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Items: 26


Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells.

Surve SV, Myers PJ, Clayton SA, Watkins SC, Lazzara MJ, Sorkin A.

Mol Biol Cell. 2019 Feb 15;30(4):506-523. doi: 10.1091/mbc.E18-08-0512. Epub 2018 Dec 26.


An engineering design approach to systems biology.

Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, Lauffenburger DA.

Integr Biol (Camb). 2017 Jul 17;9(7):574-583. doi: 10.1039/c7ib00014f. Review.


Cell signaling regulation by protein phosphorylation: a multivariate, heterogeneous, and context-dependent process.

Day EK, Sosale NG, Lazzara MJ.

Curr Opin Biotechnol. 2016 Aug;40:185-192. doi: 10.1016/j.copbio.2016.06.005. Epub 2016 Jul 6. Review.


EGF augments TGFβ-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1.

Buonato JM, Lan IS, Lazzara MJ.

J Cell Sci. 2015 Nov 1;128(21):3898-909. doi: 10.1242/jcs.169599. Epub 2015 Sep 10.


EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR.

Furcht CM, Buonato JM, Lazzara MJ.

Sci Signal. 2015 May 12;8(376):ra46. doi: 10.1126/scisignal.2005697.


Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma.

Walsh AM, Kapoor GS, Buonato JM, Mathew LK, Bi Y, Davuluri RV, Martinez-Lage M, Simon MC, O'Rourke DM, Lazzara MJ.

Mol Cancer Res. 2015 Aug;13(8):1227-37. doi: 10.1158/1541-7786.MCR-14-0183-T. Epub 2015 May 1.


Identifying Determinants of EGFR-Targeted Therapeutic Biochemical Efficacy Using Computational Modeling.

Monast CS, Lazzara MJ.

CPT Pharmacometrics Syst Pharmacol. 2014 Oct 15;3:e141. doi: 10.1038/psp.2014.39.


Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis.

Fogelgren B, Zuo X, Buonato JM, Vasilyev A, Baek JI, Choi SY, Chacon-Heszele MF, Palmyre A, Polgar N, Drummond I, Park KM, Lazzara MJ, Lipschutz JH.

Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1334-41. doi: 10.1152/ajprenal.00032.2014. Epub 2014 Oct 8.


p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.

Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh AM, Nemajerova A, Lazzara MJ, Altorki NK, Krainer A, Moll UM, Lowe SW, Cartegni L, Sordella R.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3287-96. doi: 10.1073/pnas.1321640111. Epub 2014 Jul 29.


Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells.

Furcht CM, Buonato JM, Skuli N, Mathew LK, Muñoz Rojas AR, Simon MC, Lazzara MJ.

J Cell Sci. 2014 Aug 15;127(Pt 16):3555-67. doi: 10.1242/jcs.150862. Epub 2014 Jun 20.


Differential parsing of EGFR endocytic flux among parallel internalization pathways in lung cancer cells with EGFR-activating mutations.

Walsh AM, Lazzara MJ.

Integr Biol (Camb). 2014 Mar;6(3):312-23. doi: 10.1039/c3ib40176f. Epub 2014 Jan 21.


ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their sensitivity to EGFR inhibition.

Buonato JM, Lazzara MJ.

Cancer Res. 2014 Jan 1;74(1):309-19. doi: 10.1158/0008-5472.CAN-12-4721. Epub 2013 Oct 9.


Regulation of EGFR trafficking and cell signaling by Sprouty2 and MIG6 in lung cancer cells.

Walsh AM, Lazzara MJ.

J Cell Sci. 2013 Oct 1;126(Pt 19):4339-48. doi: 10.1242/jcs.123208. Epub 2013 Jul 18.


Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

Ercan D, Xu C, Yanagita M, Monast CS, Pratilas CA, Montero J, Butaney M, Shimamura T, Sholl L, Ivanova EV, Tadi M, Rogers A, Repellin C, Capelletti M, Maertens O, Goetz EM, Letai A, Garraway LA, Lazzara MJ, Rosen N, Gray NS, Wong KK, Jänne PA.

Cancer Discov. 2012 Oct;2(10):934-47. doi: 10.1158/2159-8290.CD-12-0103. Epub 2012 Sep 7.


Computational analysis of the regulation of EGFR by protein tyrosine phosphatases.

Monast CS, Furcht CM, Lazzara MJ.

Biophys J. 2012 May 2;102(9):2012-21. doi: 10.1016/j.bpj.2012.03.037.


Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations.

Furcht CM, Muñoz Rojas AR, Nihalani D, Lazzara MJ.

Oncogene. 2013 May 2;32(18):2346-55, 2355.e1-10. doi: 10.1038/onc.2012.240. Epub 2012 Jul 9.


Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.

Arif E, Wagner MC, Johnstone DB, Wong HN, George B, Pruthi PA, Lazzara MJ, Nihalani D.

Mol Cell Biol. 2011 May;31(10):2134-50. doi: 10.1128/MCB.05051-11. Epub 2011 Mar 14.


Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations.

Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA.

Cancer Res. 2010 May 1;70(9):3843-50. doi: 10.1158/0008-5472.CAN-09-3421. Epub 2010 Apr 20.


Quantitative modeling perspectives on the ErbB system of cell regulatory processes.

Lazzara MJ, Lauffenburger DA.

Exp Cell Res. 2009 Feb 15;315(4):717-25. doi: 10.1016/j.yexcr.2008.10.033. Epub 2008 Nov 5. Review.


Model of albumin reabsorption in the proximal tubule.

Lazzara MJ, Deen WM.

Am J Physiol Renal Physiol. 2007 Jan;292(1):F430-9. Epub 2006 Sep 5.


Glomerular filtration of albumin: how small is the sieving coefficient?

Deen WM, Lazzara MJ.

Kidney Int Suppl. 2004 Nov;(92):S63-4. Review.


Protein partitioning driven by excluded-volume interactions in an aqueous nonionic micellar-gel system.

van Roosmalen D, Lazzara MJ, van den Broeke LJ, Keurentjes JT, Blankschtein D.

Biotechnol Bioeng. 2004 Sep 20;87(6):695-703.


Effects of concentration on the partitioning of macromolecule mixtures in agarose gels.

Lazzara MJ, Deen WM.

J Colloid Interface Sci. 2004 Apr 15;272(2):288-97.


Effects of plasma proteins on sieving of tracer macromolecules in glomerular basement membrane.

Lazzara MJ, Deen WM.

Am J Physiol Renal Physiol. 2001 Nov;281(5):F860-8.


Structural determinants of glomerular permeability.

Deen WM, Lazzara MJ, Myers BD.

Am J Physiol Renal Physiol. 2001 Oct;281(4):F579-96. Review.


Effects of Multisolute Steric Interactions on Membrane Partition Coefficients.

Lazzara MJ, Blankschtein D, Deen WM.

J Colloid Interface Sci. 2000 Jun 1;226(1):112-122.


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