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Full genome analysis of bovine papillomavirus type 1 derived from a calf with severe cutaneous multiple papillomatosis.

Shimakura H, Dong J, Zhu W, Chambers JK, Uchida K, Kiriki K, Uematsu M, Goto Y, Yasuda M, Yamashita N, Tsuzuki M, LE DT, Hatama S, Haga T.

J Vet Med Sci. 2018 Sep 12. doi: 10.1292/jvms.18-0289. [Epub ahead of print]


CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer.

Janjigian YY, Bendell J, Calvo E, Kim JW, Ascierto PA, Sharma P, Ott PA, Peltola K, Jaeger D, Evans J, de Braud F, Chau I, Harbison CT, Dorange C, Tschaika M, Le DT.

J Clin Oncol. 2018 Aug 15:JCO2017766212. doi: 10.1200/JCO.2017.76.6212. [Epub ahead of print]


A phase I trial of a guadecitabine (SGI-110) and irinotecan in metastatic colorectal cancer patients previously exposed to irinotecan.

Lee V, Wang JS, Zahurak ML, Gootjes EC, Verheul HMW, Parkinson RM, Kerner Z, Sharma A, Rosner GL, De Jesus-Acosta A, Laheru DA, Le DT, Oganesian A, Lilly-Foreman E, Brown T, Jones PA, Baylin SB, Ahuja N, Azad NA.

Clin Cancer Res. 2018 Aug 10. pii: clincanres.0421.2018. doi: 10.1158/1078-0432.CCR-18-0421. [Epub ahead of print]


T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma.

Hopkins AC, Yarchoan M, Durham JN, Yusko EC, Rytlewski JA, Robins HS, Laheru DA, Le DT, Lutz ER, Jaffee EM.

JCI Insight. 2018 Jul 12;3(13). pii: 122092. doi: 10.1172/jci.insight.122092. [Epub ahead of print]


A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.

Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA.

Nat Med. 2018 Jul;24(7):1005-1014. doi: 10.1038/s41591-018-0070-2. Epub 2018 Jun 25.


Controlled Defect Based Ultra Broadband Full-sized Metamaterial Absorber.

Tran MC, Le DH, Pham VH, Do HT, Le DT, Dang HL, Vu DL.

Sci Rep. 2018 Jun 22;8(1):9523. doi: 10.1038/s41598-018-27920-1.


Function of the evolutionarily conserved plant methionine-S-sulfoxide reductase without the catalytic residue.

Le DT, Nguyen KL, Chu HD, Vu NT, Pham TTL, Tran LP.

Protoplasma. 2018 May 28. doi: 10.1007/s00709-018-1266-5. [Epub ahead of print]


Immunotherapy in colorectal cancer.

Le DT.

Clin Adv Hematol Oncol. 2018 Jan;16(1):22-24. No abstract available.


A new species of Leptolalax (Anura: Megophryidae) from Son Tra Peninsula, central Vietnam.

Nguyen LT, Poyarkov NAJ, Le DT, Vo BD, Phan HT, Duong TV, Murphy RW, Nguyen SN.

Zootaxa. 2018 Feb 28;4388(1):1-21. doi: 10.11646/zootaxa.4388.1.1.


Anti-cancerous effect of cis-khellactone from Angelica amurensis through the induction of three programmed cell deaths.

Jung S, Moon HI, Lee BS, Kim S, Quynh NTN, Yu J, Le DT, Sandag Z, Lee H, Lee H, Anh NH, Yang Y, Lim JS, Kim KI, Lee MS.

Oncotarget. 2018 Mar 30;9(24):16744-16757. doi: 10.18632/oncotarget.24686. eCollection 2018 Mar 30.


DNA mismatch repair in cancer.

Baretti M, Le DT.

Pharmacol Ther. 2018 Sep;189:45-62. doi: 10.1016/j.pharmthera.2018.04.004. Epub 2018 Apr 15. Review.


Stereotactic body radiation therapy for palliative management of pancreatic adenocarcinoma in elderly and medically inoperable patients.

Ryan JF, Rosati LM, Groot VP, Le DT, Zheng L, Laheru DA, Shin EJ, Jackson J, Moore J, Narang AK, Herman JM.

Oncotarget. 2018 Mar 27;9(23):16427-16436. doi: 10.18632/oncotarget.24713. eCollection 2018 Mar 27.


Clinical presentation of immune checkpoint inhibitor-induced inflammatory arthritis differs by immunotherapy regimen.

Cappelli LC, Brahmer JR, Forde PM, Le DT, Lipson EJ, Naidoo J, Zheng L, Bingham CO 3rd, Shah AA.

Semin Arthritis Rheum. 2018 Mar 21. pii: S0049-0172(18)30042-8. doi: 10.1016/j.semarthrit.2018.02.011. [Epub ahead of print]


Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis.

Adler BL, Pezhouh MK, Kim A, Luan L, Zhu Q, Gani F, Yarchoan M, Chen J, Voltaggio L, Parian A, Lazarev M, Lauwers GY, Pawlik TM, Montgomery EA, Jaffee E, Le DT, Taube JM, Anders RA.

J Intern Med. 2018 Jun;283(6):568-577. doi: 10.1111/joim.12744. Epub 2018 Mar 24.


Tensile, Thermal, Dielectric and Morphological Properties of Polyoxymethylene/Silica Nanocomposites.

Mai TT, Chinh NT, Baskaran R, Trang NTT, Thang VV, Le DTT, Minh DQ, Hoang T.

J Nanosci Nanotechnol. 2018 Jul 1;18(7):4963-4970. doi: 10.1166/jnn.2018.15352.


Feeling out a link between feeling and infant sociomoral evaluation.

Steckler CM, Liberman Z, Van de Vondervoort JW, Slevinsky J, Le DT, Hamlin JK.

Br J Dev Psychol. 2017 Dec 28. doi: 10.1111/bjdp.12232. [Epub ahead of print]


Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes.

Carrington LB, Tran BCN, Le NTH, Luong TTH, Nguyen TT, Nguyen PT, Nguyen CVV, Nguyen HTC, Vu TT, Vo LT, Le DT, Vu NT, Nguyen GT, Luu HQ, Dang AD, Hurst TP, O'Neill SL, Tran VT, Kien DTH, Nguyen NM, Wolbers M, Wills B, Simmons CP.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):361-366. doi: 10.1073/pnas.1715788115. Epub 2017 Dec 26.


A rare case of esophageal metastasis from pancreatic ductal adenocarcinoma: a case report and literature review.

Rosati LM, Kummerlowe MN, Poling J, Hacker-Prietz A, Narang AK, Shin EJ, Le DT, Fishman EK, Hruban RH, Yang SC, Weiss MJ, Herman JM.

Oncotarget. 2017 Jun 12;8(59):100942-100950. doi: 10.18632/oncotarget.18458. eCollection 2017 Nov 21.


Wound healing activity of Streptocaulon juventas root ethanolic extract.

Nguyen MC, Le DT, Kamei K, Dang TPT.

Wound Repair Regen. 2017 Nov;25(6):956-963. doi: 10.1111/wrr.12599. Epub 2018 Feb 7.


Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy.

Rao AD, Liu Y, von Eyben R, Hsu CC, Hu C, Rosati LM, Parekh A, Ng K, Hacker-Prietz A, Zheng L, Pawlik TM, Laheru DA, Jaffee EM, Weiss MJ, Le DT, Hruban RH, De Jesus-Acosta A, Wolfgang CL, Narang AK, Chang DT, Koong AC, Herman JM.

Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):486-489. doi: 10.1016/j.ijrobp.2017.10.001. Epub 2017 Oct 12.


Stereotactic Body Radiation Therapy for Isolated Local Recurrence After Surgical Resection of Pancreatic Ductal Adenocarcinoma Appears to be Safe and Effective.

Ryan JF, Groot VP, Rosati LM, Hacker-Prietz A, Narang AK, McNutt TR, Jackson JF, Le DT, Jaffee EM, Zheng L, Laheru DA, He J, Pawlik TM, Weiss MJ, Wolfgang CL, Herman JM.

Ann Surg Oncol. 2018 Jan;25(1):280-289. doi: 10.1245/s10434-017-6134-6. Epub 2017 Oct 23.


A Blueprint to Advance Colorectal Cancer Immunotherapies.

Le DT, Hubbard-Lucey VM, Morse MA, Heery CR, Dwyer A, Marsilje TH, Brodsky AN, Chan E, Deming DA, Diaz LA Jr, Fridman WH, Goldberg RM, Hamilton SR, Housseau F, Jaffee EM, Kang SP, Krishnamurthi SS, Lieu CH, Messersmith W, Sears CL, Segal NH, Yang A, Moss RA, Cha E, O'Donnell-Tormey J, Roach N, Davis AQ, McAbee K, Worrall S, Benson AB.

Cancer Immunol Res. 2017 Nov;5(11):942-949. doi: 10.1158/2326-6066.CIR-17-0375. Epub 2017 Oct 16.


Potential transmission opportunity of CTX-M-producing Escherichia coli on a large-scale chicken farm in Vietnam.

Bui TKN, Bui TMH, Ueda S, Le DT, Yamamoto Y, Hirai I.

J Glob Antimicrob Resist. 2018 Jun;13:1-6. doi: 10.1016/j.jgar.2017.09.014. Epub 2017 Oct 10.


Cutaneous Eruptions in Patients Receiving Immune Checkpoint Blockade: Clinicopathologic Analysis of the Nonlichenoid Histologic Pattern.

Kaunitz GJ, Loss M, Rizvi H, Ravi S, Cuda JD, Bleich KB, Esandrio J, Sander I, Le DT, Diaz LA Jr, Brahmer JR, Drake CG, Hollmann TJ, Lacouture ME, Hellmann MD, Lipson EJ, Taube JM.

Am J Surg Pathol. 2017 Oct;41(10):1381-1389. doi: 10.1097/PAS.0000000000000900.


Social evaluation of intentional, truly accidental, and negligently accidental helpers and harmers by 10-month-old infants.

Woo BM, Steckler CM, Le DT, Hamlin JK.

Cognition. 2017 Nov;168:154-163. doi: 10.1016/j.cognition.2017.06.029. Epub 2017 Jul 5.


Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer.

Shrestha B, Sun Y, Faisal F, Kim V, Soares K, Blair A, Herman JM, Narang A, Dholakia AS, Rosati L, Hacker-Prietz A, Chen L, Laheru DA, De Jesus-Acosta A, Le DT, Donehower R, Azad N, Diaz LA, Murphy A, Lee V, Fishman EK, Hruban RH, Liang T, Cameron JL, Makary M, Weiss MJ, Ahuja N, He J, Wolfgang CL, Huang CY, Zheng L.

Cancer Med. 2017 Jul;6(7):1552-1562. doi: 10.1002/cam4.1104. Epub 2017 Jun 21.


A new species of <i>Leptolalax</i> (Anura: Megophryidae) from northern Vietnam.

Rowley JJL, Dau VQ, Hoang HD, LE DTT, Cutajar TP, Nguyen TT.

Zootaxa. 2017 Mar 16;4243(3):544-564. doi: 10.11646/zootaxa.4243.3.7.


Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Greten TF, Duffy AG, Ciombor KK, Eyring AD, Lam BH, Joe A, Kang SP, Holdhoff M, Danilova L, Cope L, Meyer C, Zhou S, Goldberg RM, Armstrong DK, Bever KM, Fader AN, Taube J, Housseau F, Spetzler D, Xiao N, Pardoll DM, Papadopoulos N, Kinzler KW, Eshleman JR, Vogelstein B, Anders RA, Diaz LA Jr.

Science. 2017 Jul 28;357(6349):409-413. doi: 10.1126/science.aan6733. Epub 2017 Jun 8.


Inflammatory Arthritis: A Newly Recognized Adverse Event of Immune Checkpoint Blockade.

Naidoo J, Cappelli LC, Forde PM, Marrone KA, Lipson EJ, Hammers HJ, Sharfman WH, Le DT, Baer AN, Shah AA, Albayda J, Manno RL, Haque U, Gutierrez AK, Bingham CO 3rd, Brahmer JR.

Oncologist. 2017 Jun;22(6):627-630. doi: 10.1634/theoncologist.2016-0390. Epub 2017 Jun 2. No abstract available.


Tissue-Agnostic Drug Development.

Flaherty KT, Le DT, Lemery S.

Am Soc Clin Oncol Educ Book. 2017;37:222-230. doi: 10.14694/EDBK_173855.


Olaparib in combination with irinotecan, cisplatin, and mitomycin C in patients with advanced pancreatic cancer.

Yarchoan M, Myzak MC, Johnson BA 3rd, De Jesus-Acosta A, Le DT, Jaffee EM, Azad NS, Donehower RC, Zheng L, Oberstein PE, Fine RL, Laheru DA, Goggins M.

Oncotarget. 2017 Jul 4;8(27):44073-44081. doi: 10.18632/oncotarget.17237.


An Expanding Role for Immunotherapy in Colorectal Cancer.

Bever KM, Le DT.

J Natl Compr Canc Netw. 2017 Mar;15(3):401-410. Review.


Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.

Shin DS, Zaretsky JM, Escuin-Ordinas H, Garcia-Diaz A, Hu-Lieskovan S, Kalbasi A, Grasso CS, Hugo W, Sandoval S, Torrejon DY, Palaskas N, Rodriguez GA, Parisi G, Azhdam A, Chmielowski B, Cherry G, Seja E, Berent-Maoz B, Shintaku IP, Le DT, Pardoll DM, Diaz LA Jr, Tumeh PC, Graeber TG, Lo RS, Comin-Anduix B, Ribas A.

Cancer Discov. 2017 Feb;7(2):188-201. doi: 10.1158/2159-8290.CD-16-1223. Epub 2016 Nov 30.


Biallelic mutations in IRF8 impair human NK cell maturation and function.

Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS.

J Clin Invest. 2017 Jan 3;127(1):306-320. doi: 10.1172/JCI86276. Epub 2016 Nov 28.


Mesothelin Immunotherapy for Cancer: Ready for Prime Time?

Hassan R, Thomas A, Alewine C, Le DT, Jaffee EM, Pastan I.

J Clin Oncol. 2016 Dec;34(34):4171-4179. Epub 2016 Oct 31. Review.


Adhesion of the genome-sequenced Lactococcus lactis subsp. cremoris IBB477 strain is mediated by specific molecular determinants.

Radziwill-Bienkowska JM, Le DT, Szczesny P, Duviau MP, Aleksandrzak-Piekarczyk T, Loubière P, Mercier-Bonin M, Bardowski JK, Kowalczyk M.

Appl Microbiol Biotechnol. 2016 Nov;100(22):9605-9617. Epub 2016 Sep 29.


Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial.

Sharma P, Callahan MK, Bono P, Kim J, Spiliopoulou P, Calvo E, Pillai RN, Ott PA, de Braud F, Morse M, Le DT, Jaeger D, Chan E, Harbison C, Lin CS, Tschaika M, Azrilevich A, Rosenberg JE.

Lancet Oncol. 2016 Nov;17(11):1590-1598. doi: 10.1016/S1470-2045(16)30496-X. Epub 2016 Oct 9.


A new species of Cyrtodactylus (Squamata: Gekkonidae) from Ninh Binh Province, Vietnam.

Le DT, Nguyen TQ, Le MD, Ziegler T.

Zootaxa. 2016 Sep 9;4162(2):268-82. doi: 10.11646/zootaxa.4162.2.4.


Thermal Unthreading of the Lasso Peptides Astexin-2 and Astexin-3.

Allen CD, Chen MY, Trick AY, Le DT, Ferguson AL, Link AJ.

ACS Chem Biol. 2016 Nov 18;11(11):3043-3051. Epub 2016 Sep 15.


Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade.

Lee V, Murphy A, Le DT, Diaz LA Jr.

Oncologist. 2016 Oct;21(10):1200-1211. Epub 2016 Jul 13. Review.


Five new, microendemic Asian Leaf-litter Frogs (Leptolalax) from the southern Annamite mountains, Vietnam.

Rowley JJ, Tran DT, Le DT, Dau VQ, Peloso PL, Nguyen TQ, Hoang HD, Nguyen TT, Ziegler T.

Zootaxa. 2016 Mar 1;4085(1):63-102. doi: 10.11646/zootaxa.4085.1.3. Erratum in: Zootaxa. 2016 Apr 22;4105(4):400.


Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors.

Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, Le DT, Lipson EJ, Glezerman IG, Wolchok J, Cornell LD, Feldman P, Stokes MB, Zapata SA, Hodi FS, Ott PA, Yamashita M, Leaf DE.

Kidney Int. 2016 Sep;90(3):638-47. doi: 10.1016/j.kint.2016.04.008. Epub 2016 Jun 7.


Association of Autoimmune Encephalitis With Combined Immune Checkpoint Inhibitor Treatment for Metastatic Cancer.

Williams TJ, Benavides DR, Patrice KA, Dalmau JO, de Ávila AL, Le DT, Lipson EJ, Probasco JC, Mowry EM.

JAMA Neurol. 2016 Aug 1;73(8):928-33. doi: 10.1001/jamaneurol.2016.1399.


Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial.

Antonia SJ, López-Martin JA, Bendell J, Ott PA, Taylor M, Eder JP, Jäger D, Pietanza MC, Le DT, de Braud F, Morse MA, Ascierto PA, Horn L, Amin A, Pillai RN, Evans J, Chau I, Bono P, Atmaca A, Sharma P, Harbison CT, Lin CS, Christensen O, Calvo E.

Lancet Oncol. 2016 Jul;17(7):883-895. doi: 10.1016/S1470-2045(16)30098-5. Epub 2016 Jun 4. Erratum in: Lancet Oncol. 2016 Jul;17 (7):e270.


Improving Nutritional Quality of Plant Proteins Through Genetic Engineering.

Le DT, Chu HD, Le NQ.

Curr Genomics. 2016 Jun;17(3):220-9. doi: 10.2174/1389202917666160202215934.


Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial.

Muro K, Chung HC, Shankaran V, Geva R, Catenacci D, Gupta S, Eder JP, Golan T, Le DT, Burtness B, McRee AJ, Lin CC, Pathiraja K, Lunceford J, Emancipator K, Juco J, Koshiji M, Bang YJ.

Lancet Oncol. 2016 Jun;17(6):717-726. doi: 10.1016/S1470-2045(16)00175-3. Epub 2016 May 3.


Microsatellite Instability as a Biomarker for PD-1 Blockade.

Dudley JC, Lin MT, Le DT, Eshleman JR.

Clin Cancer Res. 2016 Feb 15;22(4):813-20. doi: 10.1158/1078-0432.CCR-15-1678. Review.


Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer.

Jhaveri DT, Kim MS, Thompson ED, Huang L, Sharma R, Klein AP, Zheng L, Le DT, Laheru DA, Pandey A, Jaffee EM, Anders RA.

Cancer Immunol Res. 2016 Mar;4(3):225-33. doi: 10.1158/2326-6066.CIR-15-0200-T. Epub 2016 Feb 3. Erratum in: Cancer Immunol Res. 2016 May;4(5):472.

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