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Items: 1 to 50 of 102

1.

NosL is a dedicated copper chaperone for assembly of the CuZ center of nitrous oxide reductase.

Bennett SP, Soriano-Laguna MJ, Bradley JM, Svistunenko DA, Richardson DJ, Gates AJ, Le Brun NE.

Chem Sci. 2019 Apr 18;10(19):4985-4993. doi: 10.1039/c9sc01053j. eCollection 2019 May 21.

2.

Reaction of O2 with a diiron protein generates a mixed-valent Fe2+/Fe3+ center and peroxide.

Bradley JM, Svistunenko DA, Pullin J, Hill N, Stuart RK, Palenik B, Wilson MT, Hemmings AM, Moore GR, Le Brun NE.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2058-2067. doi: 10.1073/pnas.1809913116. Epub 2019 Jan 18.

PMID:
30659147
3.

Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu, and His Residues.

Volbeda A, Martinez MTP, Crack JC, Amara P, Gigarel O, Munnoch JT, Hutchings MI, Darnault C, Le Brun NE, Fontecilla-Camps JC.

J Am Chem Soc. 2019 Feb 13;141(6):2367-2375. doi: 10.1021/jacs.8b10823. Epub 2019 Feb 1.

PMID:
30657661
4.

Mass Spectrometric Identification of [4Fe-4S](NO)x Intermediates of Nitric Oxide Sensing by Regulatory Iron-Sulfur Cluster Proteins.

Crack JC, Le Brun NE.

Chemistry. 2019 Mar 7;25(14):3675-3684. doi: 10.1002/chem.201806113. Epub 2019 Feb 7.

PMID:
30600851
5.

Electron transfer ferredoxins with unusual cluster binding motifs support secondary metabolism in many bacteria.

Child SA, Bradley JM, Pukala TL, Svistunenko DA, Le Brun NE, Bell SG.

Chem Sci. 2018 Aug 23;9(41):7948-7957. doi: 10.1039/c8sc01286e. eCollection 2018 Nov 7.

6.

Mass spectrometric studies of Cu(I)-binding to the N-terminal domains of B. subtilis CopA and influence of bacillithiol.

Kay KL, Hamilton CJ, Le Brun NE.

J Inorg Biochem. 2019 Jan;190:24-30. doi: 10.1016/j.jinorgbio.2018.10.004. Epub 2018 Oct 13.

PMID:
30342352
7.

Mass spectrometric detection of iron nitrosyls, sulfide oxidation and mycothiolation during nitrosylation of the NO sensor [4Fe-4S] NsrR.

Crack JC, Hamilton CJ, Le Brun NE.

Chem Commun (Camb). 2018 Jun 8;54(47):5992-5995. doi: 10.1039/c8cc01339j.

8.

Sensing iron availability via the fragile [4Fe-4S] cluster of the bacterial transcriptional repressor RirA.

Pellicer Martinez MT, Martinez AB, Crack JC, Holmes JD, Svistunenko DA, Johnston AWB, Cheesman MR, Todd JD, Le Brun NE.

Chem Sci. 2017 Dec 1;8(12):8451-8463. doi: 10.1039/c7sc02801f. Epub 2017 Oct 23.

9.

The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX.

Adinolfi S, Puglisi R, Crack JC, Iannuzzi C, Dal Piaz F, Konarev PV, Svergun DI, Martin S, Le Brun NE, Pastore A.

Front Mol Biosci. 2018 Feb 2;4:97. doi: 10.3389/fmolb.2017.00097. eCollection 2017.

10.

Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.

Kudhair BK, Hounslow AM, Rolfe MD, Crack JC, Hunt DM, Buxton RS, Smith LJ, Le Brun NE, Williamson MP, Green J.

Nat Commun. 2017 Dec 22;8(1):2280. doi: 10.1038/s41467-017-02418-y.

11.

Redox-sensing iron-sulfur cluster regulators.

Crack JC, Le Brun NE.

Antioxid Redox Signal. 2017 Dec 7. doi: 10.1089/ars.2017.7369. [Epub ahead of print]

PMID:
29216742
12.

The N-terminal domains of Bacillus subtilis CopA do not form a stable complex in the absence of their inter-domain linker.

Zhou L, Kay KL, Hecht O, Moore GR, Le Brun NE.

Biochim Biophys Acta Proteins Proteom. 2018 Feb;1866(2):275-282. doi: 10.1016/j.bbapap.2017.11.008. Epub 2017 Nov 14.

PMID:
29146226
13.

Redox-Sensing Iron-Sulfur Cluster Regulators.

Crack JC, Le Brun NE.

Antioxid Redox Signal. 2018 Dec 20;29(18):1809-1829. doi: 10.1089/ars.2017.7361. Epub 2017 Nov 7.

PMID:
28967283
14.

Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre.

Bradley JM, Svistunenko DA, Moore GR, Le Brun NE.

Metallomics. 2017 Oct 18;9(10):1421-1428. doi: 10.1039/c7mt00187h.

PMID:
28914315
15.

Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence.

Smith LJ, Bochkareva A, Rolfe MD, Hunt DM, Kahramanoglou C, Braun Y, Rodgers A, Blockley A, Coade S, Lougheed KEA, Hafneh NA, Glenn SM, Crack JC, Le Brun NE, Saldanha JW, Makarov V, Nobeli I, Arnvig K, Mukamolova GV, Buxton RS, Green J.

Nucleic Acids Res. 2017 Jun 20;45(11):6600-6612. doi: 10.1093/nar/gkx406.

16.

Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding.

Volbeda A, Dodd EL, Darnault C, Crack JC, Renoux O, Hutchings MI, Le Brun NE, Fontecilla-Camps JC.

Nat Commun. 2017 Apr 20;8:15052. doi: 10.1038/ncomms15052.

17.

Mass spectrometric identification of intermediates in the O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion in FNR.

Crack JC, Thomson AJ, Le Brun NE.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3215-E3223. doi: 10.1073/pnas.1620987114. Epub 2017 Apr 3.

18.

Diversity of Fe2+ entry and oxidation in ferritins.

Bradley JM, Moore GR, Le Brun NE.

Curr Opin Chem Biol. 2017 Apr;37:122-128. doi: 10.1016/j.cbpa.2017.02.027. Epub 2017 Mar 15. Review.

PMID:
28314217
19.

Kinetic analysis of copper transfer from a chaperone to its target protein mediated by complex formation.

Kay KL, Zhou L, Tenori L, Bradley JM, Singleton C, Kihlken MA, Ciofi-Baffoni S, Le Brun NE.

Chem Commun (Camb). 2017 Jan 24;53(8):1397-1400. doi: 10.1039/c6cc08966f.

PMID:
28078344
20.

NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana.

Bastow EL, Bych K, Crack JC, Le Brun NE, Balk J.

Plant J. 2017 Feb;89(3):590-600. doi: 10.1111/tpj.13409. Epub 2017 Feb 3.

21.

Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes.

Serrano PN, Wang H, Crack JC, Prior C, Hutchings MI, Thomson AJ, Kamali S, Yoda Y, Zhao J, Hu MY, Alp EE, Oganesyan VS, Le Brun NE, Cramer SP.

Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14575-14579. doi: 10.1002/anie.201607033. Epub 2016 Oct 25.

22.

Characterization of a putative NsrR homologue in Streptomyces venezuelae reveals a new member of the Rrf2 superfamily.

Munnoch JT, Martinez MT, Svistunenko DA, Crack JC, Le Brun NE, Hutchings MI.

Sci Rep. 2016 Sep 8;6:31597. doi: 10.1038/srep31597.

23.

Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.

Bradley JM, Svistunenko DA, Lawson TL, Hemmings AM, Moore GR, Le Brun NE.

Angew Chem Weinheim Bergstr Ger. 2015 Dec 1;127(49):14976-14980. Epub 2015 Oct 16.

24.

Mass spectrometry of B. subtilis CopZ: Cu(i)-binding and interactions with bacillithiol.

Kay KL, Hamilton CJ, Le Brun NE.

Metallomics. 2016 Jul 13;8(7):709-19. doi: 10.1039/c6mt00036c.

PMID:
27197762
25.

Differentiated, Promoter-specific Response of [4Fe-4S] NsrR DNA Binding to Reaction with Nitric Oxide.

Crack JC, Svistunenko DA, Munnoch J, Thomson AJ, Hutchings MI, Le Brun NE.

J Biol Chem. 2016 Apr 15;291(16):8663-72. doi: 10.1074/jbc.M115.693192. Epub 2016 Feb 17.

26.

Ferritins: furnishing proteins with iron.

Bradley JM, Le Brun NE, Moore GR.

J Biol Inorg Chem. 2016 Mar;21(1):13-28. doi: 10.1007/s00775-016-1336-0. Epub 2016 Jan 29. Review.

27.

Biochemical properties of Paracoccus denitrificans FnrP: reactions with molecular oxygen and nitric oxide.

Crack JC, Hutchings MI, Thomson AJ, Le Brun NE.

J Biol Inorg Chem. 2016 Mar;21(1):71-82. doi: 10.1007/s00775-015-1326-7. Epub 2016 Jan 20.

28.

Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.

Bradley JM, Svistunenko DA, Lawson TL, Hemmings AM, Moore GR, Le Brun NE.

Angew Chem Int Ed Engl. 2015 Dec 1;54(49):14763-7. doi: 10.1002/anie.201507486. Epub 2015 Oct 16.

29.

A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage.

Pfaffen S, Bradley JM, Abdulqadir R, Firme MR, Moore GR, Le Brun NE, Murphy ME.

J Biol Chem. 2015 Nov 20;290(47):28416-27. doi: 10.1074/jbc.M115.669713. Epub 2015 Sep 22.

30.

Three Pseudomonas putida FNR Family Proteins with Different Sensitivities to O2.

Ibrahim SA, Crack JC, Rolfe MD, Borrero-de Acuña JM, Thomson AJ, Le Brun NE, Schobert M, Stapleton MR, Green J.

J Biol Chem. 2015 Jul 3;290(27):16812-23. doi: 10.1074/jbc.M115.654079. Epub 2015 May 13.

31.

PerR controls oxidative stress defence and aerotolerance but not motility-associated phenotypes of Campylobacter jejuni.

Handley RA, Mulholland F, Reuter M, Ramachandran VK, Musk H, Clissold L, Le Brun NE, van Vliet AH.

Microbiology. 2015 Jul;161(7):1524-36. doi: 10.1099/mic.0.000109. Epub 2015 May 12.

PMID:
25968890
32.

NsrR from Streptomyces coelicolor is a nitric oxide-sensing [4Fe-4S] cluster protein with a specialized regulatory function.

Crack JC, Munnoch J, Dodd EL, Knowles F, Al Bassam MM, Kamali S, Holland AA, Cramer SP, Hamilton CJ, Johnson MK, Thomson AJ, Hutchings MI, Le Brun NE.

J Biol Chem. 2015 May 15;290(20):12689-704. doi: 10.1074/jbc.M115.643072. Epub 2015 Mar 14.

33.

The B-type channel is a major route for iron entry into the ferroxidase center and central cavity of bacterioferritin.

Wong SG, Grigg JC, Le Brun NE, Moore GR, Murphy ME, Mauk AG.

J Biol Chem. 2015 Feb 6;290(6):3732-9. doi: 10.1074/jbc.M114.623082. Epub 2014 Dec 15.

34.

Iron-sulfur clusters as biological sensors: the chemistry of reactions with molecular oxygen and nitric oxide.

Crack JC, Green J, Thomson AJ, Le Brun NE.

Acc Chem Res. 2014 Oct 21;47(10):3196-205. doi: 10.1021/ar5002507. Epub 2014 Sep 29. Review.

PMID:
25262769
35.

Influence of association state and DNA binding on the O₂-reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator.

Crack JC, Stapleton MR, Green J, Thomson AJ, Le Brun NE.

Biochem J. 2014 Oct 1;463(1):83-92. doi: 10.1042/BJ20140169.

36.

Mechanisms of iron mineralization in ferritins: one size does not fit all.

Bradley JM, Moore GR, Le Brun NE.

J Biol Inorg Chem. 2014 Aug;19(6):775-85. doi: 10.1007/s00775-014-1136-3. Epub 2014 Apr 19. Review.

PMID:
24748222
37.

Techniques for the production, isolation, and analysis of iron-sulfur proteins.

Crack JC, Green J, Thomson AJ, Le Brun NE.

Methods Mol Biol. 2014;1122:33-48. doi: 10.1007/978-1-62703-794-5_4.

PMID:
24639252
38.

Mechanism of ferrous iron binding and oxidation by ferritin from a pennate diatom.

Pfaffen S, Abdulqadir R, Le Brun NE, Murphy ME.

J Biol Chem. 2013 May 24;288(21):14917-25. doi: 10.1074/jbc.M113.454496. Epub 2013 Apr 2.

39.

Mechanism of [4Fe-4S](Cys)4 cluster nitrosylation is conserved among NO-responsive regulators.

Crack JC, Stapleton MR, Green J, Thomson AJ, Le Brun NE.

J Biol Chem. 2013 Apr 19;288(16):11492-502. doi: 10.1074/jbc.M112.439901. Epub 2013 Mar 7.

40.

Bioinorganic chemistry.

Raven E, Le Brun NE, McMaster J, Reedijk J, Robinson NJ.

Dalton Trans. 2013 Mar 7;42(9):3027-8. doi: 10.1039/c2dt90214a. Epub 2013 Jan 18. No abstract available.

PMID:
23328953
41.

Reversible cycling between cysteine persulfide-ligated [2Fe-2S] and cysteine-ligated [4Fe-4S] clusters in the FNR regulatory protein.

Zhang B, Crack JC, Subramanian S, Green J, Thomson AJ, Le Brun NE, Johnson MK.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15734-9. Epub 2012 Sep 10.

42.

CopAb, the second N-terminal soluble domain of Bacillus subtilis CopA, dominates the Cu(I)-binding properties of CopAab.

Zhou L, Singleton C, Le Brun NE.

Dalton Trans. 2012 May 21;41(19):5939-48. doi: 10.1039/c2dt30126a.

PMID:
22531974
43.

Fe-haem bound to Escherichia coli bacterioferritin accelerates iron core formation by an electron transfer mechanism.

Wong SG, Abdulqadir R, Le Brun NE, Moore GR, Mauk AG.

Biochem J. 2012 Jun 15;444(3):553-60. doi: 10.1042/BJ20112200.

PMID:
22458666
44.

Iron-sulfur cluster sensor-regulators.

Crack JC, Green J, Thomson AJ, Le Brun NE.

Curr Opin Chem Biol. 2012 Apr;16(1-2):35-44. doi: 10.1016/j.cbpa.2012.02.009. Epub 2012 Mar 2. Review.

PMID:
22387135
45.

Bacterial iron-sulfur regulatory proteins as biological sensor-switches.

Crack JC, Green J, Hutchings MI, Thomson AJ, Le Brun NE.

Antioxid Redox Signal. 2012 Nov 1;17(9):1215-31. doi: 10.1089/ars.2012.4511. Epub 2012 Mar 6. Review.

46.

Cu(I)- and proton-binding properties of the first N-terminal soluble domain of Bacillus subtilis CopA.

Zhou L, Singleton C, Hecht O, Moore GR, Le Brun NE.

FEBS J. 2012 Jan;279(2):285-98. doi: 10.1111/j.1742-4658.2011.08422.x. Epub 2011 Dec 6.

47.

Heme binding to the second, lower-affinity site of the global iron regulator Irr from Rhizobium leguminosarum promotes oligomerization.

White GF, Singleton C, Todd JD, Cheesman MR, Johnston AW, Le Brun NE.

FEBS J. 2011 Jun;278(12):2011-21. doi: 10.1111/j.1742-4658.2011.08117.x. Epub 2011 May 17.

48.

Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.

Crack JC, Smith LJ, Stapleton MR, Peck J, Watmough NJ, Buttner MJ, Buxton RS, Green J, Oganesyan VS, Thomson AJ, Le Brun NE.

J Am Chem Soc. 2011 Feb 2;133(4):1112-21. doi: 10.1021/ja109581t. Epub 2010 Dec 23.

49.

A new role for heme, facilitating release of iron from the bacterioferritin iron biomineral.

Yasmin S, Andrews SC, Moore GR, Le Brun NE.

J Biol Chem. 2011 Feb 4;286(5):3473-83. doi: 10.1074/jbc.M110.175034. Epub 2010 Nov 23.

50.

Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster.

Smith LJ, Stapleton MR, Fullstone GJ, Crack JC, Thomson AJ, Le Brun NE, Hunt DM, Harvey E, Adinolfi S, Buxton RS, Green J.

Biochem J. 2010 Dec 15;432(3):417-27. doi: 10.1042/BJ20101440.

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