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Items: 1 to 50 of 95

1.

Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.

van Heusden C, Button B, Anderson WH, Ceppe A, Morton LC, O'Neal WK, Dang H, Alexis NE, Donaldson S, Stephan H, Boucher RC, Lazarowski ER.

Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L356-L365. doi: 10.1152/ajplung.00449.2019. Epub 2019 Dec 4.

PMID:
31800264
2.

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.

Henderson AG, Anderson WH, Ceppe A, Coakley RD, Button B, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Fuller F, Almond M, Qaqish B, Kesimer M, Boucher RC.

COPD. 2018 Dec;15(6):572-580. doi: 10.1080/15412555.2019.1566892. Epub 2019 Feb 4.

3.

Cinnamaldehyde in flavored e-cigarette liquids temporarily suppresses bronchial epithelial cell ciliary motility by dysregulation of mitochondrial function.

Clapp PW, Lavrich KS, van Heusden CA, Lazarowski ER, Carson JL, Jaspers I.

Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L470-L486. doi: 10.1152/ajplung.00304.2018. Epub 2019 Jan 3.

PMID:
30604630
4.

P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata CK, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Lazarowski ER, Blackburn MR, Idzko M.

Front Immunol. 2017 Aug 22;8:1028. doi: 10.3389/fimmu.2017.01028. eCollection 2017.

5.

UDP-glucose promotes neutrophil recruitment in the lung.

Sesma JI, Weitzer CD, Livraghi-Butrico A, Dang H, Donaldson S, Alexis NE, Jacobson KA, Harden TK, Lazarowski ER.

Purinergic Signal. 2016 Dec;12(4):627-635. Epub 2016 Jul 15.

6.

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.

Dickey AS, Pineda VV, Tsunemi T, Liu PP, Miranda HC, Gilmore-Hall SK, Lomas N, Sampat KR, Buttgereit A, Torres MJ, Flores AL, Arreola M, Arbez N, Akimov SS, Gaasterland T, Lazarowski ER, Ross CA, Yeo GW, Sopher BL, Magnuson GK, Pinkerton AB, Masliah E, La Spada AR.

Nat Med. 2016 Jan;22(1):37-45. doi: 10.1038/nm.4003. Epub 2015 Dec 7.

7.

The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.

Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):182-90. doi: 10.1164/rccm.201412-2230OC.

8.

UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.

Lazarowski ER, Harden TK.

Mol Pharmacol. 2015 Jul;88(1):151-60. doi: 10.1124/mol.115.098756. Epub 2015 Mar 31. Review.

9.

Liberation of ATP secondary to hemolysis is not mutually exclusive of regulated export.

Kirby BS, Schwarzbaum PJ, Lazarowski ER, Dinenno FA, McMahon TJ.

Blood. 2015 Mar 12;125(11):1844-5. doi: 10.1182/blood-2014-11-609610. No abstract available.

10.

Inflammation promotes airway epithelial ATP release via calcium-dependent vesicular pathways.

Okada SF, Ribeiro CM, Sesma JI, Seminario-Vidal L, Abdullah LH, van Heusden C, Lazarowski ER, Boucher RC.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):814-20. doi: 10.1165/rcmb.2012-0493OC.

11.

Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes.

Leal Denis MF, Incicco JJ, Espelt MV, Verstraeten SV, Pignataro OP, Lazarowski ER, Schwarzbaum PJ.

Biochim Biophys Acta. 2013 Oct;1830(10):4692-707. doi: 10.1016/j.bbagen.2013.05.033. Epub 2013 Jun 4. Erratum in: Biochim Biophys Acta. 2014 Jun;1840(6):1837.

12.

A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Barrett MO, Sesma JI, Ball CB, Jayasekara PS, Jacobson KA, Lazarowski ER, Harden TK.

Mol Pharmacol. 2013 Jul;84(1):41-9. doi: 10.1124/mol.113.085654. Epub 2013 Apr 16.

13.

Vesicular nucleotide transporter regulates the nucleotide content in airway epithelial mucin granules.

Sesma JI, Kreda SM, Okada SF, van Heusden C, Moussa L, Jones LC, O'Neal WK, Togawa N, Hiasa M, Moriyama Y, Lazarowski ER.

Am J Physiol Cell Physiol. 2013 May 15;304(10):C976-84. doi: 10.1152/ajpcell.00371.2012. Epub 2013 Mar 6. Erratum in: Am J Physiol Cell Physiol. 2014 Feb 15;306(4):C415.

14.

PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, Lazarowski ER, Damian VA, Masliah E, La Spada AR.

Sci Transl Med. 2012 Jul 11;4(142):142ra97. doi: 10.1126/scitranslmed.3003799.

15.

The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.

Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER.

Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C490-8. doi: 10.1152/ajpcell.00138.2012. Epub 2012 Jun 6.

16.

Vesicular and conductive mechanisms of nucleotide release.

Lazarowski ER.

Purinergic Signal. 2012 Sep;8(3):359-73. doi: 10.1007/s11302-012-9304-9. Epub 2012 Apr 12. Review.

17.

Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism.

Tadie JM, Bae HB, Deshane JS, Bell CP, Lazarowski ER, Chaplin DD, Thannickal VJ, Abraham E, Zmijewski JW.

Mol Med. 2012 May 9;18:659-68. doi: 10.2119/molmed.2011.00401.

18.

VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells.

Jones LC, Moussa L, Fulcher ML, Zhu Y, Hudson EJ, O'Neal WK, Randell SH, Lazarowski ER, Boucher RC, Kreda SM.

J Physiol. 2012 Feb 1;590(3):545-62. doi: 10.1113/jphysiol.2011.222091. Epub 2011 Dec 5.

19.

Homeostasis of extracellular ATP in human erythrocytes.

Montalbetti N, Leal Denis MF, Pignataro OP, Kobatake E, Lazarowski ER, Schwarzbaum PJ.

J Biol Chem. 2011 Nov 4;286(44):38397-407. doi: 10.1074/jbc.M111.221713. Epub 2011 Sep 15.

20.

Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia.

Seminario-Vidal L, Okada SF, Sesma JI, Kreda SM, van Heusden CA, Zhu Y, Jones LC, O'Neal WK, Penuela S, Laird DW, Boucher RC, Lazarowski ER.

J Biol Chem. 2011 Jul 29;286(30):26277-86. doi: 10.1074/jbc.M111.260562. Epub 2011 May 23.

21.

Molecular mechanisms of purine and pyrimidine nucleotide release.

Lazarowski ER, Sesma JI, Seminario-Vidal L, Kreda SM.

Adv Pharmacol. 2011;61:221-61. doi: 10.1016/B978-0-12-385526-8.00008-4. Review.

PMID:
21586361
22.

Computational model for the regulation of extracellular ATP and adenosine in airway epithelia.

Garcia GJ, Picher M, Zuo P, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC.

Subcell Biochem. 2011;55:51-74. doi: 10.1007/978-94-007-1217-1_3. Review.

PMID:
21560044
23.

Nucleotide release by airway epithelia.

Lazarowski ER, Sesma JI, Seminario L, Esther CR Jr, Kreda SM.

Subcell Biochem. 2011;55:1-15. doi: 10.1007/978-94-007-1217-1_1. Review.

PMID:
21560042
24.

Erratum to: Ebselen is a potent non-competitive inhibitor of extracellular nucleoside diphosphokinase.

Seminario-Vidal L, van Heusden C, Mugesh G, Lazarowski ER.

Purinergic Signal. 2011 Jun;7(2):277. doi: 10.1007/s11302-011-9230-2. No abstract available.

25.

Ebselen is a potent non-competitive inhibitor of extracellular nucleoside diphosphokinase.

Semianrio-Vidal L, van Hesuden C, Mugesh G, Lazarowski ER.

Purinergic Signal. 2010 Dec;6(4):383-91. doi: 10.1007/s11302-010-9203-x. Epub 2010 Nov 3.

26.

Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.

Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS.

Nature. 2010 Oct 14;467(7317):863-7. doi: 10.1038/nature09413.

27.

Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium.

Okada SF, Zhang L, Kreda SM, Abdullah LH, Davis CW, Pickles RJ, Lazarowski ER, Boucher RC.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):253-60. doi: 10.1165/rcmb.2010-0253OC. Epub 2010 Oct 8.

28.

Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase.

Zmijewski JW, Banerjee S, Bae H, Friggeri A, Lazarowski ER, Abraham E.

J Biol Chem. 2010 Oct 22;285(43):33154-64. doi: 10.1074/jbc.M110.143685. Epub 2010 Aug 20.

29.

Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides.

Kreda SM, Seminario-Vidal L, van Heusden CA, O'Neal W, Jones L, Boucher RC, Lazarowski ER.

J Physiol. 2010 Jun 15;588(Pt 12):2255-67. doi: 10.1113/jphysiol.2009.186643. Epub 2010 Apr 26.

30.

Signalling and pharmacological properties of the P2Y receptor.

Harden TK, Sesma JI, Fricks IP, Lazarowski ER.

Acta Physiol (Oxf). 2010 Jun;199(2):149-60. doi: 10.1111/j.1748-1716.2010.02116.x. Epub 2010 Mar 24. Review.

31.

Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.

Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK.

Mol Pharmacol. 2009 Dec;76(6):1341-8. doi: 10.1124/mol.109.058578. Epub 2009 Sep 16.

32.

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.

Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, Park D, Woodson RI, Ostankovich M, Sharma P, Lysiak JJ, Harden TK, Leitinger N, Ravichandran KS.

Nature. 2009 Sep 10;461(7261):282-6. doi: 10.1038/nature08296.

33.

Quantification of extracellular UDP-galactose.

Lazarowski ER.

Anal Biochem. 2010 Jan 1;396(1):23-9. doi: 10.1016/j.ab.2009.08.022. Epub 2009 Aug 21.

34.

Assessment of extracellular ATP concentrations.

Seminario-Vidal L, Lazarowski ER, Okada SF.

Methods Mol Biol. 2009;574:25-36. doi: 10.1007/978-1-60327-321-3_3.

PMID:
19685297
35.

Neutrophilic inflammation is associated with altered airway hydration in stable asthmatics.

Loughlin CE, Esther CR Jr, Lazarowski ER, Alexis NE, Peden DB.

Respir Med. 2010 Jan;104(1):29-33. doi: 10.1016/j.rmed.2009.07.002. Epub 2009 Jul 30.

36.

Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways.

Seminario-Vidal L, Kreda S, Jones L, O'Neal W, Trejo J, Boucher RC, Lazarowski ER.

J Biol Chem. 2009 Jul 31;284(31):20638-48. doi: 10.1074/jbc.M109.004762. Epub 2009 May 12.

37.

[Purinergic signals].

Lazarowski ER, Schwarzbaum PJ.

Medicina (B Aires). 2009;69(2):267-76. Review. Spanish.

PMID:
19435702
38.

Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.

Fricks IP, Carter RL, Lazarowski ER, Harden TK.

J Pharmacol Exp Ther. 2009 Jul;330(1):162-8. doi: 10.1124/jpet.109.150730. Epub 2009 Apr 1.

39.

Purinergic receptors in airway epithelia.

Lazarowski ER, Boucher RC.

Curr Opin Pharmacol. 2009 Jun;9(3):262-7. doi: 10.1016/j.coph.2009.02.004. Epub 2009 Mar 13. Review.

40.

Endoplasmic reticulum/golgi nucleotide sugar transporters contribute to the cellular release of UDP-sugar signaling molecules.

Sesma JI, Esther CR Jr, Kreda SM, Jones L, O'Neal W, Nishihara S, Nicholas RA, Lazarowski ER.

J Biol Chem. 2009 May 1;284(18):12572-83. doi: 10.1074/jbc.M806759200. Epub 2009 Mar 10.

41.

Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway.

Esther CR Jr, Sesma JI, Dohlman HG, Ault AD, Clas ML, Lazarowski ER, Boucher RC.

Biochemistry. 2008 Sep 2;47(35):9269-78. doi: 10.1021/bi800855k. Epub 2008 Aug 12. Erratum in: Biochemistry. 2008 Nov 4;47(44):11693. Sesma, Juliana I [added].

42.

Influenza A virus inhibits alveolar fluid clearance in BALB/c mice.

Wolk KE, Lazarowski ER, Traylor ZP, Yu EN, Jewell NA, Durbin RK, Durbin JE, Davis IC.

Am J Respir Crit Care Med. 2008 Nov 1;178(9):969-76. doi: 10.1164/rccm.200803-455OC. Epub 2008 Aug 8.

43.

Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis.

Zuo P, Picher M, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC.

J Biol Chem. 2008 Sep 26;283(39):26805-19. doi: 10.1074/jbc.M801516200. Epub 2008 Jul 28.

44.

Extracellular purines are biomarkers of neutrophilic airway inflammation.

Esther CR Jr, Alexis NE, Clas ML, Lazarowski ER, Donaldson SH, Ribeiro CM, Moore CG, Davis SD, Boucher RC.

Eur Respir J. 2008 May;31(5):949-56. doi: 10.1183/09031936.00089807. Epub 2008 Feb 6.

45.

UDP is a competitive antagonist at the human P2Y14 receptor.

Fricks IP, Maddileti S, Carter RL, Lazarowski ER, Nicholas RA, Jacobson KA, Harden TK.

J Pharmacol Exp Ther. 2008 May;325(2):588-94. doi: 10.1124/jpet.108.136309. Epub 2008 Feb 5.

46.

Thrombin-promoted release of UDP-glucose from human astrocytoma cells.

Kreda SM, Seminario-Vidal L, Heusden Cv, Lazarowski ER.

Br J Pharmacol. 2008 Apr;153(7):1528-37. doi: 10.1038/sj.bjp.0707692. Epub 2008 Jan 21.

47.

Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases.

Hirsh AJ, Stonebraker JR, van Heusden CA, Lazarowski ER, Boucher RC, Picher M.

Biochemistry. 2007 Sep 11;46(36):10373-83. Epub 2007 Aug 15.

PMID:
17696452
48.

Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells.

Kreda SM, Okada SF, van Heusden CA, O'Neal W, Gabriel S, Abdullah L, Davis CW, Boucher RC, Lazarowski ER.

J Physiol. 2007 Oct 1;584(Pt 1):245-59. Epub 2007 Jul 26.

49.

Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection.

Davis IC, Lazarowski ER, Chen FP, Hickman-Davis JM, Sullender WM, Matalon S.

Am J Respir Cell Mol Biol. 2007 Oct;37(4):379-86. Epub 2007 May 31.

50.

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.

Weydt P, Pineda VV, Torrence AE, Libby RT, Satterfield TF, Lazarowski ER, Gilbert ML, Morton GJ, Bammler TK, Strand AD, Cui L, Beyer RP, Easley CN, Smith AC, Krainc D, Luquet S, Sweet IR, Schwartz MW, La Spada AR.

Cell Metab. 2006 Nov;4(5):349-62. Epub 2006 Oct 19.

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