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The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils.

Pellefigues C, Mehta P, Prout MS, Naidoo K, Yumnam B, Chandler J, Chappell S, Filbey K, Camberis M, Le Gros G.

Front Immunol. 2019 Sep 10;10:2143. doi: 10.3389/fimmu.2019.02143. eCollection 2019.


ILC2s-Trailblazers in the Host Response Against Intestinal Helminths.

Bouchery T, Le Gros G, Harris N.

Front Immunol. 2019 Apr 4;10:623. doi: 10.3389/fimmu.2019.00623. eCollection 2019. Review.


Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites.

Filbey KJ, Camberis M, Chandler J, Turner R, Kettle AJ, Eichenberger RM, Giacomin P, Le Gros G.

Mucosal Immunol. 2019 Mar;12(2):352-362. doi: 10.1038/s41385-018-0102-8. Epub 2018 Nov 6.


Eosinophils Determine Dermal Thickening and Water Loss in an MC903 Model of Atopic Dermatitis.

Naidoo K, Jagot F, van den Elsen L, Pellefigues C, Jones A, Luo H, Johnston K, Painter G, Roediger B, Lee J, Weninger W, Le Gros G, Forbes-Blom E.

J Invest Dermatol. 2018 Dec;138(12):2606-2616. doi: 10.1016/j.jid.2018.06.168. Epub 2018 Jun 30.


IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin.

Prout MS, Kyle RL, Ronchese F, Le Gros G.

Front Immunol. 2018 Jun 1;9:1211. doi: 10.3389/fimmu.2018.01211. eCollection 2018.


Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells.

Ochiai S, Jagot F, Kyle RL, Hyde E, White RF, Prout M, Schmidt AJ, Yamane H, Lamiable O, Le Gros G, Ronchese F.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1033-1038. doi: 10.1073/pnas.1714348115. Epub 2018 Jan 16.


De novo assembly of the complex genome of Nippostrongylus brasiliensis using MinION long reads.

Eccles D, Chandler J, Camberis M, Henrissat B, Koren S, Le Gros G, Ewbank JJ.

BMC Biol. 2018 Jan 11;16(1):6. doi: 10.1186/s12915-017-0473-4.


Toll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis.

Pellefigues C, Tang SC, Schmidt A, White RF, Lamiable O, Connor LM, Ruedl C, Dobrucki J, Le Gros G, Ronchese F.

Front Immunol. 2017 Nov 16;8:1575. doi: 10.3389/fimmu.2017.01575. eCollection 2017.


Annotated mitochondrial genome with Nanopore R9 signal for Nippostrongylus brasiliensis.

Chandler J, Camberis M, Bouchery T, Blaxter M, Le Gros G, Eccles DA.

F1000Res. 2017 Jan 19;6:56. doi: 10.12688/f1000research.10545.1. eCollection 2017.


The role of ILC2 in hookworm infection.

Filbey K, Bouchery T, Le Gros G.

Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12429. Epub 2017 May 22. Review.


IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice.

Robinson MJ, Prout M, Mearns H, Kyle R, Camberis M, Forbes-Blom EE, Paul WE, Allen CD, Le Gros G.

J Immunol. 2017 Mar 1;198(5):1815-1822. doi: 10.4049/jimmunol.1601434. Epub 2017 Jan 23.


Immunity without innate lymphoid cells.

Weinkove R, Filbey K, Le Gros G.

Nat Immunol. 2016 Oct 19;17(11):1237-1238. doi: 10.1038/ni.3567. No abstract available.


Large Particle Sorting to Isolate Live Parasitic Nematode Eggs.

Schmidt A, Bouchery T, Le Gros G, Price KM.

Curr Protoc Cytom. 2016 Apr 1;76:11.21.1-11.21.15. doi: 10.1002/0471142956.cy1121s76.


Absence of airway inflammation in a large proportion of adolescents with asthma.

Brooks CR, van Dalen CJ, Zacharasiewicz A, Simpson JL, Harper JL, Le Gros G, Gibson PG, Pearce N, Douwes J.

Respirology. 2016 Apr;21(3):460-6. doi: 10.1111/resp.12701. Epub 2015 Dec 22.


IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation.

Roediger B, Kyle R, Tay SS, Mitchell AJ, Bolton HA, Guy TV, Tan SY, Forbes-Blom E, Tong PL, Köller Y, Shklovskaya E, Iwashima M, McCoy KD, Le Gros G, Fazekas de St Groth B, Weninger W.

J Allergy Clin Immunol. 2015 Dec;136(6):1653-1663.e7. doi: 10.1016/j.jaci.2015.03.043. Epub 2015 May 27.


ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms.

Bouchery T, Kyle R, Camberis M, Shepherd A, Filbey K, Smith A, Harvie M, Painter G, Johnston K, Ferguson P, Jain R, Roediger B, Delahunt B, Weninger W, Forbes-Blom E, Le Gros G.

Nat Commun. 2015 Apr 27;6:6970. doi: 10.1038/ncomms7970.


Mechanistic studies of copper(I)-catalyzed 1,3-halogen migration.

Van Hoveln R, Hudson BM, Wedler HB, Bates DM, Le Gros G, Tantillo DJ, Schomaker JM.

J Am Chem Soc. 2015 Apr 29;137(16):5346-54. doi: 10.1021/ja511236d. Epub 2015 Apr 16.


Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

Hewitson JP, Filbey KJ, Esser-von Bieren J, Camberis M, Schwartz C, Murray J, Reynolds LA, Blair N, Robertson E, Harcus Y, Boon L, Huang SC, Yang L, Tu Y, Miller MJ, Voehringer D, Le Gros G, Harris N, Maizels RM.

PLoS Pathog. 2015 Mar 27;11(3):e1004676. doi: 10.1371/journal.ppat.1004676. eCollection 2015 Mar.


Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden.

Jang JC, Chen G, Wang SH, Barnes MA, Chung JI, Camberis M, Le Gros G, Cooper PJ, Steel C, Nutman TB, Lazar MA, Nair MG.

PLoS Pathog. 2015 Jan 8;11(1):e1004579. doi: 10.1371/journal.ppat.1004579. eCollection 2015 Jan.


Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy.

Roediger B, Kyle R, Le Gros G, Weninger W.

Curr Opin Immunol. 2014 Dec;31:108-14. doi: 10.1016/j.coi.2014.10.008. Epub 2014 Oct 28. Review.


The Differentiation of CD4(+) T-Helper Cell Subsets in the Context of Helminth Parasite Infection.

Bouchery T, Kyle R, Ronchese F, Le Gros G.

Front Immunol. 2014 Oct 15;5:487. doi: 10.3389/fimmu.2014.00487. eCollection 2014. Review.


Helminth-conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo.

Connor LM, Tang SC, Camberis M, Le Gros G, Ronchese F.

J Immunol. 2014 Sep 15;193(6):2709-17. doi: 10.4049/jimmunol.1400374. Epub 2014 Aug 8.


CD326(lo)CD103(lo)CD11b(lo) dermal dendritic cells are activated by thymic stromal lymphopoietin during contact sensitization in mice.

Ochiai S, Roediger B, Abtin A, Shklovskaya E, Fazekas de St Groth B, Yamane H, Weninger W, Le Gros G, Ronchese F.

J Immunol. 2014 Sep 1;193(5):2504-11. doi: 10.4049/jimmunol.1400536. Epub 2014 Jul 23.


IL-25 exhibits disparate roles during Th2-cell differentiation versus effector function.

Mearns H, Forbes-Blom EE, Camberis M, Tang SC, Kyle R, Harvie M, Kleinschek MA, Le Gros G.

Eur J Immunol. 2014 Jul;44(7):1976-80. doi: 10.1002/eji.201344400. Epub 2014 May 19.


IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses.

Kim S, Karasuyama H, Lopez AF, Ouyang W, Li X, Le Gros G, Min B.

Immune Netw. 2013 Dec;13(6):249-56. doi: 10.4110/in.2013.13.6.249. Epub 2013 Dec 20.


Evaluating the in vivo Th2 priming potential among common allergens.

Camberis M, Prout M, Tang SC, Forbes-Blom E, Robinson M, Kyle R, Belkaid Y, Paul W, Le Gros G.

J Immunol Methods. 2013 Aug 30;394(1-2):62-72. doi: 10.1016/j.jim.2013.05.004. Epub 2013 May 17.


Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.

Roediger B, Kyle R, Yip KH, Sumaria N, Guy TV, Kim BS, Mitchell AJ, Tay SS, Jain R, Forbes-Blom E, Chen X, Tong PL, Bolton HA, Artis D, Paul WE, Fazekas de St Groth B, Grimbaldeston MA, Le Gros G, Weninger W.

Nat Immunol. 2013 Jun;14(6):564-73. doi: 10.1038/ni.2584. Epub 2013 Apr 21.


Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection.

Harvie M, Camberis M, Le Gros G.

Front Immunol. 2013 Mar 20;4:74. doi: 10.3389/fimmu.2013.00074. eCollection 2013.


Mucosal trapping and degradation of Nippostrongylus brasiliensis occurs in the absence of STAT6.

Van Panhuys N, Camberis M, Yamada M, Tegoshi T, Arizono N, Le Gros G.

Parasitology. 2013 Jun;140(7):833-43. doi: 10.1017/S0031182012002260. Epub 2013 Feb 27.


How epigenetic imprinting contributes to stabilizing the Th2 phenotype.

Robinson M, McConnell MJ, Le Gros G.

Immunol Cell Biol. 2012 Nov;90(10):917-8. doi: 10.1038/icb.2012.47. Epub 2012 Sep 25. No abstract available.


Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion.

Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF.

J Leukoc Biol. 2012 Nov;92(5):999-1009. doi: 10.1189/jlb.0512242. Epub 2012 Aug 31.


Antibodies and IL-3 support helminth-induced basophil expansion.

Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss MM, Hewitson JP, Merky P, Verbeek JS, Bourquin C, Camberis M, Prout M, Maizels RM, Le Gros G, Harris NL.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14954-9. doi: 10.1073/pnas.1117584109. Epub 2012 Aug 28.


Allergen-specific CTL require perforin expression to suppress allergic airway inflammation.

Enomoto N, Hyde E, Ma JZ, Yang J, Forbes-Blom E, Delahunt B, Le Gros G, Ronchese F.

J Immunol. 2012 Feb 15;188(4):1734-41. doi: 10.4049/jimmunol.1102699. Epub 2012 Jan 16.


Staphylococcal-derived superantigen enhances peanut induced Th2 responses in the skin.

Forbes-Blom E, Camberis M, Prout M, Tang SC, Le Gros G.

Clin Exp Allergy. 2012 Feb;42(2):305-14. doi: 10.1111/j.1365-2222.2011.03861.x. Epub 2011 Sep 21.


Basophils are the major producers of IL-4 during primary helminth infection.

van Panhuys N, Prout M, Forbes E, Min B, Paul WE, Le Gros G.

J Immunol. 2011 Mar 1;186(5):2719-28. doi: 10.4049/jimmunol.1000940. Epub 2011 Jan 26.


The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites.

Harvie M, Camberis M, Tang SC, Delahunt B, Paul W, Le Gros G.

Infect Immun. 2010 Sep;78(9):3753-62. doi: 10.1128/IAI.00502-09. Epub 2010 Jul 6.


A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination.

Connor LM, Harvie MC, Rich FJ, Quinn KM, Brinkmann V, Le Gros G, Kirman JR.

Eur J Immunol. 2010 Sep;40(9):2482-92. doi: 10.1002/eji.200940279.


Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses.

Forbes E, van Panhuys N, Min B, Le Gros G.

Immunol Cell Biol. 2010 Mar-Apr;88(3):240-3. doi: 10.1038/icb.2009.101. Epub 2009 Dec 15. Review.


Blimp-1 induced by IL-4 plays a critical role in suppressing IL-2 production in activated CD4 T cells.

Wang L, van Panhuys N, Hu-Li J, Kim S, Le Gros G, Min B.

J Immunol. 2008 Oct 15;181(8):5249-56.


In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation.

van Panhuys N, Tang SC, Prout M, Camberis M, Scarlett D, Roberts J, Hu-Li J, Paul WE, Le Gros G.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12423-8. doi: 10.1073/pnas.0806372105. Epub 2008 Aug 21.


Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

Le Gros G, Ben-Sasson SZ, Seder R, Finkelman FD, Paul WE.

J Immunol. 2008 Sep 1;181(5):2943-51. No abstract available.


T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival.

Shen T, Kim S, Do JS, Wang L, Lantz C, Urban JF, Le Gros G, Min B.

Int Immunol. 2008 Sep;20(9):1201-9. doi: 10.1093/intimm/dxn077. Epub 2008 Jul 15.


Epigenetic regulation of Th2 cytokine expression in atopic diseases.

van Panhuys N, Le Gros G, McConnell MJ.

Tissue Antigens. 2008 Aug;72(2):91-7. doi: 10.1111/j.1399-0039.2008.01068.x. Epub 2008 Jun 28. Review.


Farm exposure in utero may protect against asthma, hay fever and eczema.

Douwes J, Cheng S, Travier N, Cohet C, Niesink A, McKenzie J, Cunningham C, Le Gros G, von Mutius E, Pearce N.

Eur Respir J. 2008 Sep;32(3):603-11. doi: 10.1183/09031936.00033707. Epub 2008 Apr 30.


Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus.

Camberis M, Le Gros G, Urban J Jr.

Curr Protoc Immunol. 2003 Aug;Chapter 19:Unit 19.12. doi: 10.1002/0471142735.im1912s55. Review.


Lifelong farm exposure may strongly reduce the risk of asthma in adults.

Douwes J, Travier N, Huang K, Cheng S, McKenzie J, Le Gros G, von Mutius E, Pearce N.

Allergy. 2007 Oct;62(10):1158-65.


Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils.

Oh K, Shen T, Le Gros G, Min B.

Blood. 2007 Apr 1;109(7):2921-7.


Basophils: a potential liaison between innate and adaptive immunity.

Min B, Le Gros G, Paul WE.

Allergol Int. 2006 Jun;55(2):99-104. Review.


Critical role of preproenkephalin in experimental autoimmune encephalomyelitis.

Weir C, McNeill A, Hook S, Harvie M, La Flamme AC, Le Gros G, Bäckström BT.

J Neuroimmunol. 2006 Oct;179(1-2):18-25. Epub 2006 Aug 9.


Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation.

Harris NL, Watt V, MacLenachan S, Diehl S, Marsland BJ, Rincon M, Le Gros G.

Microbes Infect. 2006 Jan;8(1):232-7. Epub 2005 Sep 12.


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