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Items: 1 to 50 of 136

1.

Mesenchymal stromal cells modulate tissue repair responses within the injured vocal fold.

Nagubothu SR, Sugars RV, Tudzarovski N, Andrén AT, Bottai M, Davies LC, Hertegård S, Le Blanc K.

Laryngoscope. 2019 Mar 5. doi: 10.1002/lary.27885. [Epub ahead of print]

PMID:
30835853
2.

Challenges for mesenchymal stromal cell therapies.

Martin I, Galipeau J, Kessler C, Le Blanc K, Dazzi F.

Sci Transl Med. 2019 Feb 20;11(480). pii: eaat2189. doi: 10.1126/scitranslmed.aat2189. Review.

PMID:
30787168
3.

Author Accountability in Biomedical Research.

Caplan A, Badylak SF, Caplan AI, Davies LC, Strömblad S, Weiss DJ, Le Blanc K.

Stem Cells Dev. 2018 Nov 20. doi: 10.1089/scd.2018.0214. [Epub ahead of print] No abstract available.

4.

Quantitative chromogenic immunohistochemical image analysis in cellprofiler software.

Tollemar V, Tudzarovski N, Boberg E, Törnqvist Andrén A, Al-Adili A, Le Blanc K, Garming Legert K, Bottai M, Warfvinge G, Sugars RV.

Cytometry A. 2018 Oct;93(10):1051-1059. doi: 10.1002/cyto.a.23575. Epub 2018 Aug 8.

PMID:
30089197
5.

Second-line treatment for acute graft-versus-host disease with mesenchymal stromal cells: A decision model.

Thielen FW, Blommestein HM, Oosten LEM, Calkoen FG, Lankester AC, Zwaginga JJ, Le Blanc K, Redondo A, Sánchez-Guijo F, Algeri M, Locatelli F, Fibbe WE, Uyl-de Groot CA.

Eur J Haematol. 2018 Aug 6. doi: 10.1111/ejh.13158. [Epub ahead of print]

PMID:
30084111
6.

Manufacturing Mesenchymal Stromal Cells for the Treatment of Graft-versus-Host Disease: A Survey among Centers Affiliated with the European Society for Blood and Marrow Transplantation.

Trento C, Bernardo ME, Nagler A, Kuçi S, Bornhäuser M, Köhl U, Strunk D, Galleu A, Sanchez-Guijo F, Gaipa G, Introna M, Bukauskas A, Le Blanc K, Apperley J, Roelofs H, Van Campenhout A, Beguin Y, Kuball J, Lazzari L, Avanzini MA, Fibbe W, Chabannon C, Bonini C, Dazzi F.

Biol Blood Marrow Transplant. 2018 Nov;24(11):2365-2370. doi: 10.1016/j.bbmt.2018.07.015. Epub 2018 Jul 20.

7.

Stromal progenitor cell modulation by thalidomide in the treatment of oral chronic graft-versus-host disease.

Davies LC, Board-Davies E, Shamlou B, Boberg E, Garming-Legert K, Le Blanc K.

Cytotherapy. 2018 May;20(5):755-758. doi: 10.1016/j.jcyt.2018.02.370. Epub 2018 Mar 23. No abstract available.

PMID:
29580863
8.

Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis.

Iacobaeus E, Douagi I, Jitschin R, Marcusson-Ståhl M, Andrén AT, Gavin C, Lefsihane K, Davies LC, Mougiakakos D, Kadri N, Le Blanc K.

Immunol Cell Biol. 2018 Sep;96(8):820-830. doi: 10.1111/imcb.12042. Epub 2018 Apr 19.

PMID:
29569304
9.

MSCs-cells with many sides.

Le Blanc K, Davies LC.

Cytotherapy. 2018 Mar;20(3):273-278. doi: 10.1016/j.jcyt.2018.01.009. Epub 2018 Feb 9. Review.

PMID:
29434007
10.

Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination.

Iacobaeus E, Sugars RV, Törnqvist Andrén A, Alm JJ, Qian H, Frantzen J, Newcombe J, Alkass K, Druid H, Bottai M, Röyttä M, Le Blanc K.

Stem Cells Transl Med. 2017 Oct;6(10):1840-1851. doi: 10.1002/sctm.17-0028. Epub 2017 Sep 23.

11.

Commentary: Role of Mesenchymal Stromal Cell-Mediated Crosstalk with Macrophages in Graft-versus-Host Disease and Tissue Repair.

Davies LC, Boberg E, Le Blanc K.

Biol Blood Marrow Transplant. 2017 Jun;23(6):861-862. doi: 10.1016/j.bbmt.2017.04.006. Epub 2017 Apr 7. No abstract available.

12.

Impact of Pretransplantation Indices in Hematopoietic Stem Cell Transplantation: Knowledge of Center-Specific Outcome Data Is Pivotal before Making Index-Based Decisions.

Törlén J, Remberger M, Le Blanc K, Ljungman P, Mattsson J.

Biol Blood Marrow Transplant. 2017 Apr;23(4):677-683. doi: 10.1016/j.bbmt.2017.01.003. Epub 2017 Jan 4.

13.

Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression.

Davies LC, Heldring N, Kadri N, Le Blanc K.

Stem Cells. 2017 Mar;35(3):766-776. doi: 10.1002/stem.2509. Epub 2016 Oct 26.

14.

Type 1 Diabetes Mellitus Donor Mesenchymal Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro.

Davies LC, Alm JJ, Heldring N, Moll G, Gavin C, Batsis I, Qian H, Sigvardsson M, Nilsson B, Kyllonen LE, Salmela KT, Carlsson PO, Korsgren O, Le Blanc K.

Stem Cells Transl Med. 2016 Nov;5(11):1485-1495. doi: 10.5966/sctm.2015-0272. Epub 2016 Jul 13.

15.

MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC.

Rolandsson Enes S, Andersson Sjöland A, Skog I, Hansson L, Larsson H, Le Blanc K, Eriksson L, Bjermer L, Scheding S, Westergren-Thorsson G.

Sci Rep. 2016 Jul 6;6:29160. doi: 10.1038/srep29160.

16.

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Simonson OE, Mougiakakos D, Heldring N, Bassi G, Johansson HJ, Dalén M, Jitschin R, Rodin S, Corbascio M, El Andaloussi S, Wiklander OP, Nordin JZ, Skog J, Romain C, Koestler T, Hellgren-Johansson L, Schiller P, Joachimsson PO, Hägglund H, Mattsson M, Lehtiö J, Faridani OR, Sandberg R, Korsgren O, Krampera M, Weiss DJ, Grinnemo KH, Le Blanc K.

Stem Cells Transl Med. 2016 Jun;5(6):845. doi: 10.5966/sctm.2015-0021erratum. No abstract available.

17.

Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells.

Månsson-Broberg A, Rodin S, Bulatovic I, Ibarra C, Löfling M, Genead R, Wärdell E, Felldin U, Granath C, Alici E, Le Blanc K, Smith CIE, Salašová A, Westgren M, Sundström E, Uhlén P, Arenas E, Sylvén C, Tryggvason K, Corbascio M, Simonson OE, Österholm C, Grinnemo KH.

Stem Cell Reports. 2016 Apr 12;6(4):607-617. doi: 10.1016/j.stemcr.2016.02.014. Epub 2016 Mar 24.

18.

Heparinization of cell surfaces with short peptide-conjugated PEG-lipid regulates thromboinflammation in transplantation of human MSCs and hepatocytes.

Asif S, Ekdahl KN, Fromell K, Gustafson E, Barbu A, Le Blanc K, Nilsson B, Teramura Y.

Acta Biomater. 2016 Apr 15;35:194-205. doi: 10.1016/j.actbio.2016.02.018. Epub 2016 Feb 12.

PMID:
26876877
19.

Mesenchymal Stromal Cells Disrupt mTOR-Signaling and Aerobic Glycolysis During T-Cell Activation.

Böttcher M, Hofmann AD, Bruns H, Haibach M, Loschinski R, Saul D, Mackensen A, Le Blanc K, Jitschin R, Mougiakakos D.

Stem Cells. 2016 Feb;34(2):516-21. doi: 10.1002/stem.2234. Epub 2015 Nov 17.

20.

Mesenchymal stromal cells support endothelial cell interactions in an intramuscular islet transplantation model.

Fransson M, Brännström J, Duprez I, Essand M, Le Blanc K, Korsgren O, Magnusson PU.

Regen Med Res. 2015 Sep 30;3:1. doi: 10.1186/s40340-015-0010-9. eCollection 2015.

21.

Enhanced oral healing following local mesenchymal stromal cell therapy.

Garming-Legert K, Tour G, Sugars R, von Bahr L, Davies LC, Le Blanc K.

Oral Oncol. 2015 Dec;51(12):e97-9. doi: 10.1016/j.oraloncology.2015.09.008. Epub 2015 Oct 5. No abstract available.

PMID:
26428076
22.

MSCs: Scientific Support for Multiple Therapies.

Pittenger MF, Le Blanc K, Phinney DG, Chan JK.

Stem Cells Int. 2015;2015:280572. doi: 10.1155/2015/280572. Epub 2015 Jul 29. No abstract available.

23.

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Simonson OE, Mougiakakos D, Heldring N, Bassi G, Johansson HJ, Dalén M, Jitschin R, Rodin S, Corbascio M, El Andaloussi S, Wiklander OP, Nordin JZ, Skog J, Romain C, Koestler T, Hellgren-Johansson L, Schiller P, Joachimsson PO, Hägglund H, Mattsson M, Lehtiö J, Faridani OR, Sandberg R, Korsgren O, Krampera M, Weiss DJ, Grinnemo KH, Le Blanc K.

Stem Cells Transl Med. 2015 Oct;4(10):1199-213. doi: 10.5966/sctm.2015-0021. Epub 2015 Aug 18. Erratum in: Stem Cells Transl Med. 2016 Jun;5(6):845.

24.

Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles.

Heldring N, Mäger I, Wood MJ, Le Blanc K, Andaloussi SE.

Hum Gene Ther. 2015 Aug;26(8):506-17. doi: 10.1089/hum.2015.072. Epub 2015 Aug 3. Review.

PMID:
26153722
25.

Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation.

von Bahr L, Blennow O, Alm J, Björklund A, Malmberg KJ, Mougiakakos D, Le Blanc A, Oefner PJ, Labopin M, Ljungman P, Le Blanc K.

Bone Marrow Transplant. 2015 Sep;50(9):1217-23. doi: 10.1038/bmt.2015.123. Epub 2015 Jun 1.

PMID:
26030049
26.

Mesenchymal stromal cells to halt the progression of type 1 diabetes?

Carlsson PO, Korsgren O, Le Blanc K.

Curr Diab Rep. 2015 Jul;15(7):46. doi: 10.1007/s11892-015-0616-3. Review.

PMID:
26003192
27.

Mesenchymal stromal cells and the innate immune response.

Le Blanc K, Davies LC.

Immunol Lett. 2015 Dec;168(2):140-6. doi: 10.1016/j.imlet.2015.05.004. Epub 2015 May 15. Review.

28.

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting.

Wiklander OP, Nordin JZ, O'Loughlin A, Gustafsson Y, Corso G, Mäger I, Vader P, Lee Y, Sork H, Seow Y, Heldring N, Alvarez-Erviti L, Smith CI, Le Blanc K, Macchiarini P, Jungebluth P, Wood MJ, Andaloussi SE.

J Extracell Vesicles. 2015 Apr 20;4:26316. doi: 10.3402/jev.v4.26316. eCollection 2015.

29.

Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling.

Jitschin R, Braun M, Qorraj M, Saul D, Le Blanc K, Zenz T, Mougiakakos D.

Blood. 2015 May 28;125(22):3432-6. doi: 10.1182/blood-2014-10-607036. Epub 2015 Mar 16.

30.

Amniotic fluid - a source for clinical therapeutics in the newborn?

Ekblad Å, Qian H, Westgren M, Le Blanc K, Fossum M, Götherström C.

Stem Cells Dev. 2015 Jun 15;24(12):1405-14. doi: 10.1089/scd.2014.0426. Epub 2015 Mar 13.

PMID:
25668721
31.

Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells.

Carlsson PO, Schwarcz E, Korsgren O, Le Blanc K.

Diabetes. 2015 Feb;64(2):587-92. doi: 10.2337/db14-0656. Epub 2014 Sep 9.

32.

CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs.

Jitschin R, Braun M, Büttner M, Dettmer-Wilde K, Bricks J, Berger J, Eckart MJ, Krause SW, Oefner PJ, Le Blanc K, Mackensen A, Mougiakakos D.

Blood. 2014 Jul 31;124(5):750-60. doi: 10.1182/blood-2013-12-546416. Epub 2014 May 21.

33.

Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?

Moll G, Alm JJ, Davies LC, von Bahr L, Heldring N, Stenbeck-Funke L, Hamad OA, Hinsch R, Ignatowicz L, Locke M, Lönnies H, Lambris JD, Teramura Y, Nilsson-Ekdahl K, Nilsson B, Le Blanc K.

Stem Cells. 2014 Sep;32(9):2430-42. doi: 10.1002/stem.1729.

34.

White paper on how to go forward with cell-based advanced therapies in Europe.

Erben RG, Silva-Lima B, Reischl I, Steinhoff G, Tiedemann G, Dalemans W, Vos A, Janssen RT, Le Blanc K, van Osch GJ, Luyten FP.

Tissue Eng Part A. 2014 Oct;20(19-20):2549-54. doi: 10.1089/ten.TEA.2013.0589. Epub 2014 Jun 3.

35.

Defined serum-free media for in vitro expansion of adipose-derived mesenchymal stem cells.

Al-Saqi SH, Saliem M, Asikainen S, Quezada HC, Ekblad A, Hovatta O, Le Blanc K, Jonasson AF, Götherström C.

Cytotherapy. 2014 Jul;16(7):915-26. doi: 10.1016/j.jcyt.2014.02.006. Epub 2014 Apr 13.

PMID:
24726655
36.

Do ABO blood group antigens hamper the therapeutic efficacy of mesenchymal stromal cells?

Moll G, Hult A, von Bahr L, Alm JJ, Heldring N, Hamad OA, Stenbeck-Funke L, Larsson S, Teramura Y, Roelofs H, Nilsson B, Fibbe WE, Olsson ML, Le Blanc K.

PLoS One. 2014 Jan 13;9(1):e85040. doi: 10.1371/journal.pone.0085040. eCollection 2014.

37.

Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience.

Götherström C, Westgren M, Shaw SW, Aström E, Biswas A, Byers PH, Mattar CN, Graham GE, Taslimi J, Ewald U, Fisk NM, Yeoh AE, Lin JL, Cheng PJ, Choolani M, Le Blanc K, Chan JK.

Stem Cells Transl Med. 2014 Feb;3(2):255-64. doi: 10.5966/sctm.2013-0090. Epub 2013 Dec 16.

38.

Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?

Le Blanc K, Jitschin R, Mougiakakos D.

Oncoimmunology. 2013 Jul 1;2(7):e25009. Epub 2013 May 16.

39.

Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease.

Ball LM, Bernardo ME, Roelofs H, van Tol MJ, Contoli B, Zwaginga JJ, Avanzini MA, Conforti A, Bertaina A, Giorgiani G, Jol-van der Zijde CM, Zecca M, Le Blanc K, Frassoni F, Egeler RM, Fibbe WE, Lankester AC, Locatelli F.

Br J Haematol. 2013 Nov;163(4):501-9. doi: 10.1111/bjh.12545. Epub 2013 Aug 31.

PMID:
23992039
40.

Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation.

Jitschin R, Mougiakakos D, Von Bahr L, Völkl S, Moll G, Ringden O, Kiessling R, Linder S, Le Blanc K.

Stem Cells. 2013 Aug;31(8):1715-25. doi: 10.1002/stem.1386.

41.

A prospective randomized toxicity study to compare reduced-intensity and myeloablative conditioning in patients with myeloid leukaemia undergoing allogeneic haematopoietic stem cell transplantation.

Ringdén O, Erkers T, Aschan J, Garming-Legert K, Le Blanc K, Hägglund H, Omazic B, Svenberg P, Dahllöf G, Mattsson J, Ljungman P, Remberger M.

J Intern Med. 2013 Aug;274(2):153-62. doi: 10.1111/joim.12056. Epub 2013 Mar 25.

42.

Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoiesis without suppressing immune function: implications for off-the shelf ES-MSC therapies.

Li O, Tormin A, Sundberg B, Hyllner J, Le Blanc K, Scheding S.

PLoS One. 2013;8(1):e55319. doi: 10.1371/journal.pone.0055319. Epub 2013 Jan 29.

43.

Adenovirus serotype 5 vectors with Tat-PTD modified hexon and serotype 35 fiber show greatly enhanced transduction capacity of primary cell cultures.

Yu D, Jin C, Ramachandran M, Xu J, Nilsson B, Korsgren O, Le Blanc K, Uhrbom L, Forsberg-Nilsson K, Westermark B, Adamson R, Maitland N, Fan X, Essand M.

PLoS One. 2013;8(1):e54952. doi: 10.1371/journal.pone.0054952. Epub 2013 Jan 25.

44.

Factors with an impact on chimerism development and long-term survival after umbilical cord blood transplantation.

Berglund S, Le Blanc K, Remberger M, Gertow J, Uzunel M, Svenberg P, Winiarski J, Ljungman P, Ringdén O, Uhlin M, Mattsson J.

Transplantation. 2012 Nov 27;94(10):1066-74. doi: 10.1097/TP.0b013e31826c39b2.

PMID:
23076550
45.

Immunosuppressive CD14+HLA-DRlow/neg IDO+ myeloid cells in patients following allogeneic hematopoietic stem cell transplantation.

Mougiakakos D, Jitschin R, von Bahr L, Poschke I, Gary R, Sundberg B, Gerbitz A, Ljungman P, Le Blanc K.

Leukemia. 2013 Feb;27(2):377-88. doi: 10.1038/leu.2012.215. Epub 2012 Jul 25.

PMID:
22828446
46.

Treatment of familial hemophagocytic lymphohistiocytosis with third-party mesenchymal stromal cells.

Mougiakakos D, Machaczka M, Jitschin R, Klimkowska M, Entesarian M, Bryceson YT, Henter JI, Sander B, Le Blanc K.

Stem Cells Dev. 2012 Nov 20;21(17):3147-51. doi: 10.1089/scd.2012.0214. Epub 2012 Jul 30.

PMID:
22738174
47.

Primary mesenchymal stem and progenitor cells from bone marrow lack expression of CD44 protein.

Qian H, Le Blanc K, Sigvardsson M.

J Biol Chem. 2012 Jul 27;287(31):25795-807. doi: 10.1074/jbc.M112.339622. Epub 2012 May 31.

48.

Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation.

von Bahr L, Batsis I, Moll G, Hägg M, Szakos A, Sundberg B, Uzunel M, Ringden O, Le Blanc K.

Stem Cells. 2012 Jul;30(7):1575-8. doi: 10.1002/stem.1118.

49.

Multipotent mesenchymal stromal cells and the innate immune system.

Le Blanc K, Mougiakakos D.

Nat Rev Immunol. 2012 Apr 25;12(5):383-96. doi: 10.1038/nri3209. Review.

PMID:
22531326
50.

Are therapeutic human mesenchymal stromal cells compatible with human blood?

Moll G, Rasmusson-Duprez I, von Bahr L, Connolly-Andersen AM, Elgue G, Funke L, Hamad OA, Lönnies H, Magnusson PU, Sanchez J, Teramura Y, Nilsson-Ekdahl K, Ringdén O, Korsgren O, Nilsson B, Le Blanc K.

Stem Cells. 2012 Jul;30(7):1565-74. doi: 10.1002/stem.1111.

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