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A Genome Wide Association Study on plasma FV levels identified PLXDC2 as a new modifier of the coagulation process.

Thibord F, Hardy L, Ibrahim-Kosta M, Saut N, Pulcrano-Nicolas AS, Goumidi L, Civelek M, Eriksson P, Deleuze JF, Le Goff W, Trégouët DA, Morange PE.

J Thromb Haemost. 2019 Jul 4. doi: 10.1111/jth.14562. [Epub ahead of print]


Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis.

Galle-Treger L, Moreau M, Ballaire R, Poupel L, Huby T, Sasso E, Troise F, Poti F, Lesnik P, Le Goff W, Gautier EL, Huby T.

Cardiovasc Res. 2019 May 22. pii: cvz138. doi: 10.1093/cvr/cvz138. [Epub ahead of print]


Identification of the first Tangier disease patient in Lebanon carrying a new pathogenic variant in ABCA1.

El Khoury P, Couvert P, Elbitar S, Ghaleb Y, Abou-Khalil Y, Azar Y, Ayoub C, Superville A, Guérin M, Rabès JP, Varret M, Boileau C, Jambart S, Giral P, Carrié A, Le Goff W, Abifadel M.

J Clin Lipidol. 2018 Nov - Dec;12(6):1374-1382. doi: 10.1016/j.jacl.2018.08.013. Epub 2018 Sep 1.


Impairment of chondrogenesis and microfibrillar network in Adamtsl2 deficiency.

Delhon L, Mahaut C, Goudin N, Gaudas E, Piquand K, Le Goff W, Cormier-Daire V, Le Goff C.

FASEB J. 2019 Feb;33(2):2707-2718. doi: 10.1096/fj.201800753RR. Epub 2018 Oct 10.


HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages.

Orekhov AN, Pushkarsky T, Oishi Y, Nikiforov NG, Zhelankin AV, Dubrovsky L, Makeev VJ, Foxx K, Jin X, Kruth HS, Sobenin IA, Sukhorukov VN, Zakiev ER, Kontush A, Le Goff W, Bukrinsky M.

Exp Mol Pathol. 2018 Oct;105(2):202-207. doi: 10.1016/j.yexmp.2018.08.003. Epub 2018 Aug 16.


Hypoalphalipoproteinemia and BRAFV600E Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease.

Cohen-Aubart F, Guerin M, Poupel L, Cluzel P, Saint-Charles F, Charlotte F, Arsafi Y, Emile JF, Frisdal E, Le Goff C, Donadieu J, Amoura Z, Lesnik P, Haroche J, Le Goff W.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1913-1925. doi: 10.1161/ATVBAHA.118.310803.


Critical Role of the Human ATP-Binding Cassette G1 Transporter in Cardiometabolic Diseases.

Hardy LM, Frisdal E, Le Goff W.

Int J Mol Sci. 2017 Sep 2;18(9). pii: E1892. doi: 10.3390/ijms18091892. Review.


Modulation of Gr1low monocyte subset impacts insulin sensitivity and weight gain upon high-fat diet in female mice.

Béliard S, Le Goff W, Saint-Charles F, Poupel L, Deswaerte V, Bouchareychas L, Huby T, Lesnik P.

Int J Obes (Lond). 2017 Dec;41(12):1805-1814. doi: 10.1038/ijo.2017.179. Epub 2017 Aug 3.


Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis.

Gall J, Frisdal E, Bittar R, Le Goff W, Bruckert E, Lesnik P, Guerin M, Giral P.

J Am Heart Assoc. 2016 Nov 23;5(12). pii: e004808.


Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans.

Codoni V, Blum Y, Civelek M, Proust C, Franzén O; Cardiogenics Consortium; IDEM Leducq Consortium CADGenomics, Björkegren JL, Le Goff W, Cambien F, Lusis AJ, Trégouët DA.

G3 (Bethesda). 2016 Oct 13;6(10):3361-3371. doi: 10.1534/g3.116.033894.


Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome.

Le Goff C, Rogers C, Le Goff W, Pinto G, Bonnet D, Chrabieh M, Alibeu O, Nistchke P, Munnich A, Picard C, Cormier-Daire V.

Am J Hum Genet. 2016 Aug 4;99(2):407-13. doi: 10.1016/j.ajhg.2016.06.005. Epub 2016 Jul 14.


Lipidomic approach provides new clues toward solving the mystery of accelerated atherosclerosis in diabetes.

Borradaile N, Le Goff W.

Atherosclerosis. 2016 Aug;251:507-509. doi: 10.1016/j.atherosclerosis.2016.06.007. Epub 2016 Jun 11. No abstract available.


Extended-Release Niacin/Laropiprant Improves Overall Efficacy of Postprandial Reverse Cholesterol Transport.

El Khoury P, Waldmann E, Huby T, Gall J, Couvert P, Lacorte JM, Chapman J, Frisdal E, Lesnik P, Parhofer KG, Le Goff W, Guerin M.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):285-94. doi: 10.1161/ATVBAHA.115.306834. Epub 2015 Dec 17.


Therapeutic applications of reconstituted HDL: When structure meets function.

Darabi M, Guillas-Baudouin I, Le Goff W, Chapman MJ, Kontush A.

Pharmacol Ther. 2016 Jan;157:28-42. doi: 10.1016/j.pharmthera.2015.10.010. Epub 2015 Nov 10. Review.


Adipose ABCG1: A potential therapeutic target in obesity?

Frisdal E, Le Goff W.

Adipocyte. 2015 Mar 9;4(4):315-8. doi: 10.1080/21623945.2015.1023491. eCollection 2015 Oct-Dec.


The spectrum of neutrophilic dermatoses associated with monoclonal gammopathy: Association with IgA isotype and inflammatory profile.

Szalat R, Monsel G, Le Goff W, Battistella M, Bengouffa D, Schlageter MH, Bouaziz JD, Arnulf B, Vignon M, Lesnik P, Saussine A, Malphettes M, Lazareth A, Vignon-Pennamen MD, Bagot M, Brouet JC, Fermand JP, Rybojad M, Asli B.

J Am Acad Dermatol. 2015 Nov;73(5):809-20. doi: 10.1016/j.jaad.2015.07.031. Epub 2015 Sep 11. Review.


Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.

Bouchareychas L, Pirault J, Saint-Charles F, Deswaerte V, Le Roy T, Jessup W, Giral P, Le Goff W, Huby T, Gautier EL, Lesnik P.

Cardiovasc Res. 2015 Oct 1;108(1):111-23. doi: 10.1093/cvr/cvv177. Epub 2015 Jun 19.


HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export.

Du XM, Kim MJ, Hou L, Le Goff W, Chapman MJ, Van Eck M, Curtiss LK, Burnett JR, Cartland SP, Quinn CM, Kockx M, Kontush A, Rye KA, Kritharides L, Jessup W.

Circ Res. 2015 Mar 27;116(7):1133-42. doi: 10.1161/CIRCRESAHA.116.305485. Epub 2015 Jan 14. Erratum in: Circ Res. 2015 Jul 17;117(3):e40.


Plasma cholesterol efflux capacity from human THP-1 macrophages is reduced in HIV-infected patients: impact of HAART.

El Khoury P, Ghislain M, Villard EF, Le Goff W, Lascoux-Combe C, Yeni P, Meyer L, Vigouroux C, Goujard C, Guerin M.

J Lipid Res. 2015 Mar;56(3):692-702. doi: 10.1194/jlr.M054510. Epub 2015 Jan 8.


ABCG1 is involved in vitamin E efflux.

Olivier M, BottG R, Frisdal E, Nowick M, Plengpanich W, Desmarchelier C, Roi S, Quinn CM, Gelissen I, Jessup W, Van Eck M, Guérin M, Le Goff W, Reboul E.

Biochim Biophys Acta. 2014 Dec;1841(12):1741-51.


Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity.

Frisdal E, Le Lay S, Hooton H, Poupel L, Olivier M, Alili R, Plengpanich W, Villard EF, Gilibert S, Lhomme M, Superville A, Miftah-Alkhair L, Chapman MJ, Dallinga-Thie GM, Venteclef N, Poitou C, Tordjman J, Lesnik P, Kontush A, Huby T, Dugail I, Clement K, Guerin M, Le Goff W.

Diabetes. 2015 Mar;64(3):840-55. doi: 10.2337/db14-0245. Epub 2014 Sep 23.


A new piece in the puzzling effect of n-3 fatty acids on atherosclerosis?

Le Goff W.

Atherosclerosis. 2014 Aug;235(2):358-62. doi: 10.1016/j.atherosclerosis.2014.03.038. Epub 2014 May 22.


Improved plasma cholesterol efflux capacity from human macrophages in patients with hyperalphalipoproteinemia.

El Khoury P, Plengpanich W, Frisdal E, Le Goff W, Khovidhunkit W, Guerin M.

Atherosclerosis. 2014 May;234(1):193-9. doi: 10.1016/j.atherosclerosis.2014.02.032. Epub 2014 Mar 12.


Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection.

Bocchetta S, Maillard P, Yamamoto M, Gondeau C, Douam F, Lebreton S, Lagaye S, Pol S, Helle F, Plengpanich W, Guérin M, Bourgine M, Michel ML, Lavillette D, Roingeard P, le Goff W, Budkowska A.

PLoS One. 2014 Mar 19;9(3):e92140. doi: 10.1371/journal.pone.0092140. eCollection 2014.


Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy.

Szalat R, Pirault J, Fermand JP, Carrié A, Saint-Charles F, Olivier M, Robillard P, Frisdal E, Villard EF, Cathébras P, Bruckert E, Chapman MJ, Giral P, Guerin M, Lesnik P, Le Goff W.

J Intern Med. 2014 Sep;276(3):269-84. doi: 10.1111/joim.12195. Epub 2014 Feb 10.


Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities.

Camont L, Lhomme M, Rached F, Le Goff W, Nègre-Salvayre A, Salvayre R, Calzada C, Lagarde M, Chapman MJ, Kontush A.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2715-23. doi: 10.1161/ATVBAHA.113.301468. Epub 2013 Oct 3.


Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders.

Pakradouni J, Le Goff W, Calmel C, Antoine B, Villard E, Frisdal E, Abifadel M, Tordjman J, Poitou C, Bonnefont-Rousselot D, Bittar R, Bruckert E, Clément K, Fève B, Martinerie C, Guérin M.

PLoS One. 2013 Jun 13;8(6):e66788. doi: 10.1371/journal.pone.0066788. Print 2013.


Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels.

Villard EF, EI Khoury P, Frisdal E, Bruckert E, Clement K, Bonnefont-Rousselot D, Bittar R, Le Goff W, Guerin M.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):822-8. doi: 10.1161/ATVBAHA.112.300979. Epub 2013 Jan 31.


Endogenous CETP activity as a predictor of cardiovascular risk: determination of the optimal range.

Villard EF, Federspiel MC, Cherfils C, Fesel-Fouquier V, Bruckert E, Clement K, Bonnefont-Rousselot D, Le Goff W, Bittar R, Couvert P, Guerin M.

Atherosclerosis. 2013 Mar;227(1):165-71. doi: 10.1016/j.atherosclerosis.2012.12.024. Epub 2013 Jan 2.


Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia.

Plengpanich W, Tongkobpetch S, Shotelersuk V, Le Goff W, Khovidhunkit W.

Clin Chim Acta. 2013 Feb 1;416:92-5. doi: 10.1016/j.cca.2012.11.024. Epub 2012 Dec 5.


Elevated CETP activity improves plasma cholesterol efflux capacity from human macrophages in women.

Villard EF, El Khoury P, Duchene E, Bonnefont-Rousselot D, Clement K, Bruckert E, Bittar R, Le Goff W, Guerin M.

Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2341-9. doi: 10.1161/ATVBAHA.112.252841. Epub 2012 Aug 16.


Human ATP-binding cassette G1 controls macrophage lipoprotein lipase bioavailability and promotes foam cell formation.

Olivier M, Tanck MW, Out R, Villard EF, Lammers B, Bouchareychas L, Frisdal E, Superville A, Van Berkel T, Kastelein JJ, Eck MV, Jukema JW, Chapman MJ, Dallinga-Thie GM, Guerin M, Le Goff W.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2223-31. doi: 10.1161/ATVBAHA.111.243519. Epub 2012 Jul 5. Erratum in: Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):e147.


Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.

Abifadel M, Guerin M, Benjannet S, Rabès JP, Le Goff W, Julia Z, Hamelin J, Carreau V, Varret M, Bruckert E, Tosolini L, Meilhac O, Couvert P, Bonnefont-Rousselot D, Chapman J, Carrié A, Michel JB, Prat A, Seidah NG, Boileau C.

Atherosclerosis. 2012 Aug;223(2):394-400. doi: 10.1016/j.atherosclerosis.2012.04.006. Epub 2012 May 17.


Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial hypercholesterolemia.

Orsoni A, Villard EF, Bruckert E, Robillard P, Carrie A, Bonnefont-Rousselot D, Chapman MJ, Dallinga-Thie GM, Le Goff W, Guerin M.

J Lipid Res. 2012 Apr;53(4):767-75. doi: 10.1194/jlr.M024141. Epub 2012 Feb 15.


Functionality of postprandial larger HDL2 particles is enhanced following CETP inhibition therapy.

Bellanger N, Julia Z, Villard EF, El Khoury P, Duchene E, Chapman MJ, Fournier N, Le Goff W, Guerin M.

Atherosclerosis. 2012 Mar;221(1):160-8. doi: 10.1016/j.atherosclerosis.2011.12.027. Epub 2012 Jan 4.


Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome.

Le Goff C, Mahaut C, Abhyankar A, Le Goff W, Serre V, Afenjar A, Destrée A, di Rocco M, Héron D, Jacquemont S, Marlin S, Simon M, Tolmie J, Verloes A, Casanova JL, Munnich A, Cormier-Daire V.

Nat Genet. 2011 Dec 11;44(1):85-8. doi: 10.1038/ng.1016.


Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry.

Maillard P, Walic M, Meuleman P, Roohvand F, Huby T, Le Goff W, Leroux-Roels G, Pécheur EI, Budkowska A.

PLoS One. 2011;6(10):e26637. doi: 10.1371/journal.pone.0026637. Epub 2011 Oct 21.


Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI.

Zhao Y, Pennings M, Vrins CL, Calpe-Berdiel L, Hoekstra M, Kruijt JK, Ottenhoff R, Hildebrand RB, van der Sluis R, Jessup W, Le Goff W, Chapman MJ, Huby T, Groen AK, Van Berkel TJ, Van Eck M.

Atherosclerosis. 2011 Oct;218(2):314-22. doi: 10.1016/j.atherosclerosis.2011.07.096. Epub 2011 Jul 27.


ABCG1: not as good as expected?

Le Goff W, Dallinga-Thie GM.

Atherosclerosis. 2011 Dec;219(2):393-4. doi: 10.1016/j.atherosclerosis.2011.07.015. Epub 2011 Jul 22. No abstract available.


Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response.

Frisdal E, Lesnik P, Olivier M, Robillard P, Chapman MJ, Huby T, Guerin M, Le Goff W.

J Biol Chem. 2011 Sep 2;286(35):30926-36. doi: 10.1074/jbc.M111.264325. Epub 2011 Jul 8.


Atheroprotective reverse cholesterol transport pathway is defective in familial hypercholesterolemia.

Bellanger N, Orsoni A, Julia Z, Fournier N, Frisdal E, Duchene E, Bruckert E, Carrie A, Bonnefont-Rousselot D, Pirault J, Saint-Charles F, Chapman MJ, Lesnik P, Le Goff W, Guerin M.

Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1675-81. doi: 10.1161/ATVBAHA.111.227181. Epub 2011 Apr 28.


Cholesteryl ester transfer protein expression partially attenuates the adverse effects of SR-BI receptor deficiency on cholesterol metabolism and atherosclerosis.

El Bouhassani M, Gilibert S, Moreau M, Saint-Charles F, Tréguier M, Poti F, Chapman MJ, Le Goff W, Lesnik P, Huby T.

J Biol Chem. 2011 May 13;286(19):17227-38. doi: 10.1074/jbc.M111.220483. Epub 2011 Mar 20.


CETP deficiency due to a novel mutation in the CETP gene promoter and its effect on cholesterol efflux and selective uptake into hepatocytes.

Plengpanich W, Le Goff W, Poolsuk S, Julia Z, Guerin M, Khovidhunkit W.

Atherosclerosis. 2011 Jun;216(2):370-3. doi: 10.1016/j.atherosclerosis.2011.01.051. Epub 2011 Feb 26.


Postprandial lipemia enhances the capacity of large HDL2 particles to mediate free cholesterol efflux via SR-BI and ABCG1 pathways in type IIB hyperlipidemia.

Julia Z, Duchene E, Fournier N, Bellanger N, Chapman MJ, Le Goff W, Guerin M.

J Lipid Res. 2010 Nov;51(11):3350-8. doi: 10.1194/jlr.P009746. Epub 2010 Aug 16.


Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors.

Chapman MJ, Le Goff W, Guerin M, Kontush A.

Eur Heart J. 2010 Jan;31(2):149-64. doi: 10.1093/eurheartj/ehp399. Epub 2009 Oct 12. Review.


Stimulation of cholesterol efflux by LXR agonists in cholesterol-loaded human macrophages is ABCA1-dependent but ABCG1-independent.

Larrede S, Quinn CM, Jessup W, Frisdal E, Olivier M, Hsieh V, Kim MJ, Van Eck M, Couvert P, Carrie A, Giral P, Chapman MJ, Guerin M, Le Goff W.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1930-6. doi: 10.1161/ATVBAHA.109.194548. Epub 2009 Sep 3.


Cyclosporin A decreases apolipoprotein E secretion from human macrophages via a protein phosphatase 2B-dependent and ATP-binding cassette transporter A1 (ABCA1)-independent pathway.

Kockx M, Guo DL, Traini M, Gaus K, Kay J, Wimmer-Kleikamp S, Rentero C, Burnett JR, Le Goff W, Van Eck M, Stow JL, Jessup W, Kritharides L.

J Biol Chem. 2009 Sep 4;284(36):24144-54. doi: 10.1074/jbc.M109.032615. Epub 2009 Jul 9.


Torcetrapib differentially modulates the biological activities of HDL2 and HDL3 particles in the reverse cholesterol transport pathway.

Catalano G, Julia Z, Frisdal E, Vedie B, Fournier N, Le Goff W, Chapman MJ, Guerin M.

Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):268-75. doi: 10.1161/ATVBAHA.108.179416. Epub 2008 Nov 26.


Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects.

Catalano G, Duchene E, Julia Z, Le Goff W, Bruckert E, Chapman MJ, Guerin M.

J Lipid Res. 2008 Mar;49(3):635-43. Epub 2007 Dec 5.


Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.

Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen IC, Zhao Y, Kritharides L, Chimini G, Kuiper J, Chapman MJ, Huby T, Van Berkel TJ, Van Eck M.

Circ Res. 2008 Jan 4;102(1):113-20. Epub 2007 Oct 25.


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