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Items: 8


BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma.

Lazarus KA, Hadi F, Zambon E, Bach K, Santolla MF, Watson JK, Correia LL, Das M, Ugur R, Pensa S, Becker L, Campos LS, Ladds G, Liu P, Evan GI, McCaughan FM, Le Quesne J, Lee JH, Calado D, Khaled WT.

Nat Commun. 2018 Aug 20;9(1):3327. doi: 10.1038/s41467-018-05790-5.


The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma.

Coulson R, Liew SH, Connelly AA, Yee NS, Deb S, Kumar B, Vargas AC, O'Toole SA, Parslow AC, Poh A, Putoczki T, Morrow RJ, Alorro M, Lazarus KA, Yeap EFW, Walton KL, Harrison CA, Hannan NJ, George AJ, Clyne CD, Ernst M, Allen AM, Chand AL.

Oncotarget. 2017 Mar 21;8(12):18640-18656. doi: 10.18632/oncotarget.15553.


Estradiol regulates Tumor Necrosis Factor-α expression and secretion in Estrogen Receptor positive breast cancer cells.

To SQ, Cheung V, Lazarus KA, Knower KC, Clyne CD.

Mol Cell Endocrinol. 2014 Aug 25;394(1-2):21-8. doi: 10.1016/j.mce.2014.06.020. Epub 2014 Jul 5.


Conditional overexpression of liver receptor homolog-1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-β.

Lazarus KA, Brown KA, Young MJ, Zhao Z, Coulson RS, Chand AL, Clyne CD.

Endocrinology. 2014 May;155(5):1606-17. doi: 10.1210/en.2013-1948. Epub 2014 Feb 24.


Oestradiol reduces liver receptor homolog-1 mRNA transcript stability in breast cancer cell lines.

Lazarus KA, Zhao Z, Knower KC, To SQ, Chand AL, Clyne CD.

Biochem Biophys Res Commun. 2013 Aug 30;438(3):533-9. doi: 10.1016/j.bbrc.2013.07.101. Epub 2013 Aug 1.


The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation.

Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD.

PLoS One. 2012;7(2):e31593. doi: 10.1371/journal.pone.0031593. Epub 2012 Feb 16.


Therapeutic potential of Liver Receptor Homolog-1 modulators.

Lazarus KA, Wijayakumara D, Chand AL, Simpson ER, Clyne CD.

J Steroid Biochem Mol Biol. 2012 Jul;130(3-5):138-46. doi: 10.1016/j.jsbmb.2011.12.017. Epub 2012 Jan 14. Review.


Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter.

Fleming NI, Knower KC, Lazarus KA, Fuller PJ, Simpson ER, Clyne CD.

PLoS One. 2010 Dec 20;5(12):e14389. doi: 10.1371/journal.pone.0014389.

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