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Items: 1 to 50 of 295

1.

IUPHAR International geriatric clinical pharmacology curriculum for medical students.

Kashyap M, Thuermann P, Le Couteur DG, Abernethy DR, Hilmer SN.

Pharmacol Res. 2019 Jan 17. pii: S1043-6618(19)30087-8. doi: 10.1016/j.phrs.2019.01.032. [Epub ahead of print] No abstract available.

PMID:
30660820
2.

Ischemia/reperfusion injury in the aged liver: The importance of the sinusoidal endothelium in developing therapeutic strategies for the elderly.

Hide D, Warren A, Fernández-Iglesias A, Maeso-Díaz R, Peralta C, Le Couteur DG, Bosch J, Cogger VC, Gracia-Sancho J.

J Gerontol A Biol Sci Med Sci. 2019 Jan 14. doi: 10.1093/gerona/glz012. [Epub ahead of print]

PMID:
30649272
3.

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG.

Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.

4.

Manipulating fenestrations in young and old liver sinusoidal endothelial cells.

Hunt NJ, Lockwood GP, Warren A, Mao H, McCourt PAG, Le Couteur DG, Cogger VC.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G144-G154. doi: 10.1152/ajpgi.00179.2018. Epub 2018 Oct 4.

5.

Novel targets for delaying aging: The importance of the liver and advances in drug delivery.

Hunt NJ, McCourt PAG, Le Couteur DG, Cogger VC.

Adv Drug Deliv Rev. 2018 Oct;135:39-49. doi: 10.1016/j.addr.2018.09.006. Epub 2018 Sep 21. Review.

PMID:
30248361
6.

Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats.

Mach J, Huizer-Pajkos A, Cogger VC, McKenzie C, Le Couteur DG, Jones BE, de Cabo R, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):332. doi: 10.1093/gerona/gly160. No abstract available.

PMID:
30165374
7.

Community-dwelling older men with dementia are at high risk of hip fracture, but not any other fracture: The Concord Health and Aging in Men Project.

Hsu B, Bleicher K, Waite LM, Naganathan V, Blyth FM, Handelsman DJ, Le Couteur DG, Seibel MJ, Cumming RG.

Geriatr Gerontol Int. 2018 Oct;18(10):1479-1484. doi: 10.1111/ggi.13516. Epub 2018 Aug 30.

PMID:
30160054
8.

The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice.

Gokarn R, Solon-Biet S, Youngson NA, Wahl D, Cogger VC, McMahon AC, Cooney GJ, Ballard JWO, Raubenheimer D, Morris MJ, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):446-449. doi: 10.1093/gerona/glx186.

PMID:
30052781
9.

Does combined osteopenia/osteoporosis and sarcopenia confer greater risk of falls and fracture than either condition alone in older men? The Concord Health and Ageing in Men Project.

Scott D, Seibel M, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V.

J Gerontol A Biol Sci Med Sci. 2018 Jul 18. doi: 10.1093/gerona/gly162. [Epub ahead of print]

PMID:
30032209
10.

Future directions of resveratrol research.

Wahl D, Bernier M, Simpson SJ, de Cabo R, Le Couteur DG.

Nutr Healthy Aging. 2018 Jun 15;4(4):287-290. doi: 10.3233/NHA-170035. Review.

11.

Temporal associations between sexual function and cognitive function in community-dwelling older men: the Concord Health and Ageing in Men Project.

Hsu B, Hirani V, Waite LM, Naganathan V, Blyth FM, Le Couteur DG, Seibel MJ, Cumming RG, Handelsman DJ.

Age Ageing. 2018 Nov 1;47(6):900-904. doi: 10.1093/ageing/afy088.

PMID:
29893766
12.

Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients.

Ng BJ, Le Couteur DG, Hilmer SN.

Drugs Aging. 2018 Jun;35(6):493-521. doi: 10.1007/s40266-018-0544-4. Review.

PMID:
29705831
13.

Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.

Gokarn R, Solon-Biet SM, Cogger VC, Cooney GJ, Wahl D, McMahon AC, Mitchell JR, Mitchell SJ, Hine C, de Cabo R, Raubenheimer D, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1618-1625. doi: 10.1093/gerona/gly065.

PMID:
29688281
14.

Associations of sarcopenic obesity with the metabolic syndrome and insulin resistance over five years in older men: The Concord Health and Ageing in Men Project.

Scott D, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Seibel M, Waite LM, Hirani V.

Exp Gerontol. 2018 Jul 15;108:99-105. doi: 10.1016/j.exger.2018.04.006. Epub 2018 Apr 9.

PMID:
29649572
15.

Association rules method and big data: Evaluating frequent medication combinations associated with fractures in older adults.

Nishtala PS, Chyou TY, Held F, Le Couteur DG, Gnjidic D.

Pharmacoepidemiol Drug Saf. 2018 Oct;27(10):1123-1130. doi: 10.1002/pds.4432. Epub 2018 Apr 2.

PMID:
29611249
16.

Journal of Gerontology: Biological Sciences. A Long Tradition in Advancing Aging Biology and Translational Gerontology.

Anderson RM, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):271-272. doi: 10.1093/gerona/gly004. No abstract available.

PMID:
29509876
17.

Association between pain and the frailty phenotype in older men: longitudinal results from the Concord Health and Ageing in Men Project (CHAMP).

Megale RZ, Ferreira ML, Ferreira PH, Naganathan V, Cumming R, Hirani V, Waite LM, Seibel MJ, Le Couteur DG, Handelsman DJ, Blyth FM.

Age Ageing. 2018 May 1;47(3):381-387. doi: 10.1093/ageing/afy012.

PMID:
29474508
18.

Idalopirdine: another disappointment for people with dementia.

Le Couteur DG, Bateman B, Brayne C.

BMJ. 2018 Feb 21;360:k753. doi: 10.1136/bmj.k753. No abstract available.

PMID:
29467153
19.

The Geometric Framework for Nutrition as a tool in precision medicine.

Simpson SJ, Le Couteur DG, James DE, George J, Gunton JE, Solon-Biet SM, Raubenheimer D.

Nutr Healthy Aging. 2017 Dec 7;4(3):217-226. doi: 10.3233/NHA-170027. Review.

20.

Caloric Restriction Research: New Perspectives on the Biology of Aging.

Anderson RM, Le Couteur DG, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):1-3. doi: 10.1093/gerona/glx212. No abstract available.

21.

Health benefits of late-onset metformin treatment every other week in mice.

Alfaras I, Mitchell SJ, Mora H, Lugo DR, Warren A, Navas-Enamorado I, Hoffmann V, Hine C, Mitchell JR, Le Couteur DG, Cogger VC, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2017 Nov 20;3:16. doi: 10.1038/s41514-017-0018-7. eCollection 2017.

22.

It's the holes that matter.

Cogger VC, Mohamad M, Le Couteur DG.

Aging (Albany NY). 2017 Nov 15;9(11):2237-2238. doi: 10.18632/aging.101330. No abstract available.

23.

Sex and Aging.

Le Couteur DG, Anderson RM, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):139-140. doi: 10.1093/gerona/glx221. No abstract available.

24.

The nutritional geometry of liver disease including non-alcoholic fatty liver disease.

Simpson SJ, Raubenheimer D, Cogger VC, Macia L, Solon-Biet SM, Le Couteur DG, George J.

J Hepatol. 2018 Feb;68(2):316-325. doi: 10.1016/j.jhep.2017.10.005. Epub 2017 Nov 6. Review.

PMID:
29122389
25.

Stem Cell Transplantation for Frailty.

Le Couteur DG, Anderson RM, Newman AB, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1503-1504. doi: 10.1093/gerona/glx158. No abstract available.

26.

Total Physical Activity, Exercise Intensity, and Walking Speed as Predictors of All-Cause and Cause-Specific Mortality Over 7 Years in Older Men: The Concord Health and Aging in Men Project.

Hsu B, Merom D, Blyth FM, Naganathan V, Hirani V, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Cumming RG.

J Am Med Dir Assoc. 2018 Mar;19(3):216-222. doi: 10.1016/j.jamda.2017.08.018. Epub 2017 Oct 6.

PMID:
28993048
27.

Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project.

Hsu B, Hirani V, Cumming RG, Naganathan V, Blyth FM, Wright FC, Waite LM, Seibel MJ, Handelsman DJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2017 Jul 28. doi: 10.1093/gerona/glx142. [Epub ahead of print]

PMID:
28977375
28.

Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project.

Hsu B, Cumming RG, Blyth FM, Naganathan V, Waite LM, Le Couteur DG, Seibel MJ, Handelsman DJ.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):729-736. doi: 10.1093/gerona/glx170.

PMID:
28958048
29.

Natural history of post-void residual urine volume over 5 years in community-dwelling older men: The Concord Health and Ageing in Men Project.

Noguchi N, Chan L, Cumming RG, Blyth FM, Handelsman DJ, Waite LM, Le Couteur DG, Naganathan V.

Neurourol Urodyn. 2018 Mar;37(3):1068-1073. doi: 10.1002/nau.23415. Epub 2017 Sep 20.

PMID:
28940729
30.

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.

Wahl D, Coogan SC, Solon-Biet SM, de Cabo R, Haran JB, Raubenheimer D, Cogger VC, Mattson MP, Simpson SJ, Le Couteur DG.

Clin Interv Aging. 2017 Sep 8;12:1419-1428. doi: 10.2147/CIA.S145247. eCollection 2017. Review.

31.

Oral health of community-dwelling older Australian men: the Concord Health and Ageing in Men Project (CHAMP).

Wright F, Chu SY, Milledge KL, Valdez E, Law G, Hsu B, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Harford J, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG.

Aust Dent J. 2018 Mar;63(1):55-65. doi: 10.1111/adj.12564. Epub 2017 Oct 30.

PMID:
28853154
32.

Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP).

Ribeiro RV, Hirani V, Senior AM, Gosby AK, Cumming RG, Blyth FM, Naganathan V, Waite LM, Handelsman DJ, Kendig H, Seibel MJ, Simpson SJ, Stanaway F, Allman-Farinelli M, Le Couteur DG.

Br J Nutr. 2017 Jul;118(2):130-143. doi: 10.1017/S0007114517001738.

PMID:
28820080
33.

Texture-modified food and fluids in dementia and residential aged care facilities.

Painter V, Le Couteur DG, Waite LM.

Clin Interv Aging. 2017 Aug 2;12:1193-1203. doi: 10.2147/CIA.S140581. eCollection 2017. Review.

34.

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.

Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell AJ, Florido M, Beattie L, Walters SB, Tay SS, Lu B, Holz LE, Roediger B, Wong YC, Warren A, Ritchie W, McGuffog C, Weninger W, Le Couteur DG, Ginhoux F, Britton WJ, Heath WR, Saunders BM, McCaughan GW, Luciani F, MacDonald KPA, Ng LG, Bowen DG, Bertolino P.

Immunity. 2017 Aug 15;47(2):374-388.e6. doi: 10.1016/j.immuni.2017.07.018.

35.

Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.

Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur DG, Ishii I, Bhatia M.

PLoS One. 2017 Aug 10;12(8):e0183304. doi: 10.1371/journal.pone.0183304. eCollection 2017.

36.

Residential age care and domiciliary oral health services: Reach-OHT-The development of a metropolitan oral health programme in Sydney, Australia.

Wright FAC, Law G, Chu SK, Cullen JS, Le Couteur DG.

Gerodontology. 2017 Dec;34(4):420-426. doi: 10.1111/ger.12282. Epub 2017 Jul 19.

PMID:
28722250
37.

Longitudinal Associations Between Vitamin D Metabolites and Sarcopenia in Older Australian men: The Concord Health and Aging in Men Project.

Hirani V, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Hsu B, Handelsman DJ, Waite LM, Seibel MJ.

J Gerontol A Biol Sci Med Sci. 2017 Dec 12;73(1):131-138. doi: 10.1093/gerona/glx086.

PMID:
28549108
38.

A Comparison of Two Mouse Frailty Assessment Tools.

Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett SE, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):904-909. doi: 10.1093/gerona/glx009.

39.

Comorbidity and vascular cognitive impairment-no dementia (VCI-ND).

Le Couteur DG, Wahl D, Naismith SL.

Age Ageing. 2017 Sep 1;46(5):705-707. doi: 10.1093/ageing/afx080. No abstract available.

PMID:
28481963
40.

SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.

Razi S, Cogger VC, Kennerson M, Benson VL, McMahon AC, Blyth FM, Handelsman DJ, Seibel MJ, Hirani V, Naganathan V, Waite L, de Cabo R, Cumming RG, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):870-876. doi: 10.1093/gerona/glx018.

41.

Dietary protein, aging and nutritional geometry.

Simpson SJ, Le Couteur DG, Raubenheimer D, Solon-Biet SM, Cooney GJ, Cogger VC, Fontana L.

Ageing Res Rev. 2017 Oct;39:78-86. doi: 10.1016/j.arr.2017.03.001. Epub 2017 Mar 6. Review.

PMID:
28274839
42.

Health status, health behaviours and anxiety symptoms of older male caregivers: Findings from the Concord Health and Ageing in Men Project.

Shu CC, Cumming RG, Kendig HL, Blyth FM, Waite LM, Le Couteur DG, Handelsman DJ, Naganathan V.

Australas J Ageing. 2017 Jun;36(2):151-157. doi: 10.1111/ajag.12376. Epub 2017 Feb 16.

PMID:
28211188
43.

Solanezumab and the amyloid hypothesis for Alzheimer's disease.

Le Couteur DG, Hunter S, Brayne C.

BMJ. 2016 Dec 29;355:i6771. doi: 10.1136/bmj.i6771. No abstract available.

PMID:
28034844
44.

Polypharmacy in older adults: Association Rule and Frequent-Set Analysis to evaluate concomitant medication use.

Held F, Le Couteur DG, Blyth FM, Hirani V, Naganathan V, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG, Allore HG, Gnjidic D.

Pharmacol Res. 2017 Feb;116:39-44. doi: 10.1016/j.phrs.2016.12.018. Epub 2016 Dec 14.

PMID:
27988385
45.

Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community-dwelling older men: The Concord Health and Ageing in Men Project.

Hirani V, Naganathan V, Blyth F, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Cumming RG.

Age Ageing. 2017 May 1;46(3):413-420. doi: 10.1093/ageing/afw214.

PMID:
27932368
46.

Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints.

Holmes AJ, Chew YV, Colakoglu F, Cliff JB, Klaassens E, Read MN, Solon-Biet SM, McMahon AC, Cogger VC, Ruohonen K, Raubenheimer D, Le Couteur DG, Simpson SJ.

Cell Metab. 2017 Jan 10;25(1):140-151. doi: 10.1016/j.cmet.2016.10.021. Epub 2016 Nov 23.

47.

The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice.

Hew J, Solon-Biet SM, McMahon AC, Ruohonen K, Raubenheimer D, Ballard JW, Le Couteur DG, Nicholls C, Li Z, Maitz PK, Wang Y, Simpson SJ.

PLoS One. 2016 Nov 10;11(11):e0166175. doi: 10.1371/journal.pone.0166175. eCollection 2016.

48.

Sarcopenic Obesity and Its Temporal Associations With Changes in Bone Mineral Density, Incident Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project.

Scott D, Seibel M, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V.

J Bone Miner Res. 2017 Mar;32(3):575-583. doi: 10.1002/jbmr.3016. Epub 2016 Nov 3.

49.

Lower Urinary Tract Symptoms and Incident Falls in Community Dwelling Older Men: The Concord Health and Ageing in Men Project.

Noguchi N, Chan L, Cumming RG, Blyth FM, Handelsman DJ, Seibel MJ, Waite LM, Le Couteur DG, Naganathan V.

J Urol. 2016 Dec;196(6):1694-1699. doi: 10.1016/j.juro.2016.06.085. Epub 2016 Jun 24.

PMID:
27350076
50.

Drug Burden Index and change in cognition over time in community-dwelling older men: the CHAMP study.

Jamsen KM, Gnjidic D, Hilmer SN, Ilomäki J, Le Couteur DG, Blyth FM, Handelsman DJ, Naganathan V, Waite LM, Cumming RG, Bell JS.

Ann Med. 2017 Mar;49(2):157-164. doi: 10.1080/07853890.2016.1252053. Epub 2016 Nov 18.

PMID:
27763767

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