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DC Subsets Regulate Humoral Immune Responses by Supporting the Differentiation of Distinct Tfh Cells.

Bouteau A, Kervevan J, Su Q, Zurawski SM, Contreras V, Dereuddre-Bosquet N, Le Grand R, Zurawski G, Cardinaud S, Levy Y, Igyártó BZ.

Front Immunol. 2019 May 27;10:1134. doi: 10.3389/fimmu.2019.01134. eCollection 2019.


Cynomolgus macaque IL37 polymorphism and control of SIV infection.

Shiina T, Suzuki S, Congy-Jolivet N, Aarnink A, Garchon HJ, Dereuddre-Bosquet N, Vaslin B, Tchitchek N, Desjardins D, Autran B, Lambotte O, Theodorou I, Le Grand R, Blancher A.

Sci Rep. 2019 May 28;9(1):7981. doi: 10.1038/s41598-019-44235-x.


FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction.

Roux A, Leroy H, De Muylder B, Bracq L, Oussous S, Dusanter-Fourt I, Chougui G, Tacine R, Randriamampita C, Desjardins D, Le Grand R, Bouillaud F, Benichou S, Margottin-Goguet F, Cheynier R, Bismuth G, Mangeney M.

PLoS Pathog. 2019 May 1;15(5):e1007669. doi: 10.1371/journal.ppat.1007669. eCollection 2019 May.


Valine 11 and phenylalanine 13 have a greater impact on the T-cell response to citrullinated peptides than the 70-74 shared epitope of the DRB1 molecule in macaques.

Bitoun S, Roques P, Maillere B, Le Grand R, Mariette X.

Ann Rheum Dis. 2019 Jul;78(7):917-921. doi: 10.1136/annrheumdis-2019-215114. Epub 2019 Apr 25.


Impact of HIV/simian immunodeficiency virus infection and viral proteins on adipose tissue fibrosis and adipogenesis.

Gorwood J, Bourgeois C, Mantecon M, Atlan M, Pourcher V, Pourcher G, Le Grand R, Desjardins D, Fève B, Lambotte O, Capeau J, Béréziat V, Lagathu C.

AIDS. 2019 May 1;33(6):953-964. doi: 10.1097/QAD.0000000000002168.


Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae.

Marlin R, Nugeyre MT, Tchitchek N, Parenti M, Lefebvre C, Hocini H, Benjelloun F, Cannou C, Nozza S, Dereuddre-Bosquet N, Levy Y, Barré-Sinoussi F, Scarlatti G, Le Grand R, Menu E.

Front Immunol. 2019 Mar 12;10:430. doi: 10.3389/fimmu.2019.00430. eCollection 2019.


Enhanced Transduction of Macaca fascicularis Hematopoietic Cells with Chimeric Lentiviral Vectors.

Sii-Felice K, Castillo Padilla J, Relouzat F, Cheuzeville J, Tantawet S, Maouche L, Le Grand R, Leboulch P, Payen E.

Hum Gene Ther. 2019 May 15. doi: 10.1089/hum.2018.179. [Epub ahead of print]


The Frequencies of Immunosuppressive Cells in Adipose Tissue Differ in Human, Non-human Primate, and Mouse Models.

Laparra A, Tricot S, Le Van M, Damouche A, Gorwood J, Vaslin B, Favier B, Benoist S, Ho Tsong Fang R, Bosquet N, Le Grand R, Chapon C, Lambotte O, Bourgeois C.

Front Immunol. 2019 Feb 5;10:117. doi: 10.3389/fimmu.2019.00117. eCollection 2019.


NK cell immune responses differ after prime and boost vaccination.

Palgen JL, Tchitchek N, Huot N, Elhmouzi-Younes J, Lefebvre C, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Hocini H, Cosma A, Müller-Trutwin M, Lévy Y, Le Grand R, Beignon AS.

J Leukoc Biol. 2019 May;105(5):1055-1073. doi: 10.1002/JLB.4A1018-391RR. Epub 2019 Feb 22.


The molecular biology and HPV drug responsiveness of cynomolgus macaque papillomaviruses support their use in the development of a relevant in vivo model for antiviral drug testing.

Tombak EM, Männik A, Burk RD, Le Grand R, Ustav E, Ustav M.

PLoS One. 2019 Jan 25;14(1):e0211235. doi: 10.1371/journal.pone.0211235. eCollection 2019.


Overcoming immunogenicity issues of HIV p24 antigen by the use of innovative nanostructured lipid carriers as delivery systems: evidences in mice and non-human primates.

Bayon E, Morlieras J, Dereuddre-Bosquet N, Gonon A, Gosse L, Courant T, Le Grand R, Marche PN, Navarro FP.

NPJ Vaccines. 2018 Oct 1;3:46. doi: 10.1038/s41541-018-0086-0. eCollection 2018.


Impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques.

Murphy DJ, Desjardins D, Boyd P, Dereuddre-Bosquet N, Stimmer L, Caldwell A, Le Grand R, Kelly C, van Roey J, Malcolm RK.

Int J Pharm. 2018 Oct 25;550(1-2):300-308. doi: 10.1016/j.ijpharm.2018.08.051. Epub 2018 Aug 25.


A high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans.

Leite Pereira A, Tchitchek N, Marcos Lopez E, Lambotte O, Le Grand R, Cosma A.

Cytokine. 2018 Nov;111:97-105. doi: 10.1016/j.cyto.2018.08.018. Epub 2018 Aug 20.


In vivo imaging of bacterial colonization of the lower respiratory tract in a baboon model of Bordetella pertussis infection and transmission.

Naninck T, Coutte L, Mayet C, Contreras V, Locht C, Le Grand R, Chapon C.

Sci Rep. 2018 Aug 16;8(1):12297. doi: 10.1038/s41598-018-30896-7.


Vaccination with the Conserved Caveolin-1 Binding Motif in Human Immunodeficiency Virus Type 1 Glycoprotein gp41 Delays the Onset of Viral Infection and Provides Partial Protection in Simian/Human Immunodeficiency Virus-Challenged Cynomolgus Macaques.

Hovanessian AG, Soundaramourty C, Benferhat R, Le Grand R, Dereuddre-Bosquet N, Krust B, Estaquier J.

J Virol. 2018 Aug 29;92(18). pii: e00370-18. doi: 10.1128/JVI.00370-18. Print 2018 Sep 15.


Methotrexate and BAFF interaction prevents immunization against TNF inhibitors.

Bitoun S, Nocturne G, Ly B, Krzysiek R, Roques P, Pruvost A, Paoletti A, Pascaud J, Dönnes P, Florence K, Gleizes A, Hincelin-Mery A, Allez M, Hacein-Bey-Abina S, Mackay F, Pallardy M, Le Grand R, Mariette X.

Ann Rheum Dis. 2018 Oct;77(10):1463-1470. doi: 10.1136/annrheumdis-2018-213403. Epub 2018 Jun 23.


Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine.

Rosenbaum P, Tchitchek N, Joly C, Stimmer L, Hocini H, Dereuddre-Bosquet N, Beignon AS, Chapon C, Levy Y, Le Grand R, Martinon F.

Front Immunol. 2018 Apr 25;9:870. doi: 10.3389/fimmu.2018.00870. eCollection 2018.


Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART.

Coindre S, Tchitchek N, Alaoui L, Vaslin B, Bourgeois C, Goujard C, Avettand-Fenoel V, Lecuroux C, Bruhns P, Le Grand R, Beignon AS, Lambotte O, Favier B; ANRS CO6 PRIMO Cohort.

Front Immunol. 2018 Jun 4;9:1217. doi: 10.3389/fimmu.2018.01217. eCollection 2018.


Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection.

Parsons MS, Le Grand R, Kent SJ.

Viruses. 2018 Jun 18;10(6). pii: E333. doi: 10.3390/v10060333. Review.


Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection.

Roques P, Thiberville SD, Dupuis-Maguiraga L, Lum FM, Labadie K, Martinon F, Gras G, Lebon P, Ng LFP, de Lamballerie X, Le Grand R.

Viruses. 2018 May 17;10(5). pii: E268. doi: 10.3390/v10050268.


Whole genome sequencing in the search for genes associated with the control of SIV infection in the Mauritian macaque model.

de Manuel M, Shiina T, Suzuki S, Dereuddre-Bosquet N, Garchon HJ, Tanaka M, Congy-Jolivet N, Aarnink A, Le Grand R, Marques-Bonet T, Blancher A.

Sci Rep. 2018 May 8;8(1):7131. doi: 10.1038/s41598-018-25071-x.


Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs.

Houzet L, Pérez-Losada M, Matusali G, Deleage C, Dereuddre-Bosquet N, Satie AP, Aubry F, Becker E, Jégou B, Le Grand R, Keele BF, Crandall KA, Dejucq-Rainsford N.

J Virol. 2018 Jun 29;92(14). pii: e00133-18. doi: 10.1128/JVI.00133-18. Print 2018 Jul 15.


Differential activity of methylene blue against erythrocytic and hepatic stages of Plasmodium.

Bosson-Vanga H, Franetich JF, Soulard V, Sossau D, Tefit M, Kane B, Vaillant JC, Borrmann S, Müller O, Dereuddre-Bosquet N, Le Grand R, Silvie O, Mazier D.

Malar J. 2018 Apr 3;17(1):143. doi: 10.1186/s12936-018-2300-y.


Correction: Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection.

Echebli N, Tchitchek N, Dupuy S, Bruel T, Passaes C, Bosquet N, Le Grand R, Bourgeois C, Favier B, Cheynier R, Lambotte O, Vaslin B.

PLoS One. 2018 Feb 23;13(2):e0193629. doi: 10.1371/journal.pone.0193629. eCollection 2018.


Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response.

Palgen JL, Tchitchek N, Elhmouzi-Younes J, Delandre S, Namet I, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Cosma A, Lévy Y, Le Grand R, Beignon AS.

Sci Rep. 2018 Feb 15;8(1):3087. doi: 10.1038/s41598-018-21222-2.


Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection.

Echebli N, Tchitchek N, Dupuy S, Bruel T, Peireira Bittencourt Passaes C, Bosquet N, Le Grand R, Bourgeois C, Favier B, Cheynier R, Lambotte O, Vaslin B.

PLoS One. 2018 Jan 11;13(1):e0190334. doi: 10.1371/journal.pone.0190334. eCollection 2018. Erratum in: PLoS One. 2018 Feb 23;13(2):e0193629.


ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments.

Wu Y, Pons V, Goudet A, Panigai L, Fischer A, Herweg JA, Kali S, Davey RA, Laporte J, Bouclier C, Yousfi R, Aubenque C, Merer G, Gobbo E, Lopez R, Gillet C, Cojean S, Popoff MR, Clayette P, Le Grand R, Boulogne C, Tordo N, Lemichez E, Loiseau PM, Rudel T, Sauvaire D, Cintrat JC, Gillet D, Barbier J.

Sci Rep. 2017 Nov 14;7(1):15567. doi: 10.1038/s41598-017-15466-7.


Early SIV and HIV infection promotes the LILRB2/MHC-I inhibitory axis in cDCs.

Alaoui L, Palomino G, Zurawski S, Zurawski G, Coindre S, Dereuddre-Bosquet N, Lecuroux C, Goujard C, Vaslin B, Bourgeois C, Roques P, Le Grand R, Lambotte O, Favier B.

Cell Mol Life Sci. 2018 May;75(10):1871-1887. doi: 10.1007/s00018-017-2712-9. Epub 2017 Nov 13.


Fibered Confocal Fluorescence Microscopy for the Noninvasive Imaging of Langerhans Cells in Macaques.

Todorova B, Salabert N, Tricot S, Boisgard R, Rathaux M, Le Grand R, Chapon C.

Contrast Media Mol Imaging. 2017 Jun 7;2017:3127908. doi: 10.1155/2017/3127908. eCollection 2017.


A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data.

Platon L, Pejoski D, Gautreau G, Targat B, Le Grand R, Beignon AS, Tchitchek N.

Methods. 2018 Jan 1;132:66-75. doi: 10.1016/j.ymeth.2017.09.005. Epub 2017 Sep 14.


Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry.

Marlin R, Nugeyre MT, Tchitchek N, Parenti M, Hocini H, Benjelloun F, Cannou C, Dereuddre-Bosquet N, Levy Y, Barré-Sinoussi F, Scarlatti G, Le Grand R, Menu E.

J Immunol. 2017 Sep 1;199(5):1923-1932. doi: 10.4049/jimmunol.1700320. Epub 2017 Jul 31.


Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques.

Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.

Sci Rep. 2017 Jun 23;7(1):4122. doi: 10.1038/s41598-017-04547-2.


In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry.

Elhmouzi-Younes J, Palgen JL, Tchitchek N, Delandre S, Namet I, Bodinham CL, Pizzoferro K, Lewis DJM, Le Grand R, Cosma A, Beignon AS.

Cytometry A. 2017 Oct;91(10):969-982. doi: 10.1002/cyto.a.23107. Epub 2017 Apr 26.


Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus.

Roques P, Ljungberg K, Kümmerer BM, Gosse L, Dereuddre-Bosquet N, Tchitchek N, Hallengärd D, García-Arriaza J, Meinke A, Esteban M, Merits A, Le Grand R, Liljeström P.

JCI Insight. 2017 Mar 23;2(6):e83527. doi: 10.1172/jci.insight.83527.


Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species.

Cubi R, Vembar SS, Biton A, Franetich JF, Bordessoulles M, Sossau D, Zanghi G, Bosson-Vanga H, Benard M, Moreno A, Dereuddre-Bosquet N, Le Grand R, Scherf A, Mazier D.

Cell Microbiol. 2017 Aug;19(8). doi: 10.1111/cmi.12735. Epub 2017 Mar 13.


RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.

Wilson JA, Prow NA, Schroder WA, Ellis JJ, Cumming HE, Gearing LJ, Poo YS, Taylor A, Hertzog PJ, Di Giallonardo F, Hueston L, Le Grand R, Tang B, Le TT, Gardner J, Mahalingam S, Roques P, Bird PI, Suhrbier A.

PLoS Pathog. 2017 Feb 16;13(2):e1006155. doi: 10.1371/journal.ppat.1006155. eCollection 2017 Feb.


Sublingual Priming with a HIV gp41-Based Subunit Vaccine Elicits Mucosal Antibodies and Persistent B Memory Responses in Non-Human Primates.

Bekri S, Bourdely P, Luci C, Dereuddre-Bosquet N, Su B, Martinon F, Braud VM, Luque I, Mateo PL, Crespillo S, Conejero-Lara F, Moog C, Le Grand R, Anjuère F.

Front Immunol. 2017 Feb 1;8:63. doi: 10.3389/fimmu.2017.00063. eCollection 2017.


Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes.

Lempp FA, Wiedtke E, Qu B, Roques P, Chemin I, Vondran FWR, Le Grand R, Grimm D, Urban S.

Hepatology. 2017 Sep;66(3):703-716. doi: 10.1002/hep.29112. Epub 2017 Jul 18.


Different Expression of Interferon-Stimulated Genes in Response to HIV-1 Infection in Dendritic Cells Based on Their Maturation State.

Calonge E, Bermejo M, Diez-Fuertes F, Mangeot I, González N, Coiras M, Jiménez Tormo L, García-Perez J, Dereuddre-Bosquet N, Le Grand R, Alcamí J.

J Virol. 2017 Mar 29;91(8). pii: e01379-16. doi: 10.1128/JVI.01379-16. Print 2017 Apr 15.


Comprehensive Mass Cytometry Analysis of Cell Cycle, Activation, and Coinhibitory Receptors Expression in CD4 T Cells from Healthy and HIV-Infected Individuals.

Corneau A, Cosma A, Even S, Katlama C, Le Grand R, Frachet V, Blanc C, Autran B.

Cytometry B Clin Cytom. 2017 Jan;92(1):21-32. doi: 10.1002/cyto.b.21502. Review. Erratum in: Cytometry B Clin Cytom. 2017 May;92 (3):236-237.


SPADEVizR: an R package for visualization, analysis and integration of SPADE results.

Gautreau G, Pejoski D, Le Grand R, Cosma A, Beignon AS, Tchitchek N.

Bioinformatics. 2017 Mar 1;33(5):779-781. doi: 10.1093/bioinformatics/btw708.


Report of the Cent Gardes HIV Vaccines Conference, Part 2: The cellular immune response. Fondation Mérieux Conference Center, Veyrier-du-Lac, France, 25-27 October 2015.

Girard MP, Le-Grand R, Picot V, Longuet C, Nabel GJ.

Vaccine. 2016 Nov 4;34(46):5470-5473. doi: 10.1016/j.vaccine.2016.09.034. Epub 2016 Sep 28. No abstract available.


CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge.

Ariën KK, Baleux F, Desjardins D, Porrot F, Coïc YM, Michiels J, Bouchemal K, Bonnaffé D, Bruel T, Schwartz O, Le Grand R, Vanham G, Dereuddre-Bosquet N, Lortat-Jacob H.

Sci Rep. 2016 Oct 10;6:34829. doi: 10.1038/srep34829.


Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales.

Gupta N, Noël R, Goudet A, Hinsinger K, Michau A, Pons V, Abdelkafi H, Secher T, Shima A, Shtanko O, Sakurai Y, Cojean S, Pomel S, Liévin-Le Moal V, Leignel V, Herweg JA, Fischer A, Johannes L, Harrison K, Beard PM, Clayette P, Le Grand R, Rayner JO, Rudel T, Vacus J, Loiseau PM, Davey RA, Oswald E, Cintrat JC, Barbier J, Gillet D.

Chem Biol Interact. 2017 Apr 1;267:96-103. doi: 10.1016/j.cbi.2016.10.005. Epub 2016 Oct 3.


Report of the Cent Gardes HIV Vaccines Conference. Part 1: The antibody response; Fondation Mérieux Conference Center, Veyrier-du-Lac, France, 25-27 October 2015.

Girard MP, Le-Grand R, Picot V, Longuet C, Nabel GJ.

Vaccine. 2016 Jun 30;34(31):3557-61. doi: 10.1016/j.vaccine.2016.05.024. Epub 2016 May 20.


Identification of Vaccine-Altered Circulating B Cell Phenotypes Using Mass Cytometry and a Two-Step Clustering Analysis.

Pejoski D, Tchitchek N, Rodriguez Pozo A, Elhmouzi-Younes J, Yousfi-Bogniaho R, Rogez-Kreuz C, Clayette P, Dereuddre-Bosquet N, Lévy Y, Cosma A, Le Grand R, Beignon AS.

J Immunol. 2016 Jun 1;196(11):4814-31. doi: 10.4049/jimmunol.1502005. Epub 2016 May 2.


Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication.

Lahaye X, Satoh T, Gentili M, Cerboni S, Silvin A, Conrad C, Ahmed-Belkacem A, Rodriguez EC, Guichou JF, Bosquet N, Piel M, Le Grand R, King MC, Pawlotsky JM, Manel N.

Cell Rep. 2016 Apr 26;15(4):879-892. doi: 10.1016/j.celrep.2016.03.074. Epub 2016 Apr 14.


Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates.

Le Grand R, Dereuddre-Bosquet N, Dispinseri S, Gosse L, Desjardins D, Shen X, Tolazzi M, Ochsenbauer C, Saidi H, Tomaras G, Prague M, Barnett SW, Thiebaut R, Cope A, Scarlatti G, Shattock RJ.

J Virol. 2016 May 12;90(11):5315-5328. doi: 10.1128/JVI.00230-16. Print 2016 Jun 1.


PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats.

Willemin ME, Desmots S, Le Grand R, Lestremau F, Zeman FA, Leclerc E, Moesch C, Brochot C.

Toxicol Appl Pharmacol. 2016 Mar 1;294:65-77. doi: 10.1016/j.taap.2016.01.011. Epub 2016 Jan 20.


Intradermal injection of an anti-Langerin-HIVGag fusion vaccine targets epidermal Langerhans cells in nonhuman primates and can be tracked in vivo.

Salabert N, Todorova B, Martinon F, Boisgard R, Zurawski G, Zurawski S, Dereuddre-Bosquet N, Cosma A, Kortulewski T, Banchereau J, Levy Y, Le Grand R, Chapon C.

Eur J Immunol. 2016 Mar;46(3):689-700. doi: 10.1002/eji.201545465. Epub 2016 Jan 19.

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