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Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.

Regazzetti C, Dumas K, Lacas-Gervais S, Pastor F, Peraldi P, Bonnafous S, Dugail I, Le Lay S, Valet P, Le Marchand-Brustel Y, Tran A, Gual P, Tanti JF, Cormont M, Giorgetti-Peraldi S.

Endocrinology. 2015 Mar;156(3):789-801. doi: 10.1210/en.2014-1656. Epub 2014 Dec 18.


Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice.

Garcia S, Dirat B, Tognacci T, Rochet N, Mouska X, Bonnafous S, Patouraux S, Tran A, Gual P, Le Marchand-Brustel Y, Gennero I, Gouze E.

Sci Transl Med. 2013 Sep 18;5(203):203ra124. doi: 10.1126/scitranslmed.3006247.


Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes.

Regazzetti C, Dumas K, Le Marchand-Brustel Y, Peraldi P, Tanti JF, Giorgetti-Peraldi S.

PLoS One. 2012;7(12):e52154. doi: 10.1371/journal.pone.0052154. Epub 2012 Dec 18.


Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.

Vazquez-Chantada M, Gonzalez-Lahera A, Martinez-Arranz I, Garcia-Monzon C, Regueiro MM, Garcia-Rodriguez JL, Schlangen KA, Mendibil I, Rodriguez-Ezpeleta N, Lozano JJ, Banasik K, Justesen JM, Joergensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Veyrie N, Clement K, Tordjman J, Tran A, Le Marchand-Brustel Y, Buque X, Aspichueta P, Echevarria-Uraga JJ, Martin-Duce A, Caballeria J, Gual P, Castro A, Mato JM, Martinez-Chantar ML, Aransay AM.

Hepatology. 2013 Feb;57(2):505-14. doi: 10.1002/hep.26052. Epub 2012 Nov 27.


Deciphering the role of GLUT4 N-glycosylation in adipocyte and muscle cell models.

Zaarour N, Berenguer M, Le Marchand-Brustel Y, Govers R.

Biochem J. 2012 Jul 15;445(2):265-73. doi: 10.1042/BJ20120232.


The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease.

Patouraux S, Bonnafous S, Voican CS, Anty R, Saint-Paul MC, Rosenthal-Allieri MA, Agostini H, Njike M, Barri-Ova N, Naveau S, Le Marchand-Brustel Y, Veillon P, Calès P, Perlemuter G, Tran A, Gual P.

PLoS One. 2012;7(4):e35612. doi: 10.1371/journal.pone.0035612. Epub 2012 Apr 18.


Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression.

Barr J, Caballería J, Martínez-Arranz I, Domínguez-Díez A, Alonso C, Muntané J, Pérez-Cormenzana M, García-Monzón C, Mayo R, Martín-Duce A, Romero-Gómez M, Lo Iacono O, Tordjman J, Andrade RJ, Pérez-Carreras M, Le Marchand-Brustel Y, Tran A, Fernández-Escalante C, Arévalo E, García-Unzueta M, Clement K, Crespo J, Gual P, Gómez-Fleitas M, Martínez-Chantar ML, Castro A, Lu SC, Vázquez-Chantada M, Mato JM.

J Proteome Res. 2012 Apr 6;11(4):2521-32. doi: 10.1021/pr201223p. Epub 2012 Mar 15.


Metformin and cancer therapy.

Bost F, Sahra IB, Le Marchand-Brustel Y, Tanti JF.

Curr Opin Oncol. 2012 Jan;24(1):103-8. doi: 10.1097/CCO.0b013e32834d8155. Review.


Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

Ben Sahra I, Regazzetti C, Robert G, Laurent K, Le Marchand-Brustel Y, Auberger P, Tanti JF, Giorgetti-Peraldi S, Bost F.

Cancer Res. 2011 Jul 1;71(13):4366-72. doi: 10.1158/0008-5472.CAN-10-1769. Epub 2011 May 3.


Serum markers of hepatocyte death and apoptosis are non invasive biomarkers of severe fibrosis in patients with alcoholic liver disease.

Lavallard VJ, Bonnafous S, Patouraux S, Saint-Paul MC, Rousseau D, Anty R, Le Marchand-Brustel Y, Tran A, Gual P.

PLoS One. 2011 Mar 18;6(3):e17599. doi: 10.1371/journal.pone.0017599.


C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients.

Zimmermann E, Anty R, Tordjman J, Verrijken A, Gual P, Tran A, Iannelli A, Gugenheim J, Bedossa P, Francque S, Le Marchand-Brustel Y, Clement K, Van Gaal L, Sørensen TIA, Jess T.

J Hepatol. 2011 Sep;55(3):660-665. doi: 10.1016/j.jhep.2010.12.017. Epub 2011 Jan 14.


Dimethyl sulfoxide enhances GLUT4 translocation through a reduction in GLUT4 endocytosis in insulin-stimulated 3T3-L1 adipocytes.

Berenguer M, Zhang J, Bruce MC, Martinez L, Gonzalez T, Gurtovenko AA, Xu T, Le Marchand-Brustel Y, Govers R.

Biochimie. 2011 Apr;93(4):697-709. doi: 10.1016/j.biochi.2010.12.013. Epub 2010 Dec 30.


A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.

Berenguer M, Martinez L, Giorgetti-Peraldi S, Le Marchand-Brustel Y, Govers R.

PLoS One. 2010 Dec 20;5(12):e15560. doi: 10.1371/journal.pone.0015560.


A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients.

Anty R, Iannelli A, Patouraux S, Bonnafous S, Lavallard VJ, Senni-Buratti M, Amor IB, Staccini-Myx A, Saint-Paul MC, Berthier F, Huet PM, Le Marchand-Brustel Y, Gugenheim J, Gual P, Tran A.

Aliment Pharmacol Ther. 2010 Dec;32(11-12):1315-22. doi: 10.1111/j.1365-2036.2010.04480.x. Epub 2010 Oct 7.


Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients.

Bertola A, Bonnafous S, Anty R, Patouraux S, Saint-Paul MC, Iannelli A, Gugenheim J, Barr J, Mato JM, Le Marchand-Brustel Y, Tran A, Gual P.

PLoS One. 2010 Oct 22;5(10):e13577. doi: 10.1371/journal.pone.0013577.


Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.

Jager J, Corcelle V, Grémeaux T, Laurent K, Waget A, Pagès G, Binétruy B, Le Marchand-Brustel Y, Burcelin R, Bost F, Tanti JF.

Diabetologia. 2011 Jan;54(1):180-9. doi: 10.1007/s00125-010-1944-0. Epub 2010 Oct 15.


Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease.

Barr J, Vázquez-Chantada M, Alonso C, Pérez-Cormenzana M, Mayo R, Galán A, Caballería J, Martín-Duce A, Tran A, Wagner C, Luka Z, Lu SC, Castro A, Le Marchand-Brustel Y, Martínez-Chantar ML, Veyrie N, Clément K, Tordjman J, Gual P, Mato JM.

J Proteome Res. 2010 Sep 3;9(9):4501-12. doi: 10.1021/pr1002593.


Metformin in cancer therapy: a new perspective for an old antidiabetic drug?

Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, Bost F.

Mol Cancer Ther. 2010 May;9(5):1092-9. doi: 10.1158/1535-7163.MCT-09-1186. Epub 2010 May 4. Review.


Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.

Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, Le Marchand-Brustel Y, Giorgetti-Peraldi S, Cormont M, Bertolotto C, Deckert M, Auberger P, Tanti JF, Bost F.

Cancer Res. 2010 Mar 15;70(6):2465-75. doi: 10.1158/0008-5472.CAN-09-2782. Epub 2010 Mar 9.


Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling.

Martinez L, Berenguer M, Bruce MC, Le Marchand-Brustel Y, Govers R.

Biochem Pharmacol. 2010 May 1;79(9):1300-9. doi: 10.1016/j.bcp.2009.12.013. Epub 2009 Dec 21.


Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.

Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, Richard-Bulteau H, Vignaud A, Baas D, Defour A, Freyssenet D, Tanti JF, Le-Marchand-Brustel Y, Ferrier B, Conjard-Duplany A, Romanino K, Bauché S, Hantaï D, Mueller M, Kozma SC, Thomas G, Rüegg MA, Ferry A, Pende M, Bigard X, Koulmann N, Schaeffer L, Gangloff YG.

J Cell Biol. 2009 Dec 14;187(6):859-74. doi: 10.1083/jcb.200903131.


Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes.

Regazzetti C, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S.

J Biol Chem. 2010 Feb 19;285(8):5157-64. doi: 10.1074/jbc.M109.047688. Epub 2009 Dec 8.


GLUT4 molecules are recruited at random for insertion within the plasma membrane upon insulin stimulation.

Berenguer M, Le Marchand-Brustel Y, Govers R.

FEBS Lett. 2010 Feb 5;584(3):537-42. doi: 10.1016/j.febslet.2009.11.093. Epub 2009 Dec 4.


Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.

Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF.

Diabetes. 2010 Jan;59(1):61-70. doi: 10.2337/db09-0470. Epub 2009 Oct 6.


Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.

Kaddai V, Gonzalez T, Keslair F, Grémeaux T, Bonnafous S, Gugenheim J, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M.

PLoS One. 2009 Apr 17;4(4):e5257. doi: 10.1371/journal.pone.0005257.


Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis.

Deveaux V, Cadoudal T, Ichigotani Y, Teixeira-Clerc F, Louvet A, Manin S, Nhieu JT, Belot MP, Zimmer A, Even P, Cani PD, Knauf C, Burcelin R, Bertola A, Le Marchand-Brustel Y, Gual P, Mallat A, Lotersztajn S.

PLoS One. 2009 Jun 9;4(6):e5844. doi: 10.1371/journal.pone.0005844.


Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans.

Kaddai V, Jager J, Gonzalez T, Najem-Lendom R, Bonnafous S, Tran A, Le Marchand-Brustel Y, Gual P, Tanti JF, Cormont M.

Diabetologia. 2009 May;52(5):932-40. doi: 10.1007/s00125-009-1273-3. Epub 2009 Feb 14.


Hypoxia decreases insulin signaling pathways in adipocytes.

Regazzetti C, Peraldi P, Grémeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S.

Diabetes. 2009 Jan;58(1):95-103. doi: 10.2337/db08-0457. Epub 2008 Nov 4.


Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity.

Bertola A, Deveaux V, Bonnafous S, Rousseau D, Anty R, Wakkach A, Dahman M, Tordjman J, Clément K, McQuaid SE, Frayn KN, Huet PM, Gugenheim J, Lotersztajn S, Le Marchand-Brustel Y, Tran A, Gual P.

Diabetes. 2009 Jan;58(1):125-33. doi: 10.2337/db08-0400. Epub 2008 Oct 24.


The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes.

Kaddai V, Gonzalez T, Bolla M, Le Marchand-Brustel Y, Cormont M.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E162-9. doi: 10.1152/ajpendo.00622.2007. Epub 2008 May 20.


Bariatric surgery can correct iron depletion in morbidly obese women: a link with chronic inflammation.

Anty R, Dahman M, Iannelli A, Gual P, Staccini-Myx A, Amor IB, Luciani N, Saint-Paul MC, Huet PM, Sadoul JL, Srai SK, Unwin R, Gugenheim J, Le Marchand-Brustel Y, Tran A, Bekri S.

Obes Surg. 2008 Jun;18(6):709-14. doi: 10.1007/s11695-007-9276-y. Epub 2008 Mar 11.


The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F.

Oncogene. 2008 Jun 5;27(25):3576-86. doi: 10.1038/sj.onc.1211024. Epub 2008 Jan 21.


Rab proteins in endocytosis and Glut4 trafficking.

Kaddai V, Le Marchand-Brustel Y, Cormont M.

Acta Physiol (Oxf). 2008 Jan;192(1):75-88. doi: 10.1111/j.1748-1716.2007.01787.x. Review. Erratum in: Acta Physiol (Oxf). 2008 Jun;193(2): 201-2.


p38MAP Kinase activity is required for human primary adipocyte differentiation.

Aouadi M, Jager J, Laurent K, Gonzalez T, Cormont M, Binétruy B, Le Marchand-Brustel Y, Tanti JF, Bost F.

FEBS Lett. 2007 Dec 11;581(29):5591-6. Epub 2007 Nov 13.


Osmotic regulation of cellular glucose uptake.

Gual P, Gonzalez T, Gremeaux T, Le Marchand-Brustel Y, Tanti JF.

Methods Enzymol. 2007;428:343-54.


Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway.

Bertola A, Bonnafous S, Cormont M, Anty R, Tanti JF, Tran A, Le Marchand-Brustel Y, Gual P.

J Biol Chem. 2007 Apr 6;282(14):10325-32. Epub 2007 Feb 6.


[Obesity, diabetes and insulin resistance. Alterations of insulin signalling].

Le Marchand-Brustel Y, Gual P, Aouadi M, Grémeaux T, Binétruy B, Bost F, Tanti JF.

J Soc Biol. 2006;200(1):93-7. Review. French.


Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.

Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF.

Endocrinology. 2007 Jan;148(1):241-51. Epub 2006 Oct 12.


The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.

Vukmirica J, Monzo P, Le Marchand-Brustel Y, Cormont M.

J Biol Chem. 2006 Nov 24;281(47):36360-8. Epub 2006 Sep 25.


Long-term treatment with lopinavir-ritonavir induces a reduction in peripheral adipose depots in mice.

Prot M, Heripret L, Cardot-Leccia N, Perrin C, Aouadi M, Lavrut T, Garraffo R, Dellamonica P, Durant J, Le Marchand-Brustel Y, Binétruy B.

Antimicrob Agents Chemother. 2006 Dec;50(12):3998-4004. Epub 2006 Sep 25. Erratum in: Antimicrob Agents Chemother. 2007 Apr;51(4):1587.


Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH.

Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, Saint-Paul MC, Huet PM, Sadoul JL, Gugenheim J, Srai SK, Tran A, Le Marchand-Brustel Y.

Gastroenterology. 2006 Sep;131(3):788-96.


Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.

Bloch-Damti A, Potashnik R, Gual P, Le Marchand-Brustel Y, Tanti JF, Rudich A, Bashan N.

Diabetologia. 2006 Oct;49(10):2463-73. Epub 2006 Aug 3.


Role of MAPKs in development and differentiation: lessons from knockout mice.

Aouadi M, Binetruy B, Caron L, Le Marchand-Brustel Y, Bost F.

Biochimie. 2006 Sep;88(9):1091-8. Epub 2006 Jun 27. Review.


Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation.

Barrès R, Grémeaux T, Gual P, Gonzalez T, Gugenheim J, Tran A, Le Marchand-Brustel Y, Tanti JF.

Mol Endocrinol. 2006 Nov;20(11):2864-75. Epub 2006 Jun 27.


The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH.

Anty R, Bekri S, Luciani N, Saint-Paul MC, Dahman M, Iannelli A, Amor IB, Staccini-Myx A, Huet PM, Gugenheim J, Sadoul JL, Le Marchand-Brustel Y, Tran A, Gual P.

Am J Gastroenterol. 2006 Aug;101(8):1824-33. Epub 2006 Jun 22.


The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.

Mari M, Monzo P, Kaddai V, Keslair F, Gonzalez T, Le Marchand-Brustel Y, Cormont M.

J Cell Sci. 2006 Apr 1;119(Pt 7):1297-306. Epub 2006 Mar 7.


CD2AP, Rabip4, and Rabip4': analysis of interaction with Rab4a and regulation of endosomes morphology.

Monzo P, Mari M, Kaddai V, Gonzalez T, Le Marchand-Brustel Y, Cormont M.

Methods Enzymol. 2005;403:107-18.


Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages.

Aouadi M, Laurent K, Prot M, Le Marchand-Brustel Y, Binétruy B, Bost F.

Diabetes. 2006 Feb;55(2):281-9.


p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis.

Aouadi M, Bost F, Caron L, Laurent K, Le Marchand Brustel Y, Binétruy B.

Stem Cells. 2006 May;24(5):1399-406. Epub 2006 Jan 19.


The interaction between the adaptor protein APS and Enigma is involved in actin organisation.

Barrès R, Gonzalez T, Le Marchand-Brustel Y, Tanti JF.

Exp Cell Res. 2005 Aug 15;308(2):334-44.


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