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Items: 1 to 50 of 166

1.

Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.

Pandruvada SN, Beauregard J, Benjannet S, Pata M, Lazure C, Seidah NG, Vacher J.

Mol Cell Biol. 2015 Nov 23;36(3):507-21. doi: 10.1128/MCB.00656-15. Print 2016 Feb 1.

2.

General lysosomal hydrolysis can process prorenin accurately.

Xa LK, Lacombe MJ, Mercure C, Lazure C, Reudelhuber TL.

Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R505-13. doi: 10.1152/ajpregu.00467.2013. Epub 2014 Jun 25.

3.

Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.

Ly K, Saavedra YG, Canuel M, Routhier S, Desjardins R, Hamelin J, Mayne J, Lazure C, Seidah NG, Day R.

J Biol Chem. 2014 Jun 20;289(25):17732-46. doi: 10.1074/jbc.M113.541094. Epub 2014 May 7.

4.

Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.

Refaie S, Gagnon S, Gagnon H, Desjardins R, D'Anjou F, D'Orléans-Juste P, Zhu X, Steiner DF, Seidah NG, Lazure C, Salzet M, Day R.

J Biol Chem. 2012 Apr 27;287(18):14703-17. doi: 10.1074/jbc.M111.323220. Epub 2012 Mar 6.

5.

Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice.

Denis M, Marcinkiewicz J, Zaid A, Gauthier D, Poirier S, Lazure C, Seidah NG, Prat A.

Circulation. 2012 Feb 21;125(7):894-901. doi: 10.1161/CIRCULATIONAHA.111.057406. Epub 2012 Jan 18.

PMID:
22261195
6.

The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1.

Heyd F, Chen R, Afshar K, Saba I, Lazure C, Fiolka K, Möröy T.

Biochim Biophys Acta. 2011 Apr-Jun;1809(4-6):255-61. doi: 10.1016/j.bbagrm.2011.04.009. Epub 2011 May 1.

PMID:
21570500
7.

Modulation of PC1/3 activity by self-interaction and substrate binding.

Hoshino A, Kowalska D, Jean F, Lazure C, Lindberg I.

Endocrinology. 2011 Apr;152(4):1402-11. doi: 10.1210/en.2010-1170. Epub 2011 Feb 8.

8.

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.

Roubtsova A, Munkonda MN, Awan Z, Marcinkiewicz J, Chamberland A, Lazure C, Cianflone K, Seidah NG, Prat A.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):785-91. doi: 10.1161/ATVBAHA.110.220988. Epub 2011 Jan 27.

PMID:
21273557
9.

Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.

Rousselet E, Benjannet S, Marcinkiewicz E, Asselin MC, Lazure C, Seidah NG.

J Biol Chem. 2011 Mar 18;286(11):9185-95. doi: 10.1074/jbc.M110.189936. Epub 2011 Jan 5.

10.

Complementary methods to assist subcellular fractionation in organellar proteomics.

Gauthier DJ, Lazure C.

Expert Rev Proteomics. 2008 Aug;5(4):603-17. doi: 10.1586/14789450.5.4.603. Review.

PMID:
18761470
11.

Flow cytometry-assisted purification and proteomic analysis of the corticotropes dense-core secretory granules.

Gauthier DJ, Sobota JA, Ferraro F, Mains RE, Lazure C.

Proteomics. 2008 Sep;8(18):3848-61. doi: 10.1002/pmic.200700969.

12.

Carboxyl-terminal disulfide bond of acid sphingomyelinase is critical for its secretion and enzymatic function.

Lee CY, Tamura T, Rabah N, Lee DY, Ruel I, Hafiane A, Iatan I, Nyholt D, Laporte F, Lazure C, Wada I, Krimbou L, Genest J.

Biochemistry. 2007 Dec 25;46(51):14969-78. Epub 2007 Dec 1.

PMID:
18052040
13.

The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro.

Rabah N, Gauthier D, Dikeakos JD, Reudelhuber TL, Lazure C.

FEBS J. 2007 Jul;274(13):3482-91. Epub 2007 Jun 12.

14.

Induction of epididymal boar sperm capacitation by pB1 and BSP-A1/-A2 proteins, members of the BSP protein family.

Lusignan MF, Bergeron A, Crête MH, Lazure C, Manjunath P.

Biol Reprod. 2007 Mar;76(3):424-32. Epub 2006 Nov 22.

PMID:
17123943
15.

Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme.

Rabah N, Gauthier D, Wilkes BC, Gauthier DJ, Lazure C.

J Biol Chem. 2006 Mar 17;281(11):7556-67. Epub 2006 Jan 11.

16.

Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism.

D'Amour P, Brossard JH, Rousseau L, Nguyen-Yamamoto L, Nassif E, Lazure C, Gauthier D, Lavigne JR, Zahradnik RJ.

Kidney Int. 2005 Sep;68(3):998-1007.

17.

Isolation and characterization of the major proteins of ram seminal plasma.

Bergeron A, Villemure M, Lazure C, Manjunath P.

Mol Reprod Dev. 2005 Aug;71(4):461-70.

PMID:
15892046
18.

Notch1 antiapoptotic activity is abrogated by caspase cleavage in dying T lymphocytes.

Cohen LY, Bourbonnière M, Sabbagh L, Bouchard A, Chew T, Jeannequin P, Lazure C, Sékaly RP.

Cell Death Differ. 2005 Mar;12(3):243-54.

19.
20.

Improved PC1/3 production through recombinant expression in insect cells and larvae.

Rabah N, Gauthier DJ, Gauthier D, Lazure C.

Protein Expr Purif. 2004 Oct;37(2):377-84.

PMID:
15358360
21.

Isolation and characterization of gelatin-binding bison seminal vesicle secretory proteins.

Boisvert M, Bergeron A, Lazure C, Manjunath P.

Biol Reprod. 2004 Mar;70(3):656-61. Epub 2003 Oct 29.

PMID:
14585808
22.
23.

Barley serine proteinase inhibitor 2-derived cyclic peptides as potent and selective inhibitors of convertases PC1/3 and furin.

Villemure M, Fournier A, Gauthier D, Rabah N, Wilkes BC, Lazure C.

Biochemistry. 2003 Aug 19;42(32):9659-68.

PMID:
12911307
24.

Isolation and characterization of gelatin-binding proteins from goat seminal plasma.

Villemure M, Lazure C, Manjunath P.

Reprod Biol Endocrinol. 2003 Apr 28;1:39.

26.
28.

Purification and characterization of active recombinant rat kallikrein rK9.

Zani M, Brillard-Bourdet M, Lazure C, Juliano L, Courty Y, Gauthier F, Moreau T.

Biochim Biophys Acta. 2001 Jun 11;1547(2):387-96.

PMID:
11410295
29.

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.

Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chrétien M, Seidah NG.

J Biol Chem. 2001 Apr 6;276(14):10879-87. Epub 2001 Jan 10.

30.

Comparative characterization of two forms of recombinant human SPC1 secreted from Schneider 2 cells.

Denault JB, Lazure C, Day R, Leduc R.

Protein Expr Purif. 2000 Jun;19(1):113-24.

PMID:
10833398
31.

Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment.

Touré BB, Munzer JS, Basak A, Benjannet S, Rochemont J, Lazure C, Chrétien M, Seidah NG.

J Biol Chem. 2000 Jan 28;275(4):2349-58.

32.

Enzymic characterization in vitro of recombinant proprotein convertase PC4.

Basak A, Touré BB, Lazure C, Mbikay M, Chrétien M, Seidah NG.

Biochem J. 1999 Oct 1;343 Pt 1:29-37.

33.

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.

Seidah NG, Mowla SJ, Hamelin J, Mamarbachi AM, Benjannet S, Touré BB, Basak A, Munzer JS, Marcinkiewicz J, Zhong M, Barale JC, Lazure C, Murphy RA, Chrétien M, Marcinkiewicz M.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1321-6.

34.

Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells.

Boudreault A, Gauthier D, Rondeau N, Savaria D, Seidah NG, Chrétien M, Lazure C.

Protein Expr Purif. 1998 Dec;14(3):353-66.

PMID:
9882569
35.
36.

High concentrations of the macrophage migration inhibitory factor in human seminal plasma and prostatic tissues.

Frenette G, Tremblay RR, Dubé JY, Lazure C, Lemay M.

Arch Androl. 1998 Nov-Dec;41(3):185-93.

PMID:
9805147
37.

Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates.

Johanning K, Juliano MA, Juliano L, Lazure C, Lamango NS, Steiner DF, Lindberg I.

J Biol Chem. 1998 Aug 28;273(35):22672-80.

38.

Type II domains of BSP-A1/-A2 proteins: binding properties, lipid efflux, and sperm capacitation potential.

Moreau R, Thérien I, Lazure C, Manjunath P.

Biochem Biophys Res Commun. 1998 May 8;246(1):148-54.

PMID:
9600084
39.
40.

A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples.

Lepage R, Roy L, Brossard JH, Rousseau L, Dorais C, Lazure C, D'Amour P.

Clin Chem. 1998 Apr;44(4):805-9.

41.

Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity.

Day R, Lazure C, Basak A, Boudreault A, Limperis P, Dong W, Lindberg I.

J Biol Chem. 1998 Jan 9;273(2):829-36.

42.

Phospholipase A2 from bovine seminal plasma is a platelet-activating factor acetylhydrolase.

Soubeyrand S, Lazure C, Manjunath P.

Biochem J. 1998 Jan 1;329 ( Pt 1):41-7.

43.

Human kallikrein hK2 has low kininogenase activity while prostate-specific antigen (hK3) has none.

Deperthes D, Marceau F, Frenette G, Lazure C, Tremblay RR, Dubé JY.

Biochim Biophys Acta. 1997 Nov 14;1343(1):102-6.

PMID:
9428664
44.

The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis.

Rhéaume E, Cohen LY, Uhlmann F, Lazure C, Alam A, Hurwitz J, Sékaly RP, Denis F.

EMBO J. 1997 Nov 3;16(21):6346-54.

45.

In vitro characterization of the novel proprotein convertase PC7.

Munzer JS, Basak A, Zhong M, Mamarbachi A, Hamelin J, Savaria D, Lazure C, Hendy GN, Benjannet S, Chrétien M, Seidah NG.

J Biol Chem. 1997 Aug 8;272(32):19672-81. Erratum in: J Biol Chem 1997 Nov 28;272(48):30589.

46.

Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1.

Basak A, Ernst B, Brewer D, Seidah NG, Munzer JS, Lazure C, Lajoie GA.

J Pept Res. 1997 Jun;49(6):596-603.

PMID:
9266488
47.
48.

Evolution of mammalian apolipoprotein A-I and conservation of antigenicity: correlation with primary and secondary structure.

Collet X, Marcel YL, Tremblay N, Lazure C, Milne RW, Perret B, Weech PK.

J Lipid Res. 1997 Apr;38(4):634-44.

49.

Secretion of a type II integral membrane protein induced by mutation of the transmembrane segment.

Lemire I, Lazure C, Crine P, Boileau G.

Biochem J. 1997 Feb 15;322 ( Pt 1):335-42.

50.

Purification of enzymatically active kallikrein hK2 from human seminal plasma.

Frenette G, Deperthes D, Tremblay RR, Lazure C, Dubé JY.

Biochim Biophys Acta. 1997 Feb 11;1334(1):109-15.

PMID:
9042371

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