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Items: 16


Mycobacterium tuberculosis of the RDRio genotype is the predominant cause of tuberculosis and associated with multidrug resistance in Porto Alegre City, South Brazil.

Dalla Costa ER, Lazzarini LC, Perizzolo PF, Díaz CA, Spies FS, Costa LL, Ribeiro AW, Barroco C, Schuh SJ, da Silva Pereira MA, Dias CF, Gomes HM, Unis G, Zaha A, Almeida da Silva PE, Suffys PN, Rossetti ML.

J Clin Microbiol. 2013 Apr;51(4):1071-7. doi: 10.1128/JCM.01511-12. Epub 2013 Jan 16.


Tuberculosis caused by RDRio Mycobacterium tuberculosis is not associated with differential clinical features.

Barbosa Cde B, Lazzarini LC, Elias AR, Leung JA, Ribeiro SB, da Silva MG, Duarte RS, Suffys P, Gomes HM, Kritski AL, Lapa E Silva JR, Ho JL, Boéchat N.

Int J Tuberc Lung Dis. 2012 Oct;16(10):1377-82. doi: 10.5588/ijtld.11.0709. Epub 2012 Aug 3.


Interleukin-10 and interferon-gamma patterns during tuberculosis treatment: possible association with recurrence.

Lago PM, Boéchat N, Migueis DP, Almeida AS, Lazzarini LC, Saldanha MM, Kritski AL, Ho JL, Lapa e Silva JR.

Int J Tuberc Lung Dis. 2012 May;16(5):656-9. doi: 10.5588/ijtld.11.0707. Epub 2012 Mar 8.


Mycobacterium tuberculosis spoligotypes that may derive from mixed strain infections are revealed by a novel computational approach.

Lazzarini LC, Rosenfeld J, Huard RC, Hill V, Lapa e Silva JR, DeSalle R, Rastogi N, Ho JL.

Infect Genet Evol. 2012 Jun;12(4):798-806. doi: 10.1016/j.meegid.2011.08.028. Epub 2011 Sep 5.


The total face mask is more comfortable than the oronasal mask in noninvasive ventilation but is not associated with improved outcome.

Chacur FH, Vilella Felipe LM, Fernandes CG, Lazzarini LC.

Respiration. 2011;82(5):426-30. doi: 10.1159/000324441. Epub 2011 Aug 17.


Distinct clinical and epidemiological features of tuberculosis in New York City caused by the RD(Rio) Mycobacterium tuberculosis sublineage.

Weisenberg SA, Gibson AL, Huard RC, Kurepina N, Bang H, Lazzarini LC, Chiu Y, Li J, Ahuja S, Driscoll J, Kreiswirth BN, Ho JL.

Infect Genet Evol. 2012 Jun;12(4):664-70. doi: 10.1016/j.meegid.2011.07.018. Epub 2011 Aug 2.


Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity.

Almeida AS, Lago PM, Boechat N, Huard RC, Lazzarini LC, Santos AR, Nociari M, Zhu H, Perez-Sweeney BM, Bang H, Ni Q, Huang J, Gibson AL, Flores VC, Pecanha LR, Kritski AL, Lapa e Silva JR, Ho JL.

J Immunol. 2009 Jul 1;183(1):718-31. doi: 10.4049/jimmunol.0801212. Epub 2009 Jun 17.


RDRio Mycobacterium tuberculosis infection is associated with a higher frequency of cavitary pulmonary disease.

Lazzarini LC, Spindola SM, Bang H, Gibson AL, Weisenberg S, da Silva Carvalho W, Augusto CJ, Huard RC, Kritski AL, Ho JL.

J Clin Microbiol. 2008 Jul;46(7):2175-83. doi: 10.1128/JCM.00065-08. Epub 2008 May 7.


Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family.

Gibson AL, Huard RC, Gey van Pittius NC, Lazzarini LC, Driscoll J, Kurepina N, Zozio T, Sola C, Spindola SM, Kritski AL, Fitzgerald D, Kremer K, Mardassi H, Chitale P, Brinkworth J, Garcia de Viedma D, Gicquel B, Pape JW, van Soolingen D, Kreiswirth BN, Warren RM, van Helden PD, Rastogi N, Suffys PN, Lapa e Silva J, Ho JL.

J Clin Microbiol. 2008 Apr;46(4):1259-67. doi: 10.1128/JCM.02231-07. Epub 2008 Jan 30.


Discovery of a novel Mycobacterium tuberculosis lineage that is a major cause of tuberculosis in Rio de Janeiro, Brazil.

Lazzarini LC, Huard RC, Boechat NL, Gomes HM, Oelemann MC, Kurepina N, Shashkina E, Mello FC, Gibson AL, Virginio MJ, Marsico AG, Butler WR, Kreiswirth BN, Suffys PN, Lapa E Silva JR, Ho JL.

J Clin Microbiol. 2007 Dec;45(12):3891-902. Epub 2007 Sep 26.


Low expression of antigen-presenting and costimulatory molecules by lung cells from tuberculosis patients.

Flores-Batista VC, Boechat N, Lago PM, Lazzarini LC, Pessanha LR, Almeida AS, Mafort TT, Kritski AL, Ho JL, Lapa-e-Silva JR.

Braz J Med Biol Res. 2007 Dec;40(12):1671-9. Epub 2007 Oct 29.


Necrotizing sarcoid granulomatosis in a family of patients with sarcoidosis reinforces the association between both entities.

Lazzarini LC, de Fatima do Amparo Teixeira M, Souza Rodrigues R, Marcos Nunes Valiante P.

Respiration. 2008;76(3):356-60. Epub 2007 Mar 22.


Novel genetic polymorphisms that further delineate the phylogeny of the Mycobacterium tuberculosis complex.

Huard RC, Fabre M, de Haas P, Lazzarini LC, van Soolingen D, Cousins D, Ho JL.

J Bacteriol. 2006 Jun;188(12):4271-87.


Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis.

Bonecini-Almeida MG, Ho JL, Boéchat N, Huard RC, Chitale S, Doo H, Geng J, Rego L, Lazzarini LC, Kritski AL, Johnson WD Jr, McCaffrey TA, Silva JR.

Infect Immun. 2004 May;72(5):2628-34.


The Mycobacterium tuberculosis complex-restricted gene cfp32 encodes an expressed protein that is detectable in tuberculosis patients and is positively correlated with pulmonary interleukin-10.

Huard RC, Chitale S, Leung M, Lazzarini LC, Zhu H, Shashkina E, Laal S, Conde MB, Kritski AL, Belisle JT, Kreiswirth BN, Lapa e Silva JR, Ho JL.

Infect Immun. 2003 Dec;71(12):6871-83.


PCR-based method to differentiate the subspecies of the Mycobacterium tuberculosis complex on the basis of genomic deletions.

Huard RC, Lazzarini LC, Butler WR, van Soolingen D, Ho JL.

J Clin Microbiol. 2003 Apr;41(4):1637-50.

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