Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 644

1.

Pedro Brugada and Peter Schwartz share the Lefoulon-Delalande Foundation Scientific Prize 2019.

Alto K, Carpentier A, de Gaetano G, Gros F, Haissaguerre M, Lazdunski M, Nemer M, Noble D, Sabatini DD, Samuelsson B, Taylor DA.

Eur Heart J. 2019 Aug 21;40(32):2670. doi: 10.1093/eurheartj/ehz597. No abstract available.

PMID:
31433852
2.

Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1.

Nicolas S, Zoukimian C, Bosmans F, Montnach J, Diochot S, Cuypers E, De Waard S, Béroud R, Mebs D, Craik D, Boturyn D, Lazdunski M, Tytgat J, De Waard M.

Toxins (Basel). 2019 Jun 21;11(6). pii: E367. doi: 10.3390/toxins11060367.

3.

The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia.

Widmann C, Gandin C, Petit-Paitel A, Lazdunski M, Heurteaux C.

Sci Rep. 2018 Dec 24;8(1):18062. doi: 10.1038/s41598-018-36138-0.

4.

Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin.

Poupon L, Lamoine S, Pereira V, Barriere DA, Lolignier S, Giraudet F, Aissouni Y, Meleine M, Prival L, Richard D, Kerckhove N, Authier N, Balayssac D, Eschalier A, Lazdunski M, Busserolles J.

Neuropharmacology. 2018 Sep 15;140:43-61. doi: 10.1016/j.neuropharm.2018.07.026. Epub 2018 Jul 26.

PMID:
30056126
5.

Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice.

Vincent A, Covinhes A, Barrère C, Gallot L, Thoumala S, Piot C, Heurteaux C, Lazdunski M, Nargeot J, Barrère-Lemaire S.

Sci Rep. 2017 Oct 31;7(1):14701. doi: 10.1038/s41598-017-14822-x.

6.

MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice.

Gandin C, Widmann C, Lazdunski M, Heurteaux C.

Cerebrovasc Dis. 2016;42(1-2):139-54. doi: 10.1159/000444810. Epub 2016 Apr 22.

7.

Editorial.

Lazdunski M.

Neuropharmacology. 2015 Jul;94:2-3. doi: 10.1016/j.neuropharm.2015.03.010. Epub 2015 Apr 1. No abstract available.

PMID:
25842245
8.

Positive effects of the traditional Chinese medicine MLC901 in cognitive tasks.

Lorivel T, Gandin C, Veyssière J, Lazdunski M, Heurteaux C.

J Neurosci Res. 2015 Nov;93(11):1648-63. doi: 10.1002/jnr.23591. Epub 2015 Mar 29.

9.

Acid-Sensing Ion Channels in the nervous system. Foreword.

Lingueglia E, Lazdunski M.

Neuropharmacology. 2015 Jul;94:1. doi: 10.1016/j.neuropharm.2015.03.011. Epub 2015 Mar 24. No abstract available.

PMID:
25813612
10.

Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.

Pereira V, Busserolles J, Christin M, Devilliers M, Poupon L, Legha W, Alloui A, Aissouni Y, Bourinet E, Lesage F, Eschalier A, Lazdunski M, Noël J.

Pain. 2014 Dec;155(12):2534-44. doi: 10.1016/j.pain.2014.09.013. Epub 2014 Sep 18.

PMID:
25239074
11.

MLC901, a Traditional Chinese Medicine induces neuroprotective and neuroregenerative benefits after traumatic brain injury in rats.

Quintard H, Lorivel T, Gandin C, Lazdunski M, Heurteaux C.

Neuroscience. 2014 Sep 26;277:72-86. doi: 10.1016/j.neuroscience.2014.06.047. Epub 2014 Jun 30. Erratum in: Neuroscience. 2014 Oct 10;278:265-6.

12.

Activation of TREK-1 by morphine results in analgesia without adverse side effects.

Devilliers M, Busserolles J, Lolignier S, Deval E, Pereira V, Alloui A, Christin M, Mazet B, Delmas P, Noel J, Lazdunski M, Eschalier A.

Nat Commun. 2013;4:2941. doi: 10.1038/ncomms3941.

PMID:
24346231
13.

Peripheral contribution of NGF and ASIC1a to colonic hypersensitivity in a rat model of irritable bowel syndrome.

Matricon J, Muller E, Accarie A, Meleine M, Etienne M, Voilley N, Busserolles J, Eschalier A, Lazdunski M, Bourdu S, Gelot A, Ardid D.

Neurogastroenterol Motil. 2013 Nov;25(11):e740-54. doi: 10.1111/nmo.12199. Epub 2013 Jul 31.

PMID:
23902154
14.

NeuroAiD: properties for neuroprotection and neurorepair.

Heurteaux C, Widmann C, Moha ou Maati H, Quintard H, Gandin C, Borsotto M, Veyssiere J, Onteniente B, Lazdunski M.

Cerebrovasc Dis. 2013;35 Suppl 1:1-7. doi: 10.1159/000346228. Epub 2013 Mar 14. Review.

15.

[An ionic channel involved in the skin protection against pressure].

Fromy B, Lingueglia E, Sigaudo-Roussel D, Saumet JL, Lazdunski M.

Med Sci (Paris). 2013 Feb;29(2):130-2. doi: 10.1051/medsci/2013292005. Epub 2013 Feb 28. French. No abstract available.

16.

Black mamba venom peptides target acid-sensing ion channels to abolish pain.

Diochot S, Baron A, Salinas M, Douguet D, Scarzello S, Dabert-Gay AS, Debayle D, Friend V, Alloui A, Lazdunski M, Lingueglia E.

Nature. 2012 Oct 25;490(7421):552-5. doi: 10.1038/nature11494. Epub 2012 Oct 3.

PMID:
23034652
17.

Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.

Fromy B, Lingueglia E, Sigaudo-Roussel D, Saumet JL, Lazdunski M.

Nat Med. 2012 Aug;18(8):1205-7. doi: 10.1038/nm.2844. Epub 2012 Jul 29.

PMID:
22842475
18.

Activation of ATP-sensitive potassium channels as an element of the neuroprotective effects of the Traditional Chinese Medicine MLC901 against oxygen glucose deprivation.

Moha Ou Maati H, Borsotto M, Chatelain F, Widmann C, Lazdunski M, Heurteaux C.

Neuropharmacology. 2012 Sep;63(4):692-700. doi: 10.1016/j.neuropharm.2012.05.035. Epub 2012 May 30.

PMID:
22659084
19.

MLC901, a traditional Chinese medicine protects the brain against global ischemia.

Quintard H, Borsotto M, Veyssiere J, Gandin C, Labbal F, Widmann C, Lazdunski M, Heurteaux C.

Neuropharmacology. 2011 Sep;61(4):622-31. doi: 10.1016/j.neuropharm.2011.05.003. Epub 2011 May 14.

PMID:
21605573
20.

Acid-sensing ion channels in postoperative pain.

Deval E, Noël J, Gasull X, Delaunay A, Alloui A, Friend V, Eschalier A, Lazdunski M, Lingueglia E.

J Neurosci. 2011 Apr 20;31(16):6059-66. doi: 10.1523/JNEUROSCI.5266-10.2011.

21.

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.

Descoeur J, Pereira V, Pizzoccaro A, Francois A, Ling B, Maffre V, Couette B, Busserolles J, Courteix C, Noel J, Lazdunski M, Eschalier A, Authier N, Bourinet E.

EMBO Mol Med. 2011 May;3(5):266-78. doi: 10.1002/emmm.201100134. Epub 2011 Mar 24.

22.

Spinal cord plasticity and acid-sensing ion channels involvement in a rodent model of irritable bowel syndrome.

Matricon J, Gelot A, Etienne M, Lazdunski M, Muller E, Ardid D.

Eur J Pain. 2011 Apr;15(4):335-43. doi: 10.1016/j.ejpain.2010.08.005.

PMID:
20888277
23.

Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo.

Heurteaux C, Gandin C, Borsotto M, Widmann C, Brau F, Lhuillier M, Onteniente B, Lazdunski M.

Neuropharmacology. 2010 Jun;58(7):987-1001. doi: 10.1016/j.neuropharm.2010.01.001. Epub 2010 Jan 11.

PMID:
20064536
24.

Structural elements for the generation of sustained currents by the acid pain sensor ASIC3.

Salinas M, Lazdunski M, Lingueglia E.

J Biol Chem. 2009 Nov 13;284(46):31851-9. doi: 10.1074/jbc.M109.043984. Epub 2009 Sep 24.

25.

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.

Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14628-33. doi: 10.1073/pnas.0906267106. Epub 2009 Aug 10.

26.

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.

Noël J, Zimmermann K, Busserolles J, Deval E, Alloui A, Diochot S, Guy N, Borsotto M, Reeh P, Eschalier A, Lazdunski M.

EMBO J. 2009 May 6;28(9):1308-18. doi: 10.1038/emboj.2009.57. Epub 2009 Mar 12.

27.

Sea anemone toxins affecting potassium channels.

Diochot S, Lazdunski M.

Prog Mol Subcell Biol. 2009;46:99-122. doi: 10.1007/978-3-540-87895-7_4. Review.

PMID:
19184586
28.

Acid-sensing ion channel 3 in retinal function and survival.

Ettaiche M, Deval E, Pagnotta S, Lazdunski M, Lingueglia E.

Invest Ophthalmol Vis Sci. 2009 May;50(5):2417-26. doi: 10.1167/iovs.08-3028. Epub 2008 Dec 30.

PMID:
19117938
29.

ASIC3, a sensor of acidic and primary inflammatory pain.

Deval E, Noël J, Lay N, Alloui A, Diochot S, Friend V, Jodar M, Lazdunski M, Lingueglia E.

EMBO J. 2008 Nov 19;27(22):3047-55. doi: 10.1038/emboj.2008.213. Epub 2008 Oct 16.

30.

Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking.

Sandoz G, Tardy MP, Thümmler S, Feliciangeli S, Lazdunski M, Lesage F.

J Neurosci. 2008 Aug 20;28(34):8545-52. doi: 10.1523/JNEUROSCI.1962-08.2008.

31.

Acid sensing ion channels in dorsal spinal cord neurons.

Baron A, Voilley N, Lazdunski M, Lingueglia E.

J Neurosci. 2008 Feb 6;28(6):1498-508. doi: 10.1523/JNEUROSCI.4975-07.2008.

32.

Does sumoylation control K2P1/TWIK1 background K+ channels?

Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J, Lesage F.

Cell. 2007 Aug 10;130(3):563-9.

33.

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.

Mazzuca M, Heurteaux C, Alloui A, Diochot S, Baron A, Voilley N, Blondeau N, Escoubas P, Gélot A, Cupo A, Zimmer A, Zimmer AM, Eschalier A, Lazdunski M.

Nat Neurosci. 2007 Aug;10(8):943-5. Epub 2007 Jul 15.

PMID:
17632507
34.

Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel.

Blondeau N, Pétrault O, Manta S, Giordanengo V, Gounon P, Bordet R, Lazdunski M, Heurteaux C.

Circ Res. 2007 Jul 20;101(2):176-84. Epub 2007 Jun 7.

PMID:
17556656
35.

Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis.

Wultsch T, Painsipp E, Shahbazian A, Mitrovic M, Edelsbrunner M, Lazdunski M, Waldmann R, Holzer P.

Pain. 2008 Feb;134(3):245-53. Epub 2007 May 24.

36.

APETx1 from sea anemone Anthopleura elegantissima is a gating modifier peptide toxin of the human ether-a-go-go- related potassium channel.

Zhang M, Liu XS, Diochot S, Lazdunski M, Tseng GN.

Mol Pharmacol. 2007 Aug;72(2):259-68. Epub 2007 May 1.

PMID:
17473056
37.

Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids.

Chemin J, Patel AJ, Duprat F, Sachs F, Lazdunski M, Honore E.

Pflugers Arch. 2007 Oct;455(1):97-103. Epub 2007 Mar 24.

PMID:
17384962
38.

Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link.

Garry A, Fromy B, Blondeau N, Henrion D, Brau F, Gounon P, Guy N, Heurteaux C, Lazdunski M, Saumet JL.

EMBO Rep. 2007 Apr;8(4):354-9. Epub 2007 Mar 9.

39.

Antipsychotics inhibit TREK but not TRAAK channels.

Thümmler S, Duprat F, Lazdunski M.

Biochem Biophys Res Commun. 2007 Mar 2;354(1):284-9. Epub 2007 Jan 3.

PMID:
17222806
40.

Hydrolysis of minor glycerophospholipids of plasma lipoproteins by human group IIA, V and X secretory phospholipases A2.

Pruzanski W, Lambeau G, Lazdunski M, Cho W, Kopilov J, Kuksis A.

Biochim Biophys Acta. 2007 Jan;1771(1):5-19. Epub 2006 Dec 5.

PMID:
17197234
41.

Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids.

Chemin J, Patel AJ, Delmas P, Sachs F, Lazdunski M, Honore E.

Curr Top Membr. 2007;59:155-70. doi: 10.1016/S1063-5823(06)59007-6. Epub 2007 Apr 17.

PMID:
25168137
42.

Peptides inhibitors of acid-sensing ion channels.

Diochot S, Salinas M, Baron A, Escoubas P, Lazdunski M.

Toxicon. 2007 Feb;49(2):271-84. Epub 2006 Oct 4. Review.

PMID:
17113616
43.

AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels.

Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F.

EMBO J. 2006 Dec 13;25(24):5864-72. Epub 2006 Nov 16.

44.

The background K(+) channel TASK-3 is regulated at both the transcriptional and post-transcriptional levels.

Zanzouri M, Lauritzen I, Lazdunski M, Patel A.

Biochem Biophys Res Commun. 2006 Oct 6;348(4):1350-7. Epub 2006 Aug 7.

PMID:
16925981
45.

Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype.

Heurteaux C, Lucas G, Guy N, El Yacoubi M, Thümmler S, Peng XD, Noble F, Blondeau N, Widmann C, Borsotto M, Gobbi G, Vaugeois JM, Debonnel G, Lazdunski M.

Nat Neurosci. 2006 Sep;9(9):1134-41. Epub 2006 Aug 13.

PMID:
16906152
46.

Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway.

Zanzouri M, Lauritzen I, Duprat F, Mazzuca M, Lesage F, Lazdunski M, Patel A.

J Biol Chem. 2006 Sep 29;281(39):28910-8. Epub 2006 Jul 24.

47.

PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.

Borsotto M, Cavarec L, Bouillot M, Romey G, Macciardi F, Delaye A, Nasroune M, Bastucci M, Sambucy JL, Luan JJ, Charpagne A, Jouët V, Léger R, Lazdunski M, Cohen D, Chumakov I.

Pharmacogenomics J. 2007 Apr;7(2):123-32. Epub 2006 May 30.

PMID:
16733521
48.

Silencing acid-sensing ion channel 1a alters cone-mediated retinal function.

Ettaiche M, Deval E, Cougnon M, Lazdunski M, Voilley N.

J Neurosci. 2006 May 24;26(21):5800-9.

49.

TREK-1, a K+ channel involved in polymodal pain perception.

Alloui A, Zimmermann K, Mamet J, Duprat F, Noël J, Chemin J, Guy N, Blondeau N, Voilley N, Rubat-Coudert C, Borsotto M, Romey G, Heurteaux C, Reeh P, Eschalier A, Lazdunski M.

EMBO J. 2006 Jun 7;25(11):2368-76. Epub 2006 May 4.

50.

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.

Rouault M, Rash LD, Escoubas P, Boilard E, Bollinger J, Lomonte B, Maurin T, Guillaume C, Canaan S, Deregnaucourt C, Schrével J, Doglio A, Gutiérrez JM, Lazdunski M, Gelb MH, Lambeau G.

Biochemistry. 2006 May 9;45(18):5800-16.

Supplemental Content

Loading ...
Support Center