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Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance.

Spohn R, Daruka L, Lázár V, Martins A, Vidovics F, Grézal G, Méhi O, Kintses B, Számel M, Jangir PK, Csörgő B, Györkei Á, Bódi Z, Faragó A, Bodai L, Földesi I, Kata D, Maróti G, Pap B, Wirth R, Papp B, Pál C.

Nat Commun. 2019 Oct 4;10(1):4538. doi: 10.1038/s41467-019-12364-6.


Transient antibiotic resistance calls for attention.

Lázár V, Kishony R.

Nat Microbiol. 2019 Oct;4(10):1606-1607. doi: 10.1038/s41564-019-0571-x. No abstract available.


SERS-based differential diagnosis between multiple solid malignancies: breast, colorectal, lung, ovarian and oral cancer.

Moisoiu V, Stefancu A, Gulei D, Boitor R, Magdo L, Raduly L, Pasca S, Kubelac P, Mehterov N, Chiș V, Simon M, Muresan M, Irimie AI, Baciut M, Stiufiuc R, Pavel IE, Achimas-Cadariu P, Ionescu C, Lazar V, Sarafian V, Notingher I, Leopold N, Berindan-Neagoe I.

Int J Nanomedicine. 2019 Aug 2;14:6165-6178. doi: 10.2147/IJN.S198684. eCollection 2019.


Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion.

Dunai A, Spohn R, Farkas Z, Lázár V, Györkei Á, Apjok G, Boross G, Szappanos B, Grézal G, Faragó A, Bodai L, Papp B, Pál C.

Elife. 2019 Aug 16;8. pii: e47088. doi: 10.7554/eLife.47088.


Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA.

Kundu K, Ghosh S, Sarkar R, Edri A, Brusilovsky M, Gershoni-Yahalom O, Yossef R, Shemesh A, Soria JC, Lazar V, Joshua BZ, Campbell KS, Elkabets M, Porgador A.

Cancer Immunol Res. 2019 Jul;7(7):1120-1134. doi: 10.1158/2326-6066.CIR-19-0023. Epub 2019 Jun 4.


Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations.

Apjok G, Boross G, Nyerges Á, Fekete G, Lázár V, Papp B, Pál C, Csörgő B.

Mol Biol Evol. 2019 Aug 1;36(8):1601-1611. doi: 10.1093/molbev/msz109.


Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial.

Rodon J, Soria JC, Berger R, Miller WH, Rubin E, Kugel A, Tsimberidou A, Saintigny P, Ackerstein A, Braña I, Loriot Y, Afshar M, Miller V, Wunder F, Bresson C, Martini JF, Raynaud J, Mendelsohn J, Batist G, Onn A, Tabernero J, Schilsky RL, Lazar V, Lee JJ, Kurzrock R.

Nat Med. 2019 May;25(5):751-758. doi: 10.1038/s41591-019-0424-4. Epub 2019 Apr 22.


Gut Microbiota, Host Organism, and Diet Trialogue in Diabetes and Obesity.

Lazar V, Ditu LM, Pircalabioru GG, Picu A, Petcu L, Cucu N, Chifiriuc MC.

Front Nutr. 2019 Mar 13;6:21. doi: 10.3389/fnut.2019.00021. eCollection 2019. Review.


Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy.

Ghosh S, Prasad M, Kundu K, Cohen L, Yegodayev KM, Zorea J, Joshua BZ, Lasry B, Dimitstein O, Bahat-Dinur A, Mizrachi A, Lazar V, Elkabets M, Porgador A.

Front Oncol. 2019 Jan 22;9:17. doi: 10.3389/fonc.2019.00017. eCollection 2019.


Impact of Pseudomonas aeruginosa quorum sensing signaling molecules on adhesion and inflammatory markers in endothelial cells.

Curutiu C, Iordache F, Lazar V, Pisoschi AM, Pop A, Chifiriuc MC, Hoban AM.

Beilstein J Org Chem. 2018 Oct 5;14:2580-2588. doi: 10.3762/bjoc.14.235. eCollection 2018.


A Novel Natural Antimicrobial Can Reduce the in vitro and in vivo Pathogenicity of T6SS Positive Campylobacter jejuni and Campylobacter coli Chicken Isolates.

Sima F, Stratakos AC, Ward P, Linton M, Kelly C, Pinkerton L, Stef L, Gundogdu O, Lazar V, Corcionivoschi N.

Front Microbiol. 2018 Sep 7;9:2139. doi: 10.3389/fmicb.2018.02139. eCollection 2018.


Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer.

Lazar V, Ditu LM, Pircalabioru GG, Gheorghe I, Curutiu C, Holban AM, Picu A, Petcu L, Chifiriuc MC.

Front Immunol. 2018 Aug 15;9:1830. doi: 10.3389/fimmu.2018.01830. eCollection 2018. Review.


Bioactive Natural Products 2018.

Kourkoutas Y, Chorianopoulos N, Lazar V, Di Ciccio P.

Biomed Res Int. 2018 May 27;2018:5063437. doi: 10.1155/2018/5063437. eCollection 2018. No abstract available.


Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.

Lázár V, Martins A, Spohn R, Daruka L, Grézal G, Fekete G, Számel M, Jangir PK, Kintses B, Csörgő B, Nyerges Á, Györkei Á, Kincses A, Dér A, Walter FR, Deli MA, Urbán E, Hegedűs Z, Olajos G, Méhi O, Bálint B, Nagy I, Martinek TA, Papp B, Pál C.

Nat Microbiol. 2018 Jun;3(6):718-731. doi: 10.1038/s41564-018-0164-0. Epub 2018 May 24.


Genetic alterations in sporadic triple negative breast cancer.

Pop LA, Cojocneanu-Petric RM, Pileczki V, Morar-Bolba G, Irimie A, Lazar V, Lombardo C, Paradiso A, Berindan-Neagoe I.

Breast. 2018 Apr;38:30-38. doi: 10.1016/j.breast.2017.11.006. Epub 2017 Dec 5.


Development and Biocompatibility Evaluation of Photocatalytic TiO₂/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes.

Nica IC, Stan MS, Popa M, Chifiriuc MC, Pircalabioru GG, Lazar V, Dumitrescu I, Diamandescu L, Feder M, Baibarac M, Cernea M, Maraloiu VA, Popescu T, Dinischiotu A.

Nanomaterials (Basel). 2017 Sep 19;7(9). pii: E279. doi: 10.3390/nano7090279.


Photocatalytic, Antimicrobial and Biocompatibility Features of Cotton Knit Coated with Fe-N-Doped Titanium Dioxide Nanoparticles.

Stan MS, Nica IC, Dinischiotu A, Varzaru E, Iordache OG, Dumitrescu I, Popa M, Chifiriuc MC, Pircalabioru GG, Lazar V, Bezirtzoglou E, Feder M, Diamandescu L.

Materials (Basel). 2016 Sep 21;9(9). pii: E789. doi: 10.3390/ma9090789.


Correction: Phenotypic heterogeneity promotes adaptive evolution.

Bódi Z, Farkas Z, Nevozhay D, Kalapis D, Lázár V, Csörgő B, Nyerges Á, Szamecz B, Fekete G, Papp B, Araújo H, Oliveira JL, Moura G, Santos MAS, Székely T Jr, Balázsi G, Pál C.

PLoS Biol. 2017 Jun 20;15(6):e1002607. doi: 10.1371/journal.pbio.1002607. eCollection 2017 Jun.


Antibiotic Resistance and Virulence Phenotypes of Recent Bacterial Strains Isolated from Urinary Tract Infections in Elderly Patients with Prostatic Disease.

Delcaru C, Podgoreanu P, Alexandru I, Popescu N, Măruţescu L, Bleotu C, Mogoşanu GD, Chifiriuc MC, Gluck M, Lazăr V.

Pathogens. 2017 May 31;6(2). pii: E22. doi: 10.3390/pathogens6020022.


Phenotypic heterogeneity promotes adaptive evolution.

Bódi Z, Farkas Z, Nevozhay D, Kalapis D, Lázár V, Csörgő B, Nyerges Á, Szamecz B, Fekete G, Papp B, Araújo H, Oliveira JL, Moura G, Santos MAS, Székely T Jr, Balázsi G, Pál C.

PLoS Biol. 2017 May 9;15(5):e2000644. doi: 10.1371/journal.pbio.2000644. eCollection 2017 May. Erratum in: PLoS Biol. 2017 Jun 20;15(6):e1002607.


Optimized silicon reinforcement of carbon coatings by pulsed laser technique for superior functional biomedical surfaces fabrication.

Mihailescu IN, Bociaga D, Popescu-Pelin G, Stan GE, Duta L, Socol G, Chifiriuc MC, Bleotu C, Lazar V, Husanu MA, Zgura I, Miculescu F, Negut I, Hapenciuc C.

Biofabrication. 2017 Jun 1;9(2):025029. doi: 10.1088/1758-5090/aa7076.


High-Throughput Genomics and Clinical Outcome in Hard-to-Treat Advanced Cancers: Results of the MOSCATO 01 Trial.

Massard C, Michiels S, Ferté C, Le Deley MC, Lacroix L, Hollebecque A, Verlingue L, Ileana E, Rosellini S, Ammari S, Ngo-Camus M, Bahleda R, Gazzah A, Varga A, Postel-Vinay S, Loriot Y, Even C, Breuskin I, Auger N, Job B, De Baere T, Deschamps F, Vielh P, Scoazec JY, Lazar V, Richon C, Ribrag V, Deutsch E, Angevin E, Vassal G, Eggermont A, André F, Soria JC.

Cancer Discov. 2017 Jun;7(6):586-595. doi: 10.1158/2159-8290.CD-16-1396. Epub 2017 Apr 1.


Interaction of New-Developed TiO₂-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts.

Nica IC, Stan MS, Popa M, Chifiriuc MC, Lazar V, Pircalabioru GG, Dumitrescu I, Ignat M, Feder M, Tanase LC, Mercioniu I, Diamandescu L, Dinischiotu A.

Int J Mol Sci. 2017 Jan 25;18(2). pii: E249. doi: 10.3390/ijms18020249.


Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds.

Saviuc C, Ciubucă B, Dincă G, Bleotu C, Drumea V, Chifiriuc MC, Popa M, Pircalabioru GG, Marutescu L, Lazăr V.

Int J Mol Sci. 2017 Jan 17;18(1). pii: E175. doi: 10.3390/ijms18010175.


Shared and unique patterns of phenotypic diversification along a stream gradient in two congeneric species.

Jourdan J, Krause ST, Lazar VM, Zimmer C, Sommer-Trembo C, Arias-Rodriguez L, Klaus S, Riesch R, Plath M.

Sci Rep. 2016 Dec 16;6:38971. doi: 10.1038/srep38971.


Microbial Biofilms in Urinary Tract Infections and Prostatitis: Etiology, Pathogenicity, and Combating strategies.

Delcaru C, Alexandru I, Podgoreanu P, Grosu M, Stavropoulos E, Chifiriuc MC, Lazar V.

Pathogens. 2016 Nov 30;5(4). pii: E65. Review.


Novel insight into triple-negative breast cancers, the emerging role of angiogenesis, and antiangiogenic therapy.

Braicu C, Chiorean R, Irimie A, Chira S, Tomuleasa C, Neagoe E, Paradiso A, Achimas-Cadariu P, Lazar V, Berindan-Neagoe I.

Expert Rev Mol Med. 2016 Nov 7;18:e18. Review.


MMS19 as a potential predictive marker of adjuvant chemotherapy benefit in resected non-small cell lung cancer.

Adam J, Sourisseau T, Olaussen KA, Robin A, Zhu CQ, Templier A, Civet A, Girard P, Lazar V, Validire P, Tsao MS, Soria JC, Besse B.

Cancer Biomark. 2016 Sep 26;17(3):323-333.


DUX4-induced constitutive DNA damage and oxidative stress contribute to aberrant differentiation of myoblasts from FSHD patients.

Dmitriev P, Bou Saada Y, Dib C, Ansseau E, Barat A, Hamade A, Dessen P, Robert T, Lazar V, Louzada RAN, Dupuy C, Zakharova V, Carnac G, Lipinski M, Vassetzky YS.

Free Radic Biol Med. 2016 Oct;99:244-258. doi: 10.1016/j.freeradbiomed.2016.08.007. Epub 2016 Aug 9.


Antibiotics: New recipe for targeting resistance.

Papp B, Lázár V.

Nat Chem Biol. 2016 Oct 18;12(11):891-892. doi: 10.1038/nchembio.2215. No abstract available.


First report of OXA-72 producing Acinetobacter baumannii in Romania.

Georgescu M, Gheorghe I, Dudu A, Czobor I, Costache M, Cristea VC, Lazăr V, Chifiriuc MC.

New Microbes New Infect. 2016 Jul 21;13:87-8. doi: 10.1016/j.nmni.2016.07.004. eCollection 2016 Sep.


Efficient transmission of IncFIIY and IncL plasmids and Klebsiella pneumoniae ST101 clone producing OXA-48, NDM-1 or OXA-181 in Bucharest hospitals.

Czobor I, Novais Â, Rodrigues C, Chifiriuc MC, Mihăescu G, Lazăr V, Peixe L.

Int J Antimicrob Agents. 2016 Aug;48(2):223-4. doi: 10.1016/j.ijantimicag.2016.05.004. Epub 2016 Jun 23. No abstract available.


Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications.

Rădulescu M, Holban AM, Mogoantă L, Bălşeanu TA, Mogoșanu GD, Savu D, Popescu RC, Fufă O, Grumezescu AM, Bezirtzoglou E, Lazar V, Chifiriuc MC.

Molecules. 2016 Jun 10;21(6). pii: E761. doi: 10.3390/molecules21060761.


Association of Biomarker-Based Treatment Strategies With Response Rates and Progression-Free Survival in Refractory Malignant Neoplasms: A Meta-analysis.

Schwaederle M, Zhao M, Lee JJ, Lazar V, Leyland-Jones B, Schilsky RL, Mendelsohn J, Kurzrock R.

JAMA Oncol. 2016 Nov 1;2(11):1452-1459. doi: 10.1001/jamaoncol.2016.2129.


Adaptive evolution of complex innovations through stepwise metabolic niche expansion.

Szappanos B, Fritzemeier J, Csörgő B, Lázár V, Lu X, Fekete G, Bálint B, Herczeg R, Nagy I, Notebaart RA, Lercher MJ, Pál C, Papp B.

Nat Commun. 2016 May 20;7:11607. doi: 10.1038/ncomms11607.


Virulence and resistance features of Pseudomonas aeruginosa strains isolated from chronic leg ulcers.

Georgescu M, Gheorghe I, Curutiu C, Lazar V, Bleotu C, Chifiriuc MC.

BMC Infect Dis. 2016 Mar 8;16 Suppl 1:92. doi: 10.1186/s12879-016-1396-3.


Antimicrobial coatings based on zinc oxide and orange oil for improved bioactive wound dressings and other applications.

Rădulescu M, Andronescu E, Cirja A, Holban AM, Mogoantă L, Bălşeanu TA, Cătălin B, Neagu TP, Lascăr I, Florea DA, Grumezescu AM, Ciubuca B, Lazăr V, Chifiriuc MC, Bolocan A.

Rom J Morphol Embryol. 2016;57(1):107-14.


Pregaming, Drinking Duration, and Movement as Unique Predictors of Alcohol Use and Cognitions Among Mandated College Students.

Yurasek A, Miller MB, Mastroleo N, Lazar V, Borsari B.

Subst Use Misuse. 2016 Jul 2;51(8):993-1001. doi: 10.3109/10826084.2016.1152491. Epub 2016 Apr 12.


Antagonistic activities of some Bifidobacterium sp. strains isolated from resident infant gastrointestinal microbiota on Gram-negative enteric pathogens.

Delcaru C, Alexandru I, Podgoreanu P, Cristea VC, Bleotu C, Chifiriuc MC, Bezirtzoglou E, Lazar V.

Anaerobe. 2016 Jun;39:39-44. doi: 10.1016/j.anaerobe.2016.02.010. Epub 2016 Feb 26.


A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species.

Nyerges Á, Csörgő B, Nagy I, Bálint B, Bihari P, Lázár V, Apjok G, Umenhoffer K, Bogos B, Pósfai G, Pál C.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2502-7. doi: 10.1073/pnas.1520040113. Epub 2016 Feb 16.


Efficiency of gentamicin loaded in bacterial polysaccharides microcapsules against intracellular Gram-positive and Gram-negative invasive pathogens.

Croitoru CD, Mihaiescu DE, Chifiriuc MC, Bolocan A, Bleotu C, Grumezescu AM, Saviuc CM, Lazăr V, Curuţiu C.

Rom J Morphol Embryol. 2015;56(4):1417-21.


Effects of Pseudomonas aeruginosa infection on the expression profile of transient receptor potential-like (TRPL) gene from Drosophila melanogaster.

Mihalache (Radu) MR, Raþiu AC, Neagu A, Lazãr V, Chifiriuc MC, Ecovoiu AA.

Roum Arch Microbiol Immunol. 2016 Jan-Jun;75(1-2):32-6.


Expression signature of some immunity genes triggered in Apis mellifera carpatica model by Pseudomonas entomophila experimental infection.

Neagu A, Raþiu AC, Mihalache (Radu) MR, Lazãr V, Chifiriuc MC, Ecovoiu AA.

Roum Arch Microbiol Immunol. 2016 Jan-Jun;75(1-2):18-24.


Innovative Self-Cleaning and Biocompatible Polyester Textiles Nano-Decorated with Fe-N-Doped Titanium Dioxide.

Nica IC, Stan MS, Dinischiotu A, Popa M, Chifiriuc MC, Lazar V, Pircalabioru GG, Bezirtzoglou E, Iordache OG, Varzaru E, Dumitrescu I, Feder M, Vasiliu F, Mercioniu I, Diamandescu L.

Nanomaterials (Basel). 2016 Nov 15;6(11). pii: E214. doi: 10.3390/nano6110214.


Phenotypic and Genetic Evaluation of the Influence of Pseudomonas aeruginosa Culture Fractions on the Human Mesenchymal Stem Cells Viability, Apoptotic Pathways and Cytokine Profile.

Holban AM, Bleotu C, Chifiriuc MC, Lazar V.

Curr Stem Cell Res Ther. 2017;12(2):175-180. doi: 10.2174/1574888X10666151026114817.


Chemical Composition and Antipathogenic Activity of Artemisia annua Essential Oil from Romania.

Marinas IC, Oprea E, Chifiriuc MC, Badea IA, Buleandra M, Lazar V.

Chem Biodivers. 2015 Oct;12(10):1554-64. doi: 10.1002/cbdv.201400340.


Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA Approval.

Jardim DL, Schwaederle M, Wei C, Lee JJ, Hong DS, Eggermont AM, Schilsky RL, Mendelsohn J, Lazar V, Kurzrock R.

J Natl Cancer Inst. 2015 Sep 15;107(11). pii: djv253. doi: 10.1093/jnci/djv253. Print 2015 Nov. Erratum in: J Natl Cancer Inst. 2016 Feb;108(2). pii: djv423. doi: 10.1093/jnci/djv423.


Identifying and Assessing Interesting Subgroups in a Heterogeneous Population.

Lee W, Alexeyenko A, Pernemalm M, Guegan J, Dessen P, Lazar V, Lehtiö J, Pawitan Y.

Biomed Res Int. 2015;2015:462549. doi: 10.1155/2015/462549. Epub 2015 Aug 3.


Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials.

Schwaederle M, Zhao M, Lee JJ, Eggermont AM, Schilsky RL, Mendelsohn J, Lazar V, Kurzrock R.

J Clin Oncol. 2015 Nov 10;33(32):3817-25. doi: 10.1200/JCO.2015.61.5997. Epub 2015 Aug 24. Review.

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