Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 53

1.

Effects of Dietary Fibre from the Traditional Indonesian Food, Green Cincau (Premna oblongifolia Merr.) on Preneoplastic Lesions and Short Chain Fatty Acid Production in an Azoxymethane Rat Model of Colon Cancer.

Nurdin SU, Le Leu RK, Aburto-Medina A, Young GP, Stangoulis JCR, Ball AS, Abbott CA.

Int J Mol Sci. 2018 Aug 31;19(9). pii: E2593. doi: 10.3390/ijms19092593.

2.

Propolis from Different Geographic Origins Decreases Intestinal Inflammation and Bacteroides spp. Populations in a Model of DSS-Induced Colitis.

Wang K, Jin X, Li Q, Sawaya ACHF, Le Leu RK, Conlon MA, Wu L, Hu F.

Mol Nutr Food Res. 2018 Sep;62(17):e1800080. doi: 10.1002/mnfr.201800080. Epub 2018 Aug 5.

PMID:
29889351
3.

Dietary Propolis Ameliorates Dextran Sulfate Sodium-Induced Colitis and Modulates the Gut Microbiota in Rats Fed a Western Diet.

Wang K, Jin X, You M, Tian W, Le Leu RK, Topping DL, Conlon MA, Wu L, Hu F.

Nutrients. 2017 Aug 14;9(8). pii: E875. doi: 10.3390/nu9080875.

4.

Simultaneous Assessment of the Efficacy and Toxicity of Marine Mollusc-Derived Brominated Indoles in an In Vivo Model for Early Stage Colon Cancer.

Esmaeelian B, Benkendorff K, Le Leu RK, Abbott CA.

Integr Cancer Ther. 2018 Jun;17(2):248-262. doi: 10.1177/1534735417699880. Epub 2017 Apr 5.

5.
6.

Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans.

Hu Y, McIntosh GH, Le Leu RK, Somashekar R, Meng XQ, Gopalsamy G, Bambaca L, McKinnon RA, Young GP.

Br J Nutr. 2016 Dec;116(11):1901-1911. doi: 10.1017/S0007114516003937. Epub 2016 Dec 7.

PMID:
27923410
7.

Dietary butyrylated high-amylose starch reduces azoxymethane-induced colonic O(6)-methylguanine adducts in rats as measured by immunohistochemistry and high-pressure liquid chromatography.

Le Leu RK, Scherer BL, Mano MT, Winter JM, Lannagan T, Head RJ, Lockett T, Clarke JM.

Nutr Res. 2016 Sep;36(9):982-988. doi: 10.1016/j.nutres.2016.06.006. Epub 2016 Jun 7.

PMID:
27632918
8.

Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats.

Hu Y, Le Leu RK, Christophersen CT, Somashekar R, Conlon MA, Meng XQ, Winter JM, Woodman RJ, McKinnon R, Young GP.

Carcinogenesis. 2016 Apr;37(4):366-375. doi: 10.1093/carcin/bgw019. Epub 2016 Feb 19.

PMID:
26905582
9.

Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial.

Le Leu RK, Winter JM, Christophersen CT, Young GP, Humphreys KJ, Hu Y, Gratz SW, Miller RB, Topping DL, Bird AR, Conlon MA.

Br J Nutr. 2015 Jul;114(2):220-30. doi: 10.1017/S0007114515001750. Epub 2015 Jun 17.

10.

Role of Red Meat and Resistant Starch in Promutagenic Adduct Formation, MGMT Repair, Thymic Lymphoma and Intestinal Tumourigenesis in Msh2 -Deficient Mice.

Winter JM, Hu Y, Young GP, Kohonen-Corish MR, Le Leu RK.

J Nutrigenet Nutrigenomics. 2014;7(4-6):299-313. doi: 10.1159/000381675. Epub 2015 May 27.

11.

Lowering of large bowel butyrate levels in healthy populations is unlikely to be beneficial.

Conlon MA, Bird AR, Clarke JM, Le Leu RK, Christophersen CT, Lockett TJ, Topping DL.

J Nutr. 2015 May;145(5):1030-1. doi: 10.3945/jn.114.209460. No abstract available.

PMID:
25934666
12.

Housing experimental rats in solid-based cages with digestible bedding may confound outcomes of nutritional studies.

Le Leu RK, Conlon MA, Bird AR, Clarke JM.

J Sci Food Agric. 2015 Aug 15;95(10):2155-8. doi: 10.1002/jsfa.6919. Epub 2014 Oct 18.

PMID:
25242209
13.

Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: a randomized trial.

Humphreys KJ, Conlon MA, Young GP, Topping DL, Hu Y, Winter JM, Bird AR, Cobiac L, Kennedy NA, Michael MZ, Le Leu RK.

Cancer Prev Res (Phila). 2014 Aug;7(8):786-95. doi: 10.1158/1940-6207.CAPR-14-0053.

14.
15.

Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis.

Nyskohus LS, Watson AJ, Margison GP, Le Leu RK, Kim SW, Lockett TJ, Head RJ, Young GP, Hu Y.

Mutat Res. 2013 Dec 12;758(1-2):80-6. doi: 10.1016/j.mrgentox.2013.10.001. Epub 2013 Oct 16.

PMID:
24140386
16.

Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer.

Winter J, Young GP, Hu Y, Gratz SW, Conlon MA, Le Leu RK.

Mol Nutr Food Res. 2014 Mar;58(3):550-8. doi: 10.1002/mnfr.201300430. Epub 2013 Oct 1.

PMID:
24115497
18.

Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation.

Le Leu RK, Young GP, Hu Y, Winter J, Conlon MA.

Dig Dis Sci. 2013 Dec;58(12):3475-82. doi: 10.1007/s10620-013-2844-1. Epub 2013 Aug 29.

PMID:
23990000
19.

Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers.

Hu Y, McIntosh GH, Le Leu RK, Nyskohus LS, Woodman RJ, Young GP.

PLoS One. 2013 May 23;8(5):e64362. doi: 10.1371/journal.pone.0064362. Print 2013.

20.

Gastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs.

Westley CB, Benkendorff K, McIver CM, Le Leu RK, Abbott CA.

Evid Based Complement Alternat Med. 2013;2013:837370. doi: 10.1155/2013/837370. Epub 2013 Apr 17.

21.

Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster.

Humphreys KJ, Cobiac L, Le Leu RK, Van der Hoek MB, Michael MZ.

Mol Carcinog. 2013 Jun;52(6):459-74. doi: 10.1002/mc.21879. Epub 2012 Feb 5.

PMID:
22308110
22.

Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon.

Winter J, Nyskohus L, Young GP, Hu Y, Conlon MA, Bird AR, Topping DL, Le Leu RK.

Cancer Prev Res (Phila). 2011 Nov;4(11):1920-8. doi: 10.1158/1940-6207.CAPR-11-0176. Epub 2011 Sep 1.

23.

The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjects.

Hu Y, McIntosh GH, Le Leu RK, Upton JM, Woodman RJ, Young GP.

Br J Nutr. 2011 Aug;106(4):572-82. doi: 10.1017/S0007114511000420. Epub 2011 Mar 30.

PMID:
21450115
24.

DNA methylation in the rectal mucosa is associated with crypt proliferation and fecal short-chain fatty acids.

Worthley DL, Whitehall VL, Le Leu RK, Irahara N, Buttenshaw RL, Mallitt KA, Greco SA, Ramsnes I, Winter J, Hu Y, Ogino S, Young GP, Leggett BA.

Dig Dis Sci. 2011 Feb;56(2):387-96. doi: 10.1007/s10620-010-1312-4. Epub 2010 Jul 16.

PMID:
20635146
25.

Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colon.

Hu Y, McIntosh GH, Le Leu RK, Young GP.

Br J Nutr. 2010 Jul;104(1):17-23. doi: 10.1017/S0007114510000309. Epub 2010 Mar 29.

PMID:
20346189
26.

R-flurbiprofen suppresses distal nonmucin-producing colorectal tumors in azoxymethane-treated rats, without suppressing eicosanoid production.

Martin JE, Le Leu RK, Hu Y, Young GP.

Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G860-4. doi: 10.1152/ajpgi.00330.2009. Epub 2010 Mar 25.

27.

Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventative.

Westley CB, McIver CM, Abbott CA, Le Leu RK, Benkendorff K.

Cancer Biol Ther. 2010 Mar 1;9(5):371-9. Epub 2010 Mar 8.

PMID:
20150770
28.

DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer.

Worthley DL, Whitehall VL, Buttenshaw RL, Irahara N, Greco SA, Ramsnes I, Mallitt KA, Le Leu RK, Winter J, Hu Y, Ogino S, Young GP, Leggett BA.

Oncogene. 2010 Mar 18;29(11):1653-62. doi: 10.1038/onc.2009.449. Epub 2009 Dec 7.

PMID:
19966864
29.

Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats.

Le Leu RK, Hu Y, Brown IL, Woodman RJ, Young GP.

Carcinogenesis. 2010 Feb;31(2):246-51. doi: 10.1093/carcin/bgp197. Epub 2009 Aug 20.

PMID:
19696163
30.

A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer.

Worthley DL, Le Leu RK, Whitehall VL, Conlon M, Christophersen C, Belobrajdic D, Mallitt KA, Hu Y, Irahara N, Ogino S, Leggett BA, Young GP.

Am J Clin Nutr. 2009 Sep;90(3):578-86. doi: 10.3945/ajcn.2009.28106. Epub 2009 Jul 29.

PMID:
19640954
31.

Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA-mediated real-time PCR clamping and mutant-specific probes.

Hu Y, Le Leu RK, Young GP.

Mutat Res. 2009 Jun-Jul;677(1-2):27-32. doi: 10.1016/j.mrgentox.2009.05.003. Epub 2009 May 13.

PMID:
19442760
32.

Effect of high amylose maize starches on colonic fermentation and apoptotic response to DNA-damage in the colon of rats.

Le Leu RK, Hu Y, Brown IL, Young GP.

Nutr Metab (Lond). 2009 Mar 7;6:11. doi: 10.1186/1743-7075-6-11.

33.

Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.

Hu Y, McIntosh GH, Le Leu RK, Woodman R, Young GP.

Cancer Res. 2008 Jun 15;68(12):4936-44. doi: 10.1158/0008-5472.CAN-07-6042.

34.

The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53+/- mice.

Hu Y, Le Leu RK, Belobrajdic D, Young GP.

Mol Nutr Food Res. 2008 May;52(5):558-66. doi: 10.1002/mnfr.200700258.

PMID:
18324704
35.

Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch.

Le Leu RK, Brown IL, Hu Y, Esterman A, Young GP.

Cancer Biol Ther. 2007 Oct;6(10):1621-6. Epub 2007 Jul 19.

PMID:
17932462
36.

Fermentation of starch and protein in the colon: implications for genomic instability.

Le Leu RK, Young GP.

Cancer Biol Ther. 2007 Feb;6(2):259-60. Epub 2007 Feb 23. No abstract available.

PMID:
17426435
37.

Effect of dietary resistant starch and protein on colonic fermentation and intestinal tumourigenesis in rats.

Le Leu RK, Brown IL, Hu Y, Morita T, Esterman A, Young GP.

Carcinogenesis. 2007 Feb;28(2):240-5. Epub 2006 Dec 13.

PMID:
17166881
38.

Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac.

Hu Y, Le Leu RK, Young GP.

Cancer Lett. 2007 Apr 18;248(2):234-44. Epub 2006 Sep 6.

PMID:
16950562
39.

A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon.

Le Leu RK, Brown IL, Hu Y, Bird AR, Jackson M, Esterman A, Young GP.

J Nutr. 2005 May;135(5):996-1001.

PMID:
15867271
40.

Dietary fibre and colorectal cancer: a model for environment--gene interactions.

Young GP, Hu Y, Le Leu RK, Nyskohus L.

Mol Nutr Food Res. 2005 Jun;49(6):571-84. Review.

PMID:
15864783
41.
43.

Resistant starch and colorectal neoplasia.

Young GP, Le Leu RK.

J AOAC Int. 2004 May-Jun;87(3):775-86.

PMID:
15287679
44.

Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in rats.

Le Leu RK, Brown IL, Hu Y, Young GP.

Carcinogenesis. 2003 Aug;24(8):1347-52. Epub 2003 Jun 5.

PMID:
12807738
45.

Preventing cancer: dietary lifestyle or clinical intervention?

Young GP, Le Leu RK.

Asia Pac J Clin Nutr. 2002;11 Suppl 3:S618-31.

46.
47.

The influence of dietary proteins on colon cancer risk.

McIntosh GH, Le Leu RK.

Nutr Res. 2001 Jul;21(7):1053-1066.

PMID:
11446989
48.

Folate deficiency reduces the development of colorectal cancer in rats.

Le Leu RK, Young GP, McIntosh GH.

Carcinogenesis. 2000 Dec;21(12):2261-5.

PMID:
11133816
49.
50.

Supplemental Content

Loading ...
Support Center