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Items: 1 to 50 of 317

1.

Proinflammatory Diet Increases Circulating Inflammatory Biomarkers and Falls Risk in Community-Dwelling Older Men.

Cervo MMC, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Shivappa N, Hebert JR, Hirani V.

J Nutr. 2019 Oct 26. pii: nxz256. doi: 10.1093/jn/nxz256. [Epub ahead of print]

PMID:
31665502
2.

Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.

Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ.

Nat Metab. 2019 May;1(5):532-545. doi: 10.1038/s42255-019-0059-2. Epub 2019 Apr 29.

3.

Frailty and oral health: Findings from the Concord Health and Ageing in Men Project.

Valdez E, Wright FAC, Naganathan V, Milledge K, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Cumming RG.

Gerodontology. 2019 Oct 6. doi: 10.1111/ger.12438. [Epub ahead of print]

PMID:
31588626
4.

Hallmarks of Aging in the Liver.

Hunt NJ, Kang SWS, Lockwood GP, Le Couteur DG, Cogger VC.

Comput Struct Biotechnol J. 2019 Aug 7;17:1151-1161. doi: 10.1016/j.csbj.2019.07.021. eCollection 2019. Review.

5.

Branched chain amino acids, cardiometabolic risk factors and outcomes in older men: the Concord Health and Ageing in Men Project.

Le Couteur DG, Ribeiro R, Senior A, Hsu B, Hirani V, Blyth FM, Waite LM, Simpson SJ, Naganathan V, Cumming RG, Handelsman DJ.

J Gerontol A Biol Sci Med Sci. 2019 Aug 20. pii: glz192. doi: 10.1093/gerona/glz192. [Epub ahead of print]

PMID:
31428789
6.

Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition.

Ribeiro RV, Solon-Biet SM, Pulpitel T, Senior AM, Cogger VC, Clark X, O'Sullivan J, Koay YC, Hirani V, Blyth FM, Seibel MJ, Waite LM, Naganathan V, Cumming RG, Handelsman DJ, Simpson SJ, Le Couteur DG.

Nutrients. 2019 Aug 13;11(8). pii: E1882. doi: 10.3390/nu11081882.

7.

Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes.

Kang SWS, Cogger VC, Le Couteur DG, Fu D.

Am J Physiol Cell Physiol. 2019 Nov 1;317(5):C942-C952. doi: 10.1152/ajpcell.00051.2019. Epub 2019 Aug 14.

PMID:
31411916
8.

Associations of Body Composition Trajectories with Bone Mineral Density, Muscle Function, Falls and Fractures in Older Men: The Concord Health and Ageing in Men Project.

Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V.

J Gerontol A Biol Sci Med Sci. 2019 Aug 13. pii: glz184. doi: 10.1093/gerona/glz184. [Epub ahead of print]

PMID:
31406987
9.

Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis.

Gaddam RR, Chambers S, Fraser R, Cogger VC, Le Couteur DG, Ishii I, Bhatia M.

Int J Mol Sci. 2019 Jun 29;20(13). pii: E3191. doi: 10.3390/ijms20133191.

10.

The effects of metformin on age-related changes in the liver sinusoidal endothelial cell.

Hunt NJ, Lockwood GP, Kang SWS, Pulpitel T, Clark X, Mao H, McCourt PAG, Cooney GJ, Wali JA, Le Couteur FH, Le Couteur DG, Cogger VC.

J Gerontol A Biol Sci Med Sci. 2019 Jun 14. pii: glz153. doi: 10.1093/gerona/glz153. [Epub ahead of print]

PMID:
31198956
11.

Going Beyond the Guidelines in Individualising the Use of Antihypertensive Drugs in Older Patients.

Scott IA, Hilmer SN, Le Couteur DG.

Drugs Aging. 2019 Aug;36(8):675-685. doi: 10.1007/s40266-019-00683-8.

PMID:
31175614
12.

Aging, lifestyle and dementia.

Wahl D, Solon-Biet SM, Cogger VC, Fontana L, Simpson SJ, Le Couteur DG, Ribeiro RV.

Neurobiol Dis. 2019 Oct;130:104481. doi: 10.1016/j.nbd.2019.104481. Epub 2019 May 25. Review.

PMID:
31136814
13.

Anti-aging therapies, cognitive impairment and dementia.

Wahl D, Anderson RM, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2019 May 24. pii: glz135. doi: 10.1093/gerona/glz135. [Epub ahead of print]

PMID:
31125402
14.

Anticholinergic medicines use among older adults before and after initiating dementia medicines.

Narayan SW, Pearson SA, Litchfield M, Le Couteur DG, Buckley N, McLachlan AJ, Zoega H.

Br J Clin Pharmacol. 2019 Sep;85(9):1957-1963. doi: 10.1111/bcp.13976. Epub 2019 Jul 7.

15.

Dietary macronutrient content, age-specific mortality and lifespan.

Senior AM, Solon-Biet SM, Cogger VC, Le Couteur DG, Nakagawa S, Raubenheimer D, Simpson SJ.

Proc Biol Sci. 2019 May 15;286(1902):20190393. doi: 10.1098/rspb.2019.0393.

PMID:
31039722
16.

Caregiving and all-cause mortality in older men 2005-15: the Concord Health and Ageing in Men Project.

Shu CC, Hsu B, Cumming RG, Blyth FM, Waite LM, Le Couteur DG, Handelsman DJ, Naganathan V.

Age Ageing. 2019 Jul 1;48(4):571-576. doi: 10.1093/ageing/afz039.

PMID:
31028375
17.

Oral health behaviours of older Australian men: the Concord Health and Ageing in Men Project.

Tran J, Wright F, Takara S, Shu CC, Chu SY, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Waite LM, Handelsman DJ, Seibel MJ, Milledge KL, Cumming RG.

Aust Dent J. 2019 Sep;64(3):246-255. doi: 10.1111/adj.12694. Epub 2019 May 9.

PMID:
30972755
18.

Prospective Associations Between Dietary Antioxidant Intake and Frailty in Older Australian Men: The Concord Health and Ageing in Men Project.

Das A, Cumming RG, Naganathan V, Blyth F, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Simpson SJ, Hirani V.

J Gerontol A Biol Sci Med Sci. 2019 Apr 6. pii: glz054. doi: 10.1093/gerona/glz054. [Epub ahead of print]

PMID:
30955034
19.

Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis.

Morimoto J, Senior A, Ruiz K, Wali JA, Pulpitel T, Solon-Biet SM, Cogger VC, Raubenheimer D, Le Couteur DG, Simpson SJ, Eberhard J.

PLoS One. 2019 Mar 13;14(3):e0212796. doi: 10.1371/journal.pone.0212796. eCollection 2019.

20.

Mortality Paradox of Older Italian-Born Men in Australia: The Concord Health and Ageing in Men Project.

Stanaway FF, Blyth FM, Naganathan V, Le Couteur DG, Ribeiro R, Hirani V, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG.

J Immigr Minor Health. 2019 Mar 6. doi: 10.1007/s10903-019-00874-w. [Epub ahead of print]

PMID:
30840179
21.

Organizational innovation for developing new medicines that target aging and age-related conditions.

Ford GA, Lord JM, Ferguson MA, Bountra C, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2019 Mar 6. pii: glz062. doi: 10.1093/gerona/glz062. [Epub ahead of print] No abstract available.

PMID:
30838376
22.

IUPHAR International geriatric clinical pharmacology curriculum for medical students.

Kashyap M, Thuermann P, Le Couteur DG, Abernethy DR, Hilmer SN.

Pharmacol Res. 2019 Mar;141:611-615. doi: 10.1016/j.phrs.2019.01.032. Epub 2019 Jan 17. No abstract available.

PMID:
30660820
23.

Ischemia/reperfusion injury in the aged liver: The importance of the sinusoidal endothelium in developing therapeutic strategies for the elderly.

Hide D, Warren A, Fernández-Iglesias A, Maeso-Díaz R, Peralta C, Le Couteur DG, Bosch J, Cogger VC, Gracia-Sancho J.

J Gerontol A Biol Sci Med Sci. 2019 Jan 14. doi: 10.1093/gerona/glz012. [Epub ahead of print]

PMID:
30649272
24.

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG.

Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.

25.

Manipulating fenestrations in young and old liver sinusoidal endothelial cells.

Hunt NJ, Lockwood GP, Warren A, Mao H, McCourt PAG, Le Couteur DG, Cogger VC.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G144-G154. doi: 10.1152/ajpgi.00179.2018. Epub 2018 Oct 4.

26.

90th Anniversary Commentary: Caloric Restriction Effects on Aging.

Le Couteur DG, Simpson SJ.

J Nutr. 2018 Oct 1;148(10):1656-1659. doi: 10.1093/jn/nxy146. No abstract available.

PMID:
30281103
27.

Novel targets for delaying aging: The importance of the liver and advances in drug delivery.

Hunt NJ, McCourt PAG, Le Couteur DG, Cogger VC.

Adv Drug Deliv Rev. 2018 Oct;135:39-49. doi: 10.1016/j.addr.2018.09.006. Epub 2018 Sep 21. Review.

PMID:
30248361
28.

Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats.

Mach J, Huizer-Pajkos A, Cogger VC, McKenzie C, Le Couteur DG, Jones BE, de Cabo R, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):332. doi: 10.1093/gerona/gly160. No abstract available.

29.

Community-dwelling older men with dementia are at high risk of hip fracture, but not any other fracture: The Concord Health and Aging in Men Project.

Hsu B, Bleicher K, Waite LM, Naganathan V, Blyth FM, Handelsman DJ, Le Couteur DG, Seibel MJ, Cumming RG.

Geriatr Gerontol Int. 2018 Oct;18(10):1479-1484. doi: 10.1111/ggi.13516. Epub 2018 Aug 30.

PMID:
30160054
30.

The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice.

Gokarn R, Solon-Biet S, Youngson NA, Wahl D, Cogger VC, McMahon AC, Cooney GJ, Ballard JWO, Raubenheimer D, Morris MJ, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):446-449. doi: 10.1093/gerona/glx186.

PMID:
30052781
31.

Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project.

Scott D, Seibel M, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V.

J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):827-834. doi: 10.1093/gerona/gly162.

PMID:
30032209
32.

Future directions of resveratrol research.

Wahl D, Bernier M, Simpson SJ, de Cabo R, Le Couteur DG.

Nutr Healthy Aging. 2018 Jun 15;4(4):287-290. doi: 10.3233/NHA-170035. Review.

33.

Temporal associations between sexual function and cognitive function in community-dwelling older men: the Concord Health and Ageing in Men Project.

Hsu B, Hirani V, Waite LM, Naganathan V, Blyth FM, Le Couteur DG, Seibel MJ, Cumming RG, Handelsman DJ.

Age Ageing. 2018 Nov 1;47(6):900-904. doi: 10.1093/ageing/afy088.

PMID:
29893766
34.

Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients.

Ng BJ, Le Couteur DG, Hilmer SN.

Drugs Aging. 2018 Jun;35(6):493-521. doi: 10.1007/s40266-018-0544-4. Review.

PMID:
29705831
35.

Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.

Gokarn R, Solon-Biet SM, Cogger VC, Cooney GJ, Wahl D, McMahon AC, Mitchell JR, Mitchell SJ, Hine C, de Cabo R, Raubenheimer D, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1618-1625. doi: 10.1093/gerona/gly065.

36.

Associations of sarcopenic obesity with the metabolic syndrome and insulin resistance over five years in older men: The Concord Health and Ageing in Men Project.

Scott D, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Seibel M, Waite LM, Hirani V.

Exp Gerontol. 2018 Jul 15;108:99-105. doi: 10.1016/j.exger.2018.04.006. Epub 2018 Apr 9.

PMID:
29649572
37.

Association rules method and big data: Evaluating frequent medication combinations associated with fractures in older adults.

Nishtala PS, Chyou TY, Held F, Le Couteur DG, Gnjidic D.

Pharmacoepidemiol Drug Saf. 2018 Oct;27(10):1123-1130. doi: 10.1002/pds.4432. Epub 2018 Apr 2.

PMID:
29611249
38.

Journal of Gerontology: Biological Sciences. A Long Tradition in Advancing Aging Biology and Translational Gerontology.

Anderson RM, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):271-272. doi: 10.1093/gerona/gly004. No abstract available.

PMID:
29509876
39.

Association between pain and the frailty phenotype in older men: longitudinal results from the Concord Health and Ageing in Men Project (CHAMP).

Megale RZ, Ferreira ML, Ferreira PH, Naganathan V, Cumming R, Hirani V, Waite LM, Seibel MJ, Le Couteur DG, Handelsman DJ, Blyth FM.

Age Ageing. 2018 May 1;47(3):381-387. doi: 10.1093/ageing/afy012.

PMID:
29474508
40.

Idalopirdine: another disappointment for people with dementia.

Le Couteur DG, Bateman B, Brayne C.

BMJ. 2018 Feb 21;360:k753. doi: 10.1136/bmj.k753. No abstract available.

PMID:
29467153
41.

The Geometric Framework for Nutrition as a tool in precision medicine.

Simpson SJ, Le Couteur DG, James DE, George J, Gunton JE, Solon-Biet SM, Raubenheimer D.

Nutr Healthy Aging. 2017 Dec 7;4(3):217-226. doi: 10.3233/NHA-170027. Review.

42.

Caloric Restriction Research: New Perspectives on the Biology of Aging.

Anderson RM, Le Couteur DG, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):1-3. doi: 10.1093/gerona/glx212. No abstract available.

43.

Health benefits of late-onset metformin treatment every other week in mice.

Alfaras I, Mitchell SJ, Mora H, Lugo DR, Warren A, Navas-Enamorado I, Hoffmann V, Hine C, Mitchell JR, Le Couteur DG, Cogger VC, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2017 Nov 20;3:16. doi: 10.1038/s41514-017-0018-7. eCollection 2017.

44.

It's the holes that matter.

Cogger VC, Mohamad M, Le Couteur DG.

Aging (Albany NY). 2017 Nov 15;9(11):2237-2238. doi: 10.18632/aging.101330. No abstract available.

45.

Sex and Aging.

Le Couteur DG, Anderson RM, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):139-140. doi: 10.1093/gerona/glx221. No abstract available.

46.

The nutritional geometry of liver disease including non-alcoholic fatty liver disease.

Simpson SJ, Raubenheimer D, Cogger VC, Macia L, Solon-Biet SM, Le Couteur DG, George J.

J Hepatol. 2018 Feb;68(2):316-325. doi: 10.1016/j.jhep.2017.10.005. Epub 2017 Nov 6. Review.

PMID:
29122389
47.

Stem Cell Transplantation for Frailty.

Le Couteur DG, Anderson RM, Newman AB, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1503-1504. doi: 10.1093/gerona/glx158. Review. No abstract available.

48.

Total Physical Activity, Exercise Intensity, and Walking Speed as Predictors of All-Cause and Cause-Specific Mortality Over 7 Years in Older Men: The Concord Health and Aging in Men Project.

Hsu B, Merom D, Blyth FM, Naganathan V, Hirani V, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Cumming RG.

J Am Med Dir Assoc. 2018 Mar;19(3):216-222. doi: 10.1016/j.jamda.2017.08.018. Epub 2017 Oct 6.

PMID:
28993048
49.

Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project.

Hsu B, Hirani V, Cumming RG, Naganathan V, Blyth FM, Wright FC, Waite LM, Seibel MJ, Handelsman DJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):835-841. doi: 10.1093/gerona/glx142.

PMID:
28977375
50.

Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project.

Hsu B, Cumming RG, Blyth FM, Naganathan V, Waite LM, Le Couteur DG, Seibel MJ, Handelsman DJ.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):729-736. doi: 10.1093/gerona/glx170.

PMID:
28958048

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