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Items: 14

1.

Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.

Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S.

J Am Chem Soc. 2018 Oct 24;140(42):13542-13545. doi: 10.1021/jacs.8b07328. Epub 2018 Oct 4.

PMID:
30285435
2.

The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport.

May JM, Owens TW, Mandler MD, Simpson BW, Lazarus MB, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D.

J Am Chem Soc. 2017 Dec 6;139(48):17221-17224. doi: 10.1021/jacs.7b07736. Epub 2017 Nov 22.

3.

Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response.

Lazarus MB, Levin RS, Shokat KM.

Cell Signal. 2017 Jan;29:78-83. doi: 10.1016/j.cellsig.2016.10.006. Epub 2016 Oct 17.

4.

How the glycosyltransferase OGT catalyzes amide bond cleavage.

Janetzko J, Trauger SA, Lazarus MB, Walker S.

Nat Chem Biol. 2016 Nov;12(11):899-901. doi: 10.1038/nchembio.2173. Epub 2016 Sep 12.

5.

Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.

Lazarus MB, Shokat KM.

Bioorg Med Chem. 2015 Sep 1;23(17):5483-8. doi: 10.1016/j.bmc.2015.07.034. Epub 2015 Jul 26.

6.

A small molecule that inhibits OGT activity in cells.

Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S.

ACS Chem Biol. 2015 Jun 19;10(6):1392-7. doi: 10.1021/acschembio.5b00004. Epub 2015 Mar 18.

7.

Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors.

Lazarus MB, Novotny CJ, Shokat KM.

ACS Chem Biol. 2015 Jan 16;10(1):257-61. doi: 10.1021/cb500835z. Epub 2015 Jan 6.

8.

Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport.

Sherman DJ, Lazarus MB, Murphy L, Liu C, Walker S, Ruiz N, Kahne D.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4982-7. doi: 10.1073/pnas.1323516111. Epub 2014 Mar 17.

9.

HCF-1 is cleaved in the active site of O-GlcNAc transferase.

Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S.

Science. 2013 Dec 6;342(6163):1235-9. doi: 10.1126/science.1243990.

10.

Structural snapshots of the reaction coordinate for O-GlcNAc transferase.

Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S.

Nat Chem Biol. 2012 Dec;8(12):966-8. doi: 10.1038/nchembio.1109. Epub 2012 Oct 28.

11.

A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase.

Jiang J, Lazarus MB, Pasquina L, Sliz P, Walker S.

Nat Chem Biol. 2011 Nov 13;8(1):72-7. doi: 10.1038/nchembio.711.

12.

Structure of human O-GlcNAc transferase and its complex with a peptide substrate.

Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S.

Nature. 2011 Jan 27;469(7331):564-7. doi: 10.1038/nature09638. Epub 2011 Jan 16.

13.

Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism.

Boehmerle W, Splittgerber U, Lazarus MB, McKenzie KM, Johnston DG, Austin DJ, Ehrlich BE.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18356-61. Epub 2006 Nov 17.

14.

Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics.

Tiyanont K, Doan T, Lazarus MB, Fang X, Rudner DZ, Walker S.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11033-8. Epub 2006 Jul 10.

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