 24.


μ opioid receptor, social behaviour and autism spectrum disorder: reward matters.

Pellissier LP, Gandía J, Laboute T, Becker JAJ, Le Merrer J.

Br J Pharmacol. 2018 Jul;175(14):2750-2769. doi: 10.1111/bph.13808. Epub 2017 May 4. Review.


Delta Opioid Receptors: Learning and Motivation.

Pellissier LP, Pujol CN, Becker JAJ, Le Merrer J.

Handb Exp Pharmacol. 2018;247:227-260. doi: 10.1007/164_2016_89. Review.


Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons.

Tabet R, Moutin E, Becker JA, Heintz D, Fouillen L, Flatter E, Krężel W, Alunni V, Koebel P, Dembélé D, Tassone F, Bardoni B, Mandel JL, Vitale N, Muller D, Le Merrer J, Moine H.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3619-28. doi: 10.1073/pnas.1522631113. Epub 2016 May 27.


Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol.

Becker JAJ, Kieffer BL, Le Merrer J.

Addict Biol. 2017 Sep;22(5):1205-1217. doi: 10.1111/adb.12405. Epub 2016 Apr 28.


Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.

Meirsman AC, Le Merrer J, Pellissier LP, Diaz J, Clesse D, Kieffer BL, Becker JA.

Biol Psychiatry. 2016 Jun 1;79(11):917-27. doi: 10.1016/j.biopsych.2015.05.020. Epub 2015 Jun 6.


Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.

Becker JA, Clesse D, Spiegelhalter C, Schwab Y, Le Merrer J, Kieffer BL.

Neuropsychopharmacology. 2014 Aug;39(9):2049-60. doi: 10.1038/npp.2014.59. Epub 2014 Mar 12.


Impaired hippocampus-dependent and facilitated striatum-dependent behaviors in mice lacking the δ opioid receptor.

Le Merrer J, Rezai X, Scherrer G, Becker JA, Kieffer BL.

Neuropsychopharmacology. 2013 May;38(6):1050-9. doi: 10.1038/npp.2013.1. Epub 2013 Jan 4.


In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile.

Faget L, Erbs E, Le Merrer J, Scherrer G, Matifas A, Benturquia N, Noble F, Decossas M, Koch M, Kessler P, Vonesch JL, Schwab Y, Kieffer BL, Massotte D.

J Neurosci. 2012 May 23;32(21):7301-10. doi: 10.1523/JNEUROSCI.0185-12.2012.


Cholecystokinin knock-down in the basolateral amygdala has anxiolytic and antidepressant-like effects in mice.

Del Boca C, Lutz PE, Le Merrer J, Koebel P, Kieffer BL.

Neuroscience. 2012 Aug 30;218:185-95. doi: 10.1016/j.neuroscience.2012.05.022. Epub 2012 May 18.


Cues predicting drug or food reward restore morphine-induced place conditioning in mice lacking delta opioid receptors.

Le Merrer J, Faget L, Matifas A, Kieffer BL.

Psychopharmacology (Berl). 2012 Sep;223(1):99-106. doi: 10.1007/s00213-012-2693-1. Epub 2012 Apr 18.


Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network.

Le Merrer J, Befort K, Gardon O, Filliol D, Darcq E, Dembele D, Becker JA, Kieffer BL.

Addict Biol. 2012 Jan;17(1):1-12. doi: 10.1111/j.1369-1600.2011.00365.x. Epub 2011 Sep 28.


Deletion of the δ opioid receptor gene impairs place conditioning but preserves morphine reinforcement.

Le Merrer J, Plaza-Zabala A, Del Boca C, Matifas A, Maldonado R, Kieffer BL.

Biol Psychiatry. 2011 Apr 1;69(7):700-3. doi: 10.1016/j.biopsych.2010.10.021. Epub 2010 Dec 17.


Reward processing by the opioid system in the brain.

Le Merrer J, Becker JA, Befort K, Kieffer BL.

Physiol Rev. 2009 Oct;89(4):1379-412. doi: 10.1152/physrev.00005.2009. Review.


Self-administration of the GABAA agonist muscimol into the medial septum: dependence on dopaminergic mechanisms.

Gavello-Baudy S, Le Merrer J, Decorte L, David V, Cazala P.

Psychopharmacology (Berl). 2008 Dec;201(2):219-28. doi: 10.1007/s00213-008-1263-z. Epub 2008 Aug 1.


Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala.

Befort K, Filliol D, Ghate A, Darcq E, Matifas A, Muller J, Lardenois A, Thibault C, Dembele D, Le Merrer J, Becker JA, Poch O, Kieffer BL.

Eur J Neurosci. 2008 Jun;27(11):2973-84. doi: 10.1111/j.1460-9568.2008.06273.x.


Systematic gene expression mapping clusters nuclear receptors according to their function in the brain.

Gofflot F, Chartoire N, Vasseur L, Heikkinen S, Dembele D, Le Merrer J, Auwerx J.

Cell. 2007 Oct 19;131(2):405-18.


Morphine self-administration into the lateral septum depends on dopaminergic mechanisms: Evidence from pharmacology and Fos neuroimaging.

Le Merrer J, Gavello-Baudy S, Galey D, Cazala P.

Behav Brain Res. 2007 Jun 18;180(2):203-17. Epub 2007 Mar 16.


Modulation of anxiety by mu-opioid receptors of the lateral septal region in mice.

Le Merrer J, Cagniard B, Cazala P.

Pharmacol Biochem Behav. 2006 Mar;83(3):465-79. Epub 2006 Apr 19.


Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice.

Mead AN, Brown G, Le Merrer J, Stephens DN.

Psychopharmacology (Berl). 2005 Apr;179(1):164-71. Epub 2004 Dec 24.


First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice.

Béracochéa D, Cagnard B, Célérier A, le Merrer J, Pérès M, Piérard C.

Neuroreport. 2001 Feb 12;12(2):375-8.


Cognitive neuropharmacology: new perspectives for the pharmacology of cognition.

Le Merrer J, Noguès X.

Pharmacol Res. 2000 May;41(5):503-14. Review.


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